2-(2-Hydroxyethyl)phenol

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  • Identifiers

    CAS number
    7768-28-7

    Molecular formula
    C8H10O2

    SMILES
    C1=CC=C(C(=C1)CCO)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 73.82%
    Phenolic 59.92%
    Vanilla 51.81%
    Fruity 48.35%
    Balsamic 47.49%
    Floral 40.56%
    Medicinal 35.91%
    Almond 34.11%
    Bitter 34.07%
    Spicy 32.48%

     

    Flavor
    Sweet 83.99%
    Fruity 58.09%
    Floral 48.59%
    Phenolic 44.21%
    Mild 43.93%
    Bitter 40.38%
    Powdery 38.43%
    Spicy 35.18%
    Vanilla 32.33%
    Hawthorn 30.87%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    9.11 (weak base)

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    286°C

    Flash point

    • 144.81 ˚C est.

  • Synonyms

    • 2-(2-Hydroxyethyl)phenol
    • 7768-28-7
    • 2-(2-Hydroxyphenyl)ethanol
    • 2-Hydroxyphenylethanol
    • 2-Hydroxybenzeneethanol
    • o-hydroxyphenylethanol
    • C6AV79GN9F
    • NSC-101845
    • CHEBI:64803
    • DTXSID90228312
    • oHPE
    • RefChem:453965
    • DTXCID10150803
    • 231-863-3
    • 2-Hydroxyphenethyl alcohol
    • Benzeneethanol, 2-hydroxy-
    • MFCD00002890
    • o-(2-Hydroxyethyl)phenol
    • 2-(o-Hydroxyphenyl)ethanol
    • o-Hydroxyphenethyl alcohol
    • 2-hydroxy-benzeneethanol
    • NSC 101845
    • beta-(o-Hydroxyphenyl)ethanol
    • 2-phenolethanol
    • 2-HYDROXYPHENETHYLALCOHOL
    • EINECS 231-863-3
    • 2-Hydroxyethylphenol
    • UNII-C6AV79GN9F
    • SCHEMBL43837
    • 140111-61-1
    • 2-(2-hydroxy-ethyl)-phenol
    • 2-(2-hydroxyphenyl)-ethanol
    • Phenethyl alcohol, o-hydroxy-
    • SCHEMBL810350
    • SCHEMBL5074495
    • SCHEMBL5610155
    • SCHEMBL6271210
    • SCHEMBL6271213
    • CHEMBL4075005
    • SCHEMBL14931630
    • SCHEMBL29646276
    • .beta.-(o-Hydroxyphenyl)ethanol
    • 2-Hydroxyphenethyl alcohol, 99%
    • 2-(2-Hydroxyethyl)phenol, 95%
    • NSC101845
    • AKOS005259862
    • AB17761
    • CS-W016503
    • EBC-152051
    • AS-10136
    • FH147089
    • SY066615
    • DB-075363
    • NS00020119
    • ST51038029
    • EN300-179020
    • 768H287
    • F215704
    • 2-hydroxyphenylethanol; 2-(o-Hydroxyphenyl)ethanol;
    • Q27133443
    • Z1255390540
    • InChI=1/C8H10O2/c9-6-5-7-3-1-2-4-8(7)10/h1-4,9-10H,5-6H
    • 7768-28-7

  • Applications

    2-(2-Hydroxyethyl)phenol, CAS 7768-28-7, is used as a key intermediate and building block in polymer and resin synthesis, functioning as a polyol or precursor for polyurethane and polyester, and can also serve as a reactive crosslinker or additive in coatings, inks, and adhesives. Owing to its phenolic and hydroxyethyl groups, it may be regarded as a fragrance ingredient or odorant in perfumery and cosmetics, and can act as an antioxidant or stabilizer to improve the aging performance of polymers and coatings. Additionally, it may be evaluated as an intermediate for the synthesis of specialty chemicals or other phenolic derivatives in industrial applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 567.74
    methanol 618.58
    isopropanol 393.24
    water 13.51
    ethyl acetate 137.37
    n-propanol 384.15
    acetone 245.45
    n-butanol 267.45
    acetonitrile 296.33
    DMF 757.65
    toluene 31.43
    isobutanol 221.87
    1,4-dioxane 530.98
    methyl acetate 179.75
    THF 450.48
    2-butanone 171.14
    n-pentanol 153.31
    sec-butanol 216.32
    n-hexane 6.63
    ethylene glycol 307.15
    NMP 260.86
    cyclohexane 11.96
    DMSO 1254.95
    n-butyl acetate 95.89
    n-octanol 91.93
    chloroform 206.15
    n-propyl acetate 95.28
    acetic acid 281.07
    dichloromethane 270.82
    cyclohexanone 193.9
    propylene glycol 183.91
    isopropyl acetate 72.53
    DMAc 394.38
    2-ethoxyethanol 286.48
    isopentanol 160.95
    n-heptane 18.08
    ethyl formate 161.45
    1,2-dichloroethane 184.85
    n-hexanol 189.55
    2-methoxyethanol 502.12
    isobutyl acetate 56.51
    tetrachloromethane 41.13
    n-pentyl acetate 59.22
    transcutol 372.09
    n-heptanol 101.81
    ethylbenzene 28.39
    MIBK 89.04
    2-propoxyethanol 280.77
    tert-butanol 396.75
    MTBE 139.32
    2-butoxyethanol 151.12
    propionic acid 236.53
    o-xylene 37.87
    formic acid 190.19
    diethyl ether 134.1
    m-xylene 40.22
    p-xylene 33.78
    chlorobenzene 55.25
    dimethyl carbonate 75.55
    n-octane 8.72
    formamide 363.77
    cyclopentanone 274.46
    2-pentanone 132.56
    anisole 95.19
    cyclopentyl methyl ether 133.13
    gamma-butyrolactone 337.97
    1-methoxy-2-propanol 311.14
    pyridine 159.15
    3-pentanone 87.87
    furfural 236.53
    n-dodecane 8.11
    diethylene glycol 300.4
    diisopropyl ether 33.57
    tert-amyl alcohol 214.08
    acetylacetone 141.07
    n-hexadecane 8.68
    acetophenone 85.22
    methyl propionate 132.09
    isopentyl acetate 74.04
    trichloroethylene 257.47
    n-nonanol 80.72
    cyclohexanol 130.63
    benzyl alcohol 90.52
    2-ethylhexanol 91.36
    isooctanol 78.98
    dipropyl ether 103.21
    1,2-dichlorobenzene 58.64
    ethyl lactate 77.63
    propylene carbonate 147.48
    n-methylformamide 432.69
    2-pentanol 132.14
    n-pentane 8.46
    1-propoxy-2-propanol 184.11
    1-methoxy-2-propyl acetate 104.48
    2-(2-methoxypropoxy) propanol 118.85
    mesitylene 30.97
    ε-caprolactone 152.35
    p-cymene 32.17
    epichlorohydrin 346.52
    1,1,1-trichloroethane 111.07
    2-aminoethanol 400.48
    morpholine-4-carbaldehyde 324.42
    sulfolane 418.27
    2,2,4-trimethylpentane 7.82
    2-methyltetrahydrofuran 229.58
    n-hexyl acetate 85.82
    isooctane 8.38
    2-(2-butoxyethoxy)ethanol 169.09
    sec-butyl acetate 49.53
    tert-butyl acetate 88.15
    decalin 9.22
    glycerin 264.06
    diglyme 317.23
    acrylic acid 180.86
    isopropyl myristate 44.87
    n-butyric acid 231.2
    acetyl acetate 72.83
    di(2-ethylhexyl) phthalate 42.35
    ethyl propionate 75.06
    nitromethane 447.21
    1,2-diethoxyethane 119.41
    benzonitrile 91.03
    trioctyl phosphate 42.71
    1-bromopropane 85.46
    gamma-valerolactone 289.0
    n-decanol 65.2
    triethyl phosphate 45.94
    4-methyl-2-pentanol 70.88
    propionitrile 200.52
    vinylene carbonate 133.83
    1,1,2-trichlorotrifluoroethane 217.64
    DMS 60.09
    cumene 27.63
    2-octanol 60.85
    2-hexanone 95.42
    octyl acetate 58.23
    limonene 47.88
    1,2-dimethoxyethane 364.01
    ethyl orthosilicate 44.29
    tributyl phosphate 41.1
    diacetone alcohol 157.01
    N,N-dimethylaniline 75.19
    acrylonitrile 252.94
    aniline 80.62
    1,3-propanediol 388.57
    bromobenzene 47.02
    dibromomethane 151.33
    1,1,2,2-tetrachloroethane 198.4
    2-methyl-cyclohexyl acetate 60.64
    tetrabutyl urea 63.02
    diisobutyl methanol 58.1
    2-phenylethanol 91.37
    styrene 32.39
    dioctyl adipate 60.04
    dimethyl sulfate 135.07
    ethyl butyrate 85.01
    methyl lactate 108.49
    butyl lactate 64.1
    diethyl carbonate 57.94
    propanediol butyl ether 121.55
    triethyl orthoformate 57.95
    p-tert-butyltoluene 31.68
    methyl 4-tert-butylbenzoate 94.7
    morpholine 481.17
    tert-butylamine 183.91
    n-dodecanol 51.65
    dimethoxymethane 302.91
    ethylene carbonate 114.5
    cyrene 121.76
    2-ethoxyethyl acetate 80.82
    2-ethylhexyl acetate 50.91
    1,2,4-trichlorobenzene 66.21
    4-methylpyridine 121.86
    dibutyl ether 65.92
    2,6-dimethyl-4-heptanol 58.1
    DEF 184.02
    dimethyl isosorbide 165.09
    tetrachloroethylene 130.87
    eugenol 104.42
    triacetin 81.37
    span 80 107.23
    1,4-butanediol 170.58
    1,1-dichloroethane 151.08
    2-methyl-1-pentanol 104.8
    methyl formate 282.65
    2-methyl-1-butanol 150.02
    n-decane 12.02
    butyronitrile 166.83
    3,7-dimethyl-1-octanol 71.45
    1-chlorooctane 44.64
    1-chlorotetradecane 20.13
    n-nonane 11.63
    undecane 9.61
    tert-butylcyclohexane 9.74
    cyclooctane 6.17
    cyclopentanol 189.3
    tetrahydropyran 267.67
    tert-amyl methyl ether 86.54
    2,5,8-trioxanonane 233.59
    1-hexene 29.89
    2-isopropoxyethanol 177.32
    2,2,2-trifluoroethanol 111.18
    methyl butyrate 110.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction