18-Hydroxy-11-Deoxycorticosterone

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  • Identifiers

    CAS number
    379-68-0

    Molecular formula
    C21H30O4

    SMILES
    C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CO)CO

    Safety labels

  • Odor profile

    Fragrance
    Woody 64.86%
    Fruity 35.67%
    Sweet 32.45%
    Floral 31.9%
    Amber 31.15%
    Cedar 30.5%
    Fresh 28.96%
    Balsamic 28.71%
    Dry 28.39%
    Mint 26.37%

     

    Flavor
    Bitter 52.4%
    Fatty 21.35%
    Cedarleaf 21.01%
    Sweet-like 20.99%
    Fenugreek 20.69%
    Leaves 20.64%
    Alkaline 20.52%
    Ripe apricot 20.39%
    Maple syrup 20.33%
    Soil 20.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    6.44 (neutral)

    Molecular weight
    346.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    321°C

    Flash point

    • 258.47 ˚C est.

  • Synonyms

    • 379-68-0
    • 18-Hydroxy-11-deoxycorticosterone
    • 18-Hydroxydeoxycorticosterone
    • DTXSID90958920
    • 18,21-dihydroxy-4-pregnene-3,20-dione
    • RefChem:388745
    • DTXCID501386812
    • 206-834-3
    • 18,21-Dihydroxypregn-4-ene-3,20-dione
    • 11-Deoxy-18-hydroxycorticosterone
    • (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
    • Pregn-4-ene-3,20-dione, 18,21-dihydroxy-
    • 18,21-dihydroxyprogesterone
    • (1S,3aS,3bR,9aR,9bS,11aR)-1-(2-hydroxyacetyl)-11a-(hydroxymethyl)-9a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
    • EINECS 206-834-3
    • 18-OH-DOC
    • 18-Hydroxydesoxycorticosterone
    • SCHEMBL927204
    • orb2283106
    • CHEBI:195166
    • 18-Hydroxy-11-deoxy corticosterone
    • AKOS024319493
    • HY-W738639
    • PD088587
    • NS00041752
    • 18,21-Dihydroxypregn-4-ene-3,20-dione #
    • 379-68-0

  • Applications

    18-Hydroxy-11-Deoxycorticosterone (CAS 379-68-0) is primarily used as a chemical intermediate in the synthesis of mineralocorticoid steroids, including aldosterone and related analogs, providing a role in pharmaceutical manufacturing and corticosteroid synthesis. It is also used in chemical and biochemical research as a substrate and reference compound for studies of steroid biosynthesis and enzyme activity, as well as a standard for analytical laboratories conducting steroid quantification. Additionally, it may be handled as an intermediate in custom synthesis workflows and the production of specialty corticosteroids for research applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 17.0
    methanol 40.74
    isopropanol 9.23
    water 0.35
    ethyl acetate 9.9
    n-propanol 12.88
    acetone 18.45
    n-butanol 9.94
    acetonitrile 8.91
    DMF 41.09
    toluene 9.86
    isobutanol 5.57
    1,4-dioxane 31.93
    methyl acetate 6.53
    THF 63.7
    2-butanone 8.85
    n-pentanol 2.83
    sec-butanol 1.63
    n-hexane 0.09
    ethylene glycol 8.19
    NMP 12.41
    cyclohexane 0.51
    DMSO 51.84
    n-butyl acetate 7.72
    n-octanol 2.27
    chloroform 30.64
    n-propyl acetate 5.3
    acetic acid 20.02
    dichloromethane 19.11
    cyclohexanone 21.76
    propylene glycol 4.1
    isopropyl acetate 11.13
    DMAc 23.62
    2-ethoxyethanol 18.87
    isopentanol 7.5
    n-heptane 0.16
    ethyl formate 7.59
    1,2-dichloroethane 11.76
    n-hexanol 6.32
    2-methoxyethanol 59.2
    isobutyl acetate 5.16
    tetrachloromethane 4.05
    n-pentyl acetate 8.01
    transcutol 52.55
    n-heptanol 5.22
    ethylbenzene 2.8
    MIBK 11.62
    2-propoxyethanol 40.35
    tert-butanol 7.67
    MTBE 2.0
    2-butoxyethanol 23.76
    propionic acid 6.62
    o-xylene 4.99
    formic acid 18.75
    diethyl ether 5.63
    m-xylene 7.21
    p-xylene 3.39
    chlorobenzene 8.76
    dimethyl carbonate 14.1
    n-octane 0.11
    formamide 29.91
    cyclopentanone 28.27
    2-pentanone 12.21
    anisole 9.14
    cyclopentyl methyl ether 11.36
    gamma-butyrolactone 27.18
    1-methoxy-2-propanol 40.51
    pyridine 24.71
    3-pentanone 7.93
    furfural 30.07
    n-dodecane 0.08
    diethylene glycol 46.09
    diisopropyl ether 1.8
    tert-amyl alcohol 1.53
    acetylacetone 27.74
    n-hexadecane 0.1
    acetophenone 11.04
    methyl propionate 10.2
    isopentyl acetate 9.62
    trichloroethylene 29.0
    n-nonanol 2.98
    cyclohexanol 4.97
    benzyl alcohol 11.01
    2-ethylhexanol 3.0
    isooctanol 4.26
    dipropyl ether 3.56
    1,2-dichlorobenzene 8.75
    ethyl lactate 7.5
    propylene carbonate 13.34
    n-methylformamide 28.41
    2-pentanol 2.59
    n-pentane 0.17
    1-propoxy-2-propanol 21.2
    1-methoxy-2-propyl acetate 22.76
    2-(2-methoxypropoxy) propanol 16.44
    mesitylene 3.77
    ε-caprolactone 14.45
    p-cymene 2.52
    epichlorohydrin 34.89
    1,1,1-trichloroethane 8.23
    2-aminoethanol 15.43
    morpholine-4-carbaldehyde 35.58
    sulfolane 31.49
    2,2,4-trimethylpentane 0.1
    2-methyltetrahydrofuran 7.5
    n-hexyl acetate 7.14
    isooctane 0.14
    2-(2-butoxyethoxy)ethanol 23.33
    sec-butyl acetate 4.33
    tert-butyl acetate 12.22
    decalin 0.26
    glycerin 17.28
    diglyme 45.88
    acrylic acid 9.32
    isopropyl myristate 3.09
    n-butyric acid 15.43
    acetyl acetate 14.07
    di(2-ethylhexyl) phthalate 6.37
    ethyl propionate 6.04
    nitromethane 31.88
    1,2-diethoxyethane 9.9
    benzonitrile 11.52
    trioctyl phosphate 4.13
    1-bromopropane 3.28
    gamma-valerolactone 52.64
    n-decanol 1.9
    triethyl phosphate 5.41
    4-methyl-2-pentanol 3.39
    propionitrile 9.95
    vinylene carbonate 17.71
    1,1,2-trichlorotrifluoroethane 32.65
    DMS 11.01
    cumene 1.99
    2-octanol 1.96
    2-hexanone 4.92
    octyl acetate 3.8
    limonene 2.44
    1,2-dimethoxyethane 27.5
    ethyl orthosilicate 5.12
    tributyl phosphate 3.79
    diacetone alcohol 17.89
    N,N-dimethylaniline 5.86
    acrylonitrile 17.37
    aniline 14.46
    1,3-propanediol 30.07
    bromobenzene 7.92
    dibromomethane 9.89
    1,1,2,2-tetrachloroethane 19.72
    2-methyl-cyclohexyl acetate 7.39
    tetrabutyl urea 5.82
    diisobutyl methanol 2.57
    2-phenylethanol 16.1
    styrene 3.2
    dioctyl adipate 6.09
    dimethyl sulfate 19.77
    ethyl butyrate 6.49
    methyl lactate 14.66
    butyl lactate 11.07
    diethyl carbonate 5.54
    propanediol butyl ether 13.28
    triethyl orthoformate 6.92
    p-tert-butyltoluene 2.49
    methyl 4-tert-butylbenzoate 15.97
    morpholine 28.03
    tert-butylamine 2.58
    n-dodecanol 1.19
    dimethoxymethane 59.22
    ethylene carbonate 15.16
    cyrene 18.75
    2-ethoxyethyl acetate 16.98
    2-ethylhexyl acetate 6.16
    1,2,4-trichlorobenzene 10.98
    4-methylpyridine 16.29
    dibutyl ether 1.88
    2,6-dimethyl-4-heptanol 2.57
    DEF 10.14
    dimethyl isosorbide 29.17
    tetrachloroethylene 16.49
    eugenol 18.82
    triacetin 13.02
    span 80 12.15
    1,4-butanediol 5.79
    1,1-dichloroethane 8.08
    2-methyl-1-pentanol 2.35
    methyl formate 19.27
    2-methyl-1-butanol 3.36
    n-decane 0.18
    butyronitrile 8.32
    3,7-dimethyl-1-octanol 2.57
    1-chlorooctane 0.93
    1-chlorotetradecane 0.34
    n-nonane 0.14
    undecane 0.11
    tert-butylcyclohexane 0.18
    cyclooctane 0.2
    cyclopentanol 5.29
    tetrahydropyran 13.81
    tert-amyl methyl ether 1.44
    2,5,8-trioxanonane 29.33
    1-hexene 0.46
    2-isopropoxyethanol 10.61
    2,2,2-trifluoroethanol 12.56
    methyl butyrate 6.73

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction