2-(Benzyloxy) ethanol

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  • Identifiers

    CAS number
    622-08-2

    Molecular formula
    C9H12O2

    SMILES
    C1=CC=C(C=C1)COCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Rose 56.21%
    Fruity 43.49%
    Floral 41.71%
    Sweet 37.26%
    Balsamic 32.58%
    Almond 29.37%
    Fresh 27.49%
    Honey 27.28%
    Green 27.16%
    Hyacinth 26.78%

     

    Flavor
    Sweet 71.68%
    Floral 59.82%
    Rose 51.77%
    Fruity 48.58%
    Honey 38.65%
    Chocolate 37.03%
    Bitter 36.37%
    Hyacinth 36.06%
    Balsam 35.84%
    Spicy 34.84%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    6.14 (neutral)

    Molecular weight
    152.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • LESS THAN -75 °C

    Boiling point

    • 256 °C @ 760 MM HG

    Flash point

    • 126.08 ˚C est.
    • 265 °F OC

    Solubility expt.

    • SOL IN WATER, ALCOHOL, ETHER

  • Synonyms

    • 2-(Benzyloxy)ethanol
    • 622-08-2
    • 2-Benzyloxyethanol
    • Ethylene glycol monobenzyl ether
    • Ethanol, 2-(phenylmethoxy)-
    • 2-Benzyloxy-1-ethanol
    • Benzyl-PEG2-alcohol
    • Benzyl cellosolve
    • 2-(benzyloxy)ethan-1-ol
    • Glycol monobenzyl ether
    • Glycol benzyl ether
    • 2-Benzyloxy ethanol
    • Ethanol, 2-(benzyloxy)-
    • Benzylcelosolv
    • 1-O-Benzylethanediol
    • Benzyl Glycol
    • 2-phenylmethoxyethanol
    • 2-(BENZYLOXY) ETHANOL
    • 2-benzyloxyethyl alcohol
    • HSDB 2104
    • NSC 8886
    • EINECS 210-719-3
    • MFCD00002868
    • 2-benzyloxy-ethanol
    • BRN 2043566
    • AI3-01040
    • UNII-06S8147L47
    • NSC-8886
    • DTXSID3060744
    • BENZYL 2-HYDROXYETHYL ETHER
    • 4-06-00-02241 (Beilstein Handbook Reference)
    • ETHYLENE GLYCOL BENZYL ETHER
    • 2-(BENZYLOXY) ETHANOL [HSDB]
    • 06S8147L47
    • Benzylcelosolv [Czech]
    • 2benzyloxyethanol
    • 2-benzyloxylethanol
    • benzyloxy-2-ethanol
    • Benzyl 'cellosolve'
    • 2-(benzyloxy)etanol
    • Ethanol, 2(benzyloxy)
    • BENZYL'CELLOSOLVE'
    • 2-(Benzyloxy)-1-ethanol
    • Ethanol, 2(phenylmethoxy)
    • WLN: Q2O1R
    • SCHEMBL23340
    • BENZYL GLYCOL [INCI]
    • 2-(Benzyloxy)ethanol, 98%
    • DTXCID6043256
    • 4-(2-hydroxyethoxy)methylbenzene
    • NSC8886
    • Benzyl-PEG-OH, 5,000 MW
    • BCP19562
    • AKOS009156913
    • CS-W007853
    • FB39552
    • HY-W007853
    • PB47466
    • AS-11798
    • BP-22208
    • BP-29787
    • PD127103
    • SY015814
    • DB-000834
    • B0426
    • NS00034961
    • EN300-83836
    • P17494
    • Q27236216
    • F0001-1657
    • Z854223062

  • Applications

    2-(Benzyloxy) ethanol (CAS 622-08-2) is a common organic synthesis intermediate; it is widely used as a protecting group for hydroxyls in diols (benzyl ether) during carbohydrate and complex molecule synthesis, enabling selective functionalization. It also serves as a precursor to benzyl glycidyl ether, an epoxy resin monomer used in coatings, adhesives, and other polymer formulations. In addition, it functions as a building block in polymer chemistry and resin production, and as a starting point for pharmaceutical and agrochemical intermediate synthesis via protected diol strategies. Depending on formulation goals and local regulations, it may be handled under specific regulatory controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1743.5
    methanol 2256.87
    isopropanol 884.95
    water 9.22
    ethyl acetate 603.25
    n-propanol 1123.74
    acetone 595.77
    n-butanol 805.27
    acetonitrile 661.69
    DMF 733.71
    toluene 76.15
    isobutanol 578.29
    1,4-dioxane 1070.49
    methyl acetate 524.78
    THF 752.61
    2-butanone 376.51
    n-pentanol 391.91
    sec-butanol 567.15
    n-hexane 15.34
    ethylene glycol 755.97
    NMP 328.22
    cyclohexane 50.62
    DMSO 2175.16
    n-butyl acetate 271.05
    n-octanol 95.57
    chloroform 781.43
    n-propyl acetate 301.33
    acetic acid 1852.1
    dichloromethane 869.02
    cyclohexanone 477.96
    propylene glycol 688.12
    isopropyl acetate 178.8
    DMAc 402.32
    2-ethoxyethanol 809.11
    isopentanol 423.35
    n-heptane 26.92
    ethyl formate 434.12
    1,2-dichloroethane 628.35
    n-hexanol 349.61
    2-methoxyethanol 1621.63
    isobutyl acetate 144.09
    tetrachloromethane 77.8
    n-pentyl acetate 96.19
    transcutol 1677.53
    n-heptanol 107.82
    ethylbenzene 43.71
    MIBK 144.73
    2-propoxyethanol 576.27
    tert-butanol 772.93
    MTBE 255.5
    2-butoxyethanol 263.77
    propionic acid 922.76
    o-xylene 57.23
    formic acid 824.64
    diethyl ether 402.46
    m-xylene 54.19
    p-xylene 51.7
    chlorobenzene 158.36
    dimethyl carbonate 143.16
    n-octane 7.44
    formamide 1109.16
    cyclopentanone 480.83
    2-pentanone 299.02
    anisole 167.86
    cyclopentyl methyl ether 298.81
    gamma-butyrolactone 694.1
    1-methoxy-2-propanol 737.79
    pyridine 570.63
    3-pentanone 192.55
    furfural 614.45
    n-dodecane 6.37
    diethylene glycol 639.67
    diisopropyl ether 57.0
    tert-amyl alcohol 435.87
    acetylacetone 300.18
    n-hexadecane 6.98
    acetophenone 156.41
    methyl propionate 377.7
    isopentyl acetate 189.14
    trichloroethylene 1015.6
    n-nonanol 82.13
    cyclohexanol 436.65
    benzyl alcohol 202.92
    2-ethylhexanol 159.22
    isooctanol 85.92
    dipropyl ether 209.17
    1,2-dichlorobenzene 144.78
    ethyl lactate 168.87
    propylene carbonate 359.35
    n-methylformamide 799.41
    2-pentanol 374.89
    n-pentane 21.63
    1-propoxy-2-propanol 376.06
    1-methoxy-2-propyl acetate 231.11
    2-(2-methoxypropoxy) propanol 211.57
    mesitylene 36.61
    ε-caprolactone 422.11
    p-cymene 43.5
    epichlorohydrin 805.55
    1,1,1-trichloroethane 269.77
    2-aminoethanol 1075.82
    morpholine-4-carbaldehyde 587.37
    sulfolane 723.69
    2,2,4-trimethylpentane 13.12
    2-methyltetrahydrofuran 491.71
    n-hexyl acetate 139.22
    isooctane 10.41
    2-(2-butoxyethoxy)ethanol 337.19
    sec-butyl acetate 133.31
    tert-butyl acetate 157.21
    decalin 17.36
    glycerin 793.74
    diglyme 739.54
    acrylic acid 703.94
    isopropyl myristate 54.73
    n-butyric acid 996.08
    acetyl acetate 237.82
    di(2-ethylhexyl) phthalate 60.85
    ethyl propionate 208.71
    nitromethane 1815.6
    1,2-diethoxyethane 325.18
    benzonitrile 185.15
    trioctyl phosphate 46.39
    1-bromopropane 227.57
    gamma-valerolactone 675.2
    n-decanol 60.52
    triethyl phosphate 89.88
    4-methyl-2-pentanol 131.1
    propionitrile 439.09
    vinylene carbonate 347.12
    1,1,2-trichlorotrifluoroethane 761.63
    DMS 132.01
    cumene 36.72
    2-octanol 52.34
    2-hexanone 193.77
    octyl acetate 69.99
    limonene 75.24
    1,2-dimethoxyethane 838.44
    ethyl orthosilicate 92.85
    tributyl phosphate 61.94
    diacetone alcohol 264.7
    N,N-dimethylaniline 98.27
    acrylonitrile 569.74
    aniline 250.16
    1,3-propanediol 1169.07
    bromobenzene 127.4
    dibromomethane 472.28
    1,1,2,2-tetrachloroethane 755.03
    2-methyl-cyclohexyl acetate 130.34
    tetrabutyl urea 81.83
    diisobutyl methanol 81.9
    2-phenylethanol 158.0
    styrene 64.76
    dioctyl adipate 102.08
    dimethyl sulfate 220.88
    ethyl butyrate 220.08
    methyl lactate 236.04
    butyl lactate 121.18
    diethyl carbonate 151.55
    propanediol butyl ether 244.27
    triethyl orthoformate 150.27
    p-tert-butyltoluene 40.95
    methyl 4-tert-butylbenzoate 126.33
    morpholine 1317.1
    tert-butylamine 380.88
    n-dodecanol 47.33
    dimethoxymethane 497.0
    ethylene carbonate 313.95
    cyrene 177.76
    2-ethoxyethyl acetate 165.98
    2-ethylhexyl acetate 130.76
    1,2,4-trichlorobenzene 175.49
    4-methylpyridine 297.41
    dibutyl ether 120.48
    2,6-dimethyl-4-heptanol 81.9
    DEF 418.17
    dimethyl isosorbide 269.11
    tetrachloroethylene 522.27
    eugenol 144.98
    triacetin 175.36
    span 80 181.51
    1,4-butanediol 397.84
    1,1-dichloroethane 378.87
    2-methyl-1-pentanol 237.9
    methyl formate 519.45
    2-methyl-1-butanol 423.02
    n-decane 10.78
    butyronitrile 383.56
    3,7-dimethyl-1-octanol 95.88
    1-chlorooctane 49.41
    1-chlorotetradecane 19.0
    n-nonane 10.51
    undecane 7.91
    tert-butylcyclohexane 14.65
    cyclooctane 14.51
    cyclopentanol 439.49
    tetrahydropyran 760.39
    tert-amyl methyl ether 161.58
    2,5,8-trioxanonane 433.98
    1-hexene 74.55
    2-isopropoxyethanol 409.38
    2,2,2-trifluoroethanol 427.22
    methyl butyrate 321.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction