2-(4-Aminophenyl)acetamide

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  • Identifiers

    CAS number
    6633-76-7

    Molecular formula
    C8H10N2O

    SMILES
    C1=CC(=CC=C1CC(=O)N)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Grape 35.13%
    Sweet 34.71%
    Floral 33.18%
    Meaty 30.76%
    Animal 29.26%
    Cheesy 27.57%
    Honey 26.84%
    Odorless 25.16%
    Fruity 24.55%
    Citrus 24.42%

     

    Flavor
    Mild 39.84%
    Odorless 27.09%
    Sweet 26.33%
    Floral 25.66%
    Fruity 25.25%
    Sour 24.13%
    Honey 23.67%
    Honeysuckle 22.55%
    Meaty 22.45%
    Phenolic 22.18%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    5.17 (weak acid)

    Molecular weight
    150.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    383°C

    Flash point

    • 176.33 ˚C est.

  • Synonyms

    • 2-(4-aminophenyl)acetamide
    • DTXSID50285527
    • RefChem:456707
    • DTXCID30236678
    • 809-825-8
    • 6633-76-7
    • Benzeneacetamide, 4-amino- (9CI)
    • MFCD06796370
    • 4-aminophenylacetamide
    • (4-aminophenyl)acetamide
    • 4-AMino-benzeneacetaMide
    • Benzeneacetamide, 4-amino-
    • NSC42162
    • 2-(4-aminophenyl)-acetamide
    • SCHEMBL687483
    • SCHEMBL4605217
    • SCHEMBL6686356
    • Benzeneacetamide,4-amino-(9ci)
    • GAA63376
    • NSC-42162
    • AKOS000133902
    • BS-13422
    • SY066916
    • DB-329307
    • CS-0096271
    • EN300-36276
    • F305578
    • Z234895133
    • 6633-76-7

  • Applications

    2-(4-Aminophenyl)acetamide (CAS 6633-76-7) is primarily used as an intermediate in pharmaceutical synthesis, serving as a building block for drug molecules. It also functions as a precursor in the production of aromatic dyes and pigments. In the polymers and coatings sector, it can be used as a functionalized aromatic intermediate for specialty polymers and pigment-related additives. It may be employed in coatings and inks as a colorant precursor or component of dye systems. Additionally, it serves as a general organic synthesis building block in research settings, subject to regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 20.54
    methanol 61.71
    isopropanol 7.01
    water 42.31
    ethyl acetate 4.13
    n-propanol 8.6
    acetone 20.61
    n-butanol 5.15
    acetonitrile 5.32
    DMF 47.82
    toluene 0.52
    isobutanol 4.4
    1,4-dioxane 3.76
    methyl acetate 8.29
    THF 16.77
    2-butanone 11.97
    n-pentanol 4.1
    sec-butanol 4.87
    n-hexane 0.28
    ethylene glycol 40.48
    NMP 84.73
    cyclohexane 0.07
    DMSO 105.86
    n-butyl acetate 4.68
    n-octanol 2.19
    chloroform 1.36
    n-propyl acetate 3.38
    acetic acid 38.76
    dichloromethane 1.03
    cyclohexanone 8.49
    propylene glycol 30.46
    isopropyl acetate 2.5
    DMAc 101.91
    2-ethoxyethanol 24.54
    isopentanol 4.65
    n-heptane 0.3
    ethyl formate 8.93
    1,2-dichloroethane 1.05
    n-hexanol 6.38
    2-methoxyethanol 48.53
    isobutyl acetate 1.9
    tetrachloromethane 1.62
    n-pentyl acetate 2.69
    transcutol 25.06
    n-heptanol 3.73
    ethylbenzene 0.67
    MIBK 4.09
    2-propoxyethanol 23.44
    tert-butanol 9.2
    MTBE 2.77
    2-butoxyethanol 12.22
    propionic acid 20.02
    o-xylene 0.95
    formic acid 117.96
    diethyl ether 1.47
    m-xylene 0.73
    p-xylene 0.92
    chlorobenzene 0.79
    dimethyl carbonate 8.05
    n-octane 0.09
    formamide 94.74
    cyclopentanone 23.52
    2-pentanone 6.01
    anisole 3.58
    cyclopentyl methyl ether 4.19
    gamma-butyrolactone 30.58
    1-methoxy-2-propanol 21.6
    pyridine 3.73
    3-pentanone 5.01
    furfural 34.72
    n-dodecane 0.05
    diethylene glycol 41.55
    diisopropyl ether 0.61
    tert-amyl alcohol 8.04
    acetylacetone 10.93
    n-hexadecane 0.06
    acetophenone 6.48
    methyl propionate 7.4
    isopentyl acetate 4.6
    trichloroethylene 3.02
    n-nonanol 1.91
    cyclohexanol 2.44
    benzyl alcohol 4.85
    2-ethylhexanol 3.22
    isooctanol 2.74
    dipropyl ether 2.27
    1,2-dichlorobenzene 1.34
    ethyl lactate 8.61
    propylene carbonate 13.38
    n-methylformamide 47.13
    2-pentanol 2.27
    n-pentane 0.13
    1-propoxy-2-propanol 12.85
    1-methoxy-2-propyl acetate 9.12
    2-(2-methoxypropoxy) propanol 15.2
    mesitylene 0.57
    ε-caprolactone 9.58
    p-cymene 1.21
    epichlorohydrin 12.31
    1,1,1-trichloroethane 1.66
    2-aminoethanol 40.3
    morpholine-4-carbaldehyde 38.2
    sulfolane 63.63
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 7.0
    n-hexyl acetate 3.41
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 14.5
    sec-butyl acetate 1.96
    tert-butyl acetate 4.32
    decalin 0.14
    glycerin 72.43
    diglyme 23.97
    acrylic acid 28.45
    isopropyl myristate 1.24
    n-butyric acid 12.48
    acetyl acetate 4.26
    di(2-ethylhexyl) phthalate 3.78
    ethyl propionate 3.65
    nitromethane 54.73
    1,2-diethoxyethane 2.74
    benzonitrile 2.74
    trioctyl phosphate 2.51
    1-bromopropane 0.46
    gamma-valerolactone 33.83
    n-decanol 1.34
    triethyl phosphate 4.25
    4-methyl-2-pentanol 2.01
    propionitrile 3.17
    vinylene carbonate 10.51
    1,1,2-trichlorotrifluoroethane 36.84
    DMS 4.73
    cumene 0.75
    2-octanol 1.63
    2-hexanone 4.7
    octyl acetate 2.03
    limonene 1.51
    1,2-dimethoxyethane 21.47
    ethyl orthosilicate 3.59
    tributyl phosphate 2.79
    diacetone alcohol 13.67
    N,N-dimethylaniline 3.77
    acrylonitrile 6.47
    aniline 2.68
    1,3-propanediol 26.46
    bromobenzene 0.48
    dibromomethane 0.66
    1,1,2,2-tetrachloroethane 2.54
    2-methyl-cyclohexyl acetate 4.6
    tetrabutyl urea 4.56
    diisobutyl methanol 1.79
    2-phenylethanol 6.0
    styrene 0.57
    dioctyl adipate 2.64
    dimethyl sulfate 27.04
    ethyl butyrate 4.05
    methyl lactate 18.76
    butyl lactate 6.5
    diethyl carbonate 3.55
    propanediol butyl ether 12.55
    triethyl orthoformate 3.64
    p-tert-butyltoluene 1.17
    methyl 4-tert-butylbenzoate 9.32
    morpholine 7.01
    tert-butylamine 2.88
    n-dodecanol 0.91
    dimethoxymethane 14.52
    ethylene carbonate 6.92
    cyrene 21.32
    2-ethoxyethyl acetate 5.09
    2-ethylhexyl acetate 3.37
    1,2,4-trichlorobenzene 2.18
    4-methylpyridine 3.57
    dibutyl ether 0.86
    2,6-dimethyl-4-heptanol 1.79
    DEF 9.63
    dimethyl isosorbide 22.9
    tetrachloroethylene 3.4
    eugenol 10.88
    triacetin 6.14
    span 80 9.73
    1,4-butanediol 13.41
    1,1-dichloroethane 0.81
    2-methyl-1-pentanol 4.15
    methyl formate 34.82
    2-methyl-1-butanol 4.78
    n-decane 0.1
    butyronitrile 2.36
    3,7-dimethyl-1-octanol 2.03
    1-chlorooctane 0.43
    1-chlorotetradecane 0.16
    n-nonane 0.09
    undecane 0.07
    tert-butylcyclohexane 0.19
    cyclooctane 0.05
    cyclopentanol 5.69
    tetrahydropyran 1.82
    tert-amyl methyl ether 3.01
    2,5,8-trioxanonane 20.03
    1-hexene 0.71
    2-isopropoxyethanol 11.13
    2,2,2-trifluoroethanol 30.48
    methyl butyrate 5.33

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction