2-(2-Furanyl)-3-methylpyrazine

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  • Identifiers

    CAS number
    32737-01-2

    Molecular formula
    C9H8N2O

    SMILES
    CC1=NC=CN=C1C2=CC=CO2

    Safety labels

  • Odor profile

    Fragrance
    Roasted 79.86%
    Nutty 79.22%
    Coffee 61.69%
    Hazelnut 55.72%
    Burnt 54.65%
    Meaty 50.42%
    Musty 49.87%
    Earthy 49.7%
    Cocoa 45.69%
    Potato 42.66%

     

    Flavor
    Nutty 69.89%
    Coffee 65.49%
    Roasted 62.05%
    Cocoa 49.92%
    Roast 48.48%
    Corn 45.81%
    Hazelnut 43.69%
    Chocolate 43.66%
    Popcorn 42.02%
    Nut 41.15%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    4.39 (weak acid)

    Molecular weight
    160.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    267°C

    Flash point

    • 114.79 ˚C est.

  • Synonyms

    • 2-(2'-Furyl)-3-methylpyrazine
    • 2-(2-Furanyl)-3-methylpyrazine
    • 3-Methyl-2-(2'-furyl)pyrazine
    • D839T4J4N4
    • Pyrazine, 2-(2-furanyl)-3-methyl-
    • UNII-D839T4J4N4
    • 32737-01-2
    • RefChem:197562
    • Methyl-furylpyrazin
    • SCHEMBL19718899
    • 32737-01-2

  • Applications

    2-(2-Furanyl)-3-methylpyrazine (CAS 32737-01-2) is commonly used as an odorant and flavoring ingredient in perfumery and food flavor formulations, imparting roasted-nutty notes; it is also viewed as a building block or intermediate in industrial chemical synthesis and is studied for pharmaceutical and agrochemical applications (R&D). In cosmetics and personal care, it can serve as a fragrance ingredient in relevant product categories.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 138.41
    methanol 188.27
    isopropanol 82.0
    water 10.21
    ethyl acetate 85.34
    n-propanol 110.85
    acetone 136.51
    n-butanol 84.3
    acetonitrile 164.54
    DMF 442.58
    toluene 83.58
    isobutanol 86.12
    1,4-dioxane 185.67
    methyl acetate 98.11
    THF 216.65
    2-butanone 107.49
    n-pentanol 77.52
    sec-butanol 75.7
    n-hexane 7.92
    ethylene glycol 109.88
    NMP 297.61
    cyclohexane 21.45
    DMSO 516.04
    n-butyl acetate 56.45
    n-octanol 54.9
    chloroform 360.66
    n-propyl acetate 57.95
    acetic acid 130.71
    dichloromethane 539.78
    cyclohexanone 173.86
    propylene glycol 74.91
    isopropyl acetate 47.06
    DMAc 306.48
    2-ethoxyethanol 145.71
    isopentanol 68.09
    n-heptane 16.11
    ethyl formate 127.02
    1,2-dichloroethane 247.58
    n-hexanol 74.01
    2-methoxyethanol 251.82
    isobutyl acetate 40.91
    tetrachloromethane 66.21
    n-pentyl acetate 49.18
    transcutol 193.52
    n-heptanol 47.69
    ethylbenzene 51.16
    MIBK 55.84
    2-propoxyethanol 132.69
    tert-butanol 83.49
    MTBE 50.25
    2-butoxyethanol 80.74
    propionic acid 103.86
    o-xylene 72.38
    formic acid 88.69
    diethyl ether 66.16
    m-xylene 63.39
    p-xylene 73.43
    chlorobenzene 129.34
    dimethyl carbonate 80.0
    n-octane 8.82
    formamide 150.87
    cyclopentanone 192.2
    2-pentanone 80.1
    anisole 98.79
    cyclopentyl methyl ether 107.44
    gamma-butyrolactone 224.82
    1-methoxy-2-propanol 147.79
    pyridine 218.07
    3-pentanone 76.31
    furfural 267.32
    n-dodecane 9.85
    diethylene glycol 151.85
    diisopropyl ether 22.81
    tert-amyl alcohol 71.96
    acetylacetone 98.18
    n-hexadecane 11.21
    acetophenone 99.62
    methyl propionate 103.16
    isopentyl acetate 52.07
    trichloroethylene 395.88
    n-nonanol 48.63
    cyclohexanol 84.35
    benzyl alcohol 109.37
    2-ethylhexanol 52.88
    isooctanol 39.87
    dipropyl ether 55.92
    1,2-dichlorobenzene 125.3
    ethyl lactate 62.84
    propylene carbonate 137.29
    n-methylformamide 225.51
    2-pentanol 49.62
    n-pentane 10.68
    1-propoxy-2-propanol 84.6
    1-methoxy-2-propyl acetate 73.63
    2-(2-methoxypropoxy) propanol 80.24
    mesitylene 41.23
    ε-caprolactone 129.94
    p-cymene 46.11
    epichlorohydrin 278.58
    1,1,1-trichloroethane 163.94
    2-aminoethanol 122.8
    morpholine-4-carbaldehyde 265.78
    sulfolane 328.13
    2,2,4-trimethylpentane 8.7
    2-methyltetrahydrofuran 132.16
    n-hexyl acetate 71.2
    isooctane 6.21
    2-(2-butoxyethoxy)ethanol 102.84
    sec-butyl acetate 36.64
    tert-butyl acetate 45.99
    decalin 13.74
    glycerin 118.79
    diglyme 199.59
    acrylic acid 114.84
    isopropyl myristate 37.08
    n-butyric acid 103.98
    acetyl acetate 58.3
    di(2-ethylhexyl) phthalate 49.42
    ethyl propionate 63.73
    nitromethane 204.44
    1,2-diethoxyethane 70.54
    benzonitrile 137.21
    trioctyl phosphate 37.11
    1-bromopropane 113.69
    gamma-valerolactone 222.73
    n-decanol 40.79
    triethyl phosphate 46.49
    4-methyl-2-pentanol 33.47
    propionitrile 134.02
    vinylene carbonate 161.88
    1,1,2-trichlorotrifluoroethane 197.27
    DMS 72.78
    cumene 41.89
    2-octanol 34.17
    2-hexanone 61.09
    octyl acetate 48.81
    limonene 57.25
    1,2-dimethoxyethane 216.91
    ethyl orthosilicate 40.54
    tributyl phosphate 40.54
    diacetone alcohol 75.29
    N,N-dimethylaniline 83.32
    acrylonitrile 197.74
    aniline 107.98
    1,3-propanediol 122.24
    bromobenzene 139.97
    dibromomethane 305.3
    1,1,2,2-tetrachloroethane 276.15
    2-methyl-cyclohexyl acetate 56.7
    tetrabutyl urea 61.89
    diisobutyl methanol 33.07
    2-phenylethanol 86.7
    styrene 63.47
    dioctyl adipate 56.93
    dimethyl sulfate 144.73
    ethyl butyrate 63.86
    methyl lactate 88.95
    butyl lactate 51.73
    diethyl carbonate 56.78
    propanediol butyl ether 77.37
    triethyl orthoformate 50.15
    p-tert-butyltoluene 39.79
    methyl 4-tert-butylbenzoate 85.54
    morpholine 183.05
    tert-butylamine 57.25
    n-dodecanol 35.88
    dimethoxymethane 209.04
    ethylene carbonate 122.23
    cyrene 102.46
    2-ethoxyethyl acetate 65.01
    2-ethylhexyl acetate 42.76
    1,2,4-trichlorobenzene 140.47
    4-methylpyridine 178.32
    dibutyl ether 48.93
    2,6-dimethyl-4-heptanol 33.07
    DEF 145.48
    dimethyl isosorbide 125.51
    tetrachloroethylene 195.83
    eugenol 90.41
    triacetin 72.98
    span 80 74.94
    1,4-butanediol 79.4
    1,1-dichloroethane 184.15
    2-methyl-1-pentanol 65.53
    methyl formate 201.36
    2-methyl-1-butanol 71.05
    n-decane 13.34
    butyronitrile 119.53
    3,7-dimethyl-1-octanol 48.21
    1-chlorooctane 44.39
    1-chlorotetradecane 24.13
    n-nonane 12.48
    undecane 11.25
    tert-butylcyclohexane 11.68
    cyclooctane 8.85
    cyclopentanol 104.37
    tetrahydropyran 123.27
    tert-amyl methyl ether 49.02
    2,5,8-trioxanonane 146.53
    1-hexene 30.94
    2-isopropoxyethanol 89.32
    2,2,2-trifluoroethanol 75.93
    methyl butyrate 85.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction