2-Ethoxytetrahydrofuran

Overview IFRA Request a quote

  • Identifiers

    CAS number
    13436-46-9

    Molecular formula
    C6H12O2

    SMILES
    CCOC1CCCO1

    Safety labels

  • Odor profile

    Fragrance
    Ethereal 80.69%
    Fruity 80.0%
    Sweet 54.43%
    Green 49.97%
    Alcoholic 47.39%
    Fermented 44.39%
    Rummy 40.75%
    Solvent 36.99%
    Pungent 33.82%
    Cognac 31.92%

     

    Flavor
    Sweet 52.78%
    Vegetable 47.93%
    Green 38.28%
    Earthy 34.61%
    Caramel 33.05%
    Fruit 29.43%
    Nutty 27.31%
    Oily 27.24%
    Musty 27.2%
    Fatty 26.12%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    7.37 (neutral)

    Molecular weight
    116.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    135°C

    Flash point

    • 31.71 ˚C est.

  • Synonyms

    • 2-Ethoxytetrahydrofuran
    • RefChem:471691
    • 13436-46-9
    • 2-ethoxyoxolane
    • Furan, 2-ethoxytetrahydro-
    • FURAN,2-ETHOXYTETRAHYDRO-
    • EINECS 236-569-9
    • 2-?Ethoxytetrahydrofura?n
    • SCHEMBL239230
    • SCHEMBL497923
    • 2-Ethoxytetrahydrofuran, 99%
    • Ethyl tetrahydro-2-furyl ether
    • SCHEMBL3623443
    • SCHEMBL3623445
    • SCHEMBL7072184
    • (+/-)-2-Ethoxytetrahydrofuran
    • DTXSID10928589
    • AKOS015915920
    • DB-042235
    • G77277
    • 13436-46-9

  • Applications

    2-Ethoxytetrahydrofuran is commonly used as a solvent or reaction medium in organic synthesis, enabling stable, high-purity reactions and serving as a versatile platform for downstream product preparation. It also functions as an intermediate/precursor for the synthesis of other organic compounds, including pharmaceuticals and specialty chemicals. In polymer and plastics chemistry, it can serve as a scaffold for functionalized THF derivatives used in formulations or as building blocks in copolymer structures. It may be employed as a specialty solvent or processing aid in coatings, inks, and adhesives. In some advanced manufacturing contexts, it may be considered for electronics manufacturing and precision cleaning formulations, depending on regulatory constraints. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3484.25
    methanol 5034.12
    isopropanol 2396.95
    water 39.07
    ethyl acetate 1677.48
    n-propanol 2391.13
    acetone 2456.62
    n-butanol 2202.02
    acetonitrile 3135.55
    DMF 2424.08
    toluene 801.6
    isobutanol 1828.3
    1,4-dioxane 2431.75
    methyl acetate 1628.37
    THF 3008.67
    2-butanone 1834.79
    n-pentanol 1525.7
    sec-butanol 2114.97
    n-hexane 472.56
    ethylene glycol 1144.15
    NMP 1994.67
    cyclohexane 507.25
    DMSO 3256.64
    n-butyl acetate 1197.27
    n-octanol 885.28
    chloroform 7080.92
    n-propyl acetate 1126.09
    acetic acid 4260.15
    dichloromethane 6525.56
    cyclohexanone 2259.56
    propylene glycol 1171.5
    isopropyl acetate 976.91
    DMAc 1787.33
    2-ethoxyethanol 2035.4
    isopentanol 1709.98
    n-heptane 310.08
    ethyl formate 1249.5
    1,2-dichloroethane 2585.64
    n-hexanol 1483.09
    2-methoxyethanol 2979.75
    isobutyl acetate 714.74
    tetrachloromethane 1405.62
    n-pentyl acetate 783.56
    transcutol 3511.44
    n-heptanol 694.64
    ethylbenzene 438.12
    MIBK 867.36
    2-propoxyethanol 2110.53
    tert-butanol 2400.18
    MTBE 1631.61
    2-butoxyethanol 1090.15
    propionic acid 2261.08
    o-xylene 528.11
    formic acid 1593.27
    diethyl ether 1861.18
    m-xylene 535.83
    p-xylene 618.78
    chlorobenzene 1518.93
    dimethyl carbonate 505.54
    n-octane 123.06
    formamide 1385.33
    cyclopentanone 2339.07
    2-pentanone 1456.46
    anisole 928.57
    cyclopentyl methyl ether 1528.04
    gamma-butyrolactone 2492.17
    1-methoxy-2-propanol 2062.72
    pyridine 2258.39
    3-pentanone 1051.23
    furfural 2457.72
    n-dodecane 111.25
    diethylene glycol 1564.03
    diisopropyl ether 554.7
    tert-amyl alcohol 1939.32
    acetylacetone 1334.99
    n-hexadecane 121.47
    acetophenone 847.93
    methyl propionate 1172.24
    isopentyl acetate 927.76
    trichloroethylene 4685.24
    n-nonanol 677.63
    cyclohexanol 1674.87
    benzyl alcohol 977.15
    2-ethylhexanol 783.29
    isooctanol 549.25
    dipropyl ether 941.28
    1,2-dichlorobenzene 1255.17
    ethyl lactate 548.02
    propylene carbonate 1441.26
    n-methylformamide 1761.24
    2-pentanol 1461.32
    n-pentane 455.91
    1-propoxy-2-propanol 1375.22
    1-methoxy-2-propyl acetate 866.98
    2-(2-methoxypropoxy) propanol 811.83
    mesitylene 361.94
    ε-caprolactone 1883.24
    p-cymene 353.06
    epichlorohydrin 2644.11
    1,1,1-trichloroethane 2741.8
    2-aminoethanol 1752.55
    morpholine-4-carbaldehyde 2068.82
    sulfolane 2711.26
    2,2,4-trimethylpentane 238.72
    2-methyltetrahydrofuran 2454.89
    n-hexyl acetate 1191.73
    isooctane 163.42
    2-(2-butoxyethoxy)ethanol 1154.6
    sec-butyl acetate 746.39
    tert-butyl acetate 915.86
    decalin 228.39
    glycerin 1508.13
    diglyme 1940.86
    acrylic acid 2002.36
    isopropyl myristate 415.65
    n-butyric acid 2576.65
    acetyl acetate 1182.71
    di(2-ethylhexyl) phthalate 394.02
    ethyl propionate 852.42
    nitromethane 3664.52
    1,2-diethoxyethane 1177.5
    benzonitrile 1520.65
    trioctyl phosphate 304.3
    1-bromopropane 1898.34
    gamma-valerolactone 2372.89
    n-decanol 454.21
    triethyl phosphate 356.94
    4-methyl-2-pentanol 736.85
    propionitrile 2090.28
    vinylene carbonate 1363.65
    1,1,2-trichlorotrifluoroethane 2466.01
    DMS 683.51
    cumene 346.35
    2-octanol 540.21
    2-hexanone 1158.91
    octyl acetate 517.42
    limonene 550.38
    1,2-dimethoxyethane 2428.87
    ethyl orthosilicate 363.53
    tributyl phosphate 377.5
    diacetone alcohol 1029.1
    N,N-dimethylaniline 637.55
    acrylonitrile 2383.54
    aniline 1195.85
    1,3-propanediol 1804.83
    bromobenzene 1615.7
    dibromomethane 4173.81
    1,1,2,2-tetrachloroethane 3604.79
    2-methyl-cyclohexyl acetate 571.21
    tetrabutyl urea 444.86
    diisobutyl methanol 434.48
    2-phenylethanol 800.17
    styrene 620.21
    dioctyl adipate 565.79
    dimethyl sulfate 814.47
    ethyl butyrate 827.16
    methyl lactate 751.27
    butyl lactate 601.76
    diethyl carbonate 500.69
    propanediol butyl ether 1114.42
    triethyl orthoformate 534.62
    p-tert-butyltoluene 329.85
    methyl 4-tert-butylbenzoate 707.36
    morpholine 2712.33
    tert-butylamine 1654.78
    n-dodecanol 341.65
    dimethoxymethane 1444.41
    ethylene carbonate 1124.81
    cyrene 718.51
    2-ethoxyethyl acetate 815.72
    2-ethylhexyl acetate 710.13
    1,2,4-trichlorobenzene 1437.29
    4-methylpyridine 2142.98
    dibutyl ether 877.37
    2,6-dimethyl-4-heptanol 434.48
    DEF 1719.46
    dimethyl isosorbide 1066.87
    tetrachloroethylene 2716.8
    eugenol 725.92
    triacetin 916.02
    span 80 789.76
    1,4-butanediol 1024.41
    1,1-dichloroethane 3058.76
    2-methyl-1-pentanol 1250.34
    methyl formate 1284.19
    2-methyl-1-butanol 1720.46
    n-decane 179.28
    butyronitrile 2223.72
    3,7-dimethyl-1-octanol 747.5
    1-chlorooctane 576.89
    1-chlorotetradecane 222.16
    n-nonane 196.41
    undecane 135.18
    tert-butylcyclohexane 246.51
    cyclooctane 181.05
    cyclopentanol 1914.62
    tetrahydropyran 2320.74
    tert-amyl methyl ether 1177.69
    2,5,8-trioxanonane 1199.37
    1-hexene 1120.7
    2-isopropoxyethanol 1380.85
    2,2,2-trifluoroethanol 1138.98
    methyl butyrate 1275.43

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction