2-Butyl-3,5,6-trimethylpyrazine

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  • Identifiers

    CAS number
    10132-38-4

    Molecular formula
    C11H18N2

    SMILES
    CCCCC1=NC(=C(N=C1C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Nutty 53.97%
    Burnt 51.53%
    Earthy 50.15%
    Roasted 49.39%
    Musty 45.61%
    Sweet 40.06%
    Cocoa 38.8%
    Hazelnut 38.09%
    Chocolate 34.02%
    Coffee 32.53%

     

    Flavor
    Earthy 50.66%
    Nutty 49.42%
    Roasted 48.14%
    Musty 46.51%
    Burnt 41.06%
    Hazelnut 39.13%
    Meaty 38.64%
    Potato 37.58%
    Cocoa 35.33%
    Roast 33.26%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    5.4 (weak acid)

    Molecular weight
    178.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    254°C

    Flash point

    • 96.22 ˚C est.

  • Synonyms

    • 2-Butyl-3,5,6-trimethylpyrazine
    • 10132-38-4
    • Butyltrimethylpyrazine
    • 2,3,5-Trimethyl-6-butylpyrazine
    • Trimethylbutylpyrazine
    • Pyrazine, butyltrimethyl-
    • SCHEMBL10496068
    • SCHEMBL29500174
    • LHDGCKPZCAXIBB-UHFFFAOYSA-N
    • HS-3537
    • NS00113829
    • 10132-38-4

  • Applications

    For 2-Butyl-3,5,6-trimethylpyrazine (CAS 10132-38-4), real-world applications are primarily in fragrance and flavor contexts: it is used as an aroma ingredient in perfumery and personal care formulations, providing roasted/nutty notes and contributing to fragrance intensity; in the food and beverage sector it can serve as a flavoring component to reinforce certain roasted or nutty character; in household products such as cleaners and air fresheners it functions as an odorant to improve scent performance; in coatings and inks, it may be incorporated to provide or modulate fragrance in product formulations, subject to regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 592.51
    methanol 587.35
    isopropanol 482.78
    water 0.79
    ethyl acetate 788.31
    n-propanol 617.63
    acetone 737.95
    n-butanol 676.94
    acetonitrile 474.5
    DMF 985.35
    toluene 806.23
    isobutanol 563.28
    1,4-dioxane 1228.47
    methyl acetate 656.06
    THF 1670.29
    2-butanone 792.9
    n-pentanol 508.64
    sec-butanol 594.46
    n-hexane 443.7
    ethylene glycol 76.47
    NMP 1140.7
    cyclohexane 623.7
    DMSO 646.68
    n-butyl acetate 1237.53
    n-octanol 431.79
    chloroform 3557.02
    n-propyl acetate 569.25
    acetic acid 474.91
    dichloromethane 2891.16
    cyclohexanone 1605.07
    propylene glycol 135.82
    isopropyl acetate 554.61
    DMAc 958.99
    2-ethoxyethanol 441.42
    isopentanol 642.95
    n-heptane 270.19
    ethyl formate 594.17
    1,2-dichloroethane 1614.1
    n-hexanol 815.66
    2-methoxyethanol 645.32
    isobutyl acetate 472.9
    tetrachloromethane 854.84
    n-pentyl acetate 662.13
    transcutol 1052.97
    n-heptanol 429.9
    ethylbenzene 504.39
    MIBK 482.24
    2-propoxyethanol 740.62
    tert-butanol 561.36
    MTBE 884.51
    2-butoxyethanol 511.35
    propionic acid 422.98
    o-xylene 530.61
    formic acid 126.62
    diethyl ether 921.09
    m-xylene 527.23
    p-xylene 698.26
    chlorobenzene 1129.02
    dimethyl carbonate 285.26
    n-octane 143.78
    formamide 157.08
    cyclopentanone 1444.21
    2-pentanone 702.19
    anisole 558.04
    cyclopentyl methyl ether 1015.6
    gamma-butyrolactone 1484.25
    1-methoxy-2-propanol 500.39
    pyridine 1260.7
    3-pentanone 673.41
    furfural 1196.47
    n-dodecane 97.14
    diethylene glycol 353.53
    diisopropyl ether 355.53
    tert-amyl alcohol 620.68
    acetylacetone 720.27
    n-hexadecane 112.16
    acetophenone 528.43
    methyl propionate 583.9
    isopentyl acetate 1094.89
    trichloroethylene 2693.81
    n-nonanol 367.61
    cyclohexanol 772.05
    benzyl alcohol 455.47
    2-ethylhexanol 625.73
    isooctanol 354.57
    dipropyl ether 706.76
    1,2-dichlorobenzene 1029.43
    ethyl lactate 232.29
    propylene carbonate 999.86
    n-methylformamide 398.91
    2-pentanol 493.94
    n-pentane 287.59
    1-propoxy-2-propanol 625.04
    1-methoxy-2-propyl acetate 691.22
    2-(2-methoxypropoxy) propanol 382.04
    mesitylene 363.0
    ε-caprolactone 1163.44
    p-cymene 387.8
    epichlorohydrin 1497.7
    1,1,1-trichloroethane 1702.64
    2-aminoethanol 190.05
    morpholine-4-carbaldehyde 927.69
    sulfolane 1359.11
    2,2,4-trimethylpentane 170.06
    2-methyltetrahydrofuran 1363.89
    n-hexyl acetate 815.84
    isooctane 107.59
    2-(2-butoxyethoxy)ethanol 476.95
    sec-butyl acetate 431.33
    tert-butyl acetate 519.85
    decalin 251.03
    glycerin 158.01
    diglyme 880.12
    acrylic acid 349.7
    isopropyl myristate 330.95
    n-butyric acid 784.81
    acetyl acetate 552.72
    di(2-ethylhexyl) phthalate 300.61
    ethyl propionate 495.38
    nitromethane 625.17
    1,2-diethoxyethane 753.46
    benzonitrile 814.25
    trioctyl phosphate 230.49
    1-bromopropane 1232.35
    gamma-valerolactone 1424.66
    n-decanol 274.46
    triethyl phosphate 316.01
    4-methyl-2-pentanol 314.32
    propionitrile 624.51
    vinylene carbonate 921.73
    1,1,2-trichlorotrifluoroethane 786.73
    DMS 528.38
    cumene 359.43
    2-octanol 355.92
    2-hexanone 640.86
    octyl acetate 400.7
    limonene 566.58
    1,2-dimethoxyethane 945.74
    ethyl orthosilicate 322.74
    tributyl phosphate 296.5
    diacetone alcohol 415.1
    N,N-dimethylaniline 463.66
    acrylonitrile 615.85
    aniline 660.7
    1,3-propanediol 344.29
    bromobenzene 1401.74
    dibromomethane 2148.51
    1,1,2,2-tetrachloroethane 2445.99
    2-methyl-cyclohexyl acetate 525.68
    tetrabutyl urea 358.94
    diisobutyl methanol 299.59
    2-phenylethanol 588.09
    styrene 597.98
    dioctyl adipate 399.89
    dimethyl sulfate 395.66
    ethyl butyrate 665.91
    methyl lactate 227.37
    butyl lactate 420.33
    diethyl carbonate 460.72
    propanediol butyl ether 371.94
    triethyl orthoformate 476.26
    p-tert-butyltoluene 357.33
    methyl 4-tert-butylbenzoate 455.74
    morpholine 1162.56
    tert-butylamine 484.58
    n-dodecanol 220.16
    dimethoxymethane 670.5
    ethylene carbonate 815.59
    cyrene 361.34
    2-ethoxyethyl acetate 627.72
    2-ethylhexyl acetate 935.6
    1,2,4-trichlorobenzene 1033.75
    4-methylpyridine 1377.78
    dibutyl ether 686.8
    2,6-dimethyl-4-heptanol 299.59
    DEF 878.83
    dimethyl isosorbide 733.64
    tetrachloroethylene 1746.3
    eugenol 431.55
    triacetin 475.32
    span 80 405.89
    1,4-butanediol 175.74
    1,1-dichloroethane 1628.44
    2-methyl-1-pentanol 534.65
    methyl formate 398.32
    2-methyl-1-butanol 659.42
    n-decane 165.82
    butyronitrile 819.25
    3,7-dimethyl-1-octanol 403.68
    1-chlorooctane 489.58
    1-chlorotetradecane 197.92
    n-nonane 187.11
    undecane 122.11
    tert-butylcyclohexane 221.85
    cyclooctane 229.14
    cyclopentanol 702.81
    tetrahydropyran 1496.73
    tert-amyl methyl ether 715.37
    2,5,8-trioxanonane 571.21
    1-hexene 804.35
    2-isopropoxyethanol 345.12
    2,2,2-trifluoroethanol 183.57
    methyl butyrate 727.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction