2-Ethoxy-3-ethylpyrazine

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  • Identifiers

    CAS number
    35243-43-7

    Molecular formula
    C8H12N2O

    SMILES
    CCC1=NC=CN=C1OCC

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 75.87%
    Earthy 67.25%
    Roasted 65.92%
    Green 55.37%
    Potato 48.23%
    Hazelnut 46.87%
    Musty 46.48%
    Cocoa 42.87%
    Vegetable 42.14%
    Burnt 34.24%

     

    Flavor
    Nutty 53.66%
    Earthy 52.92%
    Potato 39.64%
    Roasted 37.13%
    Musty 35.12%
    Sweet 33.4%
    Green 32.33%
    Coffee 31.88%
    Vegetable 30.12%
    Pepper 28.72%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    5.39 (weak acid)

    Molecular weight
    152.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    230°C

    Flash point

    • 88.06 ˚C est.

    Solubility expt.

    • Practically insoluble to insoluble in water
    • Soluble (in ethanol)

  • Synonyms

    • 2-Ethoxy-3-ethylpyrazine
    • 35243-43-7
    • 3-ethyl-2-ethoxypyrazine
    • FEMA No. 4633
    • Pyrazine, 2-ethoxy-3-ethyl-
    • 2-ETHOXY- 3-ETHYLPYRAZINE
    • UNII-147QYV8K8V
    • 147QYV8K8V
    • Pyrazine, 2-ethoxy-3-ethyl
    • Pyrazine, 3-ethoxy-2-ethyl
    • DTXSID00188736
    • MFCD00038026
    • SCHEMBL2585538
    • DTXCID60111227
    • AKOS006281407
    • DB-021012
    • CS-0359209
    • E0812
    • NS00113870
    • D90573
    • Q27251596
    • 662-723-3

  • Applications

    2-Ethoxy-3-ethylpyrazine (CAS 35243-43-7) is primarily used as an aroma compound and fragrance intermediate in perfumery, contributing roasted, nutty, and savory notes. It is also evaluated as a flavor precursor in the flavor industry. In cosmetics and personal care, it can serve as a fragrance ingredient. In household products, it can function as an odorant or fragrance component for cleaners and air fresheners. In industrial manufacturing, it is used as a chemical intermediate for the synthesis of pyrazine-based specialty chemicals, and can serve as a precursor for more complex compounds used in pharmaceuticals.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 687.41
    methanol 991.92
    isopropanol 468.66
    water 5.36
    ethyl acetate 812.9
    n-propanol 571.64
    acetone 1036.64
    n-butanol 484.65
    acetonitrile 1260.21
    DMF 1415.28
    toluene 471.73
    isobutanol 446.47
    1,4-dioxane 946.16
    methyl acetate 825.01
    THF 1005.99
    2-butanone 733.29
    n-pentanol 448.3
    sec-butanol 468.49
    n-hexane 97.33
    ethylene glycol 243.97
    NMP 1159.72
    cyclohexane 234.1
    DMSO 1465.89
    n-butyl acetate 737.03
    n-octanol 317.55
    chloroform 4328.91
    n-propyl acetate 592.01
    acetic acid 1397.27
    dichloromethane 5208.12
    cyclohexanone 1138.07
    propylene glycol 219.89
    isopropyl acetate 405.99
    DMAc 938.01
    2-ethoxyethanol 638.86
    isopentanol 381.9
    n-heptane 110.35
    ethyl formate 981.97
    1,2-dichloroethane 2369.95
    n-hexanol 420.42
    2-methoxyethanol 947.54
    isobutyl acetate 293.13
    tetrachloromethane 767.31
    n-pentyl acetate 457.68
    transcutol 942.47
    n-heptanol 258.86
    ethylbenzene 309.84
    MIBK 283.13
    2-propoxyethanol 601.2
    tert-butanol 466.48
    MTBE 345.14
    2-butoxyethanol 416.47
    propionic acid 801.28
    o-xylene 323.59
    formic acid 512.41
    diethyl ether 483.39
    m-xylene 290.07
    p-xylene 479.65
    chlorobenzene 1147.55
    dimethyl carbonate 384.64
    n-octane 62.06
    formamide 721.95
    cyclopentanone 1155.62
    2-pentanone 530.73
    anisole 519.66
    cyclopentyl methyl ether 496.62
    gamma-butyrolactone 1631.26
    1-methoxy-2-propanol 559.04
    pyridine 1599.25
    3-pentanone 486.66
    furfural 1766.98
    n-dodecane 59.39
    diethylene glycol 450.51
    diisopropyl ether 149.89
    tert-amyl alcohol 408.06
    acetylacetone 664.86
    n-hexadecane 67.88
    acetophenone 553.43
    methyl propionate 669.93
    isopentyl acetate 501.34
    trichloroethylene 4390.87
    n-nonanol 263.29
    cyclohexanol 508.77
    benzyl alcohol 526.88
    2-ethylhexanol 315.83
    isooctanol 203.12
    dipropyl ether 328.55
    1,2-dichlorobenzene 1082.48
    ethyl lactate 314.49
    propylene carbonate 1079.78
    n-methylformamide 1001.21
    2-pentanol 305.81
    n-pentane 104.07
    1-propoxy-2-propanol 431.83
    1-methoxy-2-propyl acetate 463.17
    2-(2-methoxypropoxy) propanol 315.86
    mesitylene 201.4
    ε-caprolactone 982.03
    p-cymene 253.13
    epichlorohydrin 1801.91
    1,1,1-trichloroethane 1855.86
    2-aminoethanol 383.16
    morpholine-4-carbaldehyde 1030.16
    sulfolane 1724.86
    2,2,4-trimethylpentane 60.8
    2-methyltetrahydrofuran 800.44
    n-hexyl acetate 639.39
    isooctane 37.11
    2-(2-butoxyethoxy)ethanol 417.86
    sec-butyl acetate 302.71
    tert-butyl acetate 331.08
    decalin 108.01
    glycerin 319.36
    diglyme 919.38
    acrylic acid 853.41
    isopropyl myristate 234.16
    n-butyric acid 934.74
    acetyl acetate 598.17
    di(2-ethylhexyl) phthalate 239.58
    ethyl propionate 533.54
    nitromethane 1868.99
    1,2-diethoxyethane 492.69
    benzonitrile 1104.7
    trioctyl phosphate 192.4
    1-bromopropane 1077.72
    gamma-valerolactone 1329.24
    n-decanol 199.32
    triethyl phosphate 271.79
    4-methyl-2-pentanol 158.2
    propionitrile 990.9
    vinylene carbonate 1273.63
    1,1,2-trichlorotrifluoroethane 1245.5
    DMS 491.52
    cumene 227.02
    2-octanol 217.43
    2-hexanone 476.85
    octyl acetate 323.9
    limonene 329.21
    1,2-dimethoxyethane 1035.87
    ethyl orthosilicate 239.58
    tributyl phosphate 253.62
    diacetone alcohol 337.2
    N,N-dimethylaniline 370.77
    acrylonitrile 1404.85
    aniline 588.0
    1,3-propanediol 505.09
    bromobenzene 1370.9
    dibromomethane 3055.17
    1,1,2,2-tetrachloroethane 2980.65
    2-methyl-cyclohexyl acetate 365.7
    tetrabutyl urea 304.75
    diisobutyl methanol 174.45
    2-phenylethanol 465.84
    styrene 454.49
    dioctyl adipate 357.47
    dimethyl sulfate 555.92
    ethyl butyrate 564.43
    methyl lactate 357.1
    butyl lactate 352.8
    diethyl carbonate 486.31
    propanediol butyl ether 359.43
    triethyl orthoformate 363.14
    p-tert-butyltoluene 213.91
    methyl 4-tert-butylbenzoate 405.39
    morpholine 943.44
    tert-butylamine 326.79
    n-dodecanol 162.84
    dimethoxymethane 732.95
    ethylene carbonate 990.43
    cyrene 331.56
    2-ethoxyethyl acetate 508.63
    2-ethylhexyl acetate 420.37
    1,2,4-trichlorobenzene 1105.0
    4-methylpyridine 1254.3
    dibutyl ether 382.12
    2,6-dimethyl-4-heptanol 174.45
    DEF 786.61
    dimethyl isosorbide 552.26
    tetrachloroethylene 2338.23
    eugenol 432.68
    triacetin 496.54
    span 80 331.9
    1,4-butanediol 298.54
    1,1-dichloroethane 2008.04
    2-methyl-1-pentanol 353.59
    methyl formate 972.39
    2-methyl-1-butanol 397.39
    n-decane 86.26
    butyronitrile 1027.7
    3,7-dimethyl-1-octanol 255.63
    1-chlorooctane 320.61
    1-chlorotetradecane 133.62
    n-nonane 86.71
    undecane 69.43
    tert-butylcyclohexane 84.23
    cyclooctane 73.0
    cyclopentanol 588.32
    tetrahydropyran 819.78
    tert-amyl methyl ether 286.46
    2,5,8-trioxanonane 572.98
    1-hexene 297.27
    2-isopropoxyethanol 387.63
    2,2,2-trifluoroethanol 453.0
    methyl butyrate 765.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction