14-Hydroxycaryophyllene oxide

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  • Identifiers

    CAS number
    73510-14-2

    Molecular formula
    C15H24O2

    SMILES
    CC12CCC3C(CC3(C)CO)C(=C)CCC1O2

    Safety labels

  • Odor profile

    Fragrance
    Woody 68.66%
    Herbal 53.23%
    Floral 51.74%
    Fresh 45.4%
    Fruity 42.01%
    Earthy 40.33%
    Green 40.13%
    Spicy 34.57%
    Mint 33.26%
    Sweet 31.23%

     

    Flavor
    Fruity 46.85%
    Sweet 42.12%
    Spicy 39.5%
    Woody 38.98%
    Earthy 35.49%
    Herbal 30.22%
    Fruit 30.15%
    Floral 29.1%
    Minty 29.08%
    Bitter 28.53%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    7.06 (neutral)

    Molecular weight
    236.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    356°C

    Flash point

    • 143.88 ˚C est.

  • Synonyms

    • 14-Hydroxycaryophyllene oxide
    • 73510-14-2
    • RefChem:78641
    • (4,12-dimethyl-9-methylidene-5-oxatricyclo[8.2.0.04,6]dodecan-12-yl)methanol
    • Hydroxycaryophyllene
    • DTXSID00994273
    • 4,12-Dimethyl-9-methylene-5-oxatricyclo(8.2.0.0(4,6))dodecane-12-methanol
    • (4,12-Dimethyl-9-methylidene-5-oxatricyclo[8.2.0.0~4,6~]dodecan-12-yl)methanol
    • 5-Oxatricyclo(8.2.0.0(4,6))dodecane-12-methanol, 4,12-dimethyl-9-methylene-
    • 73510-14-2

  • Applications

    14-Hydroxycaryophyllene oxide (CAS 73510-14-2) is used in fragrance chemistry as an odorant and fragrance intermediate, contributing woody, spicy notes and serving as a building block for further terpene transformations; in cosmetics and personal care, it may be formulated as a fragrance component in lotions, shampoos, and other products, subject to formulation limits and local regulations; in household products, it can function as a fragrance additive for air fresheners, cleaners, and detergents to impart a persistent aroma; in industrial manufacturing, it serves as an intermediate for synthesis of other sesquiterpene derivatives or as a chiral building block in fragrance compound production; and it may be evaluated for flavor applications in specialized aroma contexts, depending on safety and regulatory considerations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 391.61
    methanol 485.7
    isopropanol 293.44
    water 2.15
    ethyl acetate 242.13
    n-propanol 262.82
    acetone 310.31
    n-butanol 257.2
    acetonitrile 241.09
    DMF 278.05
    toluene 151.31
    isobutanol 178.95
    1,4-dioxane 525.97
    methyl acetate 210.94
    THF 723.47
    2-butanone 235.22
    n-pentanol 137.77
    sec-butanol 145.86
    n-hexane 4.14
    ethylene glycol 92.21
    NMP 140.02
    cyclohexane 14.81
    DMSO 251.69
    n-butyl acetate 177.82
    n-octanol 69.95
    chloroform 550.89
    n-propyl acetate 163.29
    acetic acid 258.0
    dichloromethane 415.02
    cyclohexanone 259.45
    propylene glycol 113.59
    isopropyl acetate 203.8
    DMAc 216.67
    2-ethoxyethanol 310.84
    isopentanol 221.44
    n-heptane 7.24
    ethyl formate 188.04
    1,2-dichloroethane 204.39
    n-hexanol 148.22
    2-methoxyethanol 516.66
    isobutyl acetate 135.62
    tetrachloromethane 66.75
    n-pentyl acetate 120.41
    transcutol 990.99
    n-heptanol 86.46
    ethylbenzene 64.75
    MIBK 180.98
    2-propoxyethanol 362.58
    tert-butanol 236.95
    MTBE 162.3
    2-butoxyethanol 213.43
    propionic acid 147.18
    o-xylene 77.79
    formic acid 156.67
    diethyl ether 191.79
    m-xylene 103.47
    p-xylene 83.96
    chlorobenzene 165.65
    dimethyl carbonate 109.43
    n-octane 3.24
    formamide 250.16
    cyclopentanone 315.79
    2-pentanone 204.81
    anisole 194.11
    cyclopentyl methyl ether 187.82
    gamma-butyrolactone 316.2
    1-methoxy-2-propanol 377.35
    pyridine 352.26
    3-pentanone 126.83
    furfural 345.81
    n-dodecane 3.62
    diethylene glycol 337.28
    diisopropyl ether 59.32
    tert-amyl alcohol 125.37
    acetylacetone 292.18
    n-hexadecane 4.24
    acetophenone 160.72
    methyl propionate 168.61
    isopentyl acetate 190.95
    trichloroethylene 433.93
    n-nonanol 66.95
    cyclohexanol 133.61
    benzyl alcohol 171.02
    2-ethylhexanol 83.44
    isooctanol 76.37
    dipropyl ether 85.11
    1,2-dichlorobenzene 136.63
    ethyl lactate 104.03
    propylene carbonate 199.2
    n-methylformamide 207.51
    2-pentanol 137.94
    n-pentane 7.92
    1-propoxy-2-propanol 228.79
    1-methoxy-2-propyl acetate 258.69
    2-(2-methoxypropoxy) propanol 196.83
    mesitylene 59.19
    ε-caprolactone 233.22
    p-cymene 52.69
    epichlorohydrin 405.62
    1,1,1-trichloroethane 174.89
    2-aminoethanol 164.0
    morpholine-4-carbaldehyde 301.16
    sulfolane 225.1
    2,2,4-trimethylpentane 6.4
    2-methyltetrahydrofuran 268.34
    n-hexyl acetate 144.03
    isooctane 8.09
    2-(2-butoxyethoxy)ethanol 296.52
    sec-butyl acetate 129.83
    tert-butyl acetate 199.21
    decalin 9.46
    glycerin 173.98
    diglyme 564.67
    acrylic acid 141.05
    isopropyl myristate 61.86
    n-butyric acid 239.89
    acetyl acetate 185.92
    di(2-ethylhexyl) phthalate 74.17
    ethyl propionate 128.8
    nitromethane 353.36
    1,2-diethoxyethane 251.81
    benzonitrile 212.71
    trioctyl phosphate 51.16
    1-bromopropane 106.15
    gamma-valerolactone 474.51
    n-decanol 48.69
    triethyl phosphate 69.45
    4-methyl-2-pentanol 113.77
    propionitrile 204.36
    vinylene carbonate 232.2
    1,1,2-trichlorotrifluoroethane 282.5
    DMS 127.31
    cumene 50.03
    2-octanol 52.62
    2-hexanone 145.45
    octyl acetate 72.37
    limonene 56.68
    1,2-dimethoxyethane 454.15
    ethyl orthosilicate 70.75
    tributyl phosphate 60.06
    diacetone alcohol 211.32
    N,N-dimethylaniline 103.07
    acrylonitrile 235.66
    aniline 183.41
    1,3-propanediol 312.15
    bromobenzene 157.8
    dibromomethane 233.46
    1,1,2,2-tetrachloroethane 304.08
    2-methyl-cyclohexyl acetate 115.35
    tetrabutyl urea 70.52
    diisobutyl methanol 66.96
    2-phenylethanol 174.04
    styrene 80.42
    dioctyl adipate 90.05
    dimethyl sulfate 117.88
    ethyl butyrate 133.17
    methyl lactate 130.71
    butyl lactate 120.9
    diethyl carbonate 103.89
    propanediol butyl ether 197.73
    triethyl orthoformate 112.71
    p-tert-butyltoluene 52.17
    methyl 4-tert-butylbenzoate 134.36
    morpholine 491.58
    tert-butylamine 134.03
    n-dodecanol 35.91
    dimethoxymethane 355.91
    ethylene carbonate 210.37
    cyrene 169.32
    2-ethoxyethyl acetate 212.7
    2-ethylhexyl acetate 134.64
    1,2,4-trichlorobenzene 156.9
    4-methylpyridine 285.2
    dibutyl ether 70.82
    2,6-dimethyl-4-heptanol 66.96
    DEF 150.52
    dimethyl isosorbide 270.59
    tetrachloroethylene 197.22
    eugenol 150.23
    triacetin 170.33
    span 80 145.8
    1,4-butanediol 109.03
    1,1-dichloroethane 213.08
    2-methyl-1-pentanol 120.27
    methyl formate 167.63
    2-methyl-1-butanol 153.6
    n-decane 5.96
    butyronitrile 232.22
    3,7-dimethyl-1-octanol 85.8
    1-chlorooctane 31.81
    1-chlorotetradecane 13.67
    n-nonane 4.68
    undecane 4.46
    tert-butylcyclohexane 8.75
    cyclooctane 6.18
    cyclopentanol 139.71
    tetrahydropyran 350.51
    tert-amyl methyl ether 92.85
    2,5,8-trioxanonane 329.84
    1-hexene 25.57
    2-isopropoxyethanol 205.86
    2,2,2-trifluoroethanol 108.78
    methyl butyrate 158.73

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction