2-Aminomethyl-1-ethylpyrrolidine

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  • Identifiers

    CAS number
    26116-12-1

    Molecular formula
    C7H16N2

    SMILES
    CCN1CCCC1CN

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 85.32%
    Cheesy 56.98%
    Ripe 46.25%
    Odorless 36.31%
    Animal 35.78%
    Popcorn 25.81%
    Nutty 25.17%
    Meaty 24.02%
    Roasted 21.65%
    Savory 18.08%

     

    Flavor
    Ammoniacal 29.2%
    Roasted 26.75%
    Sulfurous 26.21%
    Fishy 24.4%
    Alkaline 24.12%
    Odorless 23.36%
    Bouillon 22.03%
    Shrimp 21.55%
    Bloody 21.23%
    Skunky 21.22%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.2

    pKa est.
    7.64 (neutral)

    Molecular weight
    128.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    183°C

    Flash point

    • 64.94 ˚C est.

  • Synonyms

    • 2-Aminomethyl-1-ethylpyrrolidine
    • RefChem:75782
    • 2-A-1-EP
    • 2-(Aminomethyl)-1-ethylpyrrolidine
    • 26116-12-1
    • (1-ethylpyrrolidin-2-yl)methanamine
    • 2-Pyrrolidinemethanamine, 1-ethyl-
    • 1-Ethylpyrrolidin-2-ylmethylamine
    • MFCD00003178
    • 1-(1-ethylpyrrolidin-2-yl)methanamine
    • n-ethyl-2-aminomethylpyrrolidine
    • (1-ethylpyrrolidin-2-yl)methylamine
    • 1-ethyl-2-aminomethylpyrrolidine
    • 2-(Aminomethyl)-N-ethylpyrrolidine
    • SULPIRIDE IMPURITY A
    • Pyrrolidine, 2-(aminomethyl)-1-ethyl-
    • K2U95PPN4Z
    • DTXSID3057698
    • 1-ethyl-2-pyrrolidinemethanamine
    • 1-Ethyl-2-(aminomethyl)pyrrolidine
    • N-Ethyl-2-(aminomethyl)pyrrolidine
    • [(2RS)-1-Ethylpyrrolidin-2-yl]methanamine
    • ((2RS)-1-ETHYLPYRROLIDIN-2-YL)METHANAMINE
    • (1-Ethyl-2-pyrrolidinyl)methanamine #
    • Amisulpride Imp. A (EP); Sulpiride Imp. A (EP); [(2RS)-1-Ethylpyrrolidin-2-yl]methanamine; Amisulpride Impurity A; Sulpiride Impurity A
    • EINECS 247-466-3
    • [(1-ethyl-2-pyrrolidinyl)methyl]amine
    • Sulpiride impurity A CRS
    • Amisulpride EP impurity A
    • UNII-K2U95PPN4Z
    • EC 247-466-3
    • SCHEMBL299670
    • n-ethyl-2-aminomethylpyrrolidin
    • orb3029485
    • SCHEMBL1490066
    • SCHEMBL9036814
    • 1-ethyl-2-aminomethlpyrrolidine
    • 2-aminomethyl-l-ethylpyrrolidine
    • CHEMBL3183533
    • DTXCID4031487
    • 1-Ethyl-2-pyrrolidinemethylamine
    • 1-ethyl-2-pyrrolidinylmethylamine
    • n-ethyl-2-aminomethyl pyrrolidine
    • 1-ethyl-2- aminomethylpyrrolidine
    • 1-ethyl-2-aminomethyl pyrrolidine
    • 1-ethyl-2-aminomethyl-pyrrolidine
    • 2-aminomethyl-1 ethyl pyrrolidine
    • 2-aminomethyl-1-ethyl pyrrolidine
    • 2-aminomethyl-1-ethyl-pyrrolidine
    • 2-aminomethyl- 1-ethyl-pyrolidine
    • N-ethyl-2-amino methyl pyrrolidine
    • 2(aminomethyl)-1-ethyl pyrrolidine
    • 2-Aminomethyl-1-(ethyl)pyrrolidine
    • ALBB-006027
    • BB_SC-06884
    • Tox21_113800
    • (-)2-Aminomethyl-1-ethylpyrrolidine
    • 1-ethyl-2-(aminomethyl)-pyrrolidine
    • 2-(aminomethyl)-1-ethyl pyrrolidine
    • 2-(aminomethyl)-1-ethyl-pyrrolidine
    • BBL004461
    • SBB048031
    • STK500375
    • (1-ethylpyrrolidin-2-yl)-methanamine
    • (1-ethylpyrrolidin-2-yl)methaneamine
    • (+)-2-aminomethyl-1-ethylpyrrolidine
    • (-)-1-ethyl-2-aminomethylpyrrolidine
    • AKOS000120735
    • AKOS016037153
    • N-Ethyl-.alpha.-aminomethylpyrrolidine
    • AC-6117
    • C-(1-ethylpyrrolidin-2-yl)methylamine
    • CS-W013458
    • DS-2625
    • EBC-170095
    • IA63832
    • LF-0506
    • PB18512
    • PB19842
    • SB21696
    • NCGC00253676-01
    • SY007096
    • 2-(Aminomethyl)-1-ethylpyrrolidine, 97%
    • 2-(Aminomethyl)-1-ethylpyrrolidine, 98%
    • SULPIRIDE IMPURITY A [EP IMPURITY]
    • (+/-)2-(aminomethyl)-1-ethyl-pyrrolidine
    • CAS-26116-12-1
    • DB-046838
    • (+/-) 2-(aminomethyl)-1-ethyl-pyrrolidine
    • A2556
    • NS00008145
    • ST45029029
    • Amisulpride Impurity A (Sulpiride Impurity A)
    • EN300-21034
    • P10007
    • C-(1-ETHYL-PYRROLIDIN-2-YL)-METHYLAMINE
    • N-((1-ETHYLPYRROLIDIN-2-YL)METHYL)AMINE
    • N-ETHYL-2-AMINOMETHYLTETRAHYDROPYRROLIDINE
    • F035937
    • SR-01000944722
    • (+/-)-2-(AMINOMETHYL)-1-ETHYLPYRROLIDINE
    • SR-01000944722-1
    • Sulpiride EP Impurity A ; Amisulpride EP Impurity A
    • F0001-0866
    • Z104486460
    • Sulpiride impurity A, European Pharmacopoeia (EP) Reference Standard
    • 26116-12-1

  • Applications

    2-Aminomethyl-1-ethylpyrrolidine (CAS 26116-12-1) is used as an intermediate in the synthesis of amine-containing compounds for pharmaceutical and agrochemical development. It provides a saturated pyrrolidine scaffold with a primary aminomethyl group at position 2, enabling downstream functionalization. In polymer and coatings chemistry, it can serve as a reactive diamine building block for crosslinking in epoxy and polyurethane systems, promoting network formation and enhanced material properties. Additionally, it may be used as a precursor to higher-value pyrrolidine derivatives in specialty materials and as a scaffold for ligand design in catalysis.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1182.25
    methanol 2017.25
    isopropanol 480.93
    water 78.33
    ethyl acetate 422.49
    n-propanol 743.98
    acetone 418.39
    n-butanol 582.27
    acetonitrile 632.22
    DMF 388.65
    toluene 101.08
    isobutanol 383.82
    1,4-dioxane 487.74
    methyl acetate 368.84
    THF 838.06
    2-butanone 300.63
    n-pentanol 259.05
    sec-butanol 302.95
    n-hexane 8.86
    ethylene glycol 421.89
    NMP 465.31
    cyclohexane 23.16
    DMSO 868.85
    n-butyl acetate 451.98
    n-octanol 81.11
    chloroform 1461.67
    n-propyl acetate 177.83
    acetic acid 1887.17
    dichloromethane 1216.52
    cyclohexanone 460.1
    propylene glycol 334.75
    isopropyl acetate 189.14
    DMAc 243.27
    2-ethoxyethanol 434.7
    isopentanol 319.31
    n-heptane 17.23
    ethyl formate 594.45
    1,2-dichloroethane 501.0
    n-hexanol 357.79
    2-methoxyethanol 997.26
    isobutyl acetate 98.98
    tetrachloromethane 312.95
    n-pentyl acetate 135.41
    transcutol 579.41
    n-heptanol 119.8
    ethylbenzene 23.95
    MIBK 110.17
    2-propoxyethanol 656.79
    tert-butanol 321.0
    MTBE 161.18
    2-butoxyethanol 267.64
    propionic acid 790.57
    o-xylene 57.7
    formic acid 1402.93
    diethyl ether 219.75
    m-xylene 66.0
    p-xylene 34.95
    chlorobenzene 274.15
    dimethyl carbonate 74.76
    n-octane 6.19
    formamide 871.08
    cyclopentanone 602.46
    2-pentanone 223.02
    anisole 84.78
    cyclopentyl methyl ether 270.21
    gamma-butyrolactone 943.19
    1-methoxy-2-propanol 438.51
    pyridine 531.54
    3-pentanone 145.24
    furfural 875.52
    n-dodecane 5.62
    diethylene glycol 561.72
    diisopropyl ether 41.51
    tert-amyl alcohol 221.08
    acetylacetone 237.28
    n-hexadecane 6.11
    acetophenone 94.65
    methyl propionate 235.88
    isopentyl acetate 268.0
    trichloroethylene 991.15
    n-nonanol 68.38
    cyclohexanol 269.01
    benzyl alcohol 147.08
    2-ethylhexanol 154.54
    isooctanol 85.16
    dipropyl ether 123.06
    1,2-dichlorobenzene 223.66
    ethyl lactate 99.14
    propylene carbonate 499.33
    n-methylformamide 733.21
    2-pentanol 212.69
    n-pentane 18.47
    1-propoxy-2-propanol 384.3
    1-methoxy-2-propyl acetate 268.68
    2-(2-methoxypropoxy) propanol 123.08
    mesitylene 38.75
    ε-caprolactone 460.3
    p-cymene 48.77
    epichlorohydrin 769.78
    1,1,1-trichloroethane 451.85
    2-aminoethanol 639.81
    morpholine-4-carbaldehyde 432.28
    sulfolane 742.86
    2,2,4-trimethylpentane 14.06
    2-methyltetrahydrofuran 522.69
    n-hexyl acetate 128.87
    isooctane 9.22
    2-(2-butoxyethoxy)ethanol 191.62
    sec-butyl acetate 86.17
    tert-butyl acetate 142.95
    decalin 9.13
    glycerin 475.62
    diglyme 350.49
    acrylic acid 730.1
    isopropyl myristate 42.4
    n-butyric acid 1064.66
    acetyl acetate 293.76
    di(2-ethylhexyl) phthalate 64.9
    ethyl propionate 112.75
    nitromethane 1456.08
    1,2-diethoxyethane 188.43
    benzonitrile 267.66
    trioctyl phosphate 48.71
    1-bromopropane 263.31
    gamma-valerolactone 770.47
    n-decanol 49.21
    triethyl phosphate 75.4
    4-methyl-2-pentanol 100.71
    propionitrile 444.67
    vinylene carbonate 517.59
    1,1,2-trichlorotrifluoroethane 627.33
    DMS 89.42
    cumene 22.59
    2-octanol 57.88
    2-hexanone 115.03
    octyl acetate 61.23
    limonene 73.15
    1,2-dimethoxyethane 332.06
    ethyl orthosilicate 74.1
    tributyl phosphate 62.6
    diacetone alcohol 185.26
    N,N-dimethylaniline 46.47
    acrylonitrile 553.99
    aniline 291.7
    1,3-propanediol 784.27
    bromobenzene 244.38
    dibromomethane 686.02
    1,1,2,2-tetrachloroethane 599.49
    2-methyl-cyclohexyl acetate 110.29
    tetrabutyl urea 61.99
    diisobutyl methanol 68.62
    2-phenylethanol 200.48
    styrene 39.72
    dioctyl adipate 65.79
    dimethyl sulfate 126.02
    ethyl butyrate 197.05
    methyl lactate 153.87
    butyl lactate 126.24
    diethyl carbonate 117.06
    propanediol butyl ether 169.58
    triethyl orthoformate 130.25
    p-tert-butyltoluene 47.94
    methyl 4-tert-butylbenzoate 97.6
    morpholine 607.38
    tert-butylamine 181.29
    n-dodecanol 37.04
    dimethoxymethane 233.4
    ethylene carbonate 420.76
    cyrene 120.09
    2-ethoxyethyl acetate 183.82
    2-ethylhexyl acetate 191.88
    1,2,4-trichlorobenzene 268.31
    4-methylpyridine 384.53
    dibutyl ether 68.42
    2,6-dimethyl-4-heptanol 68.62
    DEF 240.26
    dimethyl isosorbide 203.81
    tetrachloroethylene 528.02
    eugenol 113.81
    triacetin 111.88
    span 80 125.02
    1,4-butanediol 243.46
    1,1-dichloroethane 539.06
    2-methyl-1-pentanol 163.51
    methyl formate 510.89
    2-methyl-1-butanol 304.06
    n-decane 9.21
    butyronitrile 478.89
    3,7-dimethyl-1-octanol 85.63
    1-chlorooctane 42.98
    1-chlorotetradecane 16.38
    n-nonane 8.58
    undecane 6.79
    tert-butylcyclohexane 10.41
    cyclooctane 8.46
    cyclopentanol 388.89
    tetrahydropyran 414.15
    tert-amyl methyl ether 102.7
    2,5,8-trioxanonane 205.83
    1-hexene 35.52
    2-isopropoxyethanol 202.82
    2,2,2-trifluoroethanol 597.31
    methyl butyrate 178.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction