2-(2'-Furyl)-6-methylpyrazine

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  • Identifiers

    CAS number
    32737-03-4

    Molecular formula
    C9H8N2O

    SMILES
    CC1=CN=CC(=N1)C2=CC=CO2

    Safety labels

  • Odor profile

    Fragrance
    Roasted 75.85%
    Nutty 70.25%
    Coffee 58.17%
    Burnt 50.2%
    Hazelnut 48.68%
    Meaty 48.15%
    Fruity 46.12%
    Earthy 41.9%
    Musty 37.84%
    Cocoa 37.3%

     

    Flavor
    Coffee 61.09%
    Nutty 58.32%
    Roasted 55.08%
    Cocoa 47.3%
    Bitter 42.26%
    Roast 40.26%
    Chocolate 38.45%
    Corn 37.5%
    Hazelnut 36.62%
    Musty 36.23%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    3.72 (weak acid)

    Molecular weight
    160.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    267°C

    Flash point

    • 120.98 ˚C est.

  • Synonyms

    • 2-(2'-furyl)-6-methylpyrazine
    • 2-(2-Furyl)-6-methylpyrazine
    • TCN0VZN3Q2
    • 2-Methyl-6-(2'-furyl)pyrazine
    • UNII-TCN0VZN3Q2
    • Pyrazine, 2-(2-furanyl)-6-methyl-
    • 32737-03-4
    • RefChem:197531
    • HEVHVDDCDVZQTL-UHFFFAOYSA-N
    • 2-(furan-2-yl)-6-methylpyrazine
    • 2-(2-Furanyl)-6-methylpyrazine
    • SCHEMBL3533444
    • SCHEMBL4140166
    • SCHEMBL30562824
    • DTXSID501377138
    • 32737-03-4

  • Applications

    2-(2'-Furyl)-6-methylpyrazine (CAS 32737-03-4) is a heterocyclic compound primarily used as a synthetic intermediate and as an aroma/flavor component in fragrance and flavor applications, with potential use in cosmetics and personal care products. In practice, it is employed as a fragrance intermediate and as a precursor for fragrance formulations and flavoring in foods, beverages, and consumer household products. It is also regarded as a building block for more complex organic compounds used in research and development for pharmaceutical and agrochemical applications, and may serve as a component in polymers and specialty coating or ink formulations. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 127.02
    methanol 193.06
    isopropanol 75.54
    water 3.73
    ethyl acetate 64.19
    n-propanol 100.68
    acetone 94.79
    n-butanol 83.27
    acetonitrile 98.92
    DMF 383.25
    toluene 86.2
    isobutanol 73.12
    1,4-dioxane 132.59
    methyl acetate 75.95
    THF 179.08
    2-butanone 90.02
    n-pentanol 80.71
    sec-butanol 68.16
    n-hexane 4.25
    ethylene glycol 78.88
    NMP 223.33
    cyclohexane 15.08
    DMSO 369.46
    n-butyl acetate 47.05
    n-octanol 43.4
    chloroform 189.92
    n-propyl acetate 42.78
    acetic acid 107.74
    dichloromethane 272.79
    cyclohexanone 129.02
    propylene glycol 66.28
    isopropyl acetate 32.78
    DMAc 299.5
    2-ethoxyethanol 132.26
    isopentanol 63.15
    n-heptane 11.46
    ethyl formate 98.36
    1,2-dichloroethane 124.36
    n-hexanol 71.62
    2-methoxyethanol 223.75
    isobutyl acetate 29.33
    tetrachloromethane 24.53
    n-pentyl acetate 32.61
    transcutol 210.21
    n-heptanol 38.82
    ethylbenzene 41.1
    MIBK 39.53
    2-propoxyethanol 122.94
    tert-butanol 74.71
    MTBE 41.86
    2-butoxyethanol 71.12
    propionic acid 74.42
    o-xylene 61.3
    formic acid 82.58
    diethyl ether 49.1
    m-xylene 53.41
    p-xylene 52.87
    chlorobenzene 82.03
    dimethyl carbonate 53.8
    n-octane 4.54
    formamide 121.22
    cyclopentanone 128.64
    2-pentanone 62.59
    anisole 75.7
    cyclopentyl methyl ether 81.62
    gamma-butyrolactone 142.27
    1-methoxy-2-propanol 133.99
    pyridine 182.11
    3-pentanone 55.49
    furfural 207.13
    n-dodecane 6.16
    diethylene glycol 130.6
    diisopropyl ether 14.26
    tert-amyl alcohol 62.8
    acetylacetone 62.12
    n-hexadecane 6.83
    acetophenone 77.25
    methyl propionate 77.08
    isopentyl acetate 40.87
    trichloroethylene 209.78
    n-nonanol 39.82
    cyclohexanol 76.8
    benzyl alcohol 97.63
    2-ethylhexanol 47.45
    isooctanol 30.2
    dipropyl ether 48.58
    1,2-dichlorobenzene 70.68
    ethyl lactate 45.29
    propylene carbonate 92.62
    n-methylformamide 166.42
    2-pentanol 44.03
    n-pentane 6.19
    1-propoxy-2-propanol 78.6
    1-methoxy-2-propyl acetate 55.16
    2-(2-methoxypropoxy) propanol 79.82
    mesitylene 28.23
    ε-caprolactone 97.72
    p-cymene 34.89
    epichlorohydrin 181.58
    1,1,1-trichloroethane 75.04
    2-aminoethanol 103.78
    morpholine-4-carbaldehyde 209.18
    sulfolane 189.61
    2,2,4-trimethylpentane 5.39
    2-methyltetrahydrofuran 113.18
    n-hexyl acetate 46.86
    isooctane 3.45
    2-(2-butoxyethoxy)ethanol 98.19
    sec-butyl acetate 27.05
    tert-butyl acetate 29.83
    decalin 8.97
    glycerin 101.98
    diglyme 164.44
    acrylic acid 81.93
    isopropyl myristate 25.53
    n-butyric acid 85.49
    acetyl acetate 35.57
    di(2-ethylhexyl) phthalate 39.14
    ethyl propionate 43.41
    nitromethane 132.98
    1,2-diethoxyethane 64.37
    benzonitrile 102.68
    trioctyl phosphate 26.8
    1-bromopropane 76.69
    gamma-valerolactone 166.1
    n-decanol 33.5
    triethyl phosphate 32.96
    4-methyl-2-pentanol 26.88
    propionitrile 94.05
    vinylene carbonate 108.25
    1,1,2-trichlorotrifluoroethane 142.9
    DMS 45.88
    cumene 31.18
    2-octanol 24.32
    2-hexanone 49.2
    octyl acetate 34.71
    limonene 44.19
    1,2-dimethoxyethane 184.38
    ethyl orthosilicate 31.2
    tributyl phosphate 29.86
    diacetone alcohol 57.03
    N,N-dimethylaniline 66.87
    acrylonitrile 128.92
    aniline 98.45
    1,3-propanediol 108.76
    bromobenzene 83.03
    dibromomethane 157.41
    1,1,2,2-tetrachloroethane 144.98
    2-methyl-cyclohexyl acetate 44.26
    tetrabutyl urea 49.77
    diisobutyl methanol 25.49
    2-phenylethanol 75.12
    styrene 51.61
    dioctyl adipate 44.04
    dimethyl sulfate 81.4
    ethyl butyrate 49.92
    methyl lactate 67.03
    butyl lactate 38.94
    diethyl carbonate 43.44
    propanediol butyl ether 70.54
    triethyl orthoformate 40.74
    p-tert-butyltoluene 29.67
    methyl 4-tert-butylbenzoate 60.04
    morpholine 165.4
    tert-butylamine 47.59
    n-dodecanol 28.84
    dimethoxymethane 168.95
    ethylene carbonate 78.97
    cyrene 84.8
    2-ethoxyethyl acetate 47.77
    2-ethylhexyl acetate 34.08
    1,2,4-trichlorobenzene 82.89
    4-methylpyridine 157.52
    dibutyl ether 37.79
    2,6-dimethyl-4-heptanol 25.49
    DEF 116.84
    dimethyl isosorbide 102.57
    tetrachloroethylene 95.08
    eugenol 67.24
    triacetin 51.31
    span 80 66.29
    1,4-butanediol 70.17
    1,1-dichloroethane 98.72
    2-methyl-1-pentanol 66.48
    methyl formate 133.28
    2-methyl-1-butanol 66.49
    n-decane 7.92
    butyronitrile 94.91
    3,7-dimethyl-1-octanol 42.2
    1-chlorooctane 26.75
    1-chlorotetradecane 15.28
    n-nonane 6.74
    undecane 6.89
    tert-butylcyclohexane 7.45
    cyclooctane 5.28
    cyclopentanol 85.32
    tetrahydropyran 108.04
    tert-amyl methyl ether 41.5
    2,5,8-trioxanonane 137.9
    1-hexene 21.42
    2-isopropoxyethanol 80.42
    2,2,2-trifluoroethanol 47.39
    methyl butyrate 64.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction