19Alpha-Hydroxyasiatic Acid

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  • Identifiers

    CAS number
    70868-78-9

    Molecular formula
    C30H48O6

    SMILES
    C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(C[C@H]([C@@H]([C@@]5(C)CO)O)O)C)C)[C@@H]2[C@]1(C)O)C)C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 65.04%
    Balsamic 42.4%
    Spicy 41.07%
    Amber 38.61%
    Cedar 34.75%
    Dry 33.4%
    Camphoreous 32.46%
    Odorless 32.35%
    Herbal 31.89%
    Cooling 30.92%

     

    Flavor
    Bitter 50.62%
    Pine 33.68%
    Woody 33.18%
    Herbal 31.93%
    Balsam 31.0%
    Camphor 30.15%
    Minty 29.87%
    Sweet 29.38%
    Earthy 24.97%
    Odorless 24.43%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.3

    pKa est.
    5.79 (weak acid)

    Molecular weight
    504.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    143°C

    Flash point

    • 303.95 ˚C est.

  • Synonyms

    • 19Alpha-Hydroxyasiatic Acid
    • 70868-78-9
    • meyanthic acid
    • (1R,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-1,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
    • CHEBI:67915
    • 89786-84-5
    • (2alpha,3beta)-2,3,19,23-tetrahydroxyurs-12-en-28-oic acid
    • RefChem:79558
    • 23-hydroxytormentic acid
    • 23-Hydroxytormenticacid
    • 19|A-Hydroxyasiatic acid
    • 19 alpha-Hydroxyasiatic acid
    • 23-hydroxy-tormentic acid
    • 19??-Hydroxyasiatic acid
    • Niga-ichigoside F1 aglycone
    • CHEMBL515920
    • orb1684901
    • SCHEMBL5797542
    • HY-N8164
    • AKOS040760190
    • DA-49135
    • DA-60073
    • MS-29376
    • PD197605
    • CS-0140231
    • E88645
    • 23-Hydroxytormentic acid, >=95% (LC/MS-ELSD)
    • Q27136389
    • (2a,3b,4a)-2,3,19,23-Tetrahydroxyurs-12-en-28-oic acid
    • 2alpha,3beta,19alpha,23-tetrahydroxy-urs-12-en-28-oic acid
    • 89786-84-5

  • Applications

    19Alpha-Hydroxyasiatic Acid (CAS 70868-78-9) is a pentacyclic triterpenoid derived from Centella asiatica, commonly used in cosmetics and personal care as an active component with potential skin-related activity and as a basis for synthesizing other triterpenoid derivatives; it is also regarded as an intermediate in the production of triterpenoids for pharmaceutical research and industrial manufacturing; in analytical and quality-control workflows, it can serve as a reference standard for quantifying related constituents in Centella extracts; beyond these uses, it is often evaluated for inclusion in nutraceutical-type formulations or as a starting point for developing related bioactive derivatives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.18
    methanol 34.14
    isopropanol 4.52
    water 0.02
    ethyl acetate 1.85
    n-propanol 8.06
    acetone 5.5
    n-butanol 3.69
    acetonitrile 1.19
    DMF 57.98
    toluene 1.08
    isobutanol 2.84
    1,4-dioxane 21.7
    methyl acetate 2.23
    THF 51.34
    2-butanone 4.12
    n-pentanol 2.7
    sec-butanol 1.61
    n-hexane 0.07
    ethylene glycol 3.39
    NMP 22.94
    cyclohexane 0.07
    DMSO 32.62
    n-butyl acetate 1.68
    n-octanol 1.32
    chloroform 3.94
    n-propyl acetate 1.33
    acetic acid 7.31
    dichloromethane 2.59
    cyclohexanone 6.16
    propylene glycol 4.88
    isopropyl acetate 1.51
    DMAc 23.07
    2-ethoxyethanol 16.1
    isopentanol 1.87
    n-heptane 0.05
    ethyl formate 2.15
    1,2-dichloroethane 1.84
    n-hexanol 2.72
    2-methoxyethanol 40.13
    isobutyl acetate 0.93
    tetrachloromethane 0.56
    n-pentyl acetate 2.83
    transcutol 14.75
    n-heptanol 2.53
    ethylbenzene 0.57
    MIBK 1.85
    2-propoxyethanol 25.55
    tert-butanol 2.3
    MTBE 1.28
    2-butoxyethanol 13.36
    propionic acid 2.74
    o-xylene 0.62
    formic acid 8.2
    diethyl ether 2.14
    m-xylene 0.77
    p-xylene 0.61
    chlorobenzene 0.9
    dimethyl carbonate 3.4
    n-octane 0.04
    formamide 9.2
    cyclopentanone 14.13
    2-pentanone 2.94
    anisole 2.32
    cyclopentyl methyl ether 4.69
    gamma-butyrolactone 12.52
    1-methoxy-2-propanol 23.43
    pyridine 9.38
    3-pentanone 1.98
    furfural 10.2
    n-dodecane 0.01
    diethylene glycol 20.09
    diisopropyl ether 0.38
    tert-amyl alcohol 1.23
    acetylacetone 4.43
    n-hexadecane 0.02
    acetophenone 2.51
    methyl propionate 3.18
    isopentyl acetate 1.6
    trichloroethylene 4.31
    n-nonanol 1.4
    cyclohexanol 1.37
    benzyl alcohol 3.85
    2-ethylhexanol 0.85
    isooctanol 1.66
    dipropyl ether 1.32
    1,2-dichlorobenzene 0.82
    ethyl lactate 1.9
    propylene carbonate 3.24
    n-methylformamide 18.04
    2-pentanol 1.02
    n-pentane 0.06
    1-propoxy-2-propanol 10.31
    1-methoxy-2-propyl acetate 5.53
    2-(2-methoxypropoxy) propanol 5.93
    mesitylene 0.41
    ε-caprolactone 5.21
    p-cymene 0.37
    epichlorohydrin 16.34
    1,1,1-trichloroethane 0.88
    2-aminoethanol 10.75
    morpholine-4-carbaldehyde 39.13
    sulfolane 17.64
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 5.97
    n-hexyl acetate 2.75
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 10.37
    sec-butyl acetate 0.76
    tert-butyl acetate 1.84
    decalin 0.06
    glycerin 10.76
    diglyme 18.47
    acrylic acid 3.61
    isopropyl myristate 0.55
    n-butyric acid 3.38
    acetyl acetate 1.41
    di(2-ethylhexyl) phthalate 1.61
    ethyl propionate 1.18
    nitromethane 10.19
    1,2-diethoxyethane 3.24
    benzonitrile 1.66
    trioctyl phosphate 1.05
    1-bromopropane 0.69
    gamma-valerolactone 32.49
    n-decanol 0.66
    triethyl phosphate 0.83
    4-methyl-2-pentanol 0.73
    propionitrile 1.38
    vinylene carbonate 3.94
    1,1,2-trichlorotrifluoroethane 13.55
    DMS 2.52
    cumene 0.4
    2-octanol 0.93
    2-hexanone 2.02
    octyl acetate 1.03
    limonene 0.43
    1,2-dimethoxyethane 18.02
    ethyl orthosilicate 0.9
    tributyl phosphate 0.76
    diacetone alcohol 4.24
    N,N-dimethylaniline 1.94
    acrylonitrile 2.45
    aniline 2.26
    1,3-propanediol 13.03
    bromobenzene 0.68
    dibromomethane 1.38
    1,1,2,2-tetrachloroethane 3.55
    2-methyl-cyclohexyl acetate 1.42
    tetrabutyl urea 1.41
    diisobutyl methanol 0.49
    2-phenylethanol 4.2
    styrene 0.58
    dioctyl adipate 1.28
    dimethyl sulfate 5.79
    ethyl butyrate 1.09
    methyl lactate 5.03
    butyl lactate 3.75
    diethyl carbonate 0.69
    propanediol butyl ether 10.22
    triethyl orthoformate 1.4
    p-tert-butyltoluene 0.39
    methyl 4-tert-butylbenzoate 4.32
    morpholine 30.96
    tert-butylamine 0.63
    n-dodecanol 0.31
    dimethoxymethane 34.76
    ethylene carbonate 2.98
    cyrene 8.56
    2-ethoxyethyl acetate 6.11
    2-ethylhexyl acetate 1.14
    1,2,4-trichlorobenzene 1.38
    4-methylpyridine 4.63
    dibutyl ether 0.57
    2,6-dimethyl-4-heptanol 0.49
    DEF 4.59
    dimethyl isosorbide 10.04
    tetrachloroethylene 3.18
    eugenol 5.85
    triacetin 3.12
    span 80 5.41
    1,4-butanediol 4.19
    1,1-dichloroethane 1.02
    2-methyl-1-pentanol 1.35
    methyl formate 9.93
    2-methyl-1-butanol 1.65
    n-decane 0.04
    butyronitrile 1.24
    3,7-dimethyl-1-octanol 0.8
    1-chlorooctane 0.28
    1-chlorotetradecane 0.06
    n-nonane 0.04
    undecane 0.02
    tert-butylcyclohexane 0.05
    cyclooctane 0.04
    cyclopentanol 3.32
    tetrahydropyran 6.18
    tert-amyl methyl ether 0.93
    2,5,8-trioxanonane 9.85
    1-hexene 0.28
    2-isopropoxyethanol 6.34
    2,2,2-trifluoroethanol 2.19
    methyl butyrate 1.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction