2-(2-Ethoxyethyl)pyridine

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  • Identifiers

    CAS number
    28672-54-0

    Molecular formula
    C9H13NO

    SMILES
    CCOCCC1=CC=CC=N1

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 58.99%
    Earthy 44.51%
    Roasted 40.72%
    Nutty 39.93%
    Sweet 35.24%
    Floral 34.72%
    Vegetable 33.99%
    Burnt 33.38%
    Herbal 32.36%
    Fruity 31.72%

     

    Flavor
    Green 49.06%
    Earthy 38.24%
    Floral 37.2%
    Vegetable 33.6%
    Roasted 32.55%
    Fatty 32.05%
    Nutty 31.64%
    Sweet 29.42%
    Spicy 28.11%
    Bitter 28.05%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    4.45 (weak acid)

    Molecular weight
    151.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    218°C

    Flash point

    • 90.09 ˚C est.

  • Synonyms

    • 2-(2-Ethoxyethyl)pyridine
    • 28672-54-0
    • Pyridine, 2-(2-ethoxyethyl)-
    • X9650F9KG5
    • EINECS 249-140-6
    • NSC-163912
    • UNII-X9650F9KG5
    • DTXSID30182828
    • NSC 163912
    • RefChem:84048
    • DTXCID70105319
    • 249-140-6
    • BVFWKBCHXXZOJJ-UHFFFAOYSA-N
    • MFCD00023548
    • 3-oxapentylpyridine
    • NSC163912
    • SCHEMBL2093162
    • SCHEMBL2093165
    • SCHEMBL6001509
    • SCHEMBL8536855
    • AKOS006228966
    • CS-W018112
    • CS-17378
    • DB-047431
    • NS00028518
    • D72160
    • F791508
    • 28672-54-0

  • Applications

    2-(2-Ethoxyethyl)pyridine is commonly used as an organic synthesis intermediate and building block for further functionalization of pyridine-based compounds; it is often evaluated as a precursor in the preparation of pharmaceutical and agrochemical intermediates, enabling access to substituted pyridines. In catalysis and materials chemistry, it can serve as a ligand precursor for transition-metal catalysts and as a reagent for making pyridine-containing polymers and coating formulations. It may also be used as a solvent or co-solvent in laboratory-scale reactions, depending on formulation and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1878.01
    methanol 2112.23
    isopropanol 895.89
    water 11.27
    ethyl acetate 1058.64
    n-propanol 1178.59
    acetone 897.63
    n-butanol 1025.83
    acetonitrile 933.72
    DMF 1276.81
    toluene 524.49
    isobutanol 686.1
    1,4-dioxane 1871.24
    methyl acetate 795.07
    THF 1238.79
    2-butanone 686.39
    n-pentanol 581.08
    sec-butanol 661.11
    n-hexane 84.42
    ethylene glycol 689.64
    NMP 767.83
    cyclohexane 270.95
    DMSO 1970.19
    n-butyl acetate 476.88
    n-octanol 123.34
    chloroform 3255.66
    n-propyl acetate 330.22
    acetic acid 1812.87
    dichloromethane 3087.59
    cyclohexanone 995.77
    propylene glycol 618.77
    isopropyl acetate 363.8
    DMAc 1116.72
    2-ethoxyethanol 941.54
    isopentanol 605.75
    n-heptane 76.93
    ethyl formate 574.86
    1,2-dichloroethane 1695.1
    n-hexanol 564.55
    2-methoxyethanol 1749.85
    isobutyl acetate 186.46
    tetrachloromethane 482.52
    n-pentyl acetate 173.89
    transcutol 1995.44
    n-heptanol 136.9
    ethylbenzene 131.84
    MIBK 191.54
    2-propoxyethanol 847.25
    tert-butanol 734.62
    MTBE 520.93
    2-butoxyethanol 301.38
    propionic acid 975.54
    o-xylene 244.1
    formic acid 843.39
    diethyl ether 1033.31
    m-xylene 229.92
    p-xylene 167.34
    chlorobenzene 640.18
    dimethyl carbonate 241.64
    n-octane 18.24
    formamide 851.05
    cyclopentanone 761.88
    2-pentanone 493.12
    anisole 315.09
    cyclopentyl methyl ether 693.67
    gamma-butyrolactone 983.43
    1-methoxy-2-propanol 814.39
    pyridine 1667.01
    3-pentanone 473.22
    furfural 922.42
    n-dodecane 15.3
    diethylene glycol 865.67
    diisopropyl ether 134.96
    tert-amyl alcohol 522.26
    acetylacetone 514.3
    n-hexadecane 17.33
    acetophenone 245.22
    methyl propionate 718.98
    isopentyl acetate 320.54
    trichloroethylene 2652.59
    n-nonanol 111.57
    cyclohexanol 826.68
    benzyl alcohol 380.47
    2-ethylhexanol 244.9
    isooctanol 97.58
    dipropyl ether 353.92
    1,2-dichlorobenzene 486.53
    ethyl lactate 180.03
    propylene carbonate 531.24
    n-methylformamide 791.13
    2-pentanol 435.82
    n-pentane 122.11
    1-propoxy-2-propanol 492.13
    1-methoxy-2-propyl acetate 413.05
    2-(2-methoxypropoxy) propanol 266.04
    mesitylene 117.12
    ε-caprolactone 841.95
    p-cymene 89.89
    epichlorohydrin 1337.44
    1,1,1-trichloroethane 1250.51
    2-aminoethanol 977.45
    morpholine-4-carbaldehyde 1070.15
    sulfolane 887.38
    2,2,4-trimethylpentane 41.88
    2-methyltetrahydrofuran 1104.19
    n-hexyl acetate 240.31
    isooctane 23.47
    2-(2-butoxyethoxy)ethanol 403.53
    sec-butyl acetate 192.41
    tert-butyl acetate 265.83
    decalin 61.23
    glycerin 768.24
    diglyme 808.55
    acrylic acid 838.58
    isopropyl myristate 85.96
    n-butyric acid 1266.05
    acetyl acetate 583.29
    di(2-ethylhexyl) phthalate 106.26
    ethyl propionate 292.34
    nitromethane 1568.18
    1,2-diethoxyethane 652.87
    benzonitrile 454.27
    trioctyl phosphate 63.99
    1-bromopropane 937.27
    gamma-valerolactone 1132.6
    n-decanol 83.22
    triethyl phosphate 143.19
    4-methyl-2-pentanol 159.16
    propionitrile 720.15
    vinylene carbonate 568.61
    1,1,2-trichlorotrifluoroethane 1196.67
    DMS 257.32
    cumene 79.54
    2-octanol 71.87
    2-hexanone 267.32
    octyl acetate 112.01
    limonene 169.04
    1,2-dimethoxyethane 950.91
    ethyl orthosilicate 147.14
    tributyl phosphate 99.27
    diacetone alcohol 291.97
    N,N-dimethylaniline 182.1
    acrylonitrile 831.24
    aniline 837.23
    1,3-propanediol 1105.71
    bromobenzene 651.37
    dibromomethane 1889.73
    1,1,2,2-tetrachloroethane 2106.99
    2-methyl-cyclohexyl acetate 188.24
    tetrabutyl urea 132.96
    diisobutyl methanol 115.58
    2-phenylethanol 324.46
    styrene 233.37
    dioctyl adipate 142.58
    dimethyl sulfate 322.25
    ethyl butyrate 318.85
    methyl lactate 300.32
    butyl lactate 153.91
    diethyl carbonate 213.33
    propanediol butyl ether 251.33
    triethyl orthoformate 225.15
    p-tert-butyltoluene 82.55
    methyl 4-tert-butylbenzoate 161.89
    morpholine 2236.42
    tert-butylamine 493.41
    n-dodecanol 67.19
    dimethoxymethane 796.33
    ethylene carbonate 538.41
    cyrene 221.77
    2-ethoxyethyl acetate 299.85
    2-ethylhexyl acetate 257.22
    1,2,4-trichlorobenzene 571.74
    4-methylpyridine 1114.64
    dibutyl ether 228.71
    2,6-dimethyl-4-heptanol 115.58
    DEF 867.85
    dimethyl isosorbide 350.05
    tetrachloroethylene 1576.2
    eugenol 183.52
    triacetin 239.65
    span 80 224.17
    1,4-butanediol 420.98
    1,1-dichloroethane 1408.16
    2-methyl-1-pentanol 391.99
    methyl formate 510.24
    2-methyl-1-butanol 601.58
    n-decane 25.54
    butyronitrile 694.95
    3,7-dimethyl-1-octanol 129.72
    1-chlorooctane 98.13
    1-chlorotetradecane 42.5
    n-nonane 25.02
    undecane 18.92
    tert-butylcyclohexane 47.14
    cyclooctane 58.4
    cyclopentanol 653.09
    tetrahydropyran 1603.67
    tert-amyl methyl ether 358.57
    2,5,8-trioxanonane 540.62
    1-hexene 280.64
    2-isopropoxyethanol 456.4
    2,2,2-trifluoroethanol 503.3
    methyl butyrate 401.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction