2-Amino-4-methylpyridine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    695-34-1

    Molecular formula
    C6H8N2

    SMILES
    CC1=CC(=NC=C1)N

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Animal 48.93%
    Roasted 45.82%
    Nutty 44.17%
    Fishy 43.57%
    Green 43.19%
    Burnt 38.78%
    Musty 38.76%
    Meaty 35.82%
    Earthy 34.39%
    Cocoa 29.67%

     

    Flavor
    Nutty 42.59%
    Roasted 42.17%
    Cocoa 36.34%
    Coffee 35.85%
    Bitter 31.46%
    Meaty 28.91%
    Musty 28.51%
    Roast 25.98%
    Chocolate 25.76%
    Burnt 24.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    6.0 (neutral)

    Molecular weight
    108.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    220°C

    Flash point

    • 110.01 ˚C est.

  • Synonyms

    • 2-amino-4-methylpyridine
    • 4-METHYLPYRIDIN-2-AMINE
    • 695-34-1
    • 2-Amino-4-picoline
    • Ascensil
    • Aminopicoline
    • 2-Pyridinamine, 4-methyl-
    • 4-Methyl-2-pyridinamine
    • 4-Methyl-2-aminopyridine
    • 4-Methyl-2-pyridylamine
    • 4-PICOLINE, 2-AMINO-
    • RA 1226
    • VMI 20-4
    • DTXSID1044720
    • NSC-1490
    • NSC-6972
    • 394N1Z644H
    • RA-1226
    • DTXCID9024720
    • NSC-176165
    • RefChem:85219
    • 211-780-9
    • W 45 Raschig
    • 4M2AP
    • Rifaximin EP Impurity A
    • Pyridine, 2-amino-4-methyl-
    • Methyl-4 amino-2-pyridine
    • MFCD00006321
    • 4-methylpyridin-2-ylamine
    • NSC 1490
    • NSC 6972
    • W 45
    • 2-Amino-.gamma.-picoline
    • 2-amino-4-methyl-pyridine
    • 4-Methyl-pyridin-2-ylamine
    • CHEMBL40833
    • 2-amino-4-methyl pyridine
    • WLN: T6NJ BZ D1
    • alpha-Amino-gamma-picoline
    • BVF
    • EINECS 211-780-9
    • BRN 0107066
    • AI3-23984
    • UNII-394N1Z644H
    • 4-methylpyridyl amine
    • Tocris-1020
    • W-45
    • 2-amino4-methylpyridine
    • 4-methyl-pyridin-2-amine
    • 4-methyl-2-amino-pyridine
    • SCHEMBL25153
    • 5-22-09-00325 (Beilstein Handbook Reference)
    • SCHEMBL294601
    • SCHEMBL907735
    • GTPL5111
    • orb3029839
    • SCHEMBL4067922
    • SCHEMBL4720170
    • .alpha.-Amino-.gamma.-picoline
    • SCHEMBL11544278
    • SCHEMBL21515309
    • SCHEMBL29406785
    • (4-methyl-pyridin-2-yl)-amine
    • NSC1490
    • NSC6972
    • 2-Amino-4-methylpyridine, 99%
    • 2-AMINO-4-PICOLINE [MI]
    • BB_SC-12777
    • STR00701
    • AMINO-4-METHYLPYRIDINE, 2-
    • Tox21_301597
    • (4-METHYLPYRIDIN-2-YL)AMINE
    • 4-METHYLPYRIDIN-2-AMINE, 6
    • AB2620
    • BDBM50091800
    • EBC-03074
    • HSCI1_000374
    • SBB004354
    • STK385035
    • AKOS000119085
    • AB00703
    • AC-2481
    • CS-W003969
    • FA45037
    • HY-W003969
    • PS-9285
    • SB75552
    • NCGC00024943-01
    • NCGC00256313-01
    • CAS-695-34-1
    • RIFAXIMIN IMPURITY A [EP IMPURITY]
    • DB-024215
    • A0402
    • A5223
    • A9196
    • NS00036880
    • ST45053549
    • EN300-21467
    • AC-907/25014131
    • F013751
    • SR-01000597673
    • SR-01000597673-1
    • BRD-K74039237-001-01-7
    • Q24755764
    • F1995-0205
    • Z203045032
    • InChI=1/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8
    • 695-34-1

  • Applications

    2-Amino-4-methylpyridine (CAS 695-34-1) is a versatile building block used as an intermediate in organic synthesis. It is commonly employed as a precursor for the preparation of heterocyclic compounds and as a scaffold in the synthesis of pharmaceutical and agrochemical actives. It also serves as a coordinating ligand in coordination chemistry and as a catalyst-support in metal-catalyzed processes. Additionally, it is used as a building block for the development of functional materials and other specialty chemicals bearing pyridine motifs.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 889.58
    methanol 957.9
    isopropanol 338.92
    water 79.04
    ethyl acetate 364.17
    n-propanol 472.15
    acetone 572.72
    n-butanol 307.24
    acetonitrile 396.85
    DMF 427.47
    toluene 38.21
    isobutanol 184.01
    1,4-dioxane 382.43
    methyl acetate 330.0
    THF 717.92
    2-butanone 328.88
    n-pentanol 158.79
    sec-butanol 205.9
    n-hexane 7.94
    ethylene glycol 154.35
    NMP 385.24
    cyclohexane 6.59
    DMSO 536.77
    n-butyl acetate 141.39
    n-octanol 44.96
    chloroform 173.65
    n-propyl acetate 97.18
    acetic acid 821.45
    dichloromethane 138.67
    cyclohexanone 268.5
    propylene glycol 155.43
    isopropyl acetate 123.8
    DMAc 288.04
    2-ethoxyethanol 204.85
    isopentanol 135.87
    n-heptane 9.96
    ethyl formate 241.06
    1,2-dichloroethane 77.68
    n-hexanol 175.26
    2-methoxyethanol 536.13
    isobutyl acetate 45.88
    tetrachloromethane 32.66
    n-pentyl acetate 65.53
    transcutol 274.82
    n-heptanol 63.86
    ethylbenzene 4.99
    MIBK 73.95
    2-propoxyethanol 293.12
    tert-butanol 214.18
    MTBE 115.25
    2-butoxyethanol 118.18
    propionic acid 423.9
    o-xylene 19.1
    formic acid 615.9
    diethyl ether 240.62
    m-xylene 27.01
    p-xylene 10.41
    chlorobenzene 51.18
    dimethyl carbonate 92.48
    n-octane 2.9
    formamide 620.7
    cyclopentanone 442.1
    2-pentanone 238.23
    anisole 33.93
    cyclopentyl methyl ether 215.2
    gamma-butyrolactone 606.39
    1-methoxy-2-propanol 277.24
    pyridine 178.64
    3-pentanone 149.07
    furfural 291.24
    n-dodecane 2.11
    diethylene glycol 214.71
    diisopropyl ether 31.29
    tert-amyl alcohol 129.77
    acetylacetone 186.01
    n-hexadecane 2.31
    acetophenone 33.18
    methyl propionate 274.23
    isopentyl acetate 79.57
    trichloroethylene 146.36
    n-nonanol 37.85
    cyclohexanol 119.05
    benzyl alcohol 44.82
    2-ethylhexanol 57.43
    isooctanol 39.07
    dipropyl ether 76.58
    1,2-dichlorobenzene 30.76
    ethyl lactate 44.36
    propylene carbonate 196.57
    n-methylformamide 509.49
    2-pentanol 136.68
    n-pentane 11.83
    1-propoxy-2-propanol 153.74
    1-methoxy-2-propyl acetate 114.91
    2-(2-methoxypropoxy) propanol 66.53
    mesitylene 13.33
    ε-caprolactone 206.78
    p-cymene 12.64
    epichlorohydrin 328.31
    1,1,1-trichloroethane 91.48
    2-aminoethanol 296.43
    morpholine-4-carbaldehyde 289.7
    sulfolane 326.03
    2,2,4-trimethylpentane 4.43
    2-methyltetrahydrofuran 381.99
    n-hexyl acetate 69.28
    isooctane 3.76
    2-(2-butoxyethoxy)ethanol 100.85
    sec-butyl acetate 45.52
    tert-butyl acetate 84.31
    decalin 2.52
    glycerin 190.11
    diglyme 164.25
    acrylic acid 303.99
    isopropyl myristate 20.72
    n-butyric acid 449.0
    acetyl acetate 143.5
    di(2-ethylhexyl) phthalate 27.0
    ethyl propionate 77.33
    nitromethane 957.43
    1,2-diethoxyethane 102.82
    benzonitrile 68.49
    trioctyl phosphate 21.61
    1-bromopropane 60.8
    gamma-valerolactone 441.86
    n-decanol 26.79
    triethyl phosphate 26.7
    4-methyl-2-pentanol 50.03
    propionitrile 211.92
    vinylene carbonate 168.85
    1,1,2-trichlorotrifluoroethane 181.73
    DMS 55.26
    cumene 5.88
    2-octanol 33.69
    2-hexanone 90.15
    octyl acetate 33.31
    limonene 22.37
    1,2-dimethoxyethane 197.32
    ethyl orthosilicate 26.14
    tributyl phosphate 25.85
    diacetone alcohol 108.53
    N,N-dimethylaniline 20.52
    acrylonitrile 215.05
    aniline 107.38
    1,3-propanediol 349.54
    bromobenzene 35.42
    dibromomethane 89.05
    1,1,2,2-tetrachloroethane 97.79
    2-methyl-cyclohexyl acetate 36.27
    tetrabutyl urea 31.13
    diisobutyl methanol 26.13
    2-phenylethanol 61.55
    styrene 7.53
    dioctyl adipate 29.39
    dimethyl sulfate 114.84
    ethyl butyrate 69.29
    methyl lactate 110.3
    butyl lactate 49.99
    diethyl carbonate 40.86
    propanediol butyl ether 76.6
    triethyl orthoformate 45.21
    p-tert-butyltoluene 12.72
    methyl 4-tert-butylbenzoate 45.28
    morpholine 465.39
    tert-butylamine 94.65
    n-dodecanol 19.08
    dimethoxymethane 268.21
    ethylene carbonate 159.79
    cyrene 56.51
    2-ethoxyethyl acetate 93.91
    2-ethylhexyl acetate 59.03
    1,2,4-trichlorobenzene 44.28
    4-methylpyridine 151.96
    dibutyl ether 37.96
    2,6-dimethyl-4-heptanol 26.13
    DEF 192.07
    dimethyl isosorbide 96.98
    tetrachloroethylene 70.2
    eugenol 48.98
    triacetin 56.45
    span 80 62.0
    1,4-butanediol 96.58
    1,1-dichloroethane 111.77
    2-methyl-1-pentanol 80.85
    methyl formate 318.73
    2-methyl-1-butanol 137.2
    n-decane 3.71
    butyronitrile 205.87
    3,7-dimethyl-1-octanol 34.8
    1-chlorooctane 16.4
    1-chlorotetradecane 6.36
    n-nonane 3.7
    undecane 2.67
    tert-butylcyclohexane 3.38
    cyclooctane 2.32
    cyclopentanol 221.95
    tetrahydropyran 310.23
    tert-amyl methyl ether 73.08
    2,5,8-trioxanonane 109.73
    1-hexene 26.94
    2-isopropoxyethanol 101.31
    2,2,2-trifluoroethanol 252.84
    methyl butyrate 95.83

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction