2-((3-Aminopyrazolo(1,5-a)pyridin-2-yl)oxy)ethanol hydrochloride (1:1)

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  • Identifiers

    CAS number
    1079221-49-0

    Molecular formula
    C9H12ClN3O2

    SMILES
    C1=CC2=C(C(=NN2C=C1)OCCO)N.Cl

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 52.02%
    Roasted 24.49%
    Burnt 22.64%
    Fruity 21.91%
    Nutty 21.39%
    Savory 21.07%
    Cooked 20.96%
    Meaty 19.95%
    Milky 19.42%
    Grape 19.1%

     

    Flavor
    Bitter 71.85%
    Odorless 34.95%
    Mild 26.97%
    Sweet-like 24.05%
    Bland 21.91%
    Bread crust 21.08%
    Sweet 20.93%
    Musty 20.74%
    Orange flower 20.68%
    Cooked beef juice 20.42%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.88 (weak acid)

    Molecular weight
    229.66 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    662°C

    Flash point

    • 236.11 ˚C est.

  • Synonyms

    • 1079221-49-0
    • 2-[(3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy]ethanol hydrochloride (1:1)
    • 2-((3-Aminopyrazolo(1,5-a)pyridin-2-yl)oxy)ethanol hydrochloride (1:1)
    • RefChem:249296
    • Imexine FAM
    • 2-((3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy)ethanol hydrochloride
    • starbld0005027
    • SCHEMBL1151493
    • DTXSID801024736
    • ETB22149
    • NS00020369
    • Imexine FAM; 2-(2-Hydroxyethoxy)-3-aminopyrazolo[1,5-a]pyridine hydrochloride; 2-[(3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy]ethanol hydrochloride; Imexine FAM
    • 1079221-49-0

  • Applications

    2-((3-Aminopyrazolo(1,5-a)pyridin-2-yl)oxy)ethanol hydrochloride (1:1) is primarily used as a pharmaceutical research intermediate and versatile building block in medicinal chemistry, enabling the construction of heterocyclic small molecules and serving as a starting material for further functionalization of the pyrazolo-pyridine scaffold; the hydrochloride salt improves water solubility and supports in vitro screening and formulation work; it is commonly evaluated in industrial and academic settings for library synthesis and lead-structure exploration, with usage governed by local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 103.1
    methanol 241.99
    isopropanol 42.35
    water 39.74
    ethyl acetate 17.08
    n-propanol 53.15
    acetone 43.96
    n-butanol 44.0
    acetonitrile 28.22
    DMF 260.83
    toluene 2.37
    isobutanol 29.91
    1,4-dioxane 44.95
    methyl acetate 17.15
    THF 105.62
    2-butanone 20.63
    n-pentanol 28.74
    sec-butanol 29.48
    n-hexane 0.3
    ethylene glycol 174.57
    NMP 115.84
    cyclohexane 0.9
    DMSO 462.37
    n-butyl acetate 9.92
    n-octanol 6.3
    chloroform 11.04
    n-propyl acetate 11.99
    acetic acid 273.0
    dichloromethane 25.57
    cyclohexanone 47.12
    propylene glycol 107.06
    isopropyl acetate 7.07
    DMAc 135.93
    2-ethoxyethanol 176.82
    isopentanol 28.8
    n-heptane 0.73
    ethyl formate 56.2
    1,2-dichloroethane 19.59
    n-hexanol 16.46
    2-methoxyethanol 382.97
    isobutyl acetate 5.82
    tetrachloromethane 1.9
    n-pentyl acetate 8.05
    transcutol 138.27
    n-heptanol 10.06
    ethylbenzene 1.73
    MIBK 8.58
    2-propoxyethanol 74.46
    tert-butanol 26.89
    MTBE 5.89
    2-butoxyethanol 40.2
    propionic acid 54.73
    o-xylene 2.36
    formic acid 717.42
    diethyl ether 7.48
    m-xylene 1.9
    p-xylene 2.64
    chlorobenzene 6.45
    dimethyl carbonate 18.53
    n-octane 0.4
    formamide 689.18
    cyclopentanone 66.55
    2-pentanone 16.41
    anisole 8.56
    cyclopentyl methyl ether 14.84
    gamma-butyrolactone 113.38
    1-methoxy-2-propanol 132.04
    pyridine 47.44
    3-pentanone 9.36
    furfural 174.39
    n-dodecane 0.33
    diethylene glycol 165.8
    diisopropyl ether 1.37
    tert-amyl alcohol 23.82
    acetylacetone 25.86
    n-hexadecane 0.36
    acetophenone 15.7
    methyl propionate 19.29
    isopentyl acetate 9.6
    trichloroethylene 27.52
    n-nonanol 6.32
    cyclohexanol 24.61
    benzyl alcohol 31.38
    2-ethylhexanol 7.77
    isooctanol 7.7
    dipropyl ether 5.71
    1,2-dichlorobenzene 6.86
    ethyl lactate 23.83
    propylene carbonate 50.33
    n-methylformamide 227.94
    2-pentanol 14.39
    n-pentane 0.52
    1-propoxy-2-propanol 31.54
    1-methoxy-2-propyl acetate 17.24
    2-(2-methoxypropoxy) propanol 29.97
    mesitylene 1.33
    ε-caprolactone 45.9
    p-cymene 2.38
    epichlorohydrin 103.1
    1,1,1-trichloroethane 4.18
    2-aminoethanol 167.31
    morpholine-4-carbaldehyde 133.03
    sulfolane 141.02
    2,2,4-trimethylpentane 0.33
    2-methyltetrahydrofuran 33.46
    n-hexyl acetate 8.47
    isooctane 0.18
    2-(2-butoxyethoxy)ethanol 46.64
    sec-butyl acetate 5.15
    tert-butyl acetate 6.27
    decalin 0.4
    glycerin 277.6
    diglyme 83.48
    acrylic acid 83.66
    isopropyl myristate 3.4
    n-butyric acid 74.52
    acetyl acetate 11.49
    di(2-ethylhexyl) phthalate 9.16
    ethyl propionate 9.27
    nitromethane 269.77
    1,2-diethoxyethane 15.13
    benzonitrile 21.78
    trioctyl phosphate 6.36
    1-bromopropane 5.17
    gamma-valerolactone 142.27
    n-decanol 4.97
    triethyl phosphate 8.3
    4-methyl-2-pentanol 6.81
    propionitrile 17.19
    vinylene carbonate 53.75
    1,1,2-trichlorotrifluoroethane 124.2
    DMS 10.57
    cumene 1.6
    2-octanol 5.19
    2-hexanone 11.09
    octyl acetate 5.54
    limonene 3.35
    1,2-dimethoxyethane 111.56
    ethyl orthosilicate 7.35
    tributyl phosphate 6.79
    diacetone alcohol 27.42
    N,N-dimethylaniline 7.15
    acrylonitrile 39.54
    aniline 16.61
    1,3-propanediol 194.04
    bromobenzene 3.95
    dibromomethane 10.75
    1,1,2,2-tetrachloroethane 18.98
    2-methyl-cyclohexyl acetate 8.42
    tetrabutyl urea 11.2
    diisobutyl methanol 4.05
    2-phenylethanol 18.53
    styrene 2.32
    dioctyl adipate 8.13
    dimethyl sulfate 40.28
    ethyl butyrate 9.96
    methyl lactate 50.98
    butyl lactate 16.77
    diethyl carbonate 8.79
    propanediol butyl ether 39.09
    triethyl orthoformate 9.48
    p-tert-butyltoluene 1.97
    methyl 4-tert-butylbenzoate 15.42
    morpholine 76.85
    tert-butylamine 8.36
    n-dodecanol 3.89
    dimethoxymethane 83.4
    ethylene carbonate 38.93
    cyrene 47.34
    2-ethoxyethyl acetate 15.4
    2-ethylhexyl acetate 6.12
    1,2,4-trichlorobenzene 9.38
    4-methylpyridine 24.38
    dibutyl ether 4.22
    2,6-dimethyl-4-heptanol 4.05
    DEF 36.27
    dimethyl isosorbide 40.19
    tetrachloroethylene 16.63
    eugenol 25.0
    triacetin 14.48
    span 80 23.77
    1,4-butanediol 93.55
    1,1-dichloroethane 5.97
    2-methyl-1-pentanol 20.92
    methyl formate 170.61
    2-methyl-1-butanol 27.87
    n-decane 0.46
    butyronitrile 23.25
    3,7-dimethyl-1-octanol 5.84
    1-chlorooctane 1.64
    1-chlorotetradecane 0.89
    n-nonane 0.39
    undecane 0.38
    tert-butylcyclohexane 0.27
    cyclooctane 0.33
    cyclopentanol 40.18
    tetrahydropyran 23.24
    tert-amyl methyl ether 5.77
    2,5,8-trioxanonane 59.18
    1-hexene 1.34
    2-isopropoxyethanol 63.06
    2,2,2-trifluoroethanol 111.38
    methyl butyrate 19.86

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction