2-(2-Methoxyphenoxy)acetic acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    1878-85-9

    Molecular formula
    C9H10O4

    SMILES
    COC1=CC=CC=C1OCC(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 59.2%
    Vanilla 56.76%
    Creamy 44.27%
    Caramellic 41.06%
    Balsamic 37.31%
    Phenolic 35.93%
    Milky 34.73%
    Powdery 32.81%
    Dairy 30.26%
    Spicy 28.81%

     

    Flavor
    Sweet 83.54%
    Creamy 44.92%
    Caramel 41.16%
    Woody 36.33%
    Vanilla 36.31%
    Powdery 34.88%
    Balsamic 30.82%
    Spice 29.11%
    Balsam 27.96%
    Smoky 27.39%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    6.63 (neutral)

    Molecular weight
    182.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    305°C

    Flash point

    • 152.95 ˚C est.

  • Synonyms

    • 1878-85-9
    • 2-(2-Methoxyphenoxy)acetic acid
    • (2-METHOXYPHENOXY)ACETIC ACID
    • Guaiacoxyacetic acid
    • 7XVZ1X365A
    • NSC-5165
    • DTXSID5075153
    • RefChem:396012
    • DTXCID2035930
    • 217-526-3
    • 2-Methoxyphenoxyacetic acid
    • (o-Methoxyphenoxy)acetic acid
    • MFCD00014352
    • Acetic acid, (2-methoxyphenoxy)-
    • Acetic acid, 2-(2-methoxyphenoxy)-
    • o-methoxyphenoxyacetic acid
    • MLS000098986
    • (2-methoxy-phenoxy)-acetic acid
    • SMR000061890
    • F1284-1034
    • NSC 5165
    • EINECS 217-526-3
    • Acide o-methoxyphenoxyacetique [French]
    • BRN 1874501
    • UNII-7XVZ1X365A
    • Acide o-methoxyphenoxyacetique
    • AI3-10575
    • Acetic acid, (o-methoxyphenoxy)-
    • Acetic acid,2-(2-methoxyphenoxy)-
    • Opera_ID_1570
    • 3-06-00-04234 (Beilstein Handbook Reference)
    • SCHEMBL323801
    • IFLab1_005507
    • SCHEMBL3209384
    • SCHEMBL7380176
    • SCHEMBL8555114
    • SCHEMBL8555115
    • 2-(2-Methoxyphenoxy)aceticacid
    • CHEMBL1564162
    • NSC5165
    • HMS1427K07
    • HMS2185J23
    • SMSSF-0064546
    • ALBB-000231
    • BB_NC-02457
    • STR05299
    • BBL012084
    • SBB005726
    • STK049359
    • (2-Methoxyphenoxy)acetic acid, 98%
    • AKOS000295788
    • CCG-110442
    • EBC-153168
    • FM34506
    • IDI1_010910
    • ST040854
    • SY008335
    • DB-044658
    • CS-0106585
    • M0692
    • NS00021790
    • EN300-00072
    • AC-907/25014253
    • F357993
    • Q27268994
    • Z56867227
    • InChI=1/C9H10O4/c1-12-7-4-2-3-5-8(7)13-6-9(10)11/h2-5H,6H2,1H3,(H,10,11
    • 1878-85-9

  • Applications

    2-(2-Methoxyphenoxy)acetic acid is recognized as a useful intermediate in the synthesis of aroma and flavor compounds, thanks to its aryl–ether moiety. It is commonly used as a building block for fragrance ingredients in perfumery and cosmetics, and is also evaluated as a precursor for pharmaceutical intermediates. Additionally, the compound can serve as a precursor for functionalized monomers and additives used in polymers, coatings, inks, and adhesives, enabling development of specialty materials in industrial manufacturing, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 72.01
    methanol 119.63
    isopropanol 40.92
    water 5.47
    ethyl acetate 38.76
    n-propanol 41.33
    acetone 144.63
    n-butanol 27.71
    acetonitrile 37.99
    DMF 601.14
    toluene 4.7
    isobutanol 23.63
    1,4-dioxane 60.87
    methyl acetate 50.01
    THF 183.67
    2-butanone 58.75
    n-pentanol 24.13
    sec-butanol 32.21
    n-hexane 1.64
    ethylene glycol 76.85
    NMP 493.74
    cyclohexane 2.01
    DMSO 1706.65
    n-butyl acetate 47.04
    n-octanol 17.47
    chloroform 27.06
    n-propyl acetate 41.12
    acetic acid 145.62
    dichloromethane 60.5
    cyclohexanone 87.41
    propylene glycol 49.29
    isopropyl acetate 26.53
    DMAc 381.11
    2-ethoxyethanol 117.35
    isopentanol 26.33
    n-heptane 3.08
    ethyl formate 46.21
    1,2-dichloroethane 65.8
    n-hexanol 27.23
    2-methoxyethanol 183.82
    isobutyl acetate 16.53
    tetrachloromethane 6.47
    n-pentyl acetate 22.24
    transcutol 341.61
    n-heptanol 14.21
    ethylbenzene 6.76
    MIBK 32.41
    2-propoxyethanol 82.67
    tert-butanol 72.61
    MTBE 36.83
    2-butoxyethanol 40.91
    propionic acid 67.99
    o-xylene 10.72
    formic acid 178.81
    diethyl ether 26.88
    m-xylene 7.91
    p-xylene 8.03
    chlorobenzene 14.89
    dimethyl carbonate 55.48
    n-octane 1.15
    formamide 361.29
    cyclopentanone 169.46
    2-pentanone 47.05
    anisole 36.54
    cyclopentyl methyl ether 55.95
    gamma-butyrolactone 251.24
    1-methoxy-2-propanol 117.6
    pyridine 41.13
    3-pentanone 37.45
    furfural 189.34
    n-dodecane 1.02
    diethylene glycol 113.03
    diisopropyl ether 10.26
    tert-amyl alcohol 57.96
    acetylacetone 91.98
    n-hexadecane 1.14
    acetophenone 55.48
    methyl propionate 54.0
    isopentyl acetate 38.99
    trichloroethylene 96.16
    n-nonanol 15.36
    cyclohexanol 25.88
    benzyl alcohol 34.62
    2-ethylhexanol 20.29
    isooctanol 12.3
    dipropyl ether 24.11
    1,2-dichlorobenzene 25.55
    ethyl lactate 48.72
    propylene carbonate 100.62
    n-methylformamide 220.4
    2-pentanol 20.29
    n-pentane 1.61
    1-propoxy-2-propanol 60.92
    1-methoxy-2-propyl acetate 65.53
    2-(2-methoxypropoxy) propanol 76.63
    mesitylene 7.64
    ε-caprolactone 84.71
    p-cymene 11.24
    epichlorohydrin 180.33
    1,1,1-trichloroethane 23.09
    2-aminoethanol 82.03
    morpholine-4-carbaldehyde 263.59
    sulfolane 594.24
    2,2,4-trimethylpentane 2.29
    2-methyltetrahydrofuran 87.12
    n-hexyl acetate 34.11
    isooctane 1.38
    2-(2-butoxyethoxy)ethanol 83.22
    sec-butyl acetate 22.92
    tert-butyl acetate 46.64
    decalin 2.48
    glycerin 118.17
    diglyme 183.1
    acrylic acid 93.65
    isopropyl myristate 15.4
    n-butyric acid 52.56
    acetyl acetate 33.48
    di(2-ethylhexyl) phthalate 21.3
    ethyl propionate 37.38
    nitromethane 322.09
    1,2-diethoxyethane 54.86
    benzonitrile 30.79
    trioctyl phosphate 15.83
    1-bromopropane 16.29
    gamma-valerolactone 192.45
    n-decanol 11.88
    triethyl phosphate 36.13
    4-methyl-2-pentanol 14.48
    propionitrile 25.28
    vinylene carbonate 79.85
    1,1,2-trichlorotrifluoroethane 161.17
    DMS 56.66
    cumene 8.03
    2-octanol 9.64
    2-hexanone 34.98
    octyl acetate 20.01
    limonene 17.54
    1,2-dimethoxyethane 153.36
    ethyl orthosilicate 29.56
    tributyl phosphate 21.96
    diacetone alcohol 82.77
    N,N-dimethylaniline 40.65
    acrylonitrile 51.24
    aniline 20.71
    1,3-propanediol 70.87
    bromobenzene 11.58
    dibromomethane 31.1
    1,1,2,2-tetrachloroethane 76.33
    2-methyl-cyclohexyl acetate 38.78
    tetrabutyl urea 34.07
    diisobutyl methanol 14.19
    2-phenylethanol 32.23
    styrene 7.99
    dioctyl adipate 32.72
    dimethyl sulfate 186.03
    ethyl butyrate 40.69
    methyl lactate 72.86
    butyl lactate 35.04
    diethyl carbonate 35.46
    propanediol butyl ether 60.92
    triethyl orthoformate 34.9
    p-tert-butyltoluene 11.32
    methyl 4-tert-butylbenzoate 56.32
    morpholine 99.18
    tert-butylamine 31.25
    n-dodecanol 9.19
    dimethoxymethane 158.1
    ethylene carbonate 59.02
    cyrene 95.93
    2-ethoxyethyl acetate 45.04
    2-ethylhexyl acetate 29.35
    1,2,4-trichlorobenzene 32.82
    4-methylpyridine 38.58
    dibutyl ether 18.13
    2,6-dimethyl-4-heptanol 14.19
    DEF 103.33
    dimethyl isosorbide 124.82
    tetrachloroethylene 54.22
    eugenol 51.43
    triacetin 66.67
    span 80 46.92
    1,4-butanediol 41.36
    1,1-dichloroethane 23.23
    2-methyl-1-pentanol 23.3
    methyl formate 159.61
    2-methyl-1-butanol 25.29
    n-decane 1.7
    butyronitrile 21.8
    3,7-dimethyl-1-octanol 19.08
    1-chlorooctane 8.29
    1-chlorotetradecane 3.54
    n-nonane 1.61
    undecane 1.29
    tert-butylcyclohexane 2.43
    cyclooctane 1.19
    cyclopentanol 44.74
    tetrahydropyran 36.19
    tert-amyl methyl ether 36.23
    2,5,8-trioxanonane 131.3
    1-hexene 5.46
    2-isopropoxyethanol 65.64
    2,2,2-trifluoroethanol 85.74
    methyl butyrate 54.57

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction