2-Acetyl-5-ethylpyrazine

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  • Identifiers

    CAS number
    43108-58-3

    Molecular formula
    C8H10N2O

    SMILES
    CCC1=CN=C(C=N1)C(=O)C

  • Odor profile

    Fragrance
    Nutty 83.38%
    Roasted 71.59%
    Popcorn 64.72%
    Hazelnut 56.25%
    Earthy 48.38%
    Musty 45.48%
    Potato 44.89%
    Cocoa 43.61%
    Coffee 40.52%
    Burnt 36.97%

     

    Flavor
    Nutty 69.42%
    Popcorn 57.52%
    Roast 50.18%
    Roasted 48.97%
    Corn 45.41%
    Potato 45.39%
    Hazelnut 42.94%
    Earthy 41.49%
    Coffee 40.9%
    Chip 40.13%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    5.22 (weak acid)

    Molecular weight
    150.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    238°C

    Flash point

    • 117.83 ˚C est.

  • Synonyms

    • 43108-58-3
    • 2-acetyl-5-ethylpyrazine
    • 1-(5-ethylpyrazin-2-yl)ethanone
    • 2-Ethyl-5-acetylpyrazine
    • Ethanone, 1-(5-ethylpyrazinyl)-
    • 5ZYU14WFR3
    • Ethanone, 1-(5-ethyl-2-pyrazinyl)-
    • DTXSID901019788
    • 2-Ethyl-5-acetylpyrazin
    • UNII-5ZYU14WFR3
    • 2-acetyl-5-ethyl pyrazine
    • 2-Ethyl-5-acetyl pyrazine
    • SCHEMBL7940727
    • DTXCID301477681
    • NS00123452

  • Applications

    2-Acetyl-5-ethylpyrazine (CAS 43108-58-3) is used primarily as an odorant and flavor ingredient in industrial applications, with notable use in fragrance and flavor sectors; it provides roasted, nutty notes reminiscent of coffee and chocolate, and is employed in perfumery for fragrance blending and in food and beverage formulations to contribute roasty profiles; in cosmetics/personal care it serves as a fragrance component; in household products such as air fresheners and cleaners it delivers warm aroma accents; it may also function as an intermediate in the synthesis of related pyrazine aroma compounds in industrial manufacturing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 87.91
    methanol 153.16
    isopropanol 50.44
    water 3.8
    ethyl acetate 80.04
    n-propanol 61.58
    acetone 139.69
    n-butanol 62.4
    acetonitrile 124.92
    DMF 360.33
    toluene 57.81
    isobutanol 55.65
    1,4-dioxane 129.7
    methyl acetate 93.25
    THF 189.62
    2-butanone 104.22
    n-pentanol 48.73
    sec-butanol 50.58
    n-hexane 3.57
    ethylene glycol 40.69
    NMP 455.39
    cyclohexane 9.21
    DMSO 464.55
    n-butyl acetate 89.91
    n-octanol 13.5
    chloroform 362.12
    n-propyl acetate 58.07
    acetic acid 327.87
    dichloromethane 450.57
    cyclohexanone 254.11
    propylene glycol 34.33
    isopropyl acetate 46.62
    DMAc 357.78
    2-ethoxyethanol 92.78
    isopentanol 67.95
    n-heptane 2.07
    ethyl formate 123.05
    1,2-dichloroethane 247.83
    n-hexanol 43.04
    2-methoxyethanol 184.71
    isobutyl acetate 36.59
    tetrachloromethane 51.72
    n-pentyl acetate 39.85
    transcutol 493.33
    n-heptanol 17.38
    ethylbenzene 27.81
    MIBK 46.65
    2-propoxyethanol 93.15
    tert-butanol 77.76
    MTBE 49.74
    2-butoxyethanol 53.73
    propionic acid 124.31
    o-xylene 45.22
    formic acid 246.27
    diethyl ether 34.62
    m-xylene 38.63
    p-xylene 48.15
    chlorobenzene 150.68
    dimethyl carbonate 47.55
    n-octane 0.73
    formamide 367.79
    cyclopentanone 255.95
    2-pentanone 70.52
    anisole 70.27
    cyclopentyl methyl ether 78.6
    gamma-butyrolactone 338.47
    1-methoxy-2-propanol 92.13
    pyridine 248.34
    3-pentanone 61.24
    furfural 440.54
    n-dodecane 0.72
    diethylene glycol 102.32
    diisopropyl ether 11.13
    tert-amyl alcohol 73.51
    acetylacetone 111.8
    n-hexadecane 0.86
    acetophenone 93.06
    methyl propionate 73.02
    isopentyl acetate 80.87
    trichloroethylene 609.78
    n-nonanol 12.75
    cyclohexanol 79.93
    benzyl alcohol 89.47
    2-ethylhexanol 31.13
    isooctanol 16.15
    dipropyl ether 19.58
    1,2-dichlorobenzene 150.6
    ethyl lactate 40.25
    propylene carbonate 196.86
    n-methylformamide 209.53
    2-pentanol 31.64
    n-pentane 3.06
    1-propoxy-2-propanol 58.27
    1-methoxy-2-propyl acetate 83.56
    2-(2-methoxypropoxy) propanol 77.59
    mesitylene 23.91
    ε-caprolactone 193.83
    p-cymene 21.72
    epichlorohydrin 322.13
    1,1,1-trichloroethane 167.53
    2-aminoethanol 62.17
    morpholine-4-carbaldehyde 297.12
    sulfolane 440.76
    2,2,4-trimethylpentane 3.89
    2-methyltetrahydrofuran 155.47
    n-hexyl acetate 48.8
    isooctane 1.94
    2-(2-butoxyethoxy)ethanol 99.93
    sec-butyl acetate 36.36
    tert-butyl acetate 53.62
    decalin 6.11
    glycerin 76.57
    diglyme 206.5
    acrylic acid 165.36
    isopropyl myristate 16.89
    n-butyric acid 151.86
    acetyl acetate 90.17
    di(2-ethylhexyl) phthalate 34.85
    ethyl propionate 47.21
    nitromethane 502.78
    1,2-diethoxyethane 75.31
    benzonitrile 152.28
    trioctyl phosphate 18.38
    1-bromopropane 77.19
    gamma-valerolactone 336.38
    n-decanol 9.38
    triethyl phosphate 40.64
    4-methyl-2-pentanol 23.86
    propionitrile 88.2
    vinylene carbonate 198.28
    1,1,2-trichlorotrifluoroethane 303.79
    DMS 76.16
    cumene 22.1
    2-octanol 10.73
    2-hexanone 58.96
    octyl acetate 22.81
    limonene 29.56
    1,2-dimethoxyethane 151.48
    ethyl orthosilicate 36.47
    tributyl phosphate 31.11
    diacetone alcohol 79.09
    N,N-dimethylaniline 55.94
    acrylonitrile 150.21
    aniline 123.69
    1,3-propanediol 91.3
    bromobenzene 137.43
    dibromomethane 231.24
    1,1,2,2-tetrachloroethane 428.74
    2-methyl-cyclohexyl acetate 59.09
    tetrabutyl urea 41.37
    diisobutyl methanol 17.54
    2-phenylethanol 75.39
    styrene 39.16
    dioctyl adipate 39.68
    dimethyl sulfate 112.16
    ethyl butyrate 57.05
    methyl lactate 59.73
    butyl lactate 45.61
    diethyl carbonate 52.73
    propanediol butyl ether 58.21
    triethyl orthoformate 45.29
    p-tert-butyltoluene 18.29
    methyl 4-tert-butylbenzoate 60.61
    morpholine 164.87
    tert-butylamine 43.06
    n-dodecanol 7.16
    dimethoxymethane 97.86
    ethylene carbonate 150.3
    cyrene 98.03
    2-ethoxyethyl acetate 71.86
    2-ethylhexyl acetate 63.3
    1,2,4-trichlorobenzene 181.35
    4-methylpyridine 255.72
    dibutyl ether 20.06
    2,6-dimethyl-4-heptanol 17.54
    DEF 130.63
    dimethyl isosorbide 147.66
    tetrachloroethylene 296.82
    eugenol 72.0
    triacetin 67.2
    span 80 56.92
    1,4-butanediol 38.03
    1,1-dichloroethane 169.61
    2-methyl-1-pentanol 61.22
    methyl formate 165.19
    2-methyl-1-butanol 61.49
    n-decane 1.08
    butyronitrile 100.12
    3,7-dimethyl-1-octanol 21.65
    1-chlorooctane 8.2
    1-chlorotetradecane 3.61
    n-nonane 0.91
    undecane 0.86
    tert-butylcyclohexane 4.81
    cyclooctane 2.3
    cyclopentanol 90.25
    tetrahydropyran 103.49
    tert-amyl methyl ether 44.28
    2,5,8-trioxanonane 135.47
    1-hexene 17.0
    2-isopropoxyethanol 55.36
    2,2,2-trifluoroethanol 146.73
    methyl butyrate 80.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction