1,5-Anhydro-D-fructose

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  • Identifiers

    CAS number
    75414-43-6

    Molecular formula
    C6H10O5

    SMILES
    C1C(=O)[C@H]([C@@H]([C@H](O1)CO)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 60.82%
    Caramellic 47.3%
    Sweet 45.5%
    Burnt 24.14%
    Buttery 20.64%
    Woody 18.19%
    Milky 17.33%
    Malty 17.0%
    Sharp 16.27%
    Clean 15.84%

     

    Flavor
    Sweet 67.37%
    Bitter 56.7%
    Odorless 42.23%
    Sweet-like 28.34%
    Caramel 28.3%
    Cauliflower 22.86%
    Bread 22.74%
    Very mild 22.73%
    Very slight 21.99%
    Fenugreek 21.81%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.6

    pKa est.
    5.16 (weak acid)

    Molecular weight
    162.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    509°C

    Flash point

    • 178.64 ˚C est.

  • Synonyms

    • 1,5-Anhydro-D-fructose
    • 75414-43-6
    • 1,5-Anhydrofructose
    • CHEBI:16715
    • (4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-one
    • (4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-one
    • RefChem:73425
    • GlyTouCan:G58064HD
    • G58064HD
    • 1 5-ANHYDRO-D-FRUCTOSE
    • CHEMBL1234723
    • AC1Q6ETX
    • DTXSID10996864
    • NHF
    • (4S,5S)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-one
    • 1,5-Anhydrohex-2-ulose
    • SureCN246685
    • D-Fructose, 1:5-anhydro-
    • SCHEMBL246685
    • 1,5-anhydro-D-threo-hex-2-ulose
    • 1,5-anhydro-D-arabino-hex-2-ulose
    • BDBM50276379
    • MA08330
    • C06485
    • Q27102040
    • (4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)dihydro-2H-pyran-3(4H)-one
    • 75414-43-6

  • Applications

    1,5-Anhydro-D-fructose is a carbohydrate-derived platform chemical often used as a building block for the synthesis of polyols and multifunctional monomers, enabling the production of biodegradable polymers and specialty resins. In coatings and inks, it serves as a precursor to specialty monomers and polymer additives for coatings and printing applications. In cosmetics and personal care, it is evaluated as a humectant and as a chiral building block for cosmetic ingredients. In fragrance and flavor applications, it may be used as an aroma precursor or carbohydrate-derived flavor component. In cleaning and household products, it can be explored as a renewable feedstock for surfactant synthesis or stabilizers.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 9.33
    methanol 57.57
    isopropanol 3.9
    water 560.04
    ethyl acetate 2.24
    n-propanol 4.58
    acetone 3.66
    n-butanol 3.63
    acetonitrile 2.42
    DMF 245.6
    toluene 0.36
    isobutanol 2.5
    1,4-dioxane 10.28
    methyl acetate 2.02
    THF 9.51
    2-butanone 2.52
    n-pentanol 1.6
    sec-butanol 3.3
    n-hexane 0.07
    ethylene glycol 185.17
    NMP 199.65
    cyclohexane 0.55
    DMSO 841.59
    n-butyl acetate 1.25
    n-octanol 1.98
    chloroform 0.35
    n-propyl acetate 1.04
    acetic acid 47.32
    dichloromethane 0.73
    cyclohexanone 7.91
    propylene glycol 51.24
    isopropyl acetate 1.59
    DMAc 128.2
    2-ethoxyethanol 32.04
    isopentanol 2.91
    n-heptane 0.53
    ethyl formate 3.07
    1,2-dichloroethane 1.19
    n-hexanol 2.37
    2-methoxyethanol 116.98
    isobutyl acetate 0.54
    tetrachloromethane 0.32
    n-pentyl acetate 1.19
    transcutol 48.62
    n-heptanol 2.45
    ethylbenzene 0.27
    MIBK 2.22
    2-propoxyethanol 18.16
    tert-butanol 5.88
    MTBE 1.31
    2-butoxyethanol 10.56
    propionic acid 11.99
    o-xylene 0.92
    formic acid 592.36
    diethyl ether 1.17
    m-xylene 0.76
    p-xylene 0.35
    chlorobenzene 0.28
    dimethyl carbonate 6.37
    n-octane 0.23
    formamide 438.46
    cyclopentanone 10.57
    2-pentanone 2.76
    anisole 1.23
    cyclopentyl methyl ether 4.46
    gamma-butyrolactone 20.88
    1-methoxy-2-propanol 46.39
    pyridine 2.56
    3-pentanone 2.42
    furfural 27.49
    n-dodecane 0.16
    diethylene glycol 65.86
    diisopropyl ether 0.63
    tert-amyl alcohol 4.92
    acetylacetone 8.49
    n-hexadecane 0.17
    acetophenone 2.76
    methyl propionate 4.94
    isopentyl acetate 1.26
    trichloroethylene 1.32
    n-nonanol 1.93
    cyclohexanol 5.56
    benzyl alcohol 3.13
    2-ethylhexanol 1.69
    isooctanol 2.04
    dipropyl ether 1.93
    1,2-dichlorobenzene 0.53
    ethyl lactate 6.36
    propylene carbonate 7.22
    n-methylformamide 93.48
    2-pentanol 2.1
    n-pentane 0.16
    1-propoxy-2-propanol 10.63
    1-methoxy-2-propyl acetate 5.71
    2-(2-methoxypropoxy) propanol 14.42
    mesitylene 0.89
    ε-caprolactone 9.77
    p-cymene 0.91
    epichlorohydrin 7.96
    1,1,1-trichloroethane 0.34
    2-aminoethanol 90.26
    morpholine-4-carbaldehyde 120.68
    sulfolane 119.35
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 4.21
    n-hexyl acetate 1.87
    isooctane 0.11
    2-(2-butoxyethoxy)ethanol 19.33
    sec-butyl acetate 0.73
    tert-butyl acetate 2.68
    decalin 0.18
    glycerin 208.93
    diglyme 35.9
    acrylic acid 25.27
    isopropyl myristate 1.0
    n-butyric acid 7.9
    acetyl acetate 2.37
    di(2-ethylhexyl) phthalate 2.29
    ethyl propionate 1.37
    nitromethane 51.15
    1,2-diethoxyethane 3.13
    benzonitrile 1.29
    trioctyl phosphate 2.02
    1-bromopropane 0.3
    gamma-valerolactone 38.48
    n-decanol 1.52
    triethyl phosphate 2.53
    4-methyl-2-pentanol 1.66
    propionitrile 1.29
    vinylene carbonate 6.5
    1,1,2-trichlorotrifluoroethane 40.93
    DMS 3.06
    cumene 0.34
    2-octanol 1.31
    2-hexanone 1.03
    octyl acetate 1.51
    limonene 1.46
    1,2-dimethoxyethane 16.47
    ethyl orthosilicate 2.07
    tributyl phosphate 1.77
    diacetone alcohol 13.94
    N,N-dimethylaniline 2.19
    acrylonitrile 3.39
    aniline 1.73
    1,3-propanediol 65.55
    bromobenzene 0.2
    dibromomethane 0.39
    1,1,2,2-tetrachloroethane 1.62
    2-methyl-cyclohexyl acetate 1.95
    tetrabutyl urea 4.03
    diisobutyl methanol 1.76
    2-phenylethanol 2.87
    styrene 0.23
    dioctyl adipate 2.37
    dimethyl sulfate 31.35
    ethyl butyrate 1.87
    methyl lactate 25.4
    butyl lactate 3.85
    diethyl carbonate 1.36
    propanediol butyl ether 14.94
    triethyl orthoformate 2.18
    p-tert-butyltoluene 0.94
    methyl 4-tert-butylbenzoate 6.93
    morpholine 17.67
    tert-butylamine 1.75
    n-dodecanol 1.21
    dimethoxymethane 26.61
    ethylene carbonate 4.6
    cyrene 30.44
    2-ethoxyethyl acetate 2.67
    2-ethylhexyl acetate 0.95
    1,2,4-trichlorobenzene 0.87
    4-methylpyridine 1.86
    dibutyl ether 0.98
    2,6-dimethyl-4-heptanol 1.76
    DEF 19.07
    dimethyl isosorbide 23.67
    tetrachloroethylene 1.71
    eugenol 8.27
    triacetin 5.15
    span 80 11.37
    1,4-butanediol 20.72
    1,1-dichloroethane 0.28
    2-methyl-1-pentanol 1.43
    methyl formate 34.23
    2-methyl-1-butanol 2.8
    n-decane 0.24
    butyronitrile 1.14
    3,7-dimethyl-1-octanol 1.88
    1-chlorooctane 0.5
    1-chlorotetradecane 0.29
    n-nonane 0.23
    undecane 0.19
    tert-butylcyclohexane 0.12
    cyclooctane 0.36
    cyclopentanol 6.96
    tetrahydropyran 2.83
    tert-amyl methyl ether 1.99
    2,5,8-trioxanonane 31.96
    1-hexene 0.13
    2-isopropoxyethanol 11.45
    2,2,2-trifluoroethanol 56.08
    methyl butyrate 1.99

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction