1,4-Epoxycyclohexane

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  • Identifiers

    CAS number
    279-49-2

    Molecular formula
    C6H10O

    SMILES
    C1CC2CCC1O2

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Sweet 54.11%
    Mint 50.59%
    Herbal 44.82%
    Woody 43.0%
    Solvent 41.87%
    Camphoreous 38.79%
    Ethereal 36.67%
    Fresh 32.98%
    Green 27.95%
    Musty 26.92%

     

    Flavor
    Sweet 30.77%
    Animal 30.52%
    Alkaline 24.17%
    Amine 23.38%
    Cauliflower 23.05%
    Shrimp 22.26%
    Ammoniacal 22.26%
    Bitter 22.13%
    Warm 21.35%
    Beet 20.52%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    9.03 (weak base)

    Molecular weight
    98.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    123°C

    Flash point

    • 20.51 ˚C est.

  • Synonyms

    • 7-Oxabicyclo[2.2.1]heptane
    • 1,4-Epoxycyclohexane
    • 279-49-2
    • 7-Oxanorbornane
    • 1,4-Oxycyclohexane
    • 3,6-Endoxocyclohexane
    • 3,6-Endooxycyclohexane
    • EINECS 205-998-3
    • 7-OXABICYCLO(2.2.1)HEPTANE
    • Cyclohexane, 1,4-epoxy-
    • Cyclohexane, 3,6-endoxo-
    • 7-oxabicylco[2.2.1]heptane
    • DTXSID10182189
    • Bicyclo[2.2.1]heptane, 7-oxa-
    • NSC 54357
    • 7-oxabicylco(2.2.1)heptane
    • Bicyclo(2.2.1)heptane, 7-oxa-
    • NSC54357
    • MFCD00082342
    • Cyclohexane,4-epoxy-
    • Cyclohexane,6-endoxo-
    • DTXCID70104680
    • NSC-54357
    • 7-Oxabicyclo[2.2.1]heptane, 98%
    • AKOS015916396
    • CS-0450449
    • E0508
    • NS00028391
    • T72216
    • 205-998-3

  • Applications

    1,4-Epoxycyclohexane is primarily used as a reactive intermediate in the synthesis of cycloaliphatic epoxy resins and related polymers. It serves as a monomer or crosslinking component in epoxy formulations for coatings, adhesives and electronic encapsulants, contributing to improved chemical resistance and higher glass transition temperatures. It can function as a reactive diluent or feedstock for specialty epoxy systems and UV-curable coatings, enabling formulation flexibility in industrial manufacturing. As a precursor to more complex cycloaliphatic epoxy monomers, it supports polymer materials development for coatings, electronics and protective surfaces. Overall, its applications span coatings/inks, adhesives, electronics encapsulation, and polymer synthesis, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 449.94
    methanol 507.42
    isopropanol 308.86
    water 11.04
    ethyl acetate 426.3
    n-propanol 350.19
    acetone 507.62
    n-butanol 259.4
    acetonitrile 622.09
    DMF 466.35
    toluene 152.4
    isobutanol 223.96
    1,4-dioxane 616.22
    methyl acetate 490.15
    THF 620.25
    2-butanone 417.54
    n-pentanol 166.52
    sec-butanol 263.59
    n-hexane 40.38
    ethylene glycol 256.95
    NMP 396.39
    cyclohexane 56.71
    DMSO 465.25
    n-butyl acetate 152.55
    n-octanol 110.62
    chloroform 1827.97
    n-propyl acetate 167.35
    acetic acid 669.83
    dichloromethane 1277.57
    cyclohexanone 327.41
    propylene glycol 349.04
    isopropyl acetate 204.24
    DMAc 424.58
    2-ethoxyethanol 328.9
    isopentanol 179.13
    n-heptane 36.65
    ethyl formate 231.24
    1,2-dichloroethane 468.55
    n-hexanol 165.37
    2-methoxyethanol 549.5
    isobutyl acetate 103.36
    tetrachloromethane 285.24
    n-pentyl acetate 124.08
    transcutol 878.39
    n-heptanol 105.82
    ethylbenzene 68.86
    MIBK 131.23
    2-propoxyethanol 343.52
    tert-butanol 260.21
    MTBE 188.24
    2-butoxyethanol 230.06
    propionic acid 501.79
    o-xylene 95.9
    formic acid 301.79
    diethyl ether 299.8
    m-xylene 91.73
    p-xylene 96.4
    chlorobenzene 236.93
    dimethyl carbonate 165.51
    n-octane 15.53
    formamide 413.12
    cyclopentanone 500.17
    2-pentanone 266.17
    anisole 198.08
    cyclopentyl methyl ether 255.39
    gamma-butyrolactone 593.71
    1-methoxy-2-propanol 417.16
    pyridine 497.14
    3-pentanone 254.7
    furfural 525.73
    n-dodecane 14.36
    diethylene glycol 343.04
    diisopropyl ether 88.16
    tert-amyl alcohol 200.6
    acetylacetone 324.65
    n-hexadecane 15.78
    acetophenone 160.55
    methyl propionate 345.01
    isopentyl acetate 117.3
    trichloroethylene 1040.91
    n-nonanol 104.34
    cyclohexanol 192.29
    benzyl alcohol 166.77
    2-ethylhexanol 87.43
    isooctanol 80.65
    dipropyl ether 155.23
    1,2-dichlorobenzene 208.93
    ethyl lactate 121.5
    propylene carbonate 296.49
    n-methylformamide 385.53
    2-pentanol 180.38
    n-pentane 45.12
    1-propoxy-2-propanol 241.31
    1-methoxy-2-propyl acetate 207.08
    2-(2-methoxypropoxy) propanol 186.15
    mesitylene 53.22
    ε-caprolactone 314.37
    p-cymene 49.02
    epichlorohydrin 604.3
    1,1,1-trichloroethane 594.53
    2-aminoethanol 379.38
    morpholine-4-carbaldehyde 484.41
    sulfolane 451.56
    2,2,4-trimethylpentane 22.68
    2-methyltetrahydrofuran 407.07
    n-hexyl acetate 171.28
    isooctane 15.39
    2-(2-butoxyethoxy)ethanol 286.94
    sec-butyl acetate 113.97
    tert-butyl acetate 165.02
    decalin 26.74
    glycerin 375.32
    diglyme 489.87
    acrylic acid 503.45
    isopropyl myristate 73.34
    n-butyric acid 409.28
    acetyl acetate 308.82
    di(2-ethylhexyl) phthalate 71.73
    ethyl propionate 180.55
    nitromethane 892.27
    1,2-diethoxyethane 240.17
    benzonitrile 208.2
    trioctyl phosphate 49.86
    1-bromopropane 287.16
    gamma-valerolactone 563.92
    n-decanol 76.34
    triethyl phosphate 68.97
    4-methyl-2-pentanol 95.93
    propionitrile 395.73
    vinylene carbonate 307.87
    1,1,2-trichlorotrifluoroethane 615.74
    DMS 164.92
    cumene 50.48
    2-octanol 66.78
    2-hexanone 154.74
    octyl acetate 97.52
    limonene 71.01
    1,2-dimethoxyethane 342.25
    ethyl orthosilicate 66.68
    tributyl phosphate 60.92
    diacetone alcohol 193.15
    N,N-dimethylaniline 108.68
    acrylonitrile 511.12
    aniline 259.71
    1,3-propanediol 322.57
    bromobenzene 244.26
    dibromomethane 768.62
    1,1,2,2-tetrachloroethane 788.25
    2-methyl-cyclohexyl acetate 89.63
    tetrabutyl urea 70.21
    diisobutyl methanol 57.34
    2-phenylethanol 134.6
    styrene 98.02
    dioctyl adipate 102.45
    dimethyl sulfate 206.77
    ethyl butyrate 133.92
    methyl lactate 213.12
    butyl lactate 111.91
    diethyl carbonate 98.23
    propanediol butyl ether 215.95
    triethyl orthoformate 97.94
    p-tert-butyltoluene 47.88
    methyl 4-tert-butylbenzoate 141.78
    morpholine 620.83
    tert-butylamine 179.47
    n-dodecanol 58.65
    dimethoxymethane 317.89
    ethylene carbonate 244.97
    cyrene 147.88
    2-ethoxyethyl acetate 208.51
    2-ethylhexyl acetate 94.36
    1,2,4-trichlorobenzene 272.24
    4-methylpyridine 312.86
    dibutyl ether 122.55
    2,6-dimethyl-4-heptanol 57.34
    DEF 261.5
    dimethyl isosorbide 224.94
    tetrachloroethylene 533.14
    eugenol 143.28
    triacetin 216.15
    span 80 179.57
    1,4-butanediol 150.59
    1,1-dichloroethane 629.02
    2-methyl-1-pentanol 121.81
    methyl formate 266.38
    2-methyl-1-butanol 177.44
    n-decane 23.78
    butyronitrile 268.88
    3,7-dimethyl-1-octanol 98.09
    1-chlorooctane 73.91
    1-chlorotetradecane 33.11
    n-nonane 23.21
    undecane 17.69
    tert-butylcyclohexane 25.73
    cyclooctane 24.37
    cyclopentanol 275.99
    tetrahydropyran 407.81
    tert-amyl methyl ether 146.03
    2,5,8-trioxanonane 319.54
    1-hexene 107.33
    2-isopropoxyethanol 209.68
    2,2,2-trifluoroethanol 344.56
    methyl butyrate 186.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction