2-(2-Furanyl)pyrazine

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  • Identifiers

    CAS number
    32736-95-1

    Molecular formula
    C8H6N2O

    SMILES
    C1=COC(=C1)C2=NC=CN=C2

    Safety labels

  • Odor profile

    Fragrance
    Nutty 76.61%
    Roasted 65.72%
    Burnt 60.78%
    Coffee 59.11%
    Musty 52.32%
    Meaty 46.58%
    Earthy 45.03%
    Sweet 43.3%
    Hazelnut 42.54%
    Almond 37.21%

     

    Flavor
    Nutty 68.69%
    Coffee 64.9%
    Roasted 56.62%
    Corn 41.96%
    Nut 40.87%
    Chocolate 40.71%
    Cocoa 39.91%
    Vegetable 39.07%
    Roast 38.98%
    Peanut 38.74%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.5

    pKa est.
    3.91 (weak acid)

    Molecular weight
    146.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    255°C

    Flash point

    • 114.8 ˚C est.

  • Synonyms

    • 2-(furan-2-yl)pyrazine
    • 2-(2-Furanyl)pyrazine
    • 32736-95-1
    • 2-Furanylpyrazine
    • 2-(2-Furyl)pyrazine
    • NS6MOI8J59
    • (2'-Furyl)pyrazine
    • Furylpyrazine
    • 2-Furylpyrazine
    • Pyrazine, 2-furanyl-
    • starbld0044269
    • 2-(2'-Furyl)pyrazine
    • UNII-NS6MOI8J59
    • SCHEMBL570221
    • SCHEMBL5301835
    • SCHEMBL6383154
    • SCHEMBL28778209
    • DTXSID80954395
    • XAZULAQXFJZQTJ-UHFFFAOYSA-N
    • CS-35556
    • 32736-95-1

  • Applications

    2-(2-Furanyl)pyrazine (CAS 32736-95-1) is primarily used as a synthetic building block and may function as an odor-active compound in certain formulations. In fragrance and flavor contexts, it may serve as an aroma ingredient or fragrance precursor, and in cosmetics and personal care it can function as a fragrance component subject to formulation limits. The compound is also explored as an intermediate in pharmaceutical and agrochemical synthesis, providing a heteroaromatic scaffold for further functionalization. In industrial and materials contexts, it has been studied as a building block for specialty polymers and functional materials, including research into organic electronic or optoelectronic applications. Additionally, it may appear in coatings, inks, or cleaning formulations where a heteroaromatic intermediary is desired, again within strict formulation controls and regulatory compliance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 111.34
    methanol 172.96
    isopropanol 63.2
    water 10.85
    ethyl acetate 57.77
    n-propanol 81.1
    acetone 92.3
    n-butanol 61.93
    acetonitrile 130.17
    DMF 493.16
    toluene 55.85
    isobutanol 57.94
    1,4-dioxane 128.26
    methyl acetate 75.09
    THF 142.91
    2-butanone 78.05
    n-pentanol 59.95
    sec-butanol 54.02
    n-hexane 3.83
    ethylene glycol 105.94
    NMP 290.47
    cyclohexane 13.77
    DMSO 619.91
    n-butyl acetate 32.21
    n-octanol 32.45
    chloroform 169.46
    n-propyl acetate 36.81
    acetic acid 120.54
    dichloromethane 295.3
    cyclohexanone 116.07
    propylene glycol 67.69
    isopropyl acetate 28.12
    DMAc 364.72
    2-ethoxyethanol 133.32
    isopentanol 46.57
    n-heptane 10.56
    ethyl formate 89.4
    1,2-dichloroethane 156.08
    n-hexanol 45.81
    2-methoxyethanol 220.49
    isobutyl acetate 22.6
    tetrachloromethane 25.23
    n-pentyl acetate 26.02
    transcutol 218.27
    n-heptanol 28.56
    ethylbenzene 28.58
    MIBK 32.21
    2-propoxyethanol 96.13
    tert-butanol 61.44
    MTBE 31.71
    2-butoxyethanol 59.18
    propionic acid 78.49
    o-xylene 47.39
    formic acid 114.58
    diethyl ether 43.88
    m-xylene 36.6
    p-xylene 39.78
    chlorobenzene 72.48
    dimethyl carbonate 57.06
    n-octane 4.38
    formamide 196.19
    cyclopentanone 123.49
    2-pentanone 53.5
    anisole 62.63
    cyclopentyl methyl ether 67.87
    gamma-butyrolactone 154.38
    1-methoxy-2-propanol 134.12
    pyridine 195.8
    3-pentanone 53.97
    furfural 206.05
    n-dodecane 5.17
    diethylene glycol 119.82
    diisopropyl ether 12.15
    tert-amyl alcohol 47.15
    acetylacetone 59.75
    n-hexadecane 5.71
    acetophenone 68.09
    methyl propionate 73.61
    isopentyl acetate 27.08
    trichloroethylene 216.55
    n-nonanol 30.29
    cyclohexanol 65.39
    benzyl alcohol 84.47
    2-ethylhexanol 32.67
    isooctanol 23.35
    dipropyl ether 39.28
    1,2-dichlorobenzene 69.02
    ethyl lactate 43.61
    propylene carbonate 84.67
    n-methylformamide 226.58
    2-pentanol 33.71
    n-pentane 5.99
    1-propoxy-2-propanol 65.76
    1-methoxy-2-propyl acetate 43.0
    2-(2-methoxypropoxy) propanol 67.28
    mesitylene 22.4
    ε-caprolactone 89.1
    p-cymene 25.6
    epichlorohydrin 184.92
    1,1,1-trichloroethane 70.74
    2-aminoethanol 121.76
    morpholine-4-carbaldehyde 245.08
    sulfolane 223.39
    2,2,4-trimethylpentane 4.37
    2-methyltetrahydrofuran 87.91
    n-hexyl acetate 35.09
    isooctane 3.06
    2-(2-butoxyethoxy)ethanol 86.63
    sec-butyl acetate 21.36
    tert-butyl acetate 24.9
    decalin 7.52
    glycerin 122.81
    diglyme 167.29
    acrylic acid 93.56
    isopropyl myristate 20.39
    n-butyric acid 80.74
    acetyl acetate 34.52
    di(2-ethylhexyl) phthalate 29.51
    ethyl propionate 39.98
    nitromethane 187.35
    1,2-diethoxyethane 55.85
    benzonitrile 101.75
    trioctyl phosphate 21.26
    1-bromopropane 66.3
    gamma-valerolactone 159.59
    n-decanol 25.78
    triethyl phosphate 29.19
    4-methyl-2-pentanol 21.47
    propionitrile 114.06
    vinylene carbonate 98.04
    1,1,2-trichlorotrifluoroethane 156.48
    DMS 38.05
    cumene 21.95
    2-octanol 18.46
    2-hexanone 38.26
    octyl acetate 26.31
    limonene 33.08
    1,2-dimethoxyethane 173.48
    ethyl orthosilicate 25.84
    tributyl phosphate 23.43
    diacetone alcohol 49.66
    N,N-dimethylaniline 58.94
    acrylonitrile 179.49
    aniline 94.38
    1,3-propanediol 104.53
    bromobenzene 71.84
    dibromomethane 165.6
    1,1,2,2-tetrachloroethane 158.16
    2-methyl-cyclohexyl acetate 32.77
    tetrabutyl urea 41.14
    diisobutyl methanol 19.83
    2-phenylethanol 53.57
    styrene 37.85
    dioctyl adipate 35.07
    dimethyl sulfate 104.15
    ethyl butyrate 41.71
    methyl lactate 72.63
    butyl lactate 32.09
    diethyl carbonate 37.9
    propanediol butyl ether 57.93
    triethyl orthoformate 33.3
    p-tert-butyltoluene 21.78
    methyl 4-tert-butylbenzoate 53.34
    morpholine 159.93
    tert-butylamine 37.43
    n-dodecanol 22.17
    dimethoxymethane 166.18
    ethylene carbonate 76.24
    cyrene 74.45
    2-ethoxyethyl acetate 38.49
    2-ethylhexyl acetate 21.98
    1,2,4-trichlorobenzene 80.67
    4-methylpyridine 152.05
    dibutyl ether 32.15
    2,6-dimethyl-4-heptanol 19.83
    DEF 126.8
    dimethyl isosorbide 85.62
    tetrachloroethylene 108.32
    eugenol 60.37
    triacetin 45.14
    span 80 55.51
    1,4-butanediol 72.48
    1,1-dichloroethane 96.51
    2-methyl-1-pentanol 45.26
    methyl formate 164.92
    2-methyl-1-butanol 47.84
    n-decane 6.72
    butyronitrile 89.22
    3,7-dimethyl-1-octanol 31.05
    1-chlorooctane 22.0
    1-chlorotetradecane 11.95
    n-nonane 6.0
    undecane 5.87
    tert-butylcyclohexane 5.47
    cyclooctane 5.11
    cyclopentanol 76.98
    tetrahydropyran 88.56
    tert-amyl methyl ether 30.5
    2,5,8-trioxanonane 131.01
    1-hexene 15.24
    2-isopropoxyethanol 74.97
    2,2,2-trifluoroethanol 61.77
    methyl butyrate 57.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction