Molecular formula
C20H22N2O2

SMILES
CC1=CC=CC=C1C(=O)N2CCN(CC2)C(=O)C3=CC=CC=C3C

Fragrance
Odorless	37.85%
Grape	33.4%
Floral	29.06%
Sweet	28.29%
Neroli	27.96%
Bitter	26.56%
Animal	22.84%
Honey	22.76%
Citrus	21.64%
Fruity	21.02%

 

Flavor
Bitter	77.43%
Odorless	26.73%
Very strong	20.63%
Nitrile	20.31%
Indole	20.08%
Bread crust	19.95%
Cereal	19.66%
Lovage	19.48%
Orange flower	19.48%
Cedarleaf	19.43%

 

Odor impact est.
Low

XLogP3-AA
3.0

pKa est.
5.37 (weak acid)

Molecular weight
322.4 g/mol

Vapor pressure est.

• hPa @ 20°C
• hPa @ 25°C

Evaporation rate
Ultra slow

Boiling point est.
514°C

Flash point

• 208.71 ˚C est.

• NSC632538
• 1,4-Bis(2-methylbenzoyl)piperazine
• Oprea1_056045
• Oprea1_153508
• CHEMBL1994113
• SCHEMBL10722320
• AKOS000595739
• CCG-311180
• NSC-632538
• NCI60_010651
• SR-01000370368
• SR-01000370368-1
• Z62471012
• [4-(2-methylbenzoyl)piperazin-1-yl]-(o-tolyl)methanone

1,4-Bis(2-methylbenzoyl)piperazine is primarily used as an organic synthesis intermediate, providing a di-functional piperazine scaffold for the preparation of newer drug-like molecules in pharmaceutical research and development; in polymer and coatings chemistries it can serve as a building block for polyamide/polyurea segments or as a reactive crosslinking/functionalized diaryl amide intermediate used in specialty formulations; it may be evaluated as a precursor for certain specialty chemicals in coatings and inks, enabling functional materials with tailored properties; in broader industrial manufacturing it appears as an intermediate in multi-step syntheses within chemical production, with use limited by regulatory requirements and formulation constraints.

gpt-5-nano

Solvent	Solubility (g/L)
ethanol	16.39
methanol	18.91
isopropanol	9.07
water	0.23
ethyl acetate	24.56
n-propanol	15.03
acetone	35.04
n-butanol	12.06
acetonitrile	25.76
DMF	64.2
toluene	20.59
isobutanol	9.77
1,4-dioxane	51.64
methyl acetate	29.7
THF	61.48
2-butanone	47.17
n-pentanol	14.27
sec-butanol	9.89
n-hexane	0.5
ethylene glycol	3.13
NMP	54.12
cyclohexane	1.08
DMSO	46.97
n-butyl acetate	21.54
n-octanol	6.52
chloroform	254.65
n-propyl acetate	21.66
acetic acid	26.66
dichloromethane	291.05
cyclohexanone	73.74
propylene glycol	3.33
isopropyl acetate	12.31
DMAc	75.52
2-ethoxyethanol	34.05
isopentanol	10.12
n-heptane	0.47
ethyl formate	40.32
1,2-dichloroethane	123.13
n-hexanol	10.9
2-methoxyethanol	37.58
isobutyl acetate	10.81
tetrachloromethane	17.09
n-pentyl acetate	21.68
transcutol	31.05
n-heptanol	9.68
ethylbenzene	10.71
MIBK	13.2
2-propoxyethanol	30.8
tert-butanol	7.54
MTBE	4.81
2-butoxyethanol	26.01
propionic acid	21.99
o-xylene	11.58
formic acid	19.68
diethyl ether	10.94
m-xylene	9.45
p-xylene	14.87
chlorobenzene	47.5
dimethyl carbonate	14.39
n-octane	0.47
formamide	45.46
cyclopentanone	81.57
2-pentanone	27.67
anisole	17.63
cyclopentyl methyl ether	14.8
gamma-butyrolactone	94.35
1-methoxy-2-propanol	19.96
pyridine	107.24
3-pentanone	24.61
furfural	110.47
n-dodecane	0.42
diethylene glycol	21.32
diisopropyl ether	1.97
tert-amyl alcohol	8.34
acetylacetone	28.9
n-hexadecane	0.49
acetophenone	31.41
methyl propionate	24.79
isopentyl acetate	16.69
trichloroethylene	257.33
n-nonanol	7.14
cyclohexanol	10.98
benzyl alcohol	28.23
2-ethylhexanol	6.96
isooctanol	7.85
dipropyl ether	6.0
1,2-dichlorobenzene	45.07
ethyl lactate	13.64
propylene carbonate	46.46
n-methylformamide	48.84
2-pentanol	5.98
n-pentane	0.42
1-propoxy-2-propanol	16.5
1-methoxy-2-propyl acetate	20.93
2-(2-methoxypropoxy) propanol	15.72
mesitylene	4.65
ε-caprolactone	55.66
p-cymene	5.83
epichlorohydrin	131.25
1,1,1-trichloroethane	50.71
2-aminoethanol	8.19
morpholine-4-carbaldehyde	66.04
sulfolane	76.64
2,2,4-trimethylpentane	0.37
2-methyltetrahydrofuran	30.86
n-hexyl acetate	17.18
isooctane	0.22
2-(2-butoxyethoxy)ethanol	21.82
sec-butyl acetate	10.42
tert-butyl acetate	9.67
decalin	0.82
glycerin	6.73
diglyme	49.4
acrylic acid	24.09
isopropyl myristate	5.79
n-butyric acid	28.89
acetyl acetate	15.57
di(2-ethylhexyl) phthalate	10.94
ethyl propionate	17.33
nitromethane	63.06
1,2-diethoxyethane	18.47
benzonitrile	39.37
trioctyl phosphate	6.68
1-bromopropane	31.32
gamma-valerolactone	118.29
n-decanol	5.11
triethyl phosphate	10.33
4-methyl-2-pentanol	3.83
propionitrile	28.85
vinylene carbonate	57.47
1,1,2-trichlorotrifluoroethane	67.69
DMS	21.8
cumene	6.36
2-octanol	6.25
2-hexanone	23.88
octyl acetate	8.4
limonene	5.86
1,2-dimethoxyethane	54.81
ethyl orthosilicate	9.06
tributyl phosphate	8.24
diacetone alcohol	15.16
N,N-dimethylaniline	12.49
acrylonitrile	45.34
aniline	24.21
1,3-propanediol	14.64
bromobenzene	43.1
dibromomethane	130.01
1,1,2,2-tetrachloroethane	144.85
2-methyl-cyclohexyl acetate	14.96
tetrabutyl urea	12.23
diisobutyl methanol	3.68
2-phenylethanol	24.53
styrene	12.36
dioctyl adipate	11.13
dimethyl sulfate	23.93
ethyl butyrate	16.36
methyl lactate	13.92
butyl lactate	17.55
diethyl carbonate	12.73
propanediol butyl ether	13.62
triethyl orthoformate	12.18
p-tert-butyltoluene	4.35
methyl 4-tert-butylbenzoate	21.07
morpholine	53.11
tert-butylamine	3.81
n-dodecanol	3.63
dimethoxymethane	35.81
ethylene carbonate	43.57
cyrene	28.0
2-ethoxyethyl acetate	31.2
2-ethylhexyl acetate	14.8
1,2,4-trichlorobenzene	50.47
4-methylpyridine	64.67
dibutyl ether	6.3
2,6-dimethyl-4-heptanol	3.68
DEF	34.17
dimethyl isosorbide	34.81
tetrachloroethylene	105.8
eugenol	25.87
triacetin	19.54
span 80	13.44
1,4-butanediol	8.94
1,1-dichloroethane	64.33
2-methyl-1-pentanol	11.95
methyl formate	41.04
2-methyl-1-butanol	10.37
n-decane	0.75
butyronitrile	24.33
3,7-dimethyl-1-octanol	5.18
1-chlorooctane	4.58
1-chlorotetradecane	1.69
n-nonane	0.6
undecane	0.53
tert-butylcyclohexane	0.66
cyclooctane	0.31
cyclopentanol	14.89
tetrahydropyran	31.18
tert-amyl methyl ether	5.38
2,5,8-trioxanonane	28.78
1-hexene	3.85
2-isopropoxyethanol	20.0
2,2,2-trifluoroethanol	22.13
methyl butyrate	28.86

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