2-Ethyl-3-Methylpyrazine

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    15707-23-0

    Molecular formula
    C7H10N2

    SMILES
    CCC1=NC=CN=C1C

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 1001.0
    • Carbowax: 1388.0

  • Odor profile

    Nutty 87.98%
    Roasted 81.52%
    Cocoa 69.82%
    Earthy 69.79%
    Musty 66.18%
    Hazelnut 65.79%
    Potato 60.76%
    Coffee 58.69%
    Green 55.84%
    Chocolate 54.81%

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  • Properties

    XLogP3-AA
    1.1

    Molecular weight
    122.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point

    • 57.00 °C. @ 10.00 mm Hg

    Flash point est.
    64.97 ˚C

    Solubility expt.

    • soluble in water, organic solvents
    • miscible at room temperature (in ethanol)

  • Synonyms

    • 2-ETHYL-3-METHYLPYRAZINE
    • 15707-23-0
    • Pyrazine, 2-ethyl-3-methyl-
    • 2-Methyl-3-ethylpyrazine
    • 3-Ethyl-2-methylpyrazine
    • 2-Ethyl-3-methyl pyrazine
    • FEMA No. 3155
    • 2-Ethyl-3-methylpyrazine, 9CI
    • BRN 0956775
    • 2-ethyl-3-methyl-pyrazine
    • EINECS 239-799-8
    • UNII-9GF35MK66U
    • 9GF35MK66U
    • DTXSID4047464
    • 2-Methyl-3-ethyl pyrazine
    • Pyrazine, 3-ethyl-2-methyl
    • DTXCID2027464
    • FEMA 3155
    • 5-23-05-00418 (Beilstein Handbook Reference)
    • Pyrazine, ethylmethyl-
    • 2-ETHYL-3-METHYLPYRAZINE [FCC]
    • 2-ETHYL-3-METHYL-1,4-PYRAZINE
    • 2-ETHYL-3-METHYLPYRAZINE [FHFI]
    • MFCD00006150
    • 2-Methyl-3-ethyl-pyrazine
    • SCHEMBL108460
    • CHEMBL3187840
    • CHEBI:193620
    • Tox21_302613
    • AKOS015842908
    • CS-W013548
    • NCGC00256746-01
    • AC-16592
    • BS-15466
    • CAS-15707-23-0
    • DB-021037
    • E0361
    • NS00012435
    • 2-Ethyl-3-methylpyrazine, >=98%, FCC, FG
    • D90495
    • EN300-2010184
    • Q17239258
    • 2-Ethyl-3-methylpyrazine, analytical reference material
    • 239-799-8

  • Applications

    2-Ethyl-3-methylpyrazine is a flavor compound with a distinctive roasted peanut, malt, cocoa and coffee note, making it widely employed in the food industry as an aroma enhancer for instant coffee, chocolate confectionery, nut snacks, barbecue seasonings, broths, instant soups and vegetarian meat products; in addition, thanks to its high odor stability, it is used in flavor formulation for tobacco, vape liquids, gourmand-style perfumes and scented candles, and also serves as an intermediate in the synthesis of more complex pyrazine derivatives investigated for pharmaceutical and agrochemical applications, helping to build the deep brown-roasted profile that characterizes many contemporary food and beverage products.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 341.27
    methanol 614.8
    isopropanol 195.49
    water 9.99
    ethyl acetate 304.42
    n-propanol 275.41
    acetone 318.96
    n-butanol 271.69
    acetonitrile 327.77
    DMF 497.31
    toluene 249.05
    isobutanol 211.93
    1,4-dioxane 561.36
    methyl acetate 239.59
    THF 618.66
    2-butanone 292.63
    n-pentanol 212.21
    sec-butanol 198.75
    n-hexane 86.94
    ethylene glycol 113.8
    NMP 688.81
    cyclohexane 94.77
    DMSO 609.0
    n-butyl acetate 308.91
    n-octanol 113.91
    chloroform 1268.2
    n-propyl acetate 214.12
    acetic acid 360.2
    dichloromethane 1470.7
    cyclohexanone 568.46
    propylene glycol 86.79
    isopropyl acetate 179.09
    DMAc 403.68
    2-ethoxyethanol 292.13
    isopentanol 214.96
    n-heptane 55.48
    ethyl formate 281.96
    1,2-dichloroethane 773.63
    n-hexanol 210.57
    2-methoxyethanol 413.23
    isobutyl acetate 142.18
    tetrachloromethane 401.09
    n-pentyl acetate 212.99
    transcutol 614.16
    n-heptanol 116.23
    ethylbenzene 141.27
    MIBK 165.5
    2-propoxyethanol 329.69
    tert-butanol 212.42
    MTBE 234.37
    2-butoxyethanol 207.37
    propionic acid 263.49
    o-xylene 177.57
    formic acid 215.34
    diethyl ether 305.51
    m-xylene 165.6
    p-xylene 192.72
    chlorobenzene 489.31
    dimethyl carbonate 128.73
    n-octane 26.84
    formamide 230.24
    cyclopentanone 617.83
    2-pentanone 275.41
    anisole 240.75
    cyclopentyl methyl ether 356.19
    gamma-butyrolactone 737.8
    1-methoxy-2-propanol 245.09
    pyridine 531.73
    3-pentanone 258.08
    furfural 749.85
    n-dodecane 20.94
    diethylene glycol 245.47
    diisopropyl ether 100.31
    tert-amyl alcohol 227.83
    acetylacetone 275.91
    n-hexadecane 23.75
    acetophenone 222.08
    methyl propionate 248.88
    isopentyl acetate 251.34
    trichloroethylene 1238.8
    n-nonanol 98.12
    cyclohexanol 243.51
    benzyl alcohol 200.3
    2-ethylhexanol 151.39
    isooctanol 99.3
    dipropyl ether 188.65
    1,2-dichlorobenzene 455.59
    ethyl lactate 104.28
    propylene carbonate 400.29
    n-methylformamide 331.89
    2-pentanol 170.0
    n-pentane 72.0
    1-propoxy-2-propanol 214.6
    1-methoxy-2-propyl acetate 211.58
    2-(2-methoxypropoxy) propanol 160.44
    mesitylene 119.99
    ε-caprolactone 468.34
    p-cymene 115.18
    epichlorohydrin 791.23
    1,1,1-trichloroethane 691.58
    2-aminoethanol 179.98
    morpholine-4-carbaldehyde 559.78
    sulfolane 983.83
    2,2,4-trimethylpentane 46.57
    2-methyltetrahydrofuran 486.99
    n-hexyl acetate 234.61
    isooctane 29.16
    2-(2-butoxyethoxy)ethanol 218.27
    sec-butyl acetate 141.62
    tert-butyl acetate 182.25
    decalin 60.65
    glycerin 139.99
    diglyme 433.06
    acrylic acid 264.01
    isopropyl myristate 99.9
    n-butyric acid 349.3
    acetyl acetate 203.69
    di(2-ethylhexyl) phthalate 109.77
    ethyl propionate 196.73
    nitromethane 540.04
    1,2-diethoxyethane 290.47
    benzonitrile 367.17
    trioctyl phosphate 80.72
    1-bromopropane 465.38
    gamma-valerolactone 710.55
    n-decanol 74.26
    triethyl phosphate 121.03
    4-methyl-2-pentanol 95.15
    propionitrile 310.07
    vinylene carbonate 412.16
    1,1,2-trichlorotrifluoroethane 449.22
    DMS 195.52
    cumene 112.9
    2-octanol 89.52
    2-hexanone 214.09
    octyl acetate 123.18
    limonene 150.94
    1,2-dimethoxyethane 432.5
    ethyl orthosilicate 118.4
    tributyl phosphate 109.73
    diacetone alcohol 180.27
    N,N-dimethylaniline 184.13
    acrylonitrile 390.66
    aniline 299.35
    1,3-propanediol 228.02
    bromobenzene 550.85
    dibromomethane 982.8
    1,1,2,2-tetrachloroethane 911.05
    2-methyl-cyclohexyl acetate 175.8
    tetrabutyl urea 130.04
    diisobutyl methanol 88.12
    2-phenylethanol 216.11
    styrene 182.2
    dioctyl adipate 130.1
    dimethyl sulfate 230.02
    ethyl butyrate 218.25
    methyl lactate 125.15
    butyl lactate 138.49
    diethyl carbonate 165.19
    propanediol butyl ether 143.38
    triethyl orthoformate 153.84
    p-tert-butyltoluene 105.73
    methyl 4-tert-butylbenzoate 185.1
    morpholine 493.85
    tert-butylamine 167.17
    n-dodecanol 59.6
    dimethoxymethane 320.93
    ethylene carbonate 340.13
    cyrene 187.8
    2-ethoxyethyl acetate 249.35
    2-ethylhexyl acetate 222.71
    1,2,4-trichlorobenzene 493.62
    4-methylpyridine 531.31
    dibutyl ether 166.58
    2,6-dimethyl-4-heptanol 88.12
    DEF 386.13
    dimethyl isosorbide 319.38
    tetrachloroethylene 747.4
    eugenol 187.19
    triacetin 177.83
    span 80 146.41
    1,4-butanediol 127.37
    1,1-dichloroethane 629.66
    2-methyl-1-pentanol 202.54
    methyl formate 285.1
    2-methyl-1-butanol 242.28
    n-decane 32.49
    butyronitrile 343.39
    3,7-dimethyl-1-octanol 105.68
    1-chlorooctane 116.61
    1-chlorotetradecane 51.02
    n-nonane 33.93
    undecane 25.1
    tert-butylcyclohexane 59.26
    cyclooctane 42.52
    cyclopentanol 274.94
    tetrahydropyran 441.69
    tert-amyl methyl ether 207.14
    2,5,8-trioxanonane 276.75
    1-hexene 190.7
    2-isopropoxyethanol 188.9
    2,2,2-trifluoroethanol 172.54
    methyl butyrate 274.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Chicory root, roasted 2 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 4.83%
Carob bean extract 1 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 0.01%