2-Amino-5-ethylphenol hydrochloride

Overview IFRA Request a quote

  • Identifiers

    CAS number
    149861-22-3

    Molecular formula
    C8H12ClNO

    SMILES
    CCC1=CC(=C(C=C1)N)O.Cl

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 70.85%
    Smoky 53.4%
    Burnt 43.4%
    Spicy 42.82%
    Medicinal 41.71%
    Animal 32.91%
    Leathery 31.21%
    Meaty 28.1%
    Sweet 28.05%
    Musty 27.32%

     

    Flavor
    Phenolic 65.46%
    Medicinal 51.09%
    Meaty 36.49%
    Smoky 34.29%
    Spicy 34.11%
    Phenol 33.43%
    Mild 33.27%
    Smoke 32.1%
    Woody 26.91%
    Bitter 25.31%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.13 (neutral)

    Molecular weight
    173.64 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    260°C

    Flash point

    • 137.65 ˚C est.

  • Synonyms

    • 2-amino-5-ethylphenol hydrochloride
    • Colorex AEP
    • Phenol, 2-amino-5-ethyl-, hydrochloride
    • 2-AMINO-5-ETHYLPHENOL HCL
    • B5IWK1V8FX
    • Phenol, 2-amino-5-ethyl-, hydrochloride (1:1)
    • 2-Amino-5-ethylphenol HCl [INCI]
    • DTXSID40164418
    • RefChem:464589
    • DTXCID2086909
    • 149861-22-3
    • MFCD13181598
    • 2-Amino-5-ethyl-phenol hydrochloride
    • 2-amino-5-ethylphenol;hydrochloride
    • UNII-B5IWK1V8FX
    • 2-Amino-5-ethylphenolhydrochloride
    • 6-Amino-m-ethylphenol hydrochloride
    • SCHEMBL9491995
    • SCHEMBL31134106
    • 2-amino-5-ethyl-phenol;hydrochloride
    • AKOS015907884
    • SB33781
    • AS-20042
    • FA140059
    • SY102788
    • CS-0152538
    • 2-Amino-5-ethylphenol--hydrogen chloride (1/1)
    • Q27274399
    • 149861-22-3

  • Applications

    2-Amino-5-ethylphenol hydrochloride (CAS 149861-22-3) is primarily used as an intermediate in colorant synthesis, notably for azo dyes and phenolic pigments used in coatings, inks, and plastics. In cosmetics and personal care, it can act as a coupling component or precursor for oxidative hair dye systems. It is also considered a precursor for the synthesis of pharmaceutical and agrochemical compounds, and as a feedstock for other specialized synthetic routes. The hydrochloride salt improves water solubility, enabling its use as a reagent in manufacturing or analytical workflows.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 78.64
    methanol 63.32
    isopropanol 67.17
    water 1.6
    ethyl acetate 45.79
    n-propanol 59.87
    acetone 92.72
    n-butanol 42.35
    acetonitrile 88.87
    DMF 156.59
    toluene 9.37
    isobutanol 42.93
    1,4-dioxane 144.23
    methyl acetate 63.29
    THF 194.94
    2-butanone 73.38
    n-pentanol 33.71
    sec-butanol 40.99
    n-hexane 0.78
    ethylene glycol 26.88
    NMP 80.33
    cyclohexane 1.41
    DMSO 259.84
    n-butyl acetate 43.26
    n-octanol 28.64
    chloroform 58.91
    n-propyl acetate 27.88
    acetic acid 95.38
    dichloromethane 72.48
    cyclohexanone 70.58
    propylene glycol 29.99
    isopropyl acetate 23.11
    DMAc 128.3
    2-ethoxyethanol 72.27
    isopentanol 36.18
    n-heptane 2.86
    ethyl formate 58.95
    1,2-dichloroethane 43.8
    n-hexanol 61.65
    2-methoxyethanol 121.56
    isobutyl acetate 18.49
    tetrachloromethane 11.7
    n-pentyl acetate 26.1
    transcutol 117.5
    n-heptanol 39.0
    ethylbenzene 8.51
    MIBK 27.7
    2-propoxyethanol 100.74
    tert-butanol 95.55
    MTBE 47.63
    2-butoxyethanol 64.3
    propionic acid 56.01
    o-xylene 11.92
    formic acid 50.83
    diethyl ether 23.81
    m-xylene 12.71
    p-xylene 11.99
    chlorobenzene 23.05
    dimethyl carbonate 21.77
    n-octane 1.82
    formamide 89.13
    cyclopentanone 120.27
    2-pentanone 42.97
    anisole 29.11
    cyclopentyl methyl ether 35.66
    gamma-butyrolactone 138.29
    1-methoxy-2-propanol 76.94
    pyridine 64.06
    3-pentanone 27.68
    furfural 113.09
    n-dodecane 1.98
    diethylene glycol 87.0
    diisopropyl ether 7.59
    tert-amyl alcohol 56.08
    acetylacetone 53.61
    n-hexadecane 2.2
    acetophenone 29.77
    methyl propionate 39.01
    isopentyl acetate 38.48
    trichloroethylene 98.91
    n-nonanol 26.04
    cyclohexanol 24.71
    benzyl alcohol 29.81
    2-ethylhexanol 31.48
    isooctanol 30.44
    dipropyl ether 24.18
    1,2-dichlorobenzene 25.31
    ethyl lactate 21.62
    propylene carbonate 62.91
    n-methylformamide 94.13
    2-pentanol 22.23
    n-pentane 0.81
    1-propoxy-2-propanol 69.22
    1-methoxy-2-propyl acetate 46.79
    2-(2-methoxypropoxy) propanol 48.79
    mesitylene 9.73
    ε-caprolactone 58.04
    p-cymene 12.96
    epichlorohydrin 142.34
    1,1,1-trichloroethane 38.48
    2-aminoethanol 50.04
    morpholine-4-carbaldehyde 99.48
    sulfolane 149.83
    2,2,4-trimethylpentane 1.59
    2-methyltetrahydrofuran 83.4
    n-hexyl acetate 32.08
    isooctane 1.67
    2-(2-butoxyethoxy)ethanol 70.07
    sec-butyl acetate 16.05
    tert-butyl acetate 31.81
    decalin 1.95
    glycerin 54.29
    diglyme 123.17
    acrylic acid 49.76
    isopropyl myristate 16.08
    n-butyric acid 69.07
    acetyl acetate 28.32
    di(2-ethylhexyl) phthalate 21.14
    ethyl propionate 20.75
    nitromethane 170.74
    1,2-diethoxyethane 42.87
    benzonitrile 36.52
    trioctyl phosphate 18.45
    1-bromopropane 14.87
    gamma-valerolactone 136.37
    n-decanol 21.19
    triethyl phosphate 18.23
    4-methyl-2-pentanol 17.93
    propionitrile 48.04
    vinylene carbonate 58.6
    1,1,2-trichlorotrifluoroethane 81.88
    DMS 24.14
    cumene 9.44
    2-octanol 22.06
    2-hexanone 30.64
    octyl acetate 22.31
    limonene 16.12
    1,2-dimethoxyethane 108.13
    ethyl orthosilicate 17.66
    tributyl phosphate 16.83
    diacetone alcohol 52.94
    N,N-dimethylaniline 23.56
    acrylonitrile 72.14
    aniline 22.86
    1,3-propanediol 70.39
    bromobenzene 21.08
    dibromomethane 36.83
    1,1,2,2-tetrachloroethane 64.09
    2-methyl-cyclohexyl acetate 29.38
    tetrabutyl urea 23.71
    diisobutyl methanol 19.31
    2-phenylethanol 42.62
    styrene 8.47
    dioctyl adipate 23.55
    dimethyl sulfate 41.76
    ethyl butyrate 29.68
    methyl lactate 30.34
    butyl lactate 26.46
    diethyl carbonate 21.15
    propanediol butyl ether 46.88
    triethyl orthoformate 21.95
    p-tert-butyltoluene 13.22
    methyl 4-tert-butylbenzoate 42.64
    morpholine 128.04
    tert-butylamine 36.03
    n-dodecanol 16.45
    dimethoxymethane 71.1
    ethylene carbonate 45.3
    cyrene 48.96
    2-ethoxyethyl acetate 39.15
    2-ethylhexyl acetate 25.78
    1,2,4-trichlorobenzene 30.08
    4-methylpyridine 44.57
    dibutyl ether 17.49
    2,6-dimethyl-4-heptanol 19.31
    DEF 43.3
    dimethyl isosorbide 75.99
    tetrachloroethylene 41.31
    eugenol 44.62
    triacetin 32.28
    span 80 43.74
    1,4-butanediol 28.45
    1,1-dichloroethane 39.19
    2-methyl-1-pentanol 31.62
    methyl formate 75.28
    2-methyl-1-butanol 32.44
    n-decane 2.77
    butyronitrile 44.51
    3,7-dimethyl-1-octanol 23.34
    1-chlorooctane 11.84
    1-chlorotetradecane 5.59
    n-nonane 2.25
    undecane 2.33
    tert-butylcyclohexane 2.35
    cyclooctane 0.93
    cyclopentanol 40.45
    tetrahydropyran 62.08
    tert-amyl methyl ether 25.95
    2,5,8-trioxanonane 89.43
    1-hexene 4.24
    2-isopropoxyethanol 49.79
    2,2,2-trifluoroethanol 36.71
    methyl butyrate 31.45

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction