2-Amino-6-Chloro-4-Nitrophenol

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  • Identifiers

    CAS number
    6358-09-4

    Molecular formula
    C6H5ClN2O3

    SMILES
    C1=C(C=C(C(=C1N)O)Cl)[N+](=O)[O-]

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 62.89%
    Burnt 23.81%
    Phenolic 23.05%
    Sweet 22.42%
    Bitter 22.03%
    Vanilla 20.94%
    Milky 20.37%
    Savory 20.12%
    Dry 18.19%
    Creamy 17.18%

     

    Flavor
    Bitter 68.88%
    Odorless 50.91%
    Mild 34.1%
    Bland 22.49%
    Sweet-like 21.43%
    Nitrile 20.7%
    Very mild 20.34%
    Orange flower 20.07%
    Bread crust 20.06%
    Very strong 19.93%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    7.65 (neutral)

    Molecular weight
    188.57 g/mol

    Flash point

    • 168.43 ˚C est.

  • Synonyms

    • 2-AMINO-6-CHLORO-4-NITROPHENOL
    • 6358-09-4
    • Phenol, 2-amino-6-chloro-4-nitro-
    • 6-Chloro-4-nitro-2-aminophenol
    • 0ZLP5I1TMC
    • DTXSID9043855
    • RODOL 9R BASE
    • COLOREX 2A6C4NP
    • DTXCID7023855
    • RefChem:85305
    • 228-762-1
    • 2-Amino-4-nitro-6-chlorophenol
    • 2-amino-6-chloro-4-nitro-phenol
    • MFCD00035767
    • 3-Chloro-2-hydroxy-5-nitroaniline
    • 4-nitro-6-chloro-2-aminophenol
    • 6-CHLORO-2-AMINO-4-NITRO PHENOL
    • EINECS 228-762-1
    • 6358-04-9
    • 2-AMINO-4-NITRO-6-CHLORO PHENOL
    • UNII-0ZLP5I1TMC
    • SCHEMBL24932
    • SCHEMBL30163339
    • BB_SC-11746
    • Tox21_303798
    • BBL019088
    • SBB007546
    • STK683804
    • AKOS002272652
    • CS-W016775
    • SB38057
    • NCGC00356942-01
    • AC-11375
    • AS-13545
    • ST059629
    • SY050902
    • CAS-6358-09-4
    • DB-054504
    • DB-263830
    • DB-346857
    • A2245
    • NS00001829
    • H10870
    • 358A094
    • F210051
    • Q27251077
    • 6358-09-4

  • Applications

    2-Amino-6-Chloro-4-Nitrophenol is typically used as an intermediate in the manufacture of azo dyes and pigment precursors; it can serve as a building block in pharmaceutical and agrochemical synthesis; in polymer and materials science, it may act as a functional precursor for specialty polymers and materials; in coatings and inks formulations, it may be used as a colorant component and precursor for formulation; in research and development, it is used as a starting material for the synthesis of substituted phenols.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 16.32
    methanol 18.79
    isopropanol 11.48
    water 0.59
    ethyl acetate 29.07
    n-propanol 11.7
    acetone 77.24
    n-butanol 9.23
    acetonitrile 17.93
    DMF 112.21
    toluene 2.19
    isobutanol 7.61
    1,4-dioxane 43.3
    methyl acetate 52.11
    THF 130.57
    2-butanone 59.3
    n-pentanol 10.26
    sec-butanol 11.67
    n-hexane 0.22
    ethylene glycol 14.73
    NMP 197.1
    cyclohexane 0.26
    DMSO 143.46
    n-butyl acetate 22.02
    n-octanol 8.76
    chloroform 1.41
    n-propyl acetate 23.26
    acetic acid 30.06
    dichloromethane 4.0
    cyclohexanone 29.52
    propylene glycol 11.4
    isopropyl acetate 19.2
    DMAc 173.6
    2-ethoxyethanol 45.37
    isopentanol 9.7
    n-heptane 0.85
    ethyl formate 18.24
    1,2-dichloroethane 6.37
    n-hexanol 11.84
    2-methoxyethanol 55.75
    isobutyl acetate 9.9
    tetrachloromethane 0.39
    n-pentyl acetate 16.42
    transcutol 91.7
    n-heptanol 10.48
    ethylbenzene 1.95
    MIBK 17.84
    2-propoxyethanol 43.19
    tert-butanol 20.12
    MTBE 21.69
    2-butoxyethanol 29.51
    propionic acid 18.23
    o-xylene 3.0
    formic acid 29.44
    diethyl ether 16.35
    m-xylene 2.17
    p-xylene 2.92
    chlorobenzene 1.94
    dimethyl carbonate 25.4
    n-octane 0.45
    formamide 60.96
    cyclopentanone 72.0
    2-pentanone 31.79
    anisole 17.95
    cyclopentyl methyl ether 24.16
    gamma-butyrolactone 88.83
    1-methoxy-2-propanol 40.2
    pyridine 22.48
    3-pentanone 25.76
    furfural 60.32
    n-dodecane 0.44
    diethylene glycol 41.71
    diisopropyl ether 4.76
    tert-amyl alcohol 19.27
    acetylacetone 52.49
    n-hexadecane 0.51
    acetophenone 24.19
    methyl propionate 31.87
    isopentyl acetate 18.39
    trichloroethylene 8.79
    n-nonanol 8.72
    cyclohexanol 6.27
    benzyl alcohol 13.28
    2-ethylhexanol 8.32
    isooctanol 8.12
    dipropyl ether 11.82
    1,2-dichlorobenzene 2.72
    ethyl lactate 17.94
    propylene carbonate 32.6
    n-methylformamide 40.07
    2-pentanol 7.9
    n-pentane 0.31
    1-propoxy-2-propanol 28.68
    1-methoxy-2-propyl acetate 34.4
    2-(2-methoxypropoxy) propanol 35.67
    mesitylene 1.74
    ε-caprolactone 35.55
    p-cymene 3.9
    epichlorohydrin 64.88
    1,1,1-trichloroethane 2.67
    2-aminoethanol 16.19
    morpholine-4-carbaldehyde 106.98
    sulfolane 113.67
    2,2,4-trimethylpentane 0.36
    2-methyltetrahydrofuran 51.81
    n-hexyl acetate 19.64
    isooctane 0.27
    2-(2-butoxyethoxy)ethanol 40.71
    sec-butyl acetate 14.66
    tert-butyl acetate 26.43
    decalin 0.3
    glycerin 22.6
    diglyme 77.5
    acrylic acid 21.54
    isopropyl myristate 9.44
    n-butyric acid 14.53
    acetyl acetate 21.52
    di(2-ethylhexyl) phthalate 11.2
    ethyl propionate 21.13
    nitromethane 98.38
    1,2-diethoxyethane 28.43
    benzonitrile 9.32
    trioctyl phosphate 8.71
    1-bromopropane 2.51
    gamma-valerolactone 80.02
    n-decanol 6.82
    triethyl phosphate 12.54
    4-methyl-2-pentanol 5.74
    propionitrile 10.97
    vinylene carbonate 22.07
    1,1,2-trichlorotrifluoroethane 42.51
    DMS 23.77
    cumene 2.0
    2-octanol 6.76
    2-hexanone 25.52
    octyl acetate 13.24
    limonene 5.68
    1,2-dimethoxyethane 61.86
    ethyl orthosilicate 10.66
    tributyl phosphate 9.08
    diacetone alcohol 39.48
    N,N-dimethylaniline 13.92
    acrylonitrile 17.65
    aniline 6.35
    1,3-propanediol 19.23
    bromobenzene 1.28
    dibromomethane 1.67
    1,1,2,2-tetrachloroethane 6.75
    2-methyl-cyclohexyl acetate 17.31
    tetrabutyl urea 15.98
    diisobutyl methanol 5.59
    2-phenylethanol 16.43
    styrene 2.21
    dioctyl adipate 16.42
    dimethyl sulfate 50.83
    ethyl butyrate 18.69
    methyl lactate 25.11
    butyl lactate 14.57
    diethyl carbonate 13.69
    propanediol butyl ether 22.74
    triethyl orthoformate 14.54
    p-tert-butyltoluene 3.84
    methyl 4-tert-butylbenzoate 26.18
    morpholine 48.6
    tert-butylamine 7.01
    n-dodecanol 5.1
    dimethoxymethane 59.81
    ethylene carbonate 16.99
    cyrene 48.92
    2-ethoxyethyl acetate 32.0
    2-ethylhexyl acetate 13.81
    1,2,4-trichlorobenzene 4.96
    4-methylpyridine 17.06
    dibutyl ether 8.35
    2,6-dimethyl-4-heptanol 5.59
    DEF 41.38
    dimethyl isosorbide 61.36
    tetrachloroethylene 4.25
    eugenol 25.22
    triacetin 29.28
    span 80 21.0
    1,4-butanediol 12.44
    1,1-dichloroethane 3.12
    2-methyl-1-pentanol 9.81
    methyl formate 41.41
    2-methyl-1-butanol 9.24
    n-decane 0.69
    butyronitrile 8.38
    3,7-dimethyl-1-octanol 7.66
    1-chlorooctane 2.9
    1-chlorotetradecane 1.46
    n-nonane 0.58
    undecane 0.55
    tert-butylcyclohexane 0.36
    cyclooctane 0.19
    cyclopentanol 13.37
    tetrahydropyran 18.11
    tert-amyl methyl ether 19.34
    2,5,8-trioxanonane 62.61
    1-hexene 1.19
    2-isopropoxyethanol 32.09
    2,2,2-trifluoroethanol 21.15
    methyl butyrate 25.1

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction