2-Chloro-1,1,1-trifluoroethane

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  • Identifiers

    CAS number
    75-88-7

    Molecular formula
    C2H2ClF3

    SMILES
    C(C(F)(F)F)Cl

    Safety labels

    Compressed Gas
    Compressed Gas

  • Odor profile

    Fragrance
    Odorless 48.27%
    Fishy 33.97%
    Sweet 25.28%
    Cooling 20.67%
    Woody 19.86%
    Animal 19.73%
    Ripe 19.23%
    Oily 17.67%
    Savory 17.54%
    Fresh 17.5%

     

    Flavor
    Odorless 30.95%
    Sulfurous 29.38%
    Meaty 25.01%
    Sulfury 25.01%
    Mild 20.21%
    Bloody 18.96%
    Glue 18.84%
    Bouillon 18.48%
    Roasted 18.4%
    Skunky 18.4%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    6.27 (neutral)

    Molecular weight
    118.48 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -105.3 °C
    • -105.5 °C

    Boiling point

    • 6.1 °C
    • 6.9 °C

    Flash point

    • -24.26 ˚C est.

    Solubility expt.

    • In water, 9,200 mg/l @ 25 °C
    • Solubility in water, g/100ml at 25 °C: 0.89

  • Synonyms

    • 2-Chloro-1,1,1-trifluoroethane
    • 75-88-7
    • Chlorotrifluoroethane
    • 1,1,1-TRIFLUORO-2-CHLOROETHANE
    • 1-Chloro-2,2,2-trifluoroethane
    • Freon 133a
    • HCFC-133a
    • Genetron 133a
    • Forane 133a
    • Ethane, 2-chloro-1,1,1-trifluoro-
    • HCFC 133a
    • FC 133a
    • CFC 133a
    • 2,2,2-Trifluorochloroethane
    • CCRIS 154
    • CF3CH2Cl
    • 1,1,1-Trifluoroethyl chloride
    • 2,2,2-Trifluoroethyl chloride
    • HSDB 6949
    • R 133a
    • EINECS 200-912-0
    • UN1983
    • UNII-H86O899T9B
    • BRN 1733200
    • (Chloromethyl)trifluoromethane
    • DTXSID5020289
    • CHEBI:82423
    • 1-Chloro-2,2,2-trifluoroethene
    • H86O899T9B
    • 4-01-00-00128 (Beilstein Handbook Reference)
    • R-133A
    • 1,1,1-TRIFLUORO-2-CHLOROETHANE [HSDB]
    • 2-CHLORO-1,1,1-TRIFLUOROETHANE [IARC]
    • 1330-45-6
    • Chloro-1,1,1-trifluoroethane
    • 2-CHLORO-1,1,1-TRIFLUOROETHANE (IARC)
    • 2-chloro-1,1,1-trifluoro-ethane
    • trifluorochloroethane
    • ARCTON 50
    • 2,2,2Trifluorochloroethane
    • Chloro1,1,1trifluoroethane
    • 2-CTE
    • 1,1,1-trifluorochloroethane
    • 1,1,1Trifluoro2chloroethane
    • 1Chloro2,2,2trifluoroethane
    • 1,1,1Trifluoroethyl chloride
    • DTXCID50289
    • SCHEMBL297295
    • CHEMBL142556
    • Ethane, 2chloro1,1,1trifluoro
    • REFRIGERANT GAS R-133A
    • 2-chloro-1,1,1,-trifluoroethane
    • AKOS007930324
    • DB-019110
    • NS00041091
    • C19367
    • Q3596740
    • 1-Chloro-2,2,2-trifluoroethane or Refrigerant gas R 133a
    • 2-Chloro-1,1,1-trifluoroethane 100 microg/mL in Methanol
    • 1-Chloro-2,2,2-trifluoroethane or Refrigerant gas R 133a [UN1983] [Non-flammable gas]
    • 200-912-0

  • Applications

    2-Chloro-1,1,1-trifluoroethane (CAS 75-88-7) is primarily used as an intermediate in the synthesis of fluorinated organics, enabling introduction of the CF3-CH2- moiety into monomers, polymers, and specialty chemicals. It also serves as a precursor for fluorinated polymers and polymer additives to improve chemical resistance and surface properties. Additionally, it can function as a building block for fluorinated surface modifiers in coatings and inks. In certain industrial and electronics contexts, it may act as a specialty solvent or reaction medium under controlled conditions. It is also considered as an intermediate for fluorinated pharmaceutical or agrochemical intermediates, subject to regulatory constraints and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 470.41
    methanol 851.45
    isopropanol 322.85
    water 250.56
    ethyl acetate 288.49
    n-propanol 276.2
    acetone 1080.45
    n-butanol 203.15
    acetonitrile 813.28
    DMF 2205.44
    toluene 162.9
    isobutanol 196.05
    1,4-dioxane 597.37
    methyl acetate 426.85
    THF 675.96
    2-butanone 468.79
    n-pentanol 152.55
    sec-butanol 212.74
    n-hexane 76.86
    ethylene glycol 271.47
    NMP 1347.57
    cyclohexane 68.23
    DMSO 2088.12
    n-butyl acetate 131.44
    n-octanol 114.82
    chloroform 270.19
    n-propyl acetate 223.65
    acetic acid 547.52
    dichloromethane 444.13
    cyclohexanone 409.83
    propylene glycol 164.49
    isopropyl acetate 176.16
    DMAc 1545.89
    2-ethoxyethanol 455.52
    isopentanol 167.45
    n-heptane 43.94
    ethyl formate 325.17
    1,2-dichloroethane 400.19
    n-hexanol 100.7
    2-methoxyethanol 736.88
    isobutyl acetate 109.78
    tetrachloromethane 63.38
    n-pentyl acetate 108.89
    transcutol 630.34
    n-heptanol 66.34
    ethylbenzene 113.84
    MIBK 206.76
    2-propoxyethanol 292.21
    tert-butanol 364.86
    MTBE 265.43
    2-butoxyethanol 158.12
    propionic acid 262.42
    o-xylene 162.54
    formic acid 531.4
    diethyl ether 370.24
    m-xylene 132.13
    p-xylene 142.57
    chlorobenzene 119.33
    dimethyl carbonate 301.9
    n-octane 23.74
    formamide 947.19
    cyclopentanone 559.18
    2-pentanone 337.33
    anisole 279.87
    cyclopentyl methyl ether 308.5
    gamma-butyrolactone 623.58
    1-methoxy-2-propanol 483.92
    pyridine 432.79
    3-pentanone 326.63
    furfural 659.91
    n-dodecane 22.36
    diethylene glycol 321.52
    diisopropyl ether 113.49
    tert-amyl alcohol 238.14
    acetylacetone 463.59
    n-hexadecane 23.4
    acetophenone 289.69
    methyl propionate 339.19
    isopentyl acetate 95.07
    trichloroethylene 400.87
    n-nonanol 102.64
    cyclohexanol 174.99
    benzyl alcohol 196.06
    2-ethylhexanol 72.72
    isooctanol 57.05
    dipropyl ether 169.75
    1,2-dichlorobenzene 121.05
    ethyl lactate 156.14
    propylene carbonate 262.0
    n-methylformamide 970.64
    2-pentanol 149.87
    n-pentane 81.53
    1-propoxy-2-propanol 183.87
    1-methoxy-2-propyl acetate 168.1
    2-(2-methoxypropoxy) propanol 246.21
    mesitylene 99.31
    ε-caprolactone 318.5
    p-cymene 65.05
    epichlorohydrin 581.88
    1,1,1-trichloroethane 195.44
    2-aminoethanol 311.16
    morpholine-4-carbaldehyde 1187.43
    sulfolane 770.65
    2,2,4-trimethylpentane 30.26
    2-methyltetrahydrofuran 370.93
    n-hexyl acetate 163.99
    isooctane 22.23
    2-(2-butoxyethoxy)ethanol 266.05
    sec-butyl acetate 127.14
    tert-butyl acetate 176.13
    decalin 36.97
    glycerin 248.36
    diglyme 563.08
    acrylic acid 314.19
    isopropyl myristate 87.81
    n-butyric acid 209.62
    acetyl acetate 205.19
    di(2-ethylhexyl) phthalate 84.98
    ethyl propionate 231.83
    nitromethane 1251.75
    1,2-diethoxyethane 243.53
    benzonitrile 225.98
    trioctyl phosphate 66.07
    1-bromopropane 223.18
    gamma-valerolactone 768.34
    n-decanol 82.53
    triethyl phosphate 89.01
    4-methyl-2-pentanol 96.46
    propionitrile 356.71
    vinylene carbonate 288.3
    1,1,2-trichlorotrifluoroethane 350.42
    DMS 188.54
    cumene 91.19
    2-octanol 62.54
    2-hexanone 241.82
    octyl acetate 108.31
    limonene 86.86
    1,2-dimethoxyethane 918.83
    ethyl orthosilicate 82.09
    tributyl phosphate 83.68
    diacetone alcohol 242.25
    N,N-dimethylaniline 292.82
    acrylonitrile 505.19
    aniline 208.2
    1,3-propanediol 285.13
    bromobenzene 103.16
    dibromomethane 297.62
    1,1,2,2-tetrachloroethane 321.86
    2-methyl-cyclohexyl acetate 102.87
    tetrabutyl urea 158.16
    diisobutyl methanol 61.61
    2-phenylethanol 120.72
    styrene 135.05
    dioctyl adipate 130.56
    dimethyl sulfate 496.9
    ethyl butyrate 148.1
    methyl lactate 245.03
    butyl lactate 108.43
    diethyl carbonate 112.15
    propanediol butyl ether 176.42
    triethyl orthoformate 109.3
    p-tert-butyltoluene 62.54
    methyl 4-tert-butylbenzoate 193.29
    morpholine 611.14
    tert-butylamine 257.14
    n-dodecanol 70.16
    dimethoxymethane 963.95
    ethylene carbonate 232.67
    cyrene 241.86
    2-ethoxyethyl acetate 167.22
    2-ethylhexyl acetate 81.03
    1,2,4-trichlorobenzene 134.52
    4-methylpyridine 455.2
    dibutyl ether 134.32
    2,6-dimethyl-4-heptanol 61.61
    DEF 569.3
    dimethyl isosorbide 317.62
    tetrachloroethylene 224.92
    eugenol 191.41
    triacetin 210.85
    span 80 163.53
    1,4-butanediol 150.09
    1,1-dichloroethane 275.04
    2-methyl-1-pentanol 121.94
    methyl formate 800.0
    2-methyl-1-butanol 162.96
    n-decane 31.98
    butyronitrile 268.83
    3,7-dimethyl-1-octanol 97.47
    1-chlorooctane 78.37
    1-chlorotetradecane 41.95
    n-nonane 32.26
    undecane 25.68
    tert-butylcyclohexane 33.47
    cyclooctane 32.17
    cyclopentanol 206.16
    tetrahydropyran 336.21
    tert-amyl methyl ether 226.89
    2,5,8-trioxanonane 450.07
    1-hexene 144.13
    2-isopropoxyethanol 264.51
    2,2,2-trifluoroethanol 293.15
    methyl butyrate 290.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction