2-Ethoxy-3,4-dihydro-2H-pyran

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  • Identifiers

    CAS number
    103-75-3

    Molecular formula
    C7H12O2

    SMILES
    CCOC1CCC=CO1

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 59.85%
    Sweet 58.22%
    Spicy 44.77%
    Herbal 43.9%
    Ethereal 41.55%
    Green 40.62%
    Floral 32.38%
    Aromatic 31.11%
    Woody 30.57%
    Anisic 29.05%

     

    Flavor
    Green 34.62%
    Sweet 32.73%
    Fruity 29.5%
    Caramel 28.79%
    Vegetable 27.84%
    Earthy 26.96%
    Fruit 26.32%
    Musty 24.44%
    Bitter 24.3%
    Herbal 23.96%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    6.58 (neutral)

    Molecular weight
    128.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -148 °F (USCG, 1999)
    • FP: -100 °C

    Boiling point

    • 289 °F at 760 mmHg (USCG, 1999)
    • 143 °C

    Flash point

    • 41.24 ˚C est.
    • 98 °F (USCG, 1999)
    • 111 °F OC.

    Solubility expt.

    • VERY SLIGHTLY SOL IN WATER

  • Synonyms

    • 2-Ethoxy-3,4-dihydro-2H-pyran
    • 103-75-3
    • 2H-Pyran, 2-ethoxy-3,4-dihydro-
    • 2-Ethoxypyran
    • ETHOXYDIHYDROPYRAN
    • 2-Ethoxydihydropyran
    • 3,4-Dihydro-2-ethoxy-2H-pyran
    • 2-Ethoxy-3,4-dihydropyran
    • 2-Ethoxy-2,3-dihydro-4H-pyran
    • 2-Ethoxy-3,4-dihydro-2-pyran
    • 3,4-dihydro-2-ethoxy-2H-pyrane
    • 3,4-Dihydro-2H-pyran-2-yl ethyl ether
    • 2-Ethoxy-3,4-dihydro-1,2-pyran
    • HSDB 2839
    • 2-Ethoxy-2,3-dihydro(4H)pyran
    • NSC 6271
    • EINECS 203-141-8
    • BRN 0109855
    • UNII-K6DS120547
    • AI3-24750
    • NSC-6271
    • 2-Ethoxy-2,3-dihydro-.gamma.-pyran
    • DTXSID40883293
    • 3,4-DIHYDRO-2-ETHOXYPYRAN
    • K6DS120547
    • 2-ETHOXY-3,4-DIHYDRO-2H-PYRAN, (+/-)-
    • 3,4-DIHYDRO-2-ETHOXY-2H-PYRAN, (+/-)-
    • 2-Ethoxy-2,3-dihydro[4H]pyran
    • 2-Ethoxy-2,3-dihydro-gamma-pyran
    • 2Ethoxydihydropyran
    • MFCD00006561
    • 2Ethoxy3,4dihydropyran
    • 2-Ethoxy-3,2-pyran
    • 2Ethoxy3,4dihydro2pyran
    • 2Ethoxy3,4dihydro2Hpyran
    • 2Ethoxy2,3dihydrogammapyran
    • 2Ethoxy3,4dihydro1,2pyran
    • WLN: T6O BUTJ FO2
    • 2Ethoxy2,3dihydro(4H)pyran
    • 2HPyran, 2ethoxy3,4dihydro
    • SCHEMBL379887
    • NSC6271
    • DTXCID801022835
    • AAA10375
    • BBL027595
    • STK802314
    • AKOS009031552
    • 3,4-Dihydro-2-ethoxy-2H-pyran, 98%
    • AS-31061
    • DB-040483
    • CS-0076531
    • E0529
    • NS00041339
    • EN300-20557
    • 2-ETHOXY-3,4-DIHYDRO-2-PYRAN [HSDB]
    • A800800
    • 2-ETHOXYDIHYDROPYRAN, IN PREGNANCY DIAGNOSIS
    • Q27282010
    • F0001-0080
    • Z104478848

  • Applications

    2-Ethoxy-3,4-dihydro-2H-pyran (CAS 103-75-3) is commonly used as a carbonyl-protecting reagent in organic synthesis, forming THP-type acetals to shield aldehydes and ketones during multi-step sequences in pharmaceutical and fine-chemical production. It also serves as an intermediate building block for creating heterocycles and carbohydrate-derived compounds. It can function as a solvent or co-solvent for certain acid-catalyzed or dehydration-type reactions and may appear as an intermediate in industrial process routes. In fragrance and flavor chemistry, it may be evaluated as a masked carbonyl source or intermediate, depending on formulation needs and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 745.59
    methanol 861.97
    isopropanol 531.98
    water 4.97
    ethyl acetate 466.81
    n-propanol 545.24
    acetone 519.01
    n-butanol 515.3
    acetonitrile 871.92
    DMF 643.13
    toluene 337.85
    isobutanol 440.7
    1,4-dioxane 718.9
    methyl acetate 440.95
    THF 845.7
    2-butanone 453.7
    n-pentanol 407.17
    sec-butanol 491.91
    n-hexane 136.66
    ethylene glycol 210.51
    NMP 645.34
    cyclohexane 240.4
    DMSO 1037.06
    n-butyl acetate 414.81
    n-octanol 283.36
    chloroform 2476.05
    n-propyl acetate 312.31
    acetic acid 959.66
    dichloromethane 2465.37
    cyclohexanone 588.8
    propylene glycol 228.67
    isopropyl acetate 234.08
    DMAc 567.64
    2-ethoxyethanol 458.72
    isopentanol 378.48
    n-heptane 150.48
    ethyl formate 340.07
    1,2-dichloroethane 1010.24
    n-hexanol 445.8
    2-methoxyethanol 579.84
    isobutyl acetate 199.02
    tetrachloromethane 423.06
    n-pentyl acetate 245.71
    transcutol 1165.08
    n-heptanol 213.86
    ethylbenzene 200.06
    MIBK 210.21
    2-propoxyethanol 505.47
    tert-butanol 576.2
    MTBE 364.48
    2-butoxyethanol 301.76
    propionic acid 595.01
    o-xylene 232.13
    formic acid 279.65
    diethyl ether 436.45
    m-xylene 214.1
    p-xylene 273.43
    chlorobenzene 569.73
    dimethyl carbonate 154.6
    n-octane 59.63
    formamide 316.09
    cyclopentanone 613.46
    2-pentanone 346.62
    anisole 371.85
    cyclopentyl methyl ether 428.19
    gamma-butyrolactone 747.41
    1-methoxy-2-propanol 431.51
    pyridine 825.84
    3-pentanone 302.66
    furfural 762.08
    n-dodecane 56.76
    diethylene glycol 393.95
    diisopropyl ether 139.43
    tert-amyl alcohol 475.78
    acetylacetone 348.02
    n-hexadecane 61.87
    acetophenone 349.57
    methyl propionate 353.84
    isopentyl acetate 298.0
    trichloroethylene 1673.62
    n-nonanol 236.25
    cyclohexanol 481.7
    benzyl alcohol 340.03
    2-ethylhexanol 279.53
    isooctanol 179.95
    dipropyl ether 347.41
    1,2-dichlorobenzene 508.02
    ethyl lactate 188.72
    propylene carbonate 470.33
    n-methylformamide 401.35
    2-pentanol 336.56
    n-pentane 156.83
    1-propoxy-2-propanol 370.97
    1-methoxy-2-propyl acetate 263.33
    2-(2-methoxypropoxy) propanol 355.25
    mesitylene 151.08
    ε-caprolactone 554.63
    p-cymene 167.26
    epichlorohydrin 811.82
    1,1,1-trichloroethane 894.51
    2-aminoethanol 363.35
    morpholine-4-carbaldehyde 604.62
    sulfolane 926.54
    2,2,4-trimethylpentane 75.13
    2-methyltetrahydrofuran 685.06
    n-hexyl acetate 394.52
    isooctane 53.9
    2-(2-butoxyethoxy)ethanol 426.24
    sec-butyl acetate 194.49
    tert-butyl acetate 221.1
    decalin 105.53
    glycerin 293.83
    diglyme 719.61
    acrylic acid 546.66
    isopropyl myristate 181.52
    n-butyric acid 614.35
    acetyl acetate 300.6
    di(2-ethylhexyl) phthalate 185.12
    ethyl propionate 281.26
    nitromethane 869.72
    1,2-diethoxyethane 410.85
    benzonitrile 582.89
    trioctyl phosphate 137.81
    1-bromopropane 708.39
    gamma-valerolactone 634.54
    n-decanol 179.18
    triethyl phosphate 172.45
    4-methyl-2-pentanol 178.65
    propionitrile 641.41
    vinylene carbonate 488.73
    1,1,2-trichlorotrifluoroethane 667.02
    DMS 246.88
    cumene 157.91
    2-octanol 169.29
    2-hexanone 323.59
    octyl acetate 224.63
    limonene 243.92
    1,2-dimethoxyethane 665.42
    ethyl orthosilicate 159.97
    tributyl phosphate 177.29
    diacetone alcohol 258.09
    N,N-dimethylaniline 272.5
    acrylonitrile 703.31
    aniline 427.84
    1,3-propanediol 379.78
    bromobenzene 663.09
    dibromomethane 1713.33
    1,1,2,2-tetrachloroethane 1246.54
    2-methyl-cyclohexyl acetate 253.18
    tetrabutyl urea 220.41
    diisobutyl methanol 152.2
    2-phenylethanol 303.94
    styrene 289.38
    dioctyl adipate 279.37
    dimethyl sulfate 257.9
    ethyl butyrate 347.02
    methyl lactate 208.43
    butyl lactate 213.42
    diethyl carbonate 248.52
    propanediol butyl ether 304.93
    triethyl orthoformate 223.07
    p-tert-butyltoluene 155.03
    methyl 4-tert-butylbenzoate 297.5
    morpholine 721.52
    tert-butylamine 447.09
    n-dodecanol 147.26
    dimethoxymethane 388.24
    ethylene carbonate 378.74
    cyrene 290.09
    2-ethoxyethyl acetate 283.38
    2-ethylhexyl acetate 247.35
    1,2,4-trichlorobenzene 586.76
    4-methylpyridine 687.45
    dibutyl ether 326.62
    2,6-dimethyl-4-heptanol 152.2
    DEF 460.01
    dimethyl isosorbide 463.09
    tetrachloroethylene 898.81
    eugenol 298.05
    triacetin 375.4
    span 80 339.65
    1,4-butanediol 230.61
    1,1-dichloroethane 969.83
    2-methyl-1-pentanol 344.44
    methyl formate 295.38
    2-methyl-1-butanol 405.63
    n-decane 82.49
    butyronitrile 647.13
    3,7-dimethyl-1-octanol 253.3
    1-chlorooctane 237.53
    1-chlorotetradecane 110.68
    n-nonane 86.1
    undecane 65.7
    tert-butylcyclohexane 96.48
    cyclooctane 86.98
    cyclopentanol 528.42
    tetrahydropyran 673.88
    tert-amyl methyl ether 282.12
    2,5,8-trioxanonane 557.67
    1-hexene 320.73
    2-isopropoxyethanol 321.98
    2,2,2-trifluoroethanol 250.44
    methyl butyrate 387.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction