2-Acetyl-4-methylthiazole

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  • Identifiers

    CAS number
    7533-07-5

    Molecular formula
    C6H7NOS

    SMILES
    CC1=CSC(=N1)C(=O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 70.19%
    Roasted 65.06%
    Meaty 61.59%
    Sulfurous 42.65%
    Popcorn 41.81%
    Hazelnut 37.5%
    Coffee 37.18%
    Cooked 35.03%
    Burnt 34.88%
    Cocoa 30.64%

     

    Flavor
    Nutty 76.09%
    Popcorn 58.04%
    Roasted 56.91%
    Roast 54.95%
    Hazelnut 47.1%
    Corn 45.39%
    Coffee 42.72%
    Chocolate 41.24%
    Chip 41.2%
    Potato 40.16%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    5.76 (weak acid)

    Molecular weight
    141.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    204°C

    Flash point

    • 82.26 ˚C est.

  • Synonyms

    • 2-Acetyl-4-methylthiazole
    • 1-(4-Methylthiazol-2-yl)ethanone
    • 7533-07-5
    • Ethanone, 1-(4-methyl-2-thiazolyl)-
    • 1-(4-methyl-1,3-thiazol-2-yl)ethanone
    • 1-(4-METHYL-1,3-THIAZOL-2-YL)ETHAN-1-ONE
    • DTXSID20415955
    • 4-methyl-2-acetylthiazole
    • MFCD07369793
    • 2-Acetyl-4-methylthiazol
    • SCHEMBL929092
    • 76LAP734GR
    • CHEMBL5197991
    • DTXCID90366804
    • 2-Acetyl-4-methylthiazole, 97%
    • 1-(4-Methyl-2-thiazolyl)ethanone
    • 1-(4-Methyl-thiazol-2-yl)-ethanone
    • AKOS012685824
    • AB32246
    • AS-40885
    • DB-364533
    • METHYL 4-METHYL-2-THIAZOLYL KETONE
    • CS-0204369
    • KETONE, METHYL 4-METHYL-2-THIAZOLYL
    • NS00124745
    • EN300-131840
    • InChI=1/C6H7NOS/c1-4-3-9-6(7-4)5(2)8/h3H,1-2H
    • 616-211-1

  • Applications

    2-Acetyl-4-methylthiazole (CAS 7533-07-5) is widely used as an aroma and flavor compound with savory, roasted notes, applied in flavor formulations for meat and other savory foods; it is also used as a fragrance ingredient in perfumery and consumer products, delivering distinctive notes in cosmetics, soaps, and detergents; in household products it functions as an odorant in air fresheners and cleaning formulations; in industrial manufacturing it serves as an intermediate building block for the synthesis of other thiazole-containing compounds used in specialty chemicals.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 126.58
    methanol 237.81
    isopropanol 88.31
    water 13.37
    ethyl acetate 174.56
    n-propanol 100.8
    acetone 344.61
    n-butanol 89.4
    acetonitrile 191.25
    DMF 951.76
    toluene 95.13
    isobutanol 76.31
    1,4-dioxane 347.66
    methyl acetate 216.15
    THF 365.3
    2-butanone 212.63
    n-pentanol 63.98
    sec-butanol 83.83
    n-hexane 10.81
    ethylene glycol 120.15
    NMP 687.26
    cyclohexane 11.09
    DMSO 676.25
    n-butyl acetate 82.19
    n-octanol 62.62
    chloroform 305.35
    n-propyl acetate 85.21
    acetic acid 115.59
    dichloromethane 323.71
    cyclohexanone 274.18
    propylene glycol 92.54
    isopropyl acetate 105.25
    DMAc 792.48
    2-ethoxyethanol 187.87
    isopentanol 74.63
    n-heptane 10.16
    ethyl formate 156.04
    1,2-dichloroethane 224.72
    n-hexanol 68.96
    2-methoxyethanol 396.43
    isobutyl acetate 62.45
    tetrachloromethane 62.01
    n-pentyl acetate 76.32
    transcutol 287.28
    n-heptanol 45.29
    ethylbenzene 56.85
    MIBK 114.17
    2-propoxyethanol 203.33
    tert-butanol 109.94
    MTBE 111.35
    2-butoxyethanol 111.69
    propionic acid 104.65
    o-xylene 80.48
    formic acid 106.46
    diethyl ether 112.24
    m-xylene 84.52
    p-xylene 76.86
    chlorobenzene 148.41
    dimethyl carbonate 146.96
    n-octane 7.15
    formamide 157.46
    cyclopentanone 370.99
    2-pentanone 174.99
    anisole 165.32
    cyclopentyl methyl ether 176.85
    gamma-butyrolactone 383.36
    1-methoxy-2-propanol 268.26
    pyridine 215.17
    3-pentanone 156.11
    furfural 455.23
    n-dodecane 8.94
    diethylene glycol 241.24
    diisopropyl ether 42.52
    tert-amyl alcohol 91.5
    acetylacetone 298.29
    n-hexadecane 10.33
    acetophenone 158.64
    methyl propionate 184.21
    isopentyl acetate 77.79
    trichloroethylene 379.1
    n-nonanol 54.74
    cyclohexanol 87.65
    benzyl alcohol 115.66
    2-ethylhexanol 50.54
    isooctanol 40.98
    dipropyl ether 61.04
    1,2-dichlorobenzene 163.68
    ethyl lactate 86.06
    propylene carbonate 188.6
    n-methylformamide 305.15
    2-pentanol 61.11
    n-pentane 10.02
    1-propoxy-2-propanol 122.49
    1-methoxy-2-propyl acetate 131.77
    2-(2-methoxypropoxy) propanol 120.69
    mesitylene 59.57
    ε-caprolactone 211.08
    p-cymene 43.31
    epichlorohydrin 372.57
    1,1,1-trichloroethane 206.63
    2-aminoethanol 119.97
    morpholine-4-carbaldehyde 624.18
    sulfolane 535.45
    2,2,4-trimethylpentane 9.75
    2-methyltetrahydrofuran 206.3
    n-hexyl acetate 109.74
    isooctane 7.83
    2-(2-butoxyethoxy)ethanol 140.4
    sec-butyl acetate 64.41
    tert-butyl acetate 121.03
    decalin 15.85
    glycerin 178.77
    diglyme 271.32
    acrylic acid 122.91
    isopropyl myristate 52.93
    n-butyric acid 109.56
    acetyl acetate 134.49
    di(2-ethylhexyl) phthalate 61.87
    ethyl propionate 102.09
    nitromethane 399.19
    1,2-diethoxyethane 106.45
    benzonitrile 164.69
    trioctyl phosphate 45.64
    1-bromopropane 95.5
    gamma-valerolactone 490.29
    n-decanol 42.83
    triethyl phosphate 61.9
    4-methyl-2-pentanol 42.86
    propionitrile 125.83
    vinylene carbonate 198.43
    1,1,2-trichlorotrifluoroethane 292.88
    DMS 140.19
    cumene 46.2
    2-octanol 41.36
    2-hexanone 103.3
    octyl acetate 67.38
    limonene 57.49
    1,2-dimethoxyethane 333.06
    ethyl orthosilicate 57.1
    tributyl phosphate 51.32
    diacetone alcohol 153.93
    N,N-dimethylaniline 129.73
    acrylonitrile 200.92
    aniline 121.88
    1,3-propanediol 149.03
    bromobenzene 153.7
    dibromomethane 182.46
    1,1,2,2-tetrachloroethane 304.01
    2-methyl-cyclohexyl acetate 73.49
    tetrabutyl urea 80.78
    diisobutyl methanol 37.56
    2-phenylethanol 100.97
    styrene 72.15
    dioctyl adipate 72.2
    dimethyl sulfate 342.31
    ethyl butyrate 78.52
    methyl lactate 150.78
    butyl lactate 71.27
    diethyl carbonate 63.56
    propanediol butyl ether 114.25
    triethyl orthoformate 65.1
    p-tert-butyltoluene 45.91
    methyl 4-tert-butylbenzoate 126.94
    morpholine 282.01
    tert-butylamine 64.48
    n-dodecanol 35.02
    dimethoxymethane 389.52
    ethylene carbonate 150.85
    cyrene 153.53
    2-ethoxyethyl acetate 112.59
    2-ethylhexyl acetate 64.41
    1,2,4-trichlorobenzene 183.34
    4-methylpyridine 255.5
    dibutyl ether 59.43
    2,6-dimethyl-4-heptanol 37.56
    DEF 270.5
    dimethyl isosorbide 210.82
    tetrachloroethylene 189.26
    eugenol 141.82
    triacetin 115.81
    span 80 93.96
    1,4-butanediol 75.0
    1,1-dichloroethane 186.32
    2-methyl-1-pentanol 58.98
    methyl formate 294.48
    2-methyl-1-butanol 74.81
    n-decane 12.23
    butyronitrile 117.21
    3,7-dimethyl-1-octanol 56.78
    1-chlorooctane 47.99
    1-chlorotetradecane 24.57
    n-nonane 11.36
    undecane 10.2
    tert-butylcyclohexane 16.27
    cyclooctane 6.48
    cyclopentanol 113.31
    tetrahydropyran 160.89
    tert-amyl methyl ether 100.31
    2,5,8-trioxanonane 201.23
    1-hexene 35.55
    2-isopropoxyethanol 116.97
    2,2,2-trifluoroethanol 95.14
    methyl butyrate 133.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction