2-Ethoxypyridine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    14529-53-4

    Molecular formula
    C7H9NO

    SMILES
    CCOC1=CC=CC=N1

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 54.83%
    Green 52.49%
    Nutty 45.74%
    Burnt 42.96%
    Phenolic 40.41%
    Smoky 40.01%
    Earthy 39.85%
    Roasted 39.71%
    Spicy 39.23%
    Aromatic 36.28%

     

    Flavor
    Sweet 67.81%
    Fruity 44.06%
    Nutty 39.14%
    Green 35.87%
    Bitter 35.34%
    Earthy 34.04%
    Musty 32.23%
    Balsam 31.76%
    Floral 31.5%
    Chocolate 28.9%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    5.19 (weak acid)

    Molecular weight
    123.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    194°C

    Flash point

    • 60.05 ˚C est.

  • Synonyms

    • 2-Ethoxypyridine
    • 14529-53-4
    • Pyridine, 2-ethoxy-
    • 4G3BKY7JKQ
    • EINECS 238-553-7
    • AI3-60422
    • DTXSID70162967
    • RefChem:86852
    • DTXCID0085458
    • 238-553-7
    • InChI=1/C7H9NO/c1-2-9-7-5-3-4-6-8-7/h3-6H,2H2,1H
    • LISKAOIANGDBTB-UHFFFAOYSA-N
    • MFCD00023464
    • 2-Ethoxy pyridine
    • 2-Ethoxy-pyridine
    • ethyl 2-pyridinyl ether
    • UNII-4G3BKY7JKQ
    • SCHEMBL128768
    • SCHEMBL129035
    • SCHEMBL129417
    • SCHEMBL131609
    • SCHEMBL152133
    • SCHEMBL449878
    • SCHEMBL452905
    • SCHEMBL3186860
    • SCHEMBL6203272
    • CHEMBL3274301
    • SCHEMBL29968555
    • AKOS005258151
    • CS-W017767
    • SB52293
    • AC-23102
    • AS-31090
    • SY017181
    • DB-003894
    • E0870
    • NS00024725
    • ST50409816
    • AC-907/25014179
    • F049694
    • 14529-53-4

  • Applications

    2-Ethoxypyridine (CAS 14529-53-4) is mainly used as an organic intermediate for the preparation of pyridine-containing compounds, serving as a building block for pharmaceutical and agrochemical programs and enabling late-stage functionalization of heteroaromatic frameworks. It is commonly evaluated for medicinal chemistry applications to access heterocyclic motifs and as a precursor in syntheses of targeted drugs or agrochemicals. In polymer and materials chemistry, the 2-ethoxypyridine unit can be incorporated into pyridinyl-containing monomers or copolymers, imparting coordination capability and potential chelation behavior. The compound is also encountered in fragrance-related applications as a potential fragrance precursor or support for pyridine-based odorants, and may act as a ligand or co-catalyst in certain organometallic-catalyzed transformations. Applications should be guided by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 903.09
    methanol 1144.95
    isopropanol 602.41
    water 4.83
    ethyl acetate 727.19
    n-propanol 657.97
    acetone 916.25
    n-butanol 544.31
    acetonitrile 1297.8
    DMF 1236.27
    toluene 452.69
    isobutanol 513.37
    1,4-dioxane 996.77
    methyl acetate 755.13
    THF 1025.49
    2-butanone 747.92
    n-pentanol 452.87
    sec-butanol 561.85
    n-hexane 174.17
    ethylene glycol 256.6
    NMP 1021.98
    cyclohexane 294.5
    DMSO 1801.95
    n-butyl acetate 654.1
    n-octanol 346.32
    chloroform 3168.12
    n-propyl acetate 500.96
    acetic acid 1293.2
    dichloromethane 4009.25
    cyclohexanone 892.6
    propylene glycol 250.08
    isopropyl acetate 323.78
    DMAc 936.39
    2-ethoxyethanol 574.53
    isopentanol 400.7
    n-heptane 193.01
    ethyl formate 622.01
    1,2-dichloroethane 1675.07
    n-hexanol 501.51
    2-methoxyethanol 799.39
    isobutyl acetate 267.46
    tetrachloromethane 550.03
    n-pentyl acetate 355.69
    transcutol 1294.65
    n-heptanol 250.73
    ethylbenzene 283.15
    MIBK 264.44
    2-propoxyethanol 620.7
    tert-butanol 582.26
    MTBE 451.28
    2-butoxyethanol 365.12
    propionic acid 817.88
    o-xylene 291.23
    formic acid 353.19
    diethyl ether 617.36
    m-xylene 248.92
    p-xylene 404.17
    chlorobenzene 848.75
    dimethyl carbonate 315.96
    n-octane 81.85
    formamide 483.88
    cyclopentanone 940.32
    2-pentanone 506.88
    anisole 524.75
    cyclopentyl methyl ether 535.23
    gamma-butyrolactone 1150.62
    1-methoxy-2-propanol 524.97
    pyridine 1298.45
    3-pentanone 491.31
    furfural 1173.04
    n-dodecane 74.11
    diethylene glycol 437.74
    diisopropyl ether 173.2
    tert-amyl alcohol 520.64
    acetylacetone 536.91
    n-hexadecane 80.82
    acetophenone 493.58
    methyl propionate 626.57
    isopentyl acetate 427.68
    trichloroethylene 2744.4
    n-nonanol 281.86
    cyclohexanol 517.36
    benzyl alcohol 426.63
    2-ethylhexanol 342.81
    isooctanol 196.72
    dipropyl ether 482.26
    1,2-dichlorobenzene 754.24
    ethyl lactate 267.23
    propylene carbonate 738.07
    n-methylformamide 718.45
    2-pentanol 352.27
    n-pentane 173.82
    1-propoxy-2-propanol 466.23
    1-methoxy-2-propyl acetate 388.09
    2-(2-methoxypropoxy) propanol 381.37
    mesitylene 169.19
    ε-caprolactone 761.33
    p-cymene 216.1
    epichlorohydrin 1323.73
    1,1,1-trichloroethane 1389.16
    2-aminoethanol 406.22
    morpholine-4-carbaldehyde 851.1
    sulfolane 1480.66
    2,2,4-trimethylpentane 77.35
    2-methyltetrahydrofuran 822.92
    n-hexyl acetate 559.94
    isooctane 50.85
    2-(2-butoxyethoxy)ethanol 492.88
    sec-butyl acetate 270.38
    tert-butyl acetate 292.73
    decalin 122.37
    glycerin 323.28
    diglyme 955.13
    acrylic acid 771.64
    isopropyl myristate 236.9
    n-butyric acid 815.01
    acetyl acetate 448.13
    di(2-ethylhexyl) phthalate 224.72
    ethyl propionate 462.87
    nitromethane 1391.73
    1,2-diethoxyethane 566.26
    benzonitrile 859.23
    trioctyl phosphate 169.45
    1-bromopropane 1004.63
    gamma-valerolactone 923.16
    n-decanol 218.55
    triethyl phosphate 231.19
    4-methyl-2-pentanol 164.59
    propionitrile 964.18
    vinylene carbonate 840.01
    1,1,2-trichlorotrifluoroethane 909.81
    DMS 399.83
    cumene 200.33
    2-octanol 201.81
    2-hexanone 468.14
    octyl acetate 316.45
    limonene 303.12
    1,2-dimethoxyethane 988.46
    ethyl orthosilicate 207.96
    tributyl phosphate 228.89
    diacetone alcohol 315.15
    N,N-dimethylaniline 372.1
    acrylonitrile 1157.29
    aniline 549.82
    1,3-propanediol 440.14
    bromobenzene 987.35
    dibromomethane 2491.86
    1,1,2,2-tetrachloroethane 1978.58
    2-methyl-cyclohexyl acetate 333.09
    tetrabutyl urea 293.1
    diisobutyl methanol 171.53
    2-phenylethanol 392.01
    styrene 428.85
    dioctyl adipate 358.26
    dimethyl sulfate 465.48
    ethyl butyrate 546.2
    methyl lactate 297.0
    butyl lactate 289.8
    diethyl carbonate 415.46
    propanediol butyl ether 356.65
    triethyl orthoformate 323.19
    p-tert-butyltoluene 187.63
    methyl 4-tert-butylbenzoate 378.03
    morpholine 983.4
    tert-butylamine 439.8
    n-dodecanol 185.16
    dimethoxymethane 670.86
    ethylene carbonate 647.71
    cyrene 305.65
    2-ethoxyethyl acetate 404.89
    2-ethylhexyl acetate 349.07
    1,2,4-trichlorobenzene 822.62
    4-methylpyridine 1047.85
    dibutyl ether 453.75
    2,6-dimethyl-4-heptanol 171.53
    DEF 751.47
    dimethyl isosorbide 538.96
    tetrachloroethylene 1402.52
    eugenol 386.6
    triacetin 475.98
    span 80 371.39
    1,4-butanediol 275.23
    1,1-dichloroethane 1509.53
    2-methyl-1-pentanol 366.54
    methyl formate 593.67
    2-methyl-1-butanol 438.57
    n-decane 109.01
    butyronitrile 931.52
    3,7-dimethyl-1-octanol 289.36
    1-chlorooctane 327.04
    1-chlorotetradecane 151.73
    n-nonane 116.27
    undecane 86.17
    tert-butylcyclohexane 106.53
    cyclooctane 95.57
    cyclopentanol 604.78
    tetrahydropyran 887.55
    tert-amyl methyl ether 348.22
    2,5,8-trioxanonane 660.25
    1-hexene 418.39
    2-isopropoxyethanol 376.17
    2,2,2-trifluoroethanol 339.35
    methyl butyrate 628.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction