2-[2-(Methylsulfanyl)ethyl]pyridine

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  • Identifiers

    CAS number
    14143-85-2

    Molecular formula
    C8H11NS

    SMILES
    CSCCC1=CC=CC=N1

    Safety labels

  • Odor profile

    Fragrance
    Roasted 65.21%
    Sulfurous 59.04%
    Meaty 57.73%
    Vegetable 56.62%
    Nutty 50.22%
    Green 47.22%
    Coffee 46.43%
    Earthy 45.71%
    Burnt 45.04%
    Savory 41.04%

     

    Flavor
    Green 64.28%
    Vegetable 45.84%
    Roasted 44.14%
    Sulfurous 41.62%
    Onion 37.46%
    Sulfury 36.8%
    Meaty 35.39%
    Metallic 34.75%
    Earthy 32.65%
    Horseradish 30.95%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    4.37 (weak acid)

    Molecular weight
    153.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    244°C

    Flash point

    • 96.15 ˚C est.

  • Synonyms

    • 2-[2-(methylsulfanyl)ethyl]pyridine
    • 14143-85-2
    • NSC102542
    • SCHEMBL294358
    • SCHEMBL951055
    • SCHEMBL15475295
    • DTXSID90295524
    • Pyridine, 2-[2-(methylthio)ethyl]-
    • NSC-102542
    • DB-344037
    • 14143-85-2

  • Applications

    2-[2-(Methylsulfanyl)ethyl]pyridine (CAS 14143-85-2) is primarily used as an intermediate in organic synthesis, enabling the construction of heterocyclic compounds for pharmaceutical and agrochemical research. In industry, it is often evaluated as a building block for ligand design in coordination chemistry and catalysis, where the sulfur-containing side chain can influence metal binding and reaction performance. The compound may serve as a synthetic precursor for fragrance materials or perfumery intermediates, leveraging its pyridine core and thioether functionality. It also appears in specialty polymer and coatings formulations as a reactive fragment or functional handle that can be incorporated into larger architectures. Additionally, it is encountered in research settings as a versatile building block for medicinal chemistry and materials science studies, with use cases dependent on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1023.41
    methanol 904.29
    isopropanol 534.67
    water 0.81
    ethyl acetate 853.0
    n-propanol 743.88
    acetone 1213.28
    n-butanol 638.07
    acetonitrile 779.8
    DMF 1173.75
    toluene 852.57
    isobutanol 461.4
    1,4-dioxane 1856.96
    methyl acetate 728.02
    THF 1507.0
    2-butanone 921.65
    n-pentanol 499.2
    sec-butanol 442.54
    n-hexane 98.94
    ethylene glycol 215.89
    NMP 764.37
    cyclohexane 324.88
    DMSO 1901.68
    n-butyl acetate 813.85
    n-octanol 212.99
    chloroform 2873.06
    n-propyl acetate 490.48
    acetic acid 844.94
    dichloromethane 2449.92
    cyclohexanone 1427.12
    propylene glycol 255.04
    isopropyl acetate 356.65
    DMAc 761.42
    2-ethoxyethanol 578.99
    isopentanol 419.26
    n-heptane 150.66
    ethyl formate 630.69
    1,2-dichloroethane 1458.51
    n-hexanol 662.14
    2-methoxyethanol 936.45
    isobutyl acetate 297.39
    tetrachloromethane 428.64
    n-pentyl acetate 311.09
    transcutol 1970.65
    n-heptanol 239.66
    ethylbenzene 261.42
    MIBK 280.2
    2-propoxyethanol 798.49
    tert-butanol 444.31
    MTBE 362.75
    2-butoxyethanol 383.8
    propionic acid 629.99
    o-xylene 335.7
    formic acid 218.64
    diethyl ether 757.9
    m-xylene 368.9
    p-xylene 300.56
    chlorobenzene 1024.1
    dimethyl carbonate 232.59
    n-octane 41.95
    formamide 304.61
    cyclopentanone 1152.22
    2-pentanone 674.47
    anisole 431.42
    cyclopentyl methyl ether 692.74
    gamma-butyrolactone 1225.35
    1-methoxy-2-propanol 613.69
    pyridine 2057.58
    3-pentanone 549.08
    furfural 1257.61
    n-dodecane 31.9
    diethylene glycol 544.72
    diisopropyl ether 147.62
    tert-amyl alcohol 327.8
    acetylacetone 603.63
    n-hexadecane 36.73
    acetophenone 383.95
    methyl propionate 600.3
    isopentyl acetate 485.95
    trichloroethylene 2802.59
    n-nonanol 181.12
    cyclohexanol 636.81
    benzyl alcohol 431.18
    2-ethylhexanol 381.34
    isooctanol 166.68
    dipropyl ether 565.22
    1,2-dichlorobenzene 660.63
    ethyl lactate 183.92
    propylene carbonate 662.57
    n-methylformamide 576.49
    2-pentanol 338.65
    n-pentane 108.99
    1-propoxy-2-propanol 584.31
    1-methoxy-2-propyl acetate 481.53
    2-(2-methoxypropoxy) propanol 280.63
    mesitylene 185.28
    ε-caprolactone 1035.86
    p-cymene 176.92
    epichlorohydrin 1343.33
    1,1,1-trichloroethane 1159.11
    2-aminoethanol 361.57
    morpholine-4-carbaldehyde 1019.0
    sulfolane 1045.38
    2,2,4-trimethylpentane 37.67
    2-methyltetrahydrofuran 1127.54
    n-hexyl acetate 359.57
    isooctane 28.96
    2-(2-butoxyethoxy)ethanol 487.46
    sec-butyl acetate 259.47
    tert-butyl acetate 280.54
    decalin 85.39
    glycerin 328.89
    diglyme 977.59
    acrylic acid 548.49
    isopropyl myristate 138.73
    n-butyric acid 891.41
    acetyl acetate 422.6
    di(2-ethylhexyl) phthalate 143.34
    ethyl propionate 333.05
    nitromethane 1034.53
    1,2-diethoxyethane 788.32
    benzonitrile 691.79
    trioctyl phosphate 105.24
    1-bromopropane 883.74
    gamma-valerolactone 1406.29
    n-decanol 138.26
    triethyl phosphate 159.24
    4-methyl-2-pentanol 161.62
    propionitrile 684.58
    vinylene carbonate 790.65
    1,1,2-trichlorotrifluoroethane 888.6
    DMS 283.35
    cumene 134.31
    2-octanol 142.49
    2-hexanone 462.78
    octyl acetate 183.02
    limonene 284.48
    1,2-dimethoxyethane 947.17
    ethyl orthosilicate 168.84
    tributyl phosphate 136.03
    diacetone alcohol 294.16
    N,N-dimethylaniline 248.31
    acrylonitrile 780.32
    aniline 842.21
    1,3-propanediol 513.48
    bromobenzene 1118.54
    dibromomethane 1695.14
    1,1,2,2-tetrachloroethane 1888.41
    2-methyl-cyclohexyl acetate 289.98
    tetrabutyl urea 188.24
    diisobutyl methanol 167.58
    2-phenylethanol 433.19
    styrene 417.4
    dioctyl adipate 207.96
    dimethyl sulfate 298.34
    ethyl butyrate 478.93
    methyl lactate 238.89
    butyl lactate 241.55
    diethyl carbonate 286.08
    propanediol butyl ether 316.29
    triethyl orthoformate 297.77
    p-tert-butyltoluene 152.75
    methyl 4-tert-butylbenzoate 229.04
    morpholine 1773.26
    tert-butylamine 311.51
    n-dodecanol 113.48
    dimethoxymethane 721.36
    ethylene carbonate 669.58
    cyrene 260.43
    2-ethoxyethyl acetate 475.65
    2-ethylhexyl acetate 418.6
    1,2,4-trichlorobenzene 710.86
    4-methylpyridine 1443.7
    dibutyl ether 350.71
    2,6-dimethyl-4-heptanol 167.58
    DEF 774.16
    dimethyl isosorbide 424.75
    tetrachloroethylene 1409.98
    eugenol 265.93
    triacetin 307.56
    span 80 299.0
    1,4-butanediol 230.0
    1,1-dichloroethane 1315.46
    2-methyl-1-pentanol 332.28
    methyl formate 490.62
    2-methyl-1-butanol 405.12
    n-decane 53.54
    butyronitrile 779.8
    3,7-dimethyl-1-octanol 194.47
    1-chlorooctane 189.08
    1-chlorotetradecane 78.11
    n-nonane 54.97
    undecane 39.78
    tert-butylcyclohexane 60.54
    cyclooctane 87.52
    cyclopentanol 568.59
    tetrahydropyran 1787.2
    tert-amyl methyl ether 263.43
    2,5,8-trioxanonane 573.86
    1-hexene 355.21
    2-isopropoxyethanol 363.19
    2,2,2-trifluoroethanol 223.53
    methyl butyrate 501.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction