1,3-Thiazole-2-carbaldehyde

Overview IFRA Request a quote

  • Identifiers

    CAS number
    10200-59-6

    Molecular formula
    C4H3NOS

    SMILES
    C1=CSC(=N1)C=O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 73.37%
    Roasted 45.0%
    Sulfurous 39.87%
    Burnt 39.65%
    Popcorn 36.08%
    Meaty 34.33%
    Pungent 33.17%
    Coffee 33.01%
    Vegetable 30.06%
    Alliaceous 28.3%

     

    Flavor
    Nutty 57.51%
    Sulfur 50.28%
    Popcorn 37.29%
    Roasted 33.1%
    Chocolate 31.76%
    Roast 31.64%
    Bread 30.2%
    Coffee 29.43%
    Chip 29.43%
    Hazelnut 29.1%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.7

    pKa est.
    3.95 (weak acid)

    Molecular weight
    113.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    209°C

    Flash point

    • 76.53 ˚C est.

  • Synonyms

    • 1,3-thiazole-2-carbaldehyde
    • RefChem:415729
    • 688-154-0
    • 2-Thiazolecarboxaldehyde
    • 10200-59-6
    • thiazole-2-carbaldehyde
    • 2-Formylthiazole
    • Thiazole-2-carboxaldehyde
    • MFCD00142924
    • 1,3-THIAZOLE-2-CARBOXALDEHYDE
    • 2-formyl thiazole
    • 2-THIAZOLE CARBOXALDEHYDE
    • Thiazolecarboxaldehyde
    • 2-KETOTHIAZOLE
    • 2-thiazolecarbaldehyde
    • 2-thiazolecaboxaldehyde
    • thiazol-2-carbaldehyde
    • thiazol-2-carboxaldehyde
    • 2-thiazole-carboxaldehyde
    • SCHEMBL28811
    • SCHEMBL193706
    • 2-Thiazolecarboxaldehyde, 97%
    • SCHEMBL3183875
    • SCHEMBL27300889
    • DTXSID70370565
    • STR04048
    • GEO-02295
    • SBB052286
    • STL583918
    • TD8063
    • AKOS005169182
    • CS-W002420
    • FT11831
    • PB12109
    • PS-3722
    • AC-33308
    • BP-12619
    • SY005879
    • DB-006220
    • F0303
    • ST51061562
    • EN300-66987
    • 2-Formylthiazole; 1,3-Thiazole-2-carbaldehyde
    • 200T596
    • F046294
    • Q27462131
    • InChI=1/C4H3NOS/c6-3-4-5-1-2-7-4/h1-3
    • 10200-59-6

  • Applications

    1,3-Thiazole-2-carbaldehyde is commonly used as an intermediate in the synthesis of thiazole-containing compounds, serving as a building block for pharmaceutical and agrochemical candidates. It may function as a fragrance intermediate in perfumery, and as a precursor to dyes and pigments for coatings, inks, and plastics. The aldehyde enables Schiff base/imine chemistry, making it suitable for polymer and adhesive applications via crosslinking or as a reactive monomer. It can also act as a starting material or ligand precursor in the preparation of metal complexes for catalysis and advanced materials. In research and formulation work, it is used as a versatile heterocyclic aldehyde building block subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 12.64
    methanol 22.06
    isopropanol 8.36
    water 5.76
    ethyl acetate 9.74
    n-propanol 11.64
    acetone 19.04
    n-butanol 10.18
    acetonitrile 14.52
    DMF 124.87
    toluene 2.03
    isobutanol 8.45
    1,4-dioxane 19.46
    methyl acetate 18.25
    THF 27.45
    2-butanone 19.51
    n-pentanol 11.2
    sec-butanol 8.83
    n-hexane 0.32
    ethylene glycol 19.08
    NMP 128.86
    cyclohexane 0.61
    DMSO 115.55
    n-butyl acetate 11.95
    n-octanol 8.86
    chloroform 11.37
    n-propyl acetate 11.8
    acetic acid 27.39
    dichloromethane 12.16
    cyclohexanone 31.51
    propylene glycol 10.3
    isopropyl acetate 6.5
    DMAc 102.75
    2-ethoxyethanol 36.41
    isopentanol 9.84
    n-heptane 1.21
    ethyl formate 14.65
    1,2-dichloroethane 12.0
    n-hexanol 11.52
    2-methoxyethanol 51.4
    isobutyl acetate 7.31
    tetrachloromethane 2.76
    n-pentyl acetate 10.63
    transcutol 122.67
    n-heptanol 8.85
    ethylbenzene 2.42
    MIBK 9.94
    2-propoxyethanol 31.43
    tert-butanol 11.97
    MTBE 5.38
    2-butoxyethanol 25.47
    propionic acid 20.33
    o-xylene 3.91
    formic acid 41.87
    diethyl ether 4.71
    m-xylene 2.89
    p-xylene 4.04
    chlorobenzene 6.67
    dimethyl carbonate 12.82
    n-octane 0.55
    formamide 74.04
    cyclopentanone 36.7
    2-pentanone 12.55
    anisole 11.53
    cyclopentyl methyl ether 11.97
    gamma-butyrolactone 47.14
    1-methoxy-2-propanol 32.21
    pyridine 21.55
    3-pentanone 11.9
    furfural 64.7
    n-dodecane 0.64
    diethylene glycol 42.39
    diisopropyl ether 2.2
    tert-amyl alcohol 12.11
    acetylacetone 18.67
    n-hexadecane 0.72
    acetophenone 20.37
    methyl propionate 14.45
    isopentyl acetate 10.82
    trichloroethylene 27.25
    n-nonanol 8.59
    cyclohexanol 10.51
    benzyl alcohol 14.24
    2-ethylhexanol 9.03
    isooctanol 7.73
    dipropyl ether 7.79
    1,2-dichlorobenzene 10.55
    ethyl lactate 15.81
    propylene carbonate 23.03
    n-methylformamide 54.45
    2-pentanol 6.69
    n-pentane 0.37
    1-propoxy-2-propanol 23.49
    1-methoxy-2-propyl acetate 18.32
    2-(2-methoxypropoxy) propanol 36.15
    mesitylene 2.78
    ε-caprolactone 27.43
    p-cymene 4.8
    epichlorohydrin 33.24
    1,1,1-trichloroethane 8.55
    2-aminoethanol 23.33
    morpholine-4-carbaldehyde 94.02
    sulfolane 82.97
    2,2,4-trimethylpentane 0.53
    2-methyltetrahydrofuran 17.13
    n-hexyl acetate 14.07
    isooctane 0.43
    2-(2-butoxyethoxy)ethanol 45.51
    sec-butyl acetate 7.33
    tert-butyl acetate 9.3
    decalin 0.76
    glycerin 30.87
    diglyme 79.2
    acrylic acid 26.2
    isopropyl myristate 7.29
    n-butyric acid 16.85
    acetyl acetate 8.47
    di(2-ethylhexyl) phthalate 10.39
    ethyl propionate 10.6
    nitromethane 69.35
    1,2-diethoxyethane 18.95
    benzonitrile 15.79
    trioctyl phosphate 7.98
    1-bromopropane 3.72
    gamma-valerolactone 59.39
    n-decanol 6.97
    triethyl phosphate 10.88
    4-methyl-2-pentanol 5.47
    propionitrile 12.89
    vinylene carbonate 25.32
    1,1,2-trichlorotrifluoroethane 59.75
    DMS 15.48
    cumene 3.2
    2-octanol 5.93
    2-hexanone 14.08
    octyl acetate 9.87
    limonene 6.73
    1,2-dimethoxyethane 45.14
    ethyl orthosilicate 9.69
    tributyl phosphate 9.76
    diacetone alcohol 22.39
    N,N-dimethylaniline 13.89
    acrylonitrile 22.79
    aniline 8.95
    1,3-propanediol 22.62
    bromobenzene 4.61
    dibromomethane 6.28
    1,1,2,2-tetrachloroethane 21.96
    2-methyl-cyclohexyl acetate 13.29
    tetrabutyl urea 17.63
    diisobutyl methanol 5.85
    2-phenylethanol 15.0
    styrene 2.98
    dioctyl adipate 13.93
    dimethyl sulfate 34.55
    ethyl butyrate 12.11
    methyl lactate 20.56
    butyl lactate 15.35
    diethyl carbonate 10.14
    propanediol butyl ether 27.44
    triethyl orthoformate 11.51
    p-tert-butyltoluene 4.44
    methyl 4-tert-butylbenzoate 23.61
    morpholine 27.94
    tert-butylamine 6.27
    n-dodecanol 5.6
    dimethoxymethane 30.46
    ethylene carbonate 16.6
    cyrene 40.6
    2-ethoxyethyl acetate 17.24
    2-ethylhexyl acetate 8.95
    1,2,4-trichlorobenzene 14.85
    4-methylpyridine 16.7
    dibutyl ether 7.59
    2,6-dimethyl-4-heptanol 5.85
    DEF 33.34
    dimethyl isosorbide 51.48
    tetrachloroethylene 17.75
    eugenol 29.21
    triacetin 22.42
    span 80 26.02
    1,4-butanediol 14.56
    1,1-dichloroethane 6.71
    2-methyl-1-pentanol 10.61
    methyl formate 36.32
    2-methyl-1-butanol 9.47
    n-decane 0.86
    butyronitrile 11.02
    3,7-dimethyl-1-octanol 9.08
    1-chlorooctane 3.89
    1-chlorotetradecane 2.08
    n-nonane 0.74
    undecane 0.74
    tert-butylcyclohexane 0.77
    cyclooctane 0.33
    cyclopentanol 14.53
    tetrahydropyran 10.64
    tert-amyl methyl ether 6.71
    2,5,8-trioxanonane 66.21
    1-hexene 1.48
    2-isopropoxyethanol 22.45
    2,2,2-trifluoroethanol 30.14
    methyl butyrate 16.04

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction