2-Ethoxythiazole

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  • Identifiers

    CAS number
    15679-19-3

    Molecular formula
    C5H7NOS

    SMILES
    CCOC1=NC=CS1

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 68.6%
    Green 65.87%
    Sweet 59.49%
    Roasted 58.4%
    Vegetable 57.92%
    Meaty 55.62%
    Burnt 46.36%
    Coffee 43.57%
    Earthy 42.27%
    Sulfurous 42.1%

     

    Flavor
    Nutty 54.67%
    Green 51.84%
    Sweet 49.22%
    Earthy 41.82%
    Coffee 35.41%
    Vegetable 35.05%
    Fruity 33.43%
    Roasted 30.06%
    Musty 25.38%
    Potato 25.1%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    6.87 (neutral)

    Molecular weight
    129.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point

    • 157.00 to 160.00 °C. @ 760.00 mm Hg

    Flash point

    • 55.5 ˚C est.

    Solubility expt.

    • slightly
    • Insoluble in water; Soluble in organic solvents
    • Miscible at room temperature (in ethanol)

  • Synonyms

    • 2-Ethoxythiazole
    • 15679-19-3
    • 2-Ethoxy-1,3-thiazole
    • Thiazole, 2-ethoxy-
    • Ethyl 2-thiazolyl ether
    • 2-Thiazolyl ethyl ether
    • FEMA No. 3340
    • Q3O421Q24K
    • EINECS 239-760-5
    • Thiazole, ethoxy-
    • 2-ETHOXYTHIAZOLE [FHFI]
    • DTXSID00166130
    • 2-ethoxy-thiazol
    • UNII-Q3O421Q24K
    • 2-ethoxy-thiazole
    • MFCD00055026
    • SCHEMBL577582
    • DTXCID5088621
    • FEMA 3340
    • 2-Ethoxythiazole, >=99%, FG
    • AKOS006341293
    • CS-W013447
    • BP-10158
    • BS-15721
    • DB-021032
    • E0669
    • NS00021701
    • D84242
    • EN300-1196155
    • Q27286962
    • InChI=1/C5H7NOS/c1-2-7-5-6-3-4-8-5/h3-4H,2H2,1H
    • 239-760-5

  • Applications

    2-Ethoxythiazole (CAS 15679-19-3) is a sulfur–nitrogen heterocycle mainly employed as an intermediate in the synthesis of pharmaceuticals, agrochemicals and functional materials; its activated thiazole ring and lipophilic ethoxy group enable the introduction of antibacterial, antifungal or enzyme-modulating motifs into target molecules, while serving as a valuable building block for cross-coupling, heterocyclic bridging reactions and the development of drug discovery libraries, flavor/fragrance ingredients and advanced chemical sensors.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 222.98
    methanol 366.74
    isopropanol 178.4
    water 3.47
    ethyl acetate 456.82
    n-propanol 183.74
    acetone 829.01
    n-butanol 188.44
    acetonitrile 586.93
    DMF 1572.34
    toluene 260.32
    isobutanol 166.05
    1,4-dioxane 772.22
    methyl acetate 489.62
    THF 864.43
    2-butanone 546.54
    n-pentanol 201.94
    sec-butanol 185.25
    n-hexane 49.79
    ethylene glycol 149.51
    NMP 1322.57
    cyclohexane 65.74
    DMSO 1732.98
    n-butyl acetate 355.17
    n-octanol 155.73
    chloroform 1131.76
    n-propyl acetate 392.39
    acetic acid 485.18
    dichloromethane 1361.31
    cyclohexanone 749.3
    propylene glycol 116.2
    isopropyl acetate 293.18
    DMAc 1264.56
    2-ethoxyethanol 466.63
    isopentanol 183.75
    n-heptane 46.27
    ethyl formate 354.45
    1,2-dichloroethane 892.44
    n-hexanol 175.49
    2-methoxyethanol 633.65
    isobutyl acetate 259.37
    tetrachloromethane 237.37
    n-pentyl acetate 275.54
    transcutol 915.06
    n-heptanol 111.65
    ethylbenzene 178.47
    MIBK 284.97
    2-propoxyethanol 428.73
    tert-butanol 247.5
    MTBE 303.86
    2-butoxyethanol 264.41
    propionic acid 291.81
    o-xylene 213.27
    formic acid 177.34
    diethyl ether 314.56
    m-xylene 205.17
    p-xylene 269.65
    chlorobenzene 550.28
    dimethyl carbonate 331.19
    n-octane 29.95
    formamide 279.98
    cyclopentanone 1013.19
    2-pentanone 432.5
    anisole 467.38
    cyclopentyl methyl ether 414.01
    gamma-butyrolactone 1056.61
    1-methoxy-2-propanol 430.5
    pyridine 729.47
    3-pentanone 409.41
    furfural 1211.25
    n-dodecane 33.63
    diethylene glycol 419.12
    diisopropyl ether 135.9
    tert-amyl alcohol 234.8
    acetylacetone 756.58
    n-hexadecane 38.26
    acetophenone 498.75
    methyl propionate 422.51
    isopentyl acetate 295.01
    trichloroethylene 1592.49
    n-nonanol 140.82
    cyclohexanol 226.74
    benzyl alcohol 331.65
    2-ethylhexanol 147.18
    isooctanol 108.2
    dipropyl ether 223.68
    1,2-dichlorobenzene 601.35
    ethyl lactate 226.38
    propylene carbonate 552.02
    n-methylformamide 529.79
    2-pentanol 142.81
    n-pentane 41.88
    1-propoxy-2-propanol 291.57
    1-methoxy-2-propyl acetate 366.51
    2-(2-methoxypropoxy) propanol 319.93
    mesitylene 156.74
    ε-caprolactone 641.87
    p-cymene 136.96
    epichlorohydrin 1058.13
    1,1,1-trichloroethane 754.96
    2-aminoethanol 174.13
    morpholine-4-carbaldehyde 1221.72
    sulfolane 1599.99
    2,2,4-trimethylpentane 41.61
    2-methyltetrahydrofuran 570.17
    n-hexyl acetate 355.71
    isooctane 30.5
    2-(2-butoxyethoxy)ethanol 388.44
    sec-butyl acetate 254.18
    tert-butyl acetate 341.51
    decalin 67.58
    glycerin 247.24
    diglyme 791.69
    acrylic acid 374.9
    isopropyl myristate 170.11
    n-butyric acid 338.59
    acetyl acetate 425.27
    di(2-ethylhexyl) phthalate 180.24
    ethyl propionate 339.21
    nitromethane 1160.48
    1,2-diethoxyethane 407.0
    benzonitrile 578.56
    trioctyl phosphate 131.42
    1-bromopropane 365.58
    gamma-valerolactone 1143.84
    n-decanol 114.29
    triethyl phosphate 184.2
    4-methyl-2-pentanol 104.66
    propionitrile 374.12
    vinylene carbonate 610.25
    1,1,2-trichlorotrifluoroethane 795.02
    DMS 413.22
    cumene 142.78
    2-octanol 108.86
    2-hexanone 387.1
    octyl acetate 205.89
    limonene 180.2
    1,2-dimethoxyethane 916.93
    ethyl orthosilicate 169.67
    tributyl phosphate 170.87
    diacetone alcohol 329.37
    N,N-dimethylaniline 352.98
    acrylonitrile 569.3
    aniline 319.3
    1,3-propanediol 243.84
    bromobenzene 638.55
    dibromomethane 781.95
    1,1,2,2-tetrachloroethane 1148.69
    2-methyl-cyclohexyl acetate 253.16
    tetrabutyl urea 249.11
    diisobutyl methanol 106.9
    2-phenylethanol 269.08
    styrene 266.58
    dioctyl adipate 251.39
    dimethyl sulfate 706.14
    ethyl butyrate 292.54
    methyl lactate 275.52
    butyl lactate 227.59
    diethyl carbonate 231.87
    propanediol butyl ether 280.16
    triethyl orthoformate 221.59
    p-tert-butyltoluene 135.2
    methyl 4-tert-butylbenzoate 354.89
    morpholine 647.48
    tert-butylamine 160.33
    n-dodecanol 99.05
    dimethoxymethane 707.69
    ethylene carbonate 452.31
    cyrene 419.12
    2-ethoxyethyl acetate 381.05
    2-ethylhexyl acetate 258.37
    1,2,4-trichlorobenzene 706.56
    4-methylpyridine 721.68
    dibutyl ether 224.83
    2,6-dimethyl-4-heptanol 106.9
    DEF 676.37
    dimethyl isosorbide 567.71
    tetrachloroethylene 738.93
    eugenol 379.29
    triacetin 431.63
    span 80 282.35
    1,4-butanediol 169.12
    1,1-dichloroethane 678.03
    2-methyl-1-pentanol 191.69
    methyl formate 486.86
    2-methyl-1-butanol 180.22
    n-decane 44.15
    butyronitrile 360.42
    3,7-dimethyl-1-octanol 157.2
    1-chlorooctane 152.96
    1-chlorotetradecane 84.29
    n-nonane 43.19
    undecane 37.26
    tert-butylcyclohexane 64.7
    cyclooctane 35.47
    cyclopentanol 265.61
    tetrahydropyran 460.63
    tert-amyl methyl ether 268.59
    2,5,8-trioxanonane 562.2
    1-hexene 142.26
    2-isopropoxyethanol 336.43
    2,2,2-trifluoroethanol 235.94
    methyl butyrate 459.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction