2-Aminoisobutyric acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    62-57-7

    Molecular formula
    C4H9NO2

    SMILES
    CC(C)(C(=O)O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 63.31%
    Cheesy 24.34%
    Savory 20.6%
    Sour 20.26%
    Milky 20.05%
    Fishy 18.24%
    Creamy 17.5%
    Sweet 17.42%
    Buttery 16.3%
    Meaty 15.09%

     

    Flavor
    Odorless 36.44%
    Cheese 24.55%
    Sour 23.05%
    Bland 21.57%
    Acidic 21.13%
    Roquefort cheese 20.87%
    Stinky 20.4%
    Soy 20.25%
    Acrid 20.11%
    Mousy 19.72%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.8

    pKa est.
    6.65 (neutral)

    Molecular weight
    103.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    203°C

    Melting point expt.

    • 335 °C

    Flash point

    • 93.29 ˚C est.

    Solubility expt.

    • 181 mg/mL at 25 °C

  • Synonyms

    • 2-Aminoisobutyric acid
    • 62-57-7
    • 2-Methylalanine
    • 2-Amino-2-methylpropanoic acid
    • H-Aib-OH
    • ALPHA-AMINOISOBUTYRIC ACID
    • Alanine, 2-methyl-
    • 2-Amino-2-methylpropionic acid
    • alpha-Methylalanine
    • alpha-Aminoisobutanoic acid
    • NSC 16590
    • alpha,alpha-Dimethylglycine
    • a-Aminoisobutyric acid
    • 2,2-dimethylglycine
    • AIB
    • Propionic acid, 2-amino-2-methyl-
    • a-Aminoisobutyrate
    • MFCD00008049
    • 2-amino-2-methyl-propanoic acid
    • .alpha.-Aminoisobutyric acid
    • 2-amino-isobutyric acid
    • 2-Amino-2-methylpropanoate
    • 2-Aminoisobutyrate
    • EINECS 200-544-0
    • 1E7ZW41IQU
    • Aminoisobutyric acid
    • .alpha.-Aminoisobutanoic acid
    • CB 1637
    • BRN 0506496
    • alpha-Aminoisobutyrate
    • .alpha.-Methylalanine
    • CHEBI:27971
    • AI3-15082
    • NSC-16590
    • DTXSID0058772
    • .alpha.,.alpha.-Dimethylglycine
    • 4-04-00-02616 (Beilstein Handbook Reference)
    • Propanoic acid, 2-amino-2-methyl-
    • .ALPHA.-AMINOISOBUTYRIC ACID [MI]
    • Enzalutamide impurity 15
    • 2-aminoisobutyric acid (2-methylalanine)
    • |A-aminoisobutyric acid
    • UNII-1E7ZW41IQU
    • a-Methylalanine
    • 2Methylalanine
    • alphaMethylalanine
    • 2-methyl alanine
    • Alanine, 2methyl
    • a-Aminoisobutanoate
    • 2-methyl-L-alanine
    • alpha-Aminoisobutanoate
    • alpha-methyl-l-alanine
    • 2-Aminoisobutyric-acid
    • a-Aminoisobutanoic acid
    • a-amino isobutyric acid
    • alphaaminoisobutyric acid
    • .alpha.-Aminoisobutyrate
    • alpha,alphaDimethylglycine
    • alphaAminoisobutanoic acid
    • alpha -aminoisobutyric acid
    • 2Amino2methylpropanoic acid
    • 2Amino2methylpropionic acid
    • SCHEMBL23312
    • ?-AMINOISOBUTYRIC ACID
    • Propionic acid, 2amino2methyl
    • WLN: ZX1&1&VQ
    • 2-Aminoisobutyric acid, 98%
    • CHEMBL1230906
    • DTXCID4043199
    • 2-amino-2-methyl-propionic acid
    • CS-B0930
    • HY-Y0124
    • NSC16590
    • AC8052
    • BBL027672
    • LMFA01100053
    • s6270
    • STK034507
    • AKOS000195995
    • AB00918
    • AC-2694
    • DB02952
    • FA02753
    • NSC-16590;2-Methylalanine;H-Aib-OH
    • 765258-64-8
    • AS-15790
    • BP-12097
    • SY002590
    • A0323
    • NS00014649
    • EN300-53414
    • A22742
    • C03665
    • Q4596860
    • alpha-Aminoisobutyric acid, puriss., >=99.0% (NT)
    • 5085F756-CF99-4860-BBBD-469F4BDEF53C
    • F8889-8339
    • Z317024776
    • 2-Amino-2-methylpropionic acid; alpha-Aminoisobutyric acid; 2-Methylalanine
    • N-Me-alanine;N-Me-ala-oh; DL-2-Amino-iso-butyric acid;H-2-Aminoisobutyric acid
    • 65503-84-6
    • 857402-27-8

  • Applications

    2-Aminoisobutyric acid (AIB), CAS number: 62-57-7, is a non-proteinogenic amino acid widely used as a building block in peptide and peptidomimetic chemistry. It serves as a conformationally restricted residue that helps control secondary structure in synthetic peptides, supporting medicinal chemistry and structural studies. It functions as an intermediate in organic synthesis and as a research reagent in pharmaceutical and biochemical investigations. In polymer science, it can be employed as a functional monomer or linkage in specialty polymers and materials research, and may serve as a precursor for more complex derivatives. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.17
    methanol 2.92
    isopropanol 0.63
    water 122.95
    ethyl acetate 0.56
    n-propanol 0.74
    acetone 0.43
    n-butanol 0.67
    acetonitrile 0.52
    DMF 1.16
    toluene 0.15
    isobutanol 0.76
    1,4-dioxane 0.82
    methyl acetate 0.34
    THF 1.42
    2-butanone 0.54
    n-pentanol 0.51
    sec-butanol 0.85
    n-hexane 0.19
    ethylene glycol 8.31
    NMP 11.34
    cyclohexane 0.17
    DMSO 3.87
    n-butyl acetate 0.35
    n-octanol 0.63
    chloroform 0.44
    n-propyl acetate 0.29
    acetic acid 11.69
    dichloromethane 0.36
    cyclohexanone 1.19
    propylene glycol 5.6
    isopropyl acetate 0.51
    DMAc 4.35
    2-ethoxyethanol 2.46
    isopentanol 0.9
    n-heptane 0.24
    ethyl formate 0.8
    1,2-dichloroethane 0.2
    n-hexanol 0.76
    2-methoxyethanol 4.08
    isobutyl acetate 0.24
    tetrachloromethane 0.47
    n-pentyl acetate 0.5
    transcutol 5.03
    n-heptanol 1.15
    ethylbenzene 0.21
    MIBK 0.7
    2-propoxyethanol 2.73
    tert-butanol 1.47
    MTBE 0.57
    2-butoxyethanol 3.3
    propionic acid 2.54
    o-xylene 0.4
    formic acid 44.87
    diethyl ether 0.28
    m-xylene 0.3
    p-xylene 0.31
    chlorobenzene 0.15
    dimethyl carbonate 0.57
    n-octane 0.12
    formamide 18.11
    cyclopentanone 1.78
    2-pentanone 0.53
    anisole 0.35
    cyclopentyl methyl ether 0.93
    gamma-butyrolactone 2.84
    1-methoxy-2-propanol 2.58
    pyridine 0.46
    3-pentanone 0.53
    furfural 4.28
    n-dodecane 0.06
    diethylene glycol 6.8
    diisopropyl ether 0.28
    tert-amyl alcohol 2.3
    acetylacetone 1.12
    n-hexadecane 0.06
    acetophenone 0.72
    methyl propionate 0.56
    isopentyl acetate 0.55
    trichloroethylene 0.49
    n-nonanol 0.63
    cyclohexanol 0.98
    benzyl alcohol 0.65
    2-ethylhexanol 0.77
    isooctanol 1.08
    dipropyl ether 0.35
    1,2-dichlorobenzene 0.27
    ethyl lactate 1.03
    propylene carbonate 2.13
    n-methylformamide 1.73
    2-pentanol 0.62
    n-pentane 0.14
    1-propoxy-2-propanol 1.91
    1-methoxy-2-propyl acetate 1.08
    2-(2-methoxypropoxy) propanol 4.29
    mesitylene 0.33
    ε-caprolactone 1.62
    p-cymene 0.39
    epichlorohydrin 0.99
    1,1,1-trichloroethane 0.28
    2-aminoethanol 6.41
    morpholine-4-carbaldehyde 5.82
    sulfolane 8.16
    2,2,4-trimethylpentane 0.23
    2-methyltetrahydrofuran 1.1
    n-hexyl acetate 0.65
    isooctane 0.14
    2-(2-butoxyethoxy)ethanol 4.24
    sec-butyl acetate 0.32
    tert-butyl acetate 0.91
    decalin 0.15
    glycerin 18.92
    diglyme 4.54
    acrylic acid 4.03
    isopropyl myristate 0.32
    n-butyric acid 2.11
    acetyl acetate 0.7
    di(2-ethylhexyl) phthalate 1.13
    ethyl propionate 0.38
    nitromethane 3.98
    1,2-diethoxyethane 0.42
    benzonitrile 0.37
    trioctyl phosphate 0.71
    1-bromopropane 0.14
    gamma-valerolactone 3.69
    n-decanol 0.49
    triethyl phosphate 0.68
    4-methyl-2-pentanol 0.79
    propionitrile 0.31
    vinylene carbonate 1.38
    1,1,2-trichlorotrifluoroethane 5.85
    DMS 0.66
    cumene 0.32
    2-octanol 0.65
    2-hexanone 0.37
    octyl acetate 0.46
    limonene 0.52
    1,2-dimethoxyethane 1.38
    ethyl orthosilicate 0.68
    tributyl phosphate 0.71
    diacetone alcohol 3.17
    N,N-dimethylaniline 0.66
    acrylonitrile 0.46
    aniline 0.48
    1,3-propanediol 3.79
    bromobenzene 0.12
    dibromomethane 0.26
    1,1,2,2-tetrachloroethane 0.57
    2-methyl-cyclohexyl acetate 0.77
    tetrabutyl urea 1.04
    diisobutyl methanol 0.71
    2-phenylethanol 0.93
    styrene 0.14
    dioctyl adipate 0.57
    dimethyl sulfate 1.94
    ethyl butyrate 0.43
    methyl lactate 2.27
    butyl lactate 1.49
    diethyl carbonate 0.32
    propanediol butyl ether 4.26
    triethyl orthoformate 0.57
    p-tert-butyltoluene 0.42
    methyl 4-tert-butylbenzoate 2.56
    morpholine 1.09
    tert-butylamine 0.78
    n-dodecanol 0.37
    dimethoxymethane 0.81
    ethylene carbonate 0.94
    cyrene 6.87
    2-ethoxyethyl acetate 0.78
    2-ethylhexyl acetate 0.42
    1,2,4-trichlorobenzene 0.39
    4-methylpyridine 0.41
    dibutyl ether 0.23
    2,6-dimethyl-4-heptanol 0.71
    DEF 1.08
    dimethyl isosorbide 5.39
    tetrachloroethylene 0.81
    eugenol 3.01
    triacetin 1.37
    span 80 4.06
    1,4-butanediol 1.99
    1,1-dichloroethane 0.16
    2-methyl-1-pentanol 0.82
    methyl formate 1.31
    2-methyl-1-butanol 1.04
    n-decane 0.1
    butyronitrile 0.33
    3,7-dimethyl-1-octanol 0.68
    1-chlorooctane 0.18
    1-chlorotetradecane 0.1
    n-nonane 0.1
    undecane 0.08
    tert-butylcyclohexane 0.18
    cyclooctane 0.14
    cyclopentanol 1.44
    tetrahydropyran 0.4
    tert-amyl methyl ether 0.87
    2,5,8-trioxanonane 4.86
    1-hexene 0.21
    2-isopropoxyethanol 1.63
    2,2,2-trifluoroethanol 8.48
    methyl butyrate 0.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction