2-(2-Thienyl)furan

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  • Identifiers

    CAS number
    27521-80-8

    Molecular formula
    C8H6OS

    SMILES
    C1=COC(=C1)C2=CC=CS2

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sulfurous 78.98%
    Burnt 68.15%
    Coffee 62.17%
    Meaty 58.22%
    Roasted 55.95%
    Alliaceous 47.0%
    Garlic 40.85%
    Pungent 40.17%
    Mushroom 38.71%
    Savory 38.5%

     

    Flavor
    Coffee 63.71%
    Nutty 50.45%
    Sulfury 49.09%
    Roasted 46.77%
    Vegetable 38.12%
    Fishy 38.04%
    Meaty 36.74%
    Chocolate 35.46%
    Sulfur 34.98%
    Burnt 34.06%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    5.23 (weak acid)

    Molecular weight
    150.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    231°C

    Flash point

    • 66.51 ˚C est.

  • Synonyms

    • 2-(2-thienyl)furan
    • 27521-80-8
    • 2-(thiophen-2-yl)furan
    • 2-thiophen-2-ylfuran
    • Furan, 2-(2-thienyl)-
    • LN99S92PXF
    • DTXSID40335580
    • RefChem:84126
    • DTXCID40286669
    • 622-976-2
    • RVYKTPRETIBSPK-UHFFFAOYSA-N
    • furylthiole
    • 2-thiophen-2-yluran
    • 2-(2-Furanyl)thiophene
    • UNII-LN99S92PXF
    • SCHEMBL521943
    • 2-(2-Thienyl)furan, 97%
    • SCHEMBL4438309
    • SCHEMBL7862922
    • SCHEMBL8154747
    • SCHEMBL9679207
    • SCHEMBL11525040
    • SCHEMBL27636592
    • SCHEMBL27657451
    • CHEBI:173634
    • 2-(2-THIENYL)FURAN 97
    • MFCD05664273
    • AKOS000276765
    • HS-4294
    • H53428
    • 27521-80-8

  • Applications

    2-(2-Thienyl)furan (CAS 27521-80-8) is commonly used as an organic building block and intermediate in the synthesis of pharmaceuticals and agrochemicals, enabling incorporation of a thienyl–furan motif into target molecules. It is evaluated as a precursor for organic electronic materials and conjugated polymers, where the heteroaromatic scaffold can participate in small-molecule semiconductors or polymer backbones. In dye and pigment chemistry, it may be used as a fragment to develop heteroaromatic color agents. It can function as a reactive intermediate in coatings, inks, or polymer formulations to introduce thienyl/furan units into the polymer matrix. In research and development, it is used as a model substrate to study coupling reactions and synthetic methods for functionalized furan–thienyl systems.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 303.81
    methanol 347.44
    isopropanol 228.86
    water 3.67
    ethyl acetate 309.69
    n-propanol 238.7
    acetone 625.08
    n-butanol 224.87
    acetonitrile 322.57
    DMF 962.26
    toluene 223.26
    isobutanol 196.88
    1,4-dioxane 810.98
    methyl acetate 355.79
    THF 892.3
    2-butanone 420.64
    n-pentanol 222.91
    sec-butanol 211.4
    n-hexane 52.14
    ethylene glycol 196.33
    NMP 754.76
    cyclohexane 65.3
    DMSO 1223.32
    n-butyl acetate 206.42
    n-octanol 171.5
    chloroform 764.11
    n-propyl acetate 268.85
    acetic acid 291.24
    dichloromethane 772.77
    cyclohexanone 571.6
    propylene glycol 176.18
    isopropyl acetate 214.86
    DMAc 616.93
    2-ethoxyethanol 473.77
    isopentanol 206.87
    n-heptane 53.54
    ethyl formate 223.8
    1,2-dichloroethane 530.17
    n-hexanol 217.98
    2-methoxyethanol 629.1
    isobutyl acetate 198.19
    tetrachloromethane 146.5
    n-pentyl acetate 180.28
    transcutol 1039.29
    n-heptanol 138.88
    ethylbenzene 132.34
    MIBK 270.96
    2-propoxyethanol 484.13
    tert-butanol 265.12
    MTBE 268.92
    2-butoxyethanol 293.45
    propionic acid 248.2
    o-xylene 150.98
    formic acid 109.3
    diethyl ether 314.49
    m-xylene 162.92
    p-xylene 159.38
    chlorobenzene 296.0
    dimethyl carbonate 234.17
    n-octane 33.38
    formamide 206.09
    cyclopentanone 708.77
    2-pentanone 374.49
    anisole 356.24
    cyclopentyl methyl ether 407.38
    gamma-butyrolactone 629.42
    1-methoxy-2-propanol 492.95
    pyridine 475.61
    3-pentanone 305.56
    furfural 617.54
    n-dodecane 33.27
    diethylene glycol 505.22
    diisopropyl ether 129.16
    tert-amyl alcohol 229.17
    acetylacetone 476.08
    n-hexadecane 37.38
    acetophenone 313.79
    methyl propionate 319.31
    isopentyl acetate 199.79
    trichloroethylene 847.0
    n-nonanol 150.39
    cyclohexanol 239.5
    benzyl alcohol 268.28
    2-ethylhexanol 152.38
    isooctanol 126.88
    dipropyl ether 203.94
    1,2-dichlorobenzene 273.91
    ethyl lactate 184.18
    propylene carbonate 328.67
    n-methylformamide 374.72
    2-pentanol 175.08
    n-pentane 49.04
    1-propoxy-2-propanol 309.35
    1-methoxy-2-propyl acetate 259.88
    2-(2-methoxypropoxy) propanol 296.44
    mesitylene 121.7
    ε-caprolactone 416.79
    p-cymene 96.97
    epichlorohydrin 774.81
    1,1,1-trichloroethane 418.15
    2-aminoethanol 234.62
    morpholine-4-carbaldehyde 850.52
    sulfolane 889.43
    2,2,4-trimethylpentane 37.81
    2-methyltetrahydrofuran 510.87
    n-hexyl acetate 259.68
    isooctane 35.36
    2-(2-butoxyethoxy)ethanol 397.36
    sec-butyl acetate 186.49
    tert-butyl acetate 253.62
    decalin 54.96
    glycerin 308.38
    diglyme 705.56
    acrylic acid 258.05
    isopropyl myristate 132.78
    n-butyric acid 273.8
    acetyl acetate 216.08
    di(2-ethylhexyl) phthalate 125.26
    ethyl propionate 236.47
    nitromethane 555.07
    1,2-diethoxyethane 330.17
    benzonitrile 284.81
    trioctyl phosphate 98.17
    1-bromopropane 286.85
    gamma-valerolactone 772.07
    n-decanol 123.65
    triethyl phosphate 119.71
    4-methyl-2-pentanol 138.59
    propionitrile 257.53
    vinylene carbonate 330.67
    1,1,2-trichlorotrifluoroethane 498.95
    DMS 256.03
    cumene 108.51
    2-octanol 115.82
    2-hexanone 302.49
    octyl acetate 156.15
    limonene 131.46
    1,2-dimethoxyethane 684.12
    ethyl orthosilicate 116.24
    tributyl phosphate 109.29
    diacetone alcohol 323.9
    N,N-dimethylaniline 247.14
    acrylonitrile 330.01
    aniline 253.39
    1,3-propanediol 290.91
    bromobenzene 312.16
    dibromomethane 495.7
    1,1,2,2-tetrachloroethane 625.85
    2-methyl-cyclohexyl acetate 175.16
    tetrabutyl urea 154.32
    diisobutyl methanol 114.44
    2-phenylethanol 231.82
    styrene 177.8
    dioctyl adipate 177.06
    dimethyl sulfate 390.72
    ethyl butyrate 192.36
    methyl lactate 243.76
    butyl lactate 163.31
    diethyl carbonate 140.01
    propanediol butyl ether 304.18
    triethyl orthoformate 146.74
    p-tert-butyltoluene 98.14
    methyl 4-tert-butylbenzoate 254.29
    morpholine 661.28
    tert-butylamine 175.16
    n-dodecanol 104.21
    dimethoxymethane 619.26
    ethylene carbonate 265.06
    cyrene 337.68
    2-ethoxyethyl acetate 257.38
    2-ethylhexyl acetate 163.75
    1,2,4-trichlorobenzene 327.06
    4-methylpyridine 427.82
    dibutyl ether 198.3
    2,6-dimethyl-4-heptanol 114.44
    DEF 438.72
    dimethyl isosorbide 419.83
    tetrachloroethylene 408.93
    eugenol 285.33
    triacetin 275.37
    span 80 254.05
    1,4-butanediol 203.02
    1,1-dichloroethane 448.05
    2-methyl-1-pentanol 198.26
    methyl formate 319.08
    2-methyl-1-butanol 196.25
    n-decane 47.17
    butyronitrile 249.9
    3,7-dimethyl-1-octanol 163.59
    1-chlorooctane 141.85
    1-chlorotetradecane 73.21
    n-nonane 47.36
    undecane 38.66
    tert-butylcyclohexane 54.38
    cyclooctane 34.53
    cyclopentanol 276.58
    tetrahydropyran 481.24
    tert-amyl methyl ether 217.79
    2,5,8-trioxanonane 488.67
    1-hexene 137.09
    2-isopropoxyethanol 345.86
    2,2,2-trifluoroethanol 143.0
    methyl butyrate 296.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction