2-(2'-Furyl)-5-methylpyrazine

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  • Identifiers

    CAS number
    27610-38-4

    Molecular formula
    C9H8N2O

    SMILES
    CC1=CN=C(C=N1)C2=CC=CO2

    Safety labels

  • Odor profile

    Fragrance
    Roasted 78.85%
    Nutty 78.48%
    Coffee 62.56%
    Hazelnut 54.83%
    Burnt 52.48%
    Meaty 50.09%
    Earthy 48.5%
    Musty 47.41%
    Cocoa 44.94%
    Potato 42.7%

     

    Flavor
    Coffee 66.12%
    Nutty 65.94%
    Roasted 57.28%
    Cocoa 51.47%
    Roast 43.8%
    Chocolate 43.67%
    Peanut 42.23%
    Corn 41.76%
    Musty 40.0%
    Hazelnut 39.34%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    3.0 (strong acid)

    Molecular weight
    160.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    274°C

    Flash point

    • 127.95 ˚C est.

  • Synonyms

    • 2-(2'-furyl)-5-methylpyrazine
    • 27610-38-4
    • Pyrazine, 2-(2-furanyl)-5-methyl-
    • 2TT6PE0GBO
    • 2-Methyl-5-(2-furyl)pyrazine
    • UNII-2TT6PE0GBO
    • DTXSID80336197
    • RefChem:83872
    • DTXCID30287286
    • 2-(furan-2-yl)-5-methylpyrazine
    • 2-(2-Furanyl)-5-methylpyrazine
    • SCHEMBL7942160
    • 2-(2-Furyl)-5-methyl pyrazine
    • UTWJJSZAHQEJAT-UHFFFAOYSA-N
    • 2-(2-Furyl)-5(6)-methylpyrazine
    • 27610-38-4

  • Applications

    2-(2'-Furyl)-5-methylpyrazine is primarily used as an aroma-active heterocycle in flavor and fragrance formulations. In perfumery and cosmetics, it contributes roasted, nutty, coffee-like notes as an odorant or fragrance ingredient. In food processing and beverage applications, it is commonly evaluated for incorporation in flavor formulations to impart characteristic roasted notes. In household products, it can serve as a component to confer specific scent profiles, such as air fresheners or cleaners. It may also be employed as a chemical building block or intermediate in pharmaceutical and agrochemical research, supporting the synthesis of more complex heterocycles. Usage is typically governed by regulatory limits and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 93.62
    methanol 143.31
    isopropanol 52.01
    water 3.29
    ethyl acetate 62.05
    n-propanol 66.5
    acetone 75.8
    n-butanol 59.54
    acetonitrile 58.85
    DMF 237.69
    toluene 42.85
    isobutanol 57.87
    1,4-dioxane 135.71
    methyl acetate 66.75
    THF 171.55
    2-butanone 69.78
    n-pentanol 45.45
    sec-butanol 47.88
    n-hexane 1.24
    ethylene glycol 69.65
    NMP 154.31
    cyclohexane 4.87
    DMSO 252.43
    n-butyl acetate 36.28
    n-octanol 17.44
    chloroform 147.37
    n-propyl acetate 34.57
    acetic acid 132.47
    dichloromethane 176.1
    cyclohexanone 109.14
    propylene glycol 61.47
    isopropyl acetate 32.16
    DMAc 268.67
    2-ethoxyethanol 108.62
    isopentanol 61.69
    n-heptane 2.44
    ethyl formate 62.03
    1,2-dichloroethane 100.51
    n-hexanol 37.11
    2-methoxyethanol 218.69
    isobutyl acetate 28.16
    tetrachloromethane 14.74
    n-pentyl acetate 21.61
    transcutol 316.56
    n-heptanol 19.56
    ethylbenzene 16.04
    MIBK 34.85
    2-propoxyethanol 90.87
    tert-butanol 68.83
    MTBE 44.08
    2-butoxyethanol 51.48
    propionic acid 69.08
    o-xylene 29.99
    formic acid 115.74
    diethyl ether 36.75
    m-xylene 29.63
    p-xylene 25.81
    chlorobenzene 57.33
    dimethyl carbonate 44.03
    n-octane 1.06
    formamide 148.59
    cyclopentanone 114.56
    2-pentanone 48.81
    anisole 46.51
    cyclopentyl methyl ether 66.01
    gamma-butyrolactone 126.18
    1-methoxy-2-propanol 116.75
    pyridine 137.61
    3-pentanone 43.12
    furfural 178.58
    n-dodecane 1.61
    diethylene glycol 113.68
    diisopropyl ether 10.67
    tert-amyl alcohol 58.42
    acetylacetone 62.66
    n-hexadecane 1.8
    acetophenone 49.65
    methyl propionate 63.19
    isopentyl acetate 38.99
    trichloroethylene 201.96
    n-nonanol 17.73
    cyclohexanol 62.42
    benzyl alcohol 60.46
    2-ethylhexanol 25.97
    isooctanol 18.33
    dipropyl ether 21.29
    1,2-dichlorobenzene 50.64
    ethyl lactate 31.6
    propylene carbonate 74.8
    n-methylformamide 111.24
    2-pentanol 32.21
    n-pentane 1.77
    1-propoxy-2-propanol 52.59
    1-methoxy-2-propyl acetate 50.52
    2-(2-methoxypropoxy) propanol 67.71
    mesitylene 16.58
    ε-caprolactone 82.41
    p-cymene 15.22
    epichlorohydrin 169.18
    1,1,1-trichloroethane 60.35
    2-aminoethanol 92.24
    morpholine-4-carbaldehyde 165.79
    sulfolane 145.99
    2,2,4-trimethylpentane 3.47
    2-methyltetrahydrofuran 99.98
    n-hexyl acetate 31.53
    isooctane 1.9
    2-(2-butoxyethoxy)ethanol 87.23
    sec-butyl acetate 26.01
    tert-butyl acetate 32.86
    decalin 3.72
    glycerin 115.29
    diglyme 151.75
    acrylic acid 81.2
    isopropyl myristate 15.82
    n-butyric acid 86.87
    acetyl acetate 45.2
    di(2-ethylhexyl) phthalate 25.88
    ethyl propionate 32.71
    nitromethane 155.66
    1,2-diethoxyethane 56.81
    benzonitrile 57.46
    trioctyl phosphate 15.69
    1-bromopropane 37.61
    gamma-valerolactone 155.06
    n-decanol 15.14
    triethyl phosphate 24.42
    4-methyl-2-pentanol 23.63
    propionitrile 55.45
    vinylene carbonate 83.69
    1,1,2-trichlorotrifluoroethane 154.31
    DMS 42.73
    cumene 14.58
    2-octanol 11.89
    2-hexanone 34.37
    octyl acetate 20.57
    limonene 21.17
    1,2-dimethoxyethane 129.22
    ethyl orthosilicate 23.65
    tributyl phosphate 19.98
    diacetone alcohol 54.09
    N,N-dimethylaniline 38.88
    acrylonitrile 76.53
    aniline 83.47
    1,3-propanediol 103.75
    bromobenzene 51.17
    dibromomethane 84.57
    1,1,2,2-tetrachloroethane 137.26
    2-methyl-cyclohexyl acetate 32.98
    tetrabutyl urea 27.74
    diisobutyl methanol 16.36
    2-phenylethanol 48.53
    styrene 21.99
    dioctyl adipate 28.44
    dimethyl sulfate 72.35
    ethyl butyrate 31.91
    methyl lactate 54.61
    butyl lactate 26.19
    diethyl carbonate 28.3
    propanediol butyl ether 51.31
    triethyl orthoformate 28.09
    p-tert-butyltoluene 14.0
    methyl 4-tert-butylbenzoate 42.13
    morpholine 143.58
    tert-butylamine 36.97
    n-dodecanol 12.93
    dimethoxymethane 114.87
    ethylene carbonate 64.21
    cyrene 64.9
    2-ethoxyethyl acetate 40.63
    2-ethylhexyl acetate 29.98
    1,2,4-trichlorobenzene 62.4
    4-methylpyridine 108.84
    dibutyl ether 19.64
    2,6-dimethyl-4-heptanol 16.36
    DEF 79.01
    dimethyl isosorbide 81.44
    tetrachloroethylene 89.84
    eugenol 48.25
    triacetin 42.7
    span 80 44.62
    1,4-butanediol 46.34
    1,1-dichloroethane 73.33
    2-methyl-1-pentanol 48.88
    methyl formate 90.59
    2-methyl-1-butanol 58.63
    n-decane 1.96
    butyronitrile 55.71
    3,7-dimethyl-1-octanol 24.11
    1-chlorooctane 10.14
    1-chlorotetradecane 5.96
    n-nonane 1.51
    undecane 1.77
    tert-butylcyclohexane 3.38
    cyclooctane 1.61
    cyclopentanol 65.04
    tetrahydropyran 86.96
    tert-amyl methyl ether 37.36
    2,5,8-trioxanonane 114.86
    1-hexene 7.31
    2-isopropoxyethanol 61.37
    2,2,2-trifluoroethanol 62.91
    methyl butyrate 44.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction