1,5-Dimethyl-6-methylenespiro[2.4]heptane

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  • Identifiers

    CAS number
    62238-24-8

    Molecular formula
    C10H16

    SMILES
    CC1CC2(CC2C)CC1=C

  • Odor profile

    Woody 71.45%
    Spicy 47.07%
    Green 45.74%
    Citrus 43.75%
    Herbal 42.37%
    Fresh 41.16%
    Sweet 39.85%
    Dry 36.47%
    Terpenic 36.41%
    Camphoreous 33.27%

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  • Properties

    XLogP3-AA
    3.1

    pKa est.
    9.39 (weak base)

    Molecular weight
    136.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    166°C

    Flash point est.
    20.71 ˚C

  • Synonyms

    • 1,5-Dimethyl-6-methylenespiro[2.4]heptane
    • 62238-24-8
    • Spiro[2.4]heptane, 1,5-dimethyl-6-methylene-
    • DTXSID20339485
    • POOMWNXUBXZEPQ-UHFFFAOYSA-N
    • DB-301146
    • 1,5-Dimethyl-6-methylenespiro[2.4]heptane #

  • Applications

    1,5-Dimethyl-6-methylenespiro[2.4]heptane (CAS 62238-24-8) is primarily used as a reference compound and synthetic intermediate in organic research, where its strain-rich spirocyclic core enables studies of carbocation rearrangements and addition chemistry at the exocyclic methylene (selective oxidations, epoxidation, hydroformylation, and radical halogenation), and expands shape diversity for compound libraries; its rigid, hydrophobic scaffold is explored in medicinal chemistry to tune lipophilicity, permeability, and metabolic stability via late-stage functionalization, and as a building block for low-density, thermally robust, low-extractables monomers/polymers; in flavor and fragrance science, the compound and its oxidized/hydrogenated derivatives are investigated as terpene-like aroma precursors and modulators, and as analytical standards in GC/GC–MS for resolution testing and impurity mapping; it also appears in computational/QSAR workflows and machine-learning–guided optimization of catalytic conditions and reactions on spiro frameworks.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1460.63
    methanol 814.4
    isopropanol 1519.72
    water 0.65
    ethyl acetate 1481.86
    n-propanol 1353.94
    acetone 1400.07
    n-butanol 1430.69
    acetonitrile 1005.98
    DMF 801.53
    toluene 864.37
    isobutanol 1027.23
    1,4-dioxane 2051.52
    methyl acetate 1113.37
    THF 3493.54
    2-butanone 1311.15
    n-pentanol 757.61
    sec-butanol 1114.16
    n-hexane 357.64
    ethylene glycol 153.99
    NMP 387.47
    cyclohexane 389.17
    DMSO 533.88
    n-butyl acetate 1358.89
    n-octanol 537.71
    chloroform 1787.86
    n-propyl acetate 682.16
    acetic acid 397.91
    dichloromethane 1314.73
    cyclohexanone 1089.24
    propylene glycol 321.38
    isopropyl acetate 1211.22
    DMAc 594.03
    2-ethoxyethanol 875.27
    isopentanol 1224.39
    n-heptane 324.94
    ethyl formate 553.34
    1,2-dichloroethane 948.43
    n-hexanol 1635.62
    2-methoxyethanol 1383.0
    isobutyl acetate 588.13
    tetrachloromethane 433.84
    n-pentyl acetate 566.12
    transcutol 2521.63
    n-heptanol 561.57
    ethylbenzene 383.25
    MIBK 1061.51
    2-propoxyethanol 1991.36
    tert-butanol 1547.3
    MTBE 2157.09
    2-butoxyethanol 836.28
    propionic acid 456.43
    o-xylene 395.96
    formic acid 102.04
    diethyl ether 2344.49
    m-xylene 619.49
    p-xylene 425.73
    chlorobenzene 660.13
    dimethyl carbonate 354.89
    n-octane 122.88
    formamide 180.16
    cyclopentanone 1230.34
    2-pentanone 1293.83
    anisole 784.33
    cyclopentyl methyl ether 1401.97
    gamma-butyrolactone 1012.52
    1-methoxy-2-propanol 1400.92
    pyridine 1066.88
    3-pentanone 862.16
    furfural 672.15
    n-dodecane 89.23
    diethylene glycol 869.28
    diisopropyl ether 947.69
    tert-amyl alcohol 1027.99
    acetylacetone 1068.19
    n-hexadecane 99.55
    acetophenone 459.84
    methyl propionate 878.62
    isopentyl acetate 1270.33
    trichloroethylene 1213.76
    n-nonanol 483.38
    cyclohexanol 807.75
    benzyl alcohol 459.69
    2-ethylhexanol 807.29
    isooctanol 471.23
    dipropyl ether 1394.23
    1,2-dichlorobenzene 485.1
    ethyl lactate 275.63
    propylene carbonate 582.47
    n-methylformamide 438.37
    2-pentanol 1113.53
    n-pentane 435.42
    1-propoxy-2-propanol 1503.92
    1-methoxy-2-propyl acetate 1317.35
    2-(2-methoxypropoxy) propanol 657.96
    mesitylene 429.18
    ε-caprolactone 883.67
    p-cymene 322.28
    epichlorohydrin 1464.01
    1,1,1-trichloroethane 1075.69
    2-aminoethanol 396.21
    morpholine-4-carbaldehyde 791.51
    sulfolane 657.62
    2,2,4-trimethylpentane 165.57
    2-methyltetrahydrofuran 2012.3
    n-hexyl acetate 825.68
    isooctane 242.36
    2-(2-butoxyethoxy)ethanol 1024.96
    sec-butyl acetate 625.18
    tert-butyl acetate 1232.3
    decalin 172.05
    glycerin 332.41
    diglyme 1568.9
    acrylic acid 267.31
    isopropyl myristate 383.06
    n-butyric acid 878.37
    acetyl acetate 678.61
    di(2-ethylhexyl) phthalate 244.63
    ethyl propionate 644.55
    nitromethane 663.91
    1,2-diethoxyethane 1433.58
    benzonitrile 545.69
    trioctyl phosphate 210.68
    1-bromopropane 1088.15
    gamma-valerolactone 1254.84
    n-decanol 374.03
    triethyl phosphate 283.49
    4-methyl-2-pentanol 830.7
    propionitrile 1138.91
    vinylene carbonate 475.63
    1,1,2-trichlorotrifluoroethane 551.67
    DMS 539.0
    cumene 279.71
    2-octanol 386.1
    2-hexanone 779.07
    octyl acetate 415.62
    limonene 443.13
    1,2-dimethoxyethane 1537.48
    ethyl orthosilicate 314.35
    tributyl phosphate 267.32
    diacetone alcohol 929.58
    N,N-dimethylaniline 414.97
    acrylonitrile 833.84
    aniline 724.49
    1,3-propanediol 744.04
    bromobenzene 693.68
    dibromomethane 1055.16
    1,1,2,2-tetrachloroethane 1025.1
    2-methyl-cyclohexyl acetate 523.88
    tetrabutyl urea 262.02
    diisobutyl methanol 571.61
    2-phenylethanol 745.85
    styrene 437.42
    dioctyl adipate 353.74
    dimethyl sulfate 280.44
    ethyl butyrate 805.71
    methyl lactate 344.4
    butyl lactate 372.32
    diethyl carbonate 467.1
    propanediol butyl ether 611.06
    triethyl orthoformate 571.81
    p-tert-butyltoluene 356.81
    methyl 4-tert-butylbenzoate 474.0
    morpholine 2106.27
    tert-butylamine 1250.7
    n-dodecanol 290.81
    dimethoxymethane 1302.67
    ethylene carbonate 500.02
    cyrene 345.28
    2-ethoxyethyl acetate 785.41
    2-ethylhexyl acetate 895.55
    1,2,4-trichlorobenzene 512.09
    4-methylpyridine 1059.18
    dibutyl ether 855.03
    2,6-dimethyl-4-heptanol 571.61
    DEF 770.4
    dimethyl isosorbide 916.73
    tetrachloroethylene 630.02
    eugenol 412.6
    triacetin 516.61
    span 80 521.75
    1,4-butanediol 264.58
    1,1-dichloroethane 1278.68
    2-methyl-1-pentanol 650.77
    methyl formate 333.56
    2-methyl-1-butanol 953.73
    n-decane 145.83
    butyronitrile 1285.93
    3,7-dimethyl-1-octanol 650.01
    1-chlorooctane 391.66
    1-chlorotetradecane 169.49
    n-nonane 151.71
    undecane 110.94
    tert-butylcyclohexane 193.17
    cyclooctane 180.86
    cyclopentanol 769.5
    tetrahydropyran 2338.54
    tert-amyl methyl ether 1085.96
    2,5,8-trioxanonane 942.17
    1-hexene 776.31
    2-isopropoxyethanol 730.94
    2,2,2-trifluoroethanol 139.24
    methyl butyrate 668.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Chamomile, german (Argentina) 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 1.22%