2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol

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  • Identifiers

    CAS number
    1050517-23-1

    Molecular formula
    C20H30O7

    SMILES
    CC1=C(C2=C(CCC(O2)(C)C[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C(=C1O)C)C

    Safety labels

  • Odor profile

    Fragrance
    Odorless 49.02%
    Vanilla 34.99%
    Sweet 34.87%
    Phenolic 31.51%
    Spicy 28.23%
    Smoky 25.88%
    Woody 24.97%
    Creamy 23.85%
    Powdery 23.73%
    Burnt 21.49%

     

    Flavor
    Bitter 57.06%
    Odorless 30.1%
    Sweet-like 25.92%
    Bland 25.35%
    Cedarleaf 21.58%
    Eugenol 21.49%
    Parsley 21.16%
    Mentholic 20.7%
    Leaves 20.51%
    Beet 20.36%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    6.96 (neutral)

    Molecular weight
    382.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2326°C

    Flash point

    • 218.68 ˚C est.

  • Synonyms

    • 2-(alpha-d-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol
    • RefChem:188780
    • Tetramethylchromanol glucoside
    • Water soluble Vitamin E derivative
    • 1050517-23-1
    • UNII-7YWI9T8733
    • 7YWI9T8733
    • (2R,3S,4R,5R,6R)-2-(hydroxymethyl)-6-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methyl]oxane-3,4,5-triol
    • SCHEMBL542599
    • DTXSID40146931
    • Q27269036
    • 2,6-Anhydro-7-deoxy-7-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)-D-glycero-L-gulo-heptitol
    • 1050517-23-1

  • Applications

    2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol (CAS number: 1050517-23-1) is a glycosylated tocopherol derivative that is typically employed as an antioxidant and stabilizer in cosmetic and personal care formulations, helping protect photosensitive ingredients, preserve product integrity, and contribute to skin-conditioning properties. In pharmaceutical and topical drug-delivery contexts, it may be used as an antioxidant additive and has potential as a prodrug to release tocopherol in tissue. It can serve as a stabilizer or antioxidant in polymers and plastics, mitigating oxidative degradation during processing and in service. In coatings and inks, it is used as an antioxidant additive to improve formulation stability and color retention. It may also find use in household cleaning products to enhance oxidative stability of formulations. Overall, its role is primarily as an antioxidant/stabilizer, with use governed by formulation goals and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.86
    methanol 28.18
    isopropanol 1.83
    water 0.32
    ethyl acetate 1.41
    n-propanol 3.25
    acetone 5.38
    n-butanol 2.88
    acetonitrile 1.06
    DMF 23.05
    toluene 0.71
    isobutanol 1.59
    1,4-dioxane 17.9
    methyl acetate 1.42
    THF 31.07
    2-butanone 2.51
    n-pentanol 1.99
    sec-butanol 1.16
    n-hexane 0.04
    ethylene glycol 5.62
    NMP 13.88
    cyclohexane 0.09
    DMSO 115.13
    n-butyl acetate 1.13
    n-octanol 3.41
    chloroform 1.43
    n-propyl acetate 1.08
    acetic acid 14.22
    dichloromethane 1.57
    cyclohexanone 7.54
    propylene glycol 3.94
    isopropyl acetate 1.46
    DMAc 22.49
    2-ethoxyethanol 23.97
    isopentanol 2.44
    n-heptane 0.1
    ethyl formate 2.54
    1,2-dichloroethane 1.47
    n-hexanol 2.09
    2-methoxyethanol 39.75
    isobutyl acetate 0.9
    tetrachloromethane 0.34
    n-pentyl acetate 3.42
    transcutol 34.33
    n-heptanol 4.16
    ethylbenzene 0.48
    MIBK 2.61
    2-propoxyethanol 18.36
    tert-butanol 2.32
    MTBE 1.14
    2-butoxyethanol 16.64
    propionic acid 2.44
    o-xylene 0.72
    formic acid 21.94
    diethyl ether 1.32
    m-xylene 0.73
    p-xylene 0.57
    chlorobenzene 0.76
    dimethyl carbonate 3.09
    n-octane 0.1
    formamide 23.12
    cyclopentanone 10.31
    2-pentanone 3.01
    anisole 2.11
    cyclopentyl methyl ether 3.92
    gamma-butyrolactone 10.6
    1-methoxy-2-propanol 17.17
    pyridine 4.62
    3-pentanone 1.69
    furfural 13.65
    n-dodecane 0.08
    diethylene glycol 25.68
    diisopropyl ether 0.42
    tert-amyl alcohol 1.66
    acetylacetone 7.88
    n-hexadecane 0.09
    acetophenone 3.36
    methyl propionate 2.04
    isopentyl acetate 1.73
    trichloroethylene 3.06
    n-nonanol 3.7
    cyclohexanol 2.03
    benzyl alcohol 3.95
    2-ethylhexanol 1.27
    isooctanol 3.19
    dipropyl ether 1.36
    1,2-dichlorobenzene 0.94
    ethyl lactate 2.75
    propylene carbonate 4.06
    n-methylformamide 10.54
    2-pentanol 0.94
    n-pentane 0.04
    1-propoxy-2-propanol 8.41
    1-methoxy-2-propyl acetate 4.95
    2-(2-methoxypropoxy) propanol 11.73
    mesitylene 0.52
    ε-caprolactone 6.09
    p-cymene 0.64
    epichlorohydrin 14.29
    1,1,1-trichloroethane 0.64
    2-aminoethanol 8.45
    morpholine-4-carbaldehyde 29.69
    sulfolane 29.57
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 4.71
    n-hexyl acetate 4.33
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 19.04
    sec-butyl acetate 0.8
    tert-butyl acetate 2.61
    decalin 0.08
    glycerin 15.22
    diglyme 33.51
    acrylic acid 4.26
    isopropyl myristate 1.48
    n-butyric acid 3.77
    acetyl acetate 2.22
    di(2-ethylhexyl) phthalate 3.19
    ethyl propionate 1.12
    nitromethane 18.32
    1,2-diethoxyethane 5.71
    benzonitrile 1.88
    trioctyl phosphate 2.38
    1-bromopropane 0.4
    gamma-valerolactone 30.98
    n-decanol 2.22
    triethyl phosphate 1.64
    4-methyl-2-pentanol 1.07
    propionitrile 0.78
    vinylene carbonate 4.48
    1,1,2-trichlorotrifluoroethane 18.58
    DMS 2.97
    cumene 0.42
    2-octanol 2.06
    2-hexanone 1.86
    octyl acetate 2.42
    limonene 0.79
    1,2-dimethoxyethane 23.49
    ethyl orthosilicate 1.67
    tributyl phosphate 1.86
    diacetone alcohol 7.2
    N,N-dimethylaniline 1.89
    acrylonitrile 1.48
    aniline 1.73
    1,3-propanediol 14.29
    bromobenzene 0.55
    dibromomethane 0.78
    1,1,2,2-tetrachloroethane 2.78
    2-methyl-cyclohexyl acetate 2.18
    tetrabutyl urea 3.32
    diisobutyl methanol 1.03
    2-phenylethanol 4.09
    styrene 0.43
    dioctyl adipate 3.21
    dimethyl sulfate 7.88
    ethyl butyrate 1.25
    methyl lactate 5.07
    butyl lactate 5.22
    diethyl carbonate 0.93
    propanediol butyl ether 14.71
    triethyl orthoformate 1.96
    p-tert-butyltoluene 0.68
    methyl 4-tert-butylbenzoate 8.23
    morpholine 16.44
    tert-butylamine 0.61
    n-dodecanol 1.32
    dimethoxymethane 20.47
    ethylene carbonate 3.47
    cyrene 15.1
    2-ethoxyethyl acetate 7.58
    2-ethylhexyl acetate 1.2
    1,2,4-trichlorobenzene 1.47
    4-methylpyridine 2.8
    dibutyl ether 1.57
    2,6-dimethyl-4-heptanol 1.03
    DEF 4.76
    dimethyl isosorbide 17.84
    tetrachloroethylene 2.43
    eugenol 9.26
    triacetin 7.17
    span 80 9.37
    1,4-butanediol 4.97
    1,1-dichloroethane 0.49
    2-methyl-1-pentanol 1.85
    methyl formate 10.28
    2-methyl-1-butanol 1.97
    n-decane 0.18
    butyronitrile 0.98
    3,7-dimethyl-1-octanol 2.27
    1-chlorooctane 0.81
    1-chlorotetradecane 0.27
    n-nonane 0.14
    undecane 0.11
    tert-butylcyclohexane 0.07
    cyclooctane 0.07
    cyclopentanol 2.57
    tetrahydropyran 4.21
    tert-amyl methyl ether 1.15
    2,5,8-trioxanonane 24.4
    1-hexene 0.16
    2-isopropoxyethanol 10.04
    2,2,2-trifluoroethanol 5.96
    methyl butyrate 1.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction