2-(2-Furanyl)-3,5-dimethylpyrazine

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  • Identifiers

    CAS number
    54300-11-7

    Molecular formula
    C10H10N2O

    SMILES
    CC1=CN=C(C(=N1)C)C2=CC=CO2

    Safety labels

  • Odor profile

    Fragrance
    Roasted 78.72%
    Nutty 71.32%
    Coffee 57.13%
    Hazelnut 54.66%
    Burnt 52.68%
    Earthy 46.82%
    Meaty 46.21%
    Cocoa 44.51%
    Musty 42.12%
    Potato 37.93%

     

    Flavor
    Roasted 61.96%
    Coffee 60.05%
    Nutty 58.45%
    Cocoa 52.48%
    Roast 46.61%
    Hazelnut 41.51%
    Burnt 40.47%
    Musty 40.34%
    Chocolate 39.56%
    Potato 39.34%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    3.76 (weak acid)

    Molecular weight
    174.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    278°C

    Flash point

    • 128.6 ˚C est.

  • Synonyms

    • 2-(2-Furanyl)-3,5-dimethylpyrazine
    • 54300-11-7
    • RefChem:250701
    • DTXSID601297777
    • 2-(2'-Furyl)-3,5-dimethylpyrazin
    • 2-(furan-2-yl)-3,5-dimethylpyrazine
    • 54300-11-7

  • Applications

    2-(2-Furanyl)-3,5-dimethylpyrazine (CAS 54300-11-7) is primarily used as an odor-active ingredient and flavor note in fragrance and flavor formulations. In perfumery and personal care, it contributes roasted, nutty, and cocoa-like nuances as a discreet scent component. It is often evaluated for use as a fragrance ingredient in household products such as air fresheners, detergents, and cleaners. In the flavor industry, it may serve as a flavoring note in processed foods and beverages. Additionally, it may be employed as an intermediate or building block in the synthesis of other aroma compounds for industrial manufacturing, coatings/inks, and specialty polymers. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 193.37
    methanol 279.05
    isopropanol 129.34
    water 5.63
    ethyl acetate 154.78
    n-propanol 167.95
    acetone 209.64
    n-butanol 171.03
    acetonitrile 155.81
    DMF 367.28
    toluene 109.8
    isobutanol 146.53
    1,4-dioxane 299.84
    methyl acetate 152.41
    THF 482.74
    2-butanone 158.53
    n-pentanol 119.62
    sec-butanol 132.99
    n-hexane 14.88
    ethylene glycol 99.17
    NMP 347.22
    cyclohexane 27.97
    DMSO 326.4
    n-butyl acetate 95.11
    n-octanol 57.23
    chloroform 469.05
    n-propyl acetate 82.61
    acetic acid 278.1
    dichloromethane 519.03
    cyclohexanone 277.67
    propylene glycol 88.24
    isopropyl acetate 84.53
    DMAc 318.28
    2-ethoxyethanol 191.66
    isopentanol 146.51
    n-heptane 12.66
    ethyl formate 143.88
    1,2-dichloroethane 290.29
    n-hexanol 111.08
    2-methoxyethanol 354.17
    isobutyl acetate 64.72
    tetrachloromethane 66.5
    n-pentyl acetate 67.58
    transcutol 356.2
    n-heptanol 55.48
    ethylbenzene 49.89
    MIBK 96.86
    2-propoxyethanol 190.71
    tert-butanol 138.63
    MTBE 126.66
    2-butoxyethanol 98.25
    propionic acid 147.75
    o-xylene 66.26
    formic acid 171.99
    diethyl ether 156.89
    m-xylene 77.44
    p-xylene 64.97
    chlorobenzene 161.3
    dimethyl carbonate 98.46
    n-octane 6.27
    formamide 175.33
    cyclopentanone 307.54
    2-pentanone 141.69
    anisole 107.09
    cyclopentyl methyl ether 215.05
    gamma-butyrolactone 346.54
    1-methoxy-2-propanol 204.3
    pyridine 232.34
    3-pentanone 123.03
    furfural 321.28
    n-dodecane 7.03
    diethylene glycol 201.22
    diisopropyl ether 41.31
    tert-amyl alcohol 129.43
    acetylacetone 148.45
    n-hexadecane 7.93
    acetophenone 100.71
    methyl propionate 147.97
    isopentyl acetate 93.74
    trichloroethylene 529.91
    n-nonanol 51.11
    cyclohexanol 167.27
    benzyl alcohol 117.2
    2-ethylhexanol 67.77
    isooctanol 48.28
    dipropyl ether 65.65
    1,2-dichlorobenzene 140.08
    ethyl lactate 63.73
    propylene carbonate 190.88
    n-methylformamide 185.74
    2-pentanol 100.8
    n-pentane 15.7
    1-propoxy-2-propanol 107.4
    1-methoxy-2-propyl acetate 102.76
    2-(2-methoxypropoxy) propanol 96.66
    mesitylene 45.42
    ε-caprolactone 209.35
    p-cymene 38.27
    epichlorohydrin 421.42
    1,1,1-trichloroethane 214.05
    2-aminoethanol 127.86
    morpholine-4-carbaldehyde 296.4
    sulfolane 344.84
    2,2,4-trimethylpentane 14.87
    2-methyltetrahydrofuran 300.36
    n-hexyl acetate 99.65
    isooctane 9.35
    2-(2-butoxyethoxy)ethanol 130.5
    sec-butyl acetate 59.92
    tert-butyl acetate 90.61
    decalin 16.5
    glycerin 147.01
    diglyme 208.58
    acrylic acid 161.33
    isopropyl myristate 41.43
    n-butyric acid 192.54
    acetyl acetate 99.54
    di(2-ethylhexyl) phthalate 55.72
    ethyl propionate 82.06
    nitromethane 286.1
    1,2-diethoxyethane 102.95
    benzonitrile 132.48
    trioctyl phosphate 40.13
    1-bromopropane 145.2
    gamma-valerolactone 334.84
    n-decanol 39.83
    triethyl phosphate 48.07
    4-methyl-2-pentanol 60.99
    propionitrile 131.9
    vinylene carbonate 197.87
    1,1,2-trichlorotrifluoroethane 262.45
    DMS 96.4
    cumene 39.72
    2-octanol 41.59
    2-hexanone 85.15
    octyl acetate 55.26
    limonene 54.81
    1,2-dimethoxyethane 228.03
    ethyl orthosilicate 48.23
    tributyl phosphate 48.27
    diacetone alcohol 109.21
    N,N-dimethylaniline 78.49
    acrylonitrile 165.5
    aniline 147.84
    1,3-propanediol 176.14
    bromobenzene 162.61
    dibromomethane 299.51
    1,1,2,2-tetrachloroethane 354.5
    2-methyl-cyclohexyl acetate 71.22
    tetrabutyl urea 59.69
    diisobutyl methanol 39.55
    2-phenylethanol 100.49
    styrene 62.84
    dioctyl adipate 60.27
    dimethyl sulfate 147.49
    ethyl butyrate 70.26
    methyl lactate 91.58
    butyl lactate 58.92
    diethyl carbonate 56.53
    propanediol butyl ether 92.23
    triethyl orthoformate 57.02
    p-tert-butyltoluene 36.31
    methyl 4-tert-butylbenzoate 87.07
    morpholine 306.93
    tert-butylamine 91.74
    n-dodecanol 32.33
    dimethoxymethane 256.64
    ethylene carbonate 161.01
    cyrene 119.1
    2-ethoxyethyl acetate 95.09
    2-ethylhexyl acetate 75.89
    1,2,4-trichlorobenzene 161.68
    4-methylpyridine 227.4
    dibutyl ether 59.73
    2,6-dimethyl-4-heptanol 39.55
    DEF 174.02
    dimethyl isosorbide 148.38
    tetrachloroethylene 248.24
    eugenol 92.85
    triacetin 85.41
    span 80 81.62
    1,4-butanediol 91.21
    1,1-dichloroethane 239.18
    2-methyl-1-pentanol 115.75
    methyl formate 188.18
    2-methyl-1-butanol 150.99
    n-decane 10.09
    butyronitrile 150.21
    3,7-dimethyl-1-octanol 56.01
    1-chlorooctane 41.44
    1-chlorotetradecane 19.53
    n-nonane 9.46
    undecane 8.25
    tert-butylcyclohexane 15.59
    cyclooctane 9.39
    cyclopentanol 187.92
    tetrahydropyran 273.72
    tert-amyl methyl ether 111.45
    2,5,8-trioxanonane 148.47
    1-hexene 49.5
    2-isopropoxyethanol 112.48
    2,2,2-trifluoroethanol 125.66
    methyl butyrate 105.59

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction