16-Hydroxy-13-manoyl oxide

Overview IFRA Request a quote

  • Identifiers

    CAS number
    122757-60-2

    Molecular formula
    C20H34O2

    SMILES
    C[C@@]12CCCC([C@H]1CC[C@]3([C@H]2CC[C@](O3)(CO)C=C)C)(C)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 80.04%
    Amber 56.71%
    Dry 47.03%
    Cedar 45.5%
    Musk 41.14%
    Sandalwood 34.36%
    Balsamic 33.28%
    Animal 33.07%
    Vetiver 31.77%
    Camphoreous 31.54%

     

    Flavor
    Woody 62.06%
    Sweet 54.34%
    Pine 35.72%
    Herbal 35.61%
    Earthy 35.27%
    Spicy 33.87%
    Camphor 33.64%
    Balsam 30.89%
    Dry 30.57%
    Minty 30.08%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    4.9

    pKa est.
    8.03 (weak base)

    Molecular weight
    306.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    404°C

    Flash point

    • 191.57 ˚C est.

  • Synonyms

    • OH-Manoyl oxide
    • 16-Hydroxy-13-manoyl oxide
    • 122757-60-2
    • [(3R,4aS,6aR,10aR,10bS)-3-ethenyl-4a,7,7,10a-tetramethyl-2,5,6,6a,8,9,10,10b-octahydro-1H-benzo[f]chromen-3-yl]methanol
    • ((3R,4aS,6aR,10aR,10bS)-3-ethenyl-4a,7,7,10a-tetramethyl-2,5,6,6a,8,9,10,10b-octahydro-1H-benzo(f)chromen-3-yl)methanol
    • RefChem:908207
    • CHEMBL484020
    • DTXSID10924268
    • (3-Ethenyl-4a,7,7,10a-tetramethyldodecahydro-1H-naphtho[2,1-b]pyran-3-yl)methanol
    • [(3R,4aS,6aR,10aR,10bS)-3-Ethenyl-4a,7,7,10a-tetramethyldodecahydro-1H-naphtho[2,1-b]pyran-3-yl]methanol
    • 122757-60-2

  • Applications

    16-Hydroxy-13-manoyl oxide (CAS 122757-60-2) is a natural diterpene alcohol that is typically discussed as a fragrance component and as a synthetic intermediate. In industry, it is commonly evaluated as a fragrance ingredient or odorant for perfumery and cosmetics, and may serve as an intermediate in the synthesis of other terpenoid derivatives. It may be used in household products to impart or refine aroma. In industrial manufacturing, it can function as a chiral building block or functionalized intermediate for terpenoid-based specialty chemicals and related polymer applications. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 275.67
    methanol 220.8
    isopropanol 267.84
    water 0.96
    ethyl acetate 320.89
    n-propanol 311.32
    acetone 370.2
    n-butanol 293.22
    acetonitrile 225.55
    DMF 505.96
    toluene 458.79
    isobutanol 248.15
    1,4-dioxane 708.83
    methyl acetate 238.49
    THF 1540.84
    2-butanone 298.58
    n-pentanol 137.65
    sec-butanol 156.33
    n-hexane 17.3
    ethylene glycol 32.35
    NMP 413.58
    cyclohexane 70.96
    DMSO 298.48
    n-butyl acetate 293.4
    n-octanol 99.85
    chloroform 748.75
    n-propyl acetate 188.13
    acetic acid 204.41
    dichloromethane 607.13
    cyclohexanone 574.91
    propylene glycol 56.74
    isopropyl acetate 289.19
    DMAc 334.05
    2-ethoxyethanol 194.89
    isopentanol 243.64
    n-heptane 23.18
    ethyl formate 197.16
    1,2-dichloroethane 379.49
    n-hexanol 237.94
    2-methoxyethanol 349.09
    isobutyl acetate 181.1
    tetrachloromethane 142.91
    n-pentyl acetate 239.01
    transcutol 775.05
    n-heptanol 130.71
    ethylbenzene 123.71
    MIBK 264.49
    2-propoxyethanol 421.36
    tert-butanol 236.54
    MTBE 259.21
    2-butoxyethanol 240.79
    propionic acid 170.46
    o-xylene 183.96
    formic acid 63.19
    diethyl ether 382.79
    m-xylene 289.21
    p-xylene 150.79
    chlorobenzene 356.03
    dimethyl carbonate 171.04
    n-octane 8.03
    formamide 90.37
    cyclopentanone 681.86
    2-pentanone 325.47
    anisole 211.41
    cyclopentyl methyl ether 552.25
    gamma-butyrolactone 714.69
    1-methoxy-2-propanol 352.13
    pyridine 542.17
    3-pentanone 238.53
    furfural 518.72
    n-dodecane 6.04
    diethylene glycol 235.94
    diisopropyl ether 134.21
    tert-amyl alcohol 134.12
    acetylacetone 342.19
    n-hexadecane 7.42
    acetophenone 192.45
    methyl propionate 273.03
    isopentyl acetate 304.51
    trichloroethylene 662.47
    n-nonanol 94.25
    cyclohexanol 269.57
    benzyl alcohol 176.32
    2-ethylhexanol 138.66
    isooctanol 115.64
    dipropyl ether 200.3
    1,2-dichlorobenzene 287.85
    ethyl lactate 112.32
    propylene carbonate 359.71
    n-methylformamide 235.61
    2-pentanol 171.15
    n-pentane 32.36
    1-propoxy-2-propanol 315.28
    1-methoxy-2-propyl acetate 358.7
    2-(2-methoxypropoxy) propanol 187.05
    mesitylene 169.29
    ε-caprolactone 455.45
    p-cymene 102.81
    epichlorohydrin 734.58
    1,1,1-trichloroethane 353.47
    2-aminoethanol 102.62
    morpholine-4-carbaldehyde 483.12
    sulfolane 521.9
    2,2,4-trimethylpentane 17.91
    2-methyltetrahydrofuran 672.86
    n-hexyl acetate 268.17
    isooctane 20.41
    2-(2-butoxyethoxy)ethanol 263.22
    sec-butyl acetate 160.15
    tert-butyl acetate 302.83
    decalin 27.23
    glycerin 92.32
    diglyme 474.92
    acrylic acid 144.09
    isopropyl myristate 100.39
    n-butyric acid 303.84
    acetyl acetate 231.74
    di(2-ethylhexyl) phthalate 104.79
    ethyl propionate 175.42
    nitromethane 313.36
    1,2-diethoxyethane 308.99
    benzonitrile 278.63
    trioctyl phosphate 82.02
    1-bromopropane 271.81
    gamma-valerolactone 826.24
    n-decanol 65.43
    triethyl phosphate 106.08
    4-methyl-2-pentanol 128.33
    propionitrile 253.85
    vinylene carbonate 357.17
    1,1,2-trichlorotrifluoroethane 317.25
    DMS 204.17
    cumene 86.79
    2-octanol 83.64
    2-hexanone 171.46
    octyl acetate 120.08
    limonene 130.87
    1,2-dimethoxyethane 382.33
    ethyl orthosilicate 108.24
    tributyl phosphate 95.72
    diacetone alcohol 257.71
    N,N-dimethylaniline 146.43
    acrylonitrile 256.72
    aniline 305.44
    1,3-propanediol 196.73
    bromobenzene 405.29
    dibromomethane 422.48
    1,1,2,2-tetrachloroethane 512.96
    2-methyl-cyclohexyl acetate 184.07
    tetrabutyl urea 113.95
    diisobutyl methanol 99.06
    2-phenylethanol 233.52
    styrene 154.03
    dioctyl adipate 130.92
    dimethyl sulfate 207.08
    ethyl butyrate 193.59
    methyl lactate 140.43
    butyl lactate 182.68
    diethyl carbonate 135.57
    propanediol butyl ether 195.21
    triethyl orthoformate 168.44
    p-tert-butyltoluene 104.29
    methyl 4-tert-butylbenzoate 218.39
    morpholine 741.66
    tert-butylamine 167.31
    n-dodecanol 47.72
    dimethoxymethane 537.01
    ethylene carbonate 341.67
    cyrene 186.79
    2-ethoxyethyl acetate 321.89
    2-ethylhexyl acetate 248.14
    1,2,4-trichlorobenzene 321.54
    4-methylpyridine 521.82
    dibutyl ether 118.9
    2,6-dimethyl-4-heptanol 99.06
    DEF 277.72
    dimethyl isosorbide 364.17
    tetrachloroethylene 333.86
    eugenol 189.46
    triacetin 238.35
    span 80 172.31
    1,4-butanediol 64.56
    1,1-dichloroethane 376.09
    2-methyl-1-pentanol 126.76
    methyl formate 197.66
    2-methyl-1-butanol 205.18
    n-decane 12.3
    butyronitrile 282.86
    3,7-dimethyl-1-octanol 105.76
    1-chlorooctane 73.73
    1-chlorotetradecane 24.24
    n-nonane 10.64
    undecane 8.24
    tert-butylcyclohexane 22.92
    cyclooctane 26.02
    cyclopentanol 281.62
    tetrahydropyran 794.3
    tert-amyl methyl ether 160.14
    2,5,8-trioxanonane 294.93
    1-hexene 68.42
    2-isopropoxyethanol 157.24
    2,2,2-trifluoroethanol 97.16
    methyl butyrate 207.66

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction