2-Ethoxypyrazine

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  • Identifiers

    CAS number
    38028-67-0

    Molecular formula
    C6H8N2O

    SMILES
    CCOC1=NC=CN=C1

    Safety labels

  • Odor profile

    Fragrance
    Nutty 76.61%
    Roasted 67.05%
    Sweet 57.55%
    Earthy 54.14%
    Green 49.47%
    Musty 46.58%
    Hazelnut 45.19%
    Almond 41.09%
    Cocoa 40.7%
    Coffee 38.94%

     

    Flavor
    Sweet 63.45%
    Nutty 50.85%
    Musty 33.86%
    Earthy 33.71%
    Cocoa 33.58%
    Coffee 33.43%
    Fruity 32.18%
    Bitter 31.89%
    Peanut 28.98%
    Chocolate 28.2%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    4.05 (weak acid)

    Molecular weight
    124.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    200°C

    Flash point

    • 84.09 ˚C est.

  • Synonyms

    • 2-Ethoxypyrazine
    • 38028-67-0
    • Pyrazine, ethoxy-
    • Pyrazine, 2-ethoxy-
    • 3-ethoxypyrazine
    • DTXSID10878914
    • RefChem:86851
    • DTXCID101016942
    • ATIUKJHILQVQLE-UHFFFAOYSA-N
    • MFCD00014609
    • CHEMBL93554
    • SCHEMBL992408
    • SCHEMBL1376316
    • SCHEMBL1526711
    • SCHEMBL1692005
    • SCHEMBL4919180
    • SCHEMBL29489016
    • AC1594
    • AKOS006222051
    • CS-W013527
    • AC-16589
    • LS-13132
    • SY015124
    • DB-021031
    • E0697
    • NS00056838
    • EN300-7370787
    • F009616
    • 38028-67-0

  • Applications

    2-Ethoxypyrazine (CAS 38028-67-0) is an odor-active pyrazine with a green, vegetal note, used primarily as a flavor and fragrance ingredient. In food and beverage applications, it contributes green, vegetal aromas to products such as beverages, sauces, and processed foods. In perfumery, it serves as an odorant to impart green notes in fragrances and related personal care products. In cosmetics and personal care formulations, it may be used as a fragrance component to achieve green character. Additionally, it can function as an intermediate building block for the synthesis of other pyrazine derivatives used in industrial manufacturing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 149.44
    methanol 276.2
    isopropanol 86.62
    water 4.9
    ethyl acetate 106.81
    n-propanol 106.0
    acetone 141.19
    n-butanol 81.79
    acetonitrile 263.29
    DMF 354.33
    toluene 77.66
    isobutanol 75.51
    1,4-dioxane 194.16
    methyl acetate 131.49
    THF 196.1
    2-butanone 108.25
    n-pentanol 67.3
    sec-butanol 77.35
    n-hexane 11.7
    ethylene glycol 93.89
    NMP 355.9
    cyclohexane 37.22
    DMSO 568.06
    n-butyl acetate 74.02
    n-octanol 45.73
    chloroform 490.76
    n-propyl acetate 63.39
    acetic acid 341.83
    dichloromethane 670.49
    cyclohexanone 174.8
    propylene glycol 60.81
    isopropyl acetate 46.52
    DMAc 323.84
    2-ethoxyethanol 134.02
    isopentanol 59.41
    n-heptane 18.67
    ethyl formate 147.13
    1,2-dichloroethane 309.31
    n-hexanol 67.05
    2-methoxyethanol 228.81
    isobutyl acetate 34.98
    tetrachloromethane 84.73
    n-pentyl acetate 49.02
    transcutol 242.6
    n-heptanol 36.19
    ethylbenzene 43.1
    MIBK 36.12
    2-propoxyethanol 120.81
    tert-butanol 88.98
    MTBE 56.27
    2-butoxyethanol 70.93
    propionic acid 165.04
    o-xylene 64.79
    formic acid 177.83
    diethyl ether 71.02
    m-xylene 45.75
    p-xylene 65.76
    chlorobenzene 169.02
    dimethyl carbonate 62.75
    n-octane 8.14
    formamide 208.34
    cyclopentanone 190.01
    2-pentanone 65.16
    anisole 85.85
    cyclopentyl methyl ether 86.66
    gamma-butyrolactone 287.54
    1-methoxy-2-propanol 121.79
    pyridine 320.4
    3-pentanone 72.67
    furfural 362.15
    n-dodecane 8.84
    diethylene glycol 133.45
    diisopropyl ether 19.15
    tert-amyl alcohol 76.81
    acetylacetone 89.46
    n-hexadecane 9.89
    acetophenone 93.32
    methyl propionate 113.17
    isopentyl acetate 53.42
    trichloroethylene 504.74
    n-nonanol 40.79
    cyclohexanol 95.06
    benzyl alcohol 100.28
    2-ethylhexanol 48.62
    isooctanol 28.91
    dipropyl ether 57.21
    1,2-dichlorobenzene 166.28
    ethyl lactate 58.16
    propylene carbonate 171.83
    n-methylformamide 224.5
    2-pentanol 44.14
    n-pentane 14.18
    1-propoxy-2-propanol 78.74
    1-methoxy-2-propyl acetate 70.08
    2-(2-methoxypropoxy) propanol 83.95
    mesitylene 31.34
    ε-caprolactone 163.13
    p-cymene 41.06
    epichlorohydrin 286.42
    1,1,1-trichloroethane 209.07
    2-aminoethanol 114.07
    morpholine-4-carbaldehyde 270.71
    sulfolane 374.51
    2,2,4-trimethylpentane 9.35
    2-methyltetrahydrofuran 137.1
    n-hexyl acetate 70.85
    isooctane 5.16
    2-(2-butoxyethoxy)ethanol 105.6
    sec-butyl acetate 35.6
    tert-butyl acetate 41.92
    decalin 17.57
    glycerin 112.28
    diglyme 202.53
    acrylic acid 194.49
    isopropyl myristate 35.47
    n-butyric acid 163.48
    acetyl acetate 87.39
    di(2-ethylhexyl) phthalate 52.57
    ethyl propionate 66.99
    nitromethane 349.13
    1,2-diethoxyethane 81.57
    benzonitrile 185.87
    trioctyl phosphate 35.06
    1-bromopropane 140.44
    gamma-valerolactone 233.59
    n-decanol 33.28
    triethyl phosphate 56.04
    4-methyl-2-pentanol 25.3
    propionitrile 182.2
    vinylene carbonate 205.6
    1,1,2-trichlorotrifluoroethane 269.81
    DMS 71.91
    cumene 33.92
    2-octanol 26.67
    2-hexanone 52.39
    octyl acetate 47.54
    limonene 57.46
    1,2-dimethoxyethane 207.31
    ethyl orthosilicate 46.87
    tributyl phosphate 44.27
    diacetone alcohol 57.24
    N,N-dimethylaniline 74.2
    acrylonitrile 281.36
    aniline 127.12
    1,3-propanediol 113.51
    bromobenzene 181.62
    dibromomethane 384.06
    1,1,2,2-tetrachloroethane 370.04
    2-methyl-cyclohexyl acetate 60.33
    tetrabutyl urea 62.93
    diisobutyl methanol 29.92
    2-phenylethanol 83.66
    styrene 64.08
    dioctyl adipate 63.44
    dimethyl sulfate 121.18
    ethyl butyrate 77.31
    methyl lactate 86.03
    butyl lactate 51.94
    diethyl carbonate 75.95
    propanediol butyl ether 69.02
    triethyl orthoformate 62.79
    p-tert-butyltoluene 37.0
    methyl 4-tert-butylbenzoate 82.99
    morpholine 205.83
    tert-butylamine 59.49
    n-dodecanol 28.8
    dimethoxymethane 146.83
    ethylene carbonate 151.53
    cyrene 91.35
    2-ethoxyethyl acetate 64.79
    2-ethylhexyl acetate 46.19
    1,2,4-trichlorobenzene 195.86
    4-methylpyridine 229.53
    dibutyl ether 51.85
    2,6-dimethyl-4-heptanol 29.92
    DEF 157.41
    dimethyl isosorbide 138.35
    tetrachloroethylene 289.88
    eugenol 88.93
    triacetin 84.37
    span 80 80.69
    1,4-butanediol 66.56
    1,1-dichloroethane 214.47
    2-methyl-1-pentanol 56.83
    methyl formate 174.95
    2-methyl-1-butanol 63.28
    n-decane 11.73
    butyronitrile 159.2
    3,7-dimethyl-1-octanol 45.18
    1-chlorooctane 38.96
    1-chlorotetradecane 21.16
    n-nonane 11.26
    undecane 9.8
    tert-butylcyclohexane 12.57
    cyclooctane 11.46
    cyclopentanol 118.24
    tetrahydropyran 142.38
    tert-amyl methyl ether 48.99
    2,5,8-trioxanonane 153.66
    1-hexene 36.38
    2-isopropoxyethanol 75.68
    2,2,2-trifluoroethanol 115.58
    methyl butyrate 94.45

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction