2-(2,2-Dimethoxyethoxy)naphthalene

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  • Identifiers

    CAS number
    68480-07-9

    Molecular formula
    C14H16O3

    SMILES
    COC(COC1=CC2=CC=CC=C2C=C1)OC

    Safety labels

  • Odor profile

    Fragrance
    Floral 73.87%
    Green 52.11%
    Rose 48.13%
    Fruity 45.75%
    Sweet 42.16%
    Earthy 41.0%
    Fresh 36.92%
    Hyacinth 36.89%
    Honey 33.82%
    Leafy 30.89%

     

    Flavor
    Floral 70.77%
    Green 57.41%
    Bitter 55.76%
    Fruity 52.84%
    Rose 41.09%
    Sweet 38.25%
    Hyacinth 36.07%
    Earthy 35.09%
    Musty 29.03%
    Balsam 28.79%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.3

    pKa est.
    6.29 (neutral)

    Molecular weight
    232.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    342°C

    Flash point

    • 149.01 ˚C est.

  • Synonyms

    • 2-(2,2-Dimethoxyethoxy)naphthalene
    • Naphthalene, 2-(2,2-dimethoxyethoxy)-
    • AQ4BKG5JMP
    • EINECS 270-883-7
    • 2-((2,2-Dimethoxy)ethoxy)naphthalene
    • DTXSID8071568
    • RefChem:83885
    • DTXCID8046030
    • 270-883-7
    • 68480-07-9
    • UNII-AQ4BKG5JMP
    • CFMNTNDYLXCBPP-UHFFFAOYSA-N
    • AKOS015564312
    • NS00036607
    • 68480-07-9

  • Applications

    2-(2,2-Dimethoxyethoxy)naphthalene (CAS 68480-07-9) is primarily used as an organic-synthesis intermediate, where the 2,2-dimethoxyethoxy substituent functions as an acid-labile protecting group for the naphthol during multi-step sequences and can be deprotected to give the corresponding 2-naphthol. It is commonly evaluated as a precursor in the synthesis of substituted naphthalene dyes and pigments, benefiting from its aromatic framework and the removable acetal protection. In coatings, inks, and electronics, the compound may serve as a masked functional handle that participates in formulation or lithography (for example as a protected phenol compatible with photoresist processes). It can also act as a building block in polymer and pharmaceutical intermediate workflows where temporary protection of oxygen functionality is desired during coupling steps. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 139.75
    methanol 158.1
    isopropanol 75.31
    water 0.57
    ethyl acetate 566.61
    n-propanol 118.74
    acetone 90.48
    n-butanol 110.62
    acetonitrile 259.99
    DMF 44.59
    toluene 112.68
    isobutanol 62.39
    1,4-dioxane 827.85
    methyl acetate 283.4
    THF 413.68
    2-butanone 123.0
    n-pentanol 90.29
    sec-butanol 84.98
    n-hexane 18.06
    ethylene glycol 38.54
    NMP 29.14
    cyclohexane 66.44
    DMSO 238.21
    n-butyl acetate 121.93
    n-octanol 19.41
    chloroform 1235.29
    n-propyl acetate 169.03
    acetic acid 259.45
    dichloromethane 1609.08
    cyclohexanone 153.63
    propylene glycol 34.09
    isopropyl acetate 172.48
    DMAc 79.21
    2-ethoxyethanol 326.67
    isopentanol 79.66
    n-heptane 19.53
    ethyl formate 164.32
    1,2-dichloroethane 949.53
    n-hexanol 62.45
    2-methoxyethanol 326.61
    isobutyl acetate 87.83
    tetrachloromethane 115.49
    n-pentyl acetate 50.95
    transcutol 590.56
    n-heptanol 25.35
    ethylbenzene 68.17
    MIBK 66.41
    2-propoxyethanol 150.59
    tert-butanol 117.98
    MTBE 128.76
    2-butoxyethanol 73.38
    propionic acid 124.42
    o-xylene 68.18
    formic acid 96.88
    diethyl ether 468.29
    m-xylene 54.75
    p-xylene 72.74
    chlorobenzene 150.14
    dimethyl carbonate 86.61
    n-octane 7.82
    formamide 194.37
    cyclopentanone 105.92
    2-pentanone 112.62
    anisole 157.26
    cyclopentyl methyl ether 149.81
    gamma-butyrolactone 196.07
    1-methoxy-2-propanol 153.54
    pyridine 379.45
    3-pentanone 117.39
    furfural 249.46
    n-dodecane 4.88
    diethylene glycol 129.99
    diisopropyl ether 62.64
    tert-amyl alcohol 97.44
    acetylacetone 183.26
    n-hexadecane 5.58
    acetophenone 110.5
    methyl propionate 198.0
    isopentyl acetate 104.31
    trichloroethylene 1145.57
    n-nonanol 22.19
    cyclohexanol 101.38
    benzyl alcohol 100.14
    2-ethylhexanol 44.72
    isooctanol 23.44
    dipropyl ether 126.21
    1,2-dichlorobenzene 147.6
    ethyl lactate 53.82
    propylene carbonate 127.23
    n-methylformamide 69.69
    2-pentanol 68.79
    n-pentane 17.79
    1-propoxy-2-propanol 85.82
    1-methoxy-2-propyl acetate 128.0
    2-(2-methoxypropoxy) propanol 85.1
    mesitylene 35.29
    ε-caprolactone 169.86
    p-cymene 33.99
    epichlorohydrin 573.54
    1,1,1-trichloroethane 468.37
    2-aminoethanol 74.1
    morpholine-4-carbaldehyde 156.78
    sulfolane 138.14
    2,2,4-trimethylpentane 9.03
    2-methyltetrahydrofuran 267.79
    n-hexyl acetate 54.11
    isooctane 5.8
    2-(2-butoxyethoxy)ethanol 116.46
    sec-butyl acetate 108.47
    tert-butyl acetate 132.02
    decalin 20.19
    glycerin 64.46
    diglyme 344.97
    acrylic acid 111.95
    isopropyl myristate 31.46
    n-butyric acid 189.09
    acetyl acetate 299.14
    di(2-ethylhexyl) phthalate 28.2
    ethyl propionate 177.28
    nitromethane 414.18
    1,2-diethoxyethane 282.75
    benzonitrile 96.95
    trioctyl phosphate 17.43
    1-bromopropane 346.07
    gamma-valerolactone 199.07
    n-decanol 17.76
    triethyl phosphate 78.62
    4-methyl-2-pentanol 32.8
    propionitrile 169.02
    vinylene carbonate 155.93
    1,1,2-trichlorotrifluoroethane 252.77
    DMS 92.3
    cumene 40.22
    2-octanol 15.86
    2-hexanone 97.06
    octyl acetate 33.29
    limonene 44.2
    1,2-dimethoxyethane 495.19
    ethyl orthosilicate 80.47
    tributyl phosphate 29.14
    diacetone alcohol 92.77
    N,N-dimethylaniline 75.3
    acrylonitrile 181.3
    aniline 132.97
    1,3-propanediol 139.21
    bromobenzene 179.24
    dibromomethane 884.5
    1,1,2,2-tetrachloroethane 846.55
    2-methyl-cyclohexyl acetate 89.47
    tetrabutyl urea 32.56
    diisobutyl methanol 31.69
    2-phenylethanol 73.9
    styrene 89.84
    dioctyl adipate 56.65
    dimethyl sulfate 87.59
    ethyl butyrate 151.27
    methyl lactate 54.32
    butyl lactate 34.0
    diethyl carbonate 134.46
    propanediol butyl ether 36.03
    triethyl orthoformate 112.68
    p-tert-butyltoluene 30.56
    methyl 4-tert-butylbenzoate 69.5
    morpholine 628.05
    tert-butylamine 75.27
    n-dodecanol 15.48
    dimethoxymethane 191.84
    ethylene carbonate 142.32
    cyrene 75.12
    2-ethoxyethyl acetate 118.03
    2-ethylhexyl acetate 84.97
    1,2,4-trichlorobenzene 166.12
    4-methylpyridine 170.15
    dibutyl ether 70.94
    2,6-dimethyl-4-heptanol 31.69
    DEF 121.28
    dimethyl isosorbide 160.45
    tetrachloroethylene 576.89
    eugenol 68.67
    triacetin 90.49
    span 80 52.6
    1,4-butanediol 52.84
    1,1-dichloroethane 485.79
    2-methyl-1-pentanol 78.61
    methyl formate 76.5
    2-methyl-1-butanol 76.32
    n-decane 8.31
    butyronitrile 153.79
    3,7-dimethyl-1-octanol 26.44
    1-chlorooctane 26.97
    1-chlorotetradecane 12.51
    n-nonane 7.95
    undecane 6.04
    tert-butylcyclohexane 14.34
    cyclooctane 19.29
    cyclopentanol 63.71
    tetrahydropyran 479.81
    tert-amyl methyl ether 99.56
    2,5,8-trioxanonane 214.89
    1-hexene 62.15
    2-isopropoxyethanol 171.19
    2,2,2-trifluoroethanol 109.55
    methyl butyrate 178.22

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction