1,3-Dimethoxybenzene

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  • Identifiers

    CAS number
    151-10-0

    Molecular formula
    C8H10O2

    SMILES
    COC1=CC(=CC=C1)OC

  • Odor profile

    Fragrance
    Sweet 82.96%
    Fruity 59.29%
    Anisic 58.39%
    Nutty 54.53%
    Phenolic 53.34%
    Spicy 47.06%
    Earthy 46.07%
    Vanilla 41.5%
    Floral 40.19%
    Green 38.07%

     

    Flavor
    Fruity 67.85%
    Green 39.8%
    Sweet 35.37%
    Musty 32.91%
    Earthy 30.04%
    Phenolic 29.17%
    Bitter 28.23%
    Floral 27.18%
    Creamy 24.91%
    Nutty 24.03%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    6.97 (neutral)

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Melting point expt.

    • -52 °C

    Boiling point

    • 85.00 to 87.00 °C. @ 7.00 mm Hg

    Flash point

    • 72.74 ˚C est.

    Solubility expt.

    • Slightly soluble in water
    • soluble (in ethanol)

  • Synonyms

    • 1,3-Dimethoxybenzene
    • 151-10-0
    • Benzene, 1,3-dimethoxy-
    • M-DIMETHOXYBENZENE
    • Resorcinol dimethyl ether
    • 3-Methoxyanisole
    • Benzene, m-dimethoxy-
    • Dimethyl resorcinol
    • Methoxyanisole, m-
    • m-Methoxyanisole
    • Dimethylresorcinol
    • Dimethylether resorcinolu
    • FEMA No. 2385
    • m-dimethoxy-benzene
    • m-Dimethoxy benzene
    • 1,3-DIMETHOXY BENZENE
    • Dimethylether resorcinolu [Czech]
    • NSC 8699
    • EINECS 205-783-4
    • UNII-2694Z07HQY
    • DTXSID2047060
    • AI3-00845
    • 1,3-Dimethoxy-benzene
    • 2694Z07HQY
    • NSC-8699
    • meta-dimethyl hydroquinone
    • 1,3-DIMETHOXYBENZEN-2,4,5,6-D4
    • DTXCID0027060
    • CHEBI:89853
    • M-DIMETHOXYBENZENE [FHFI]
    • 3-METHOXYPHENYL METHYL ETHER
    • mMethoxyanisole
    • 3Methoxyanisole
    • mDimethoxybenzene
    • Methoxyanisole, m
    • Benzene, mdimethoxy
    • meta-dimethoxybenzene
    • MFCD00008384
    • 1,3 dimethoxybenzene
    • Benzene,3-dimethoxy-
    • resorcinol dimethylether
    • Benzene, 1,3dimethoxy
    • SCHEMBL9350
    • CHEMBL2252486
    • SCHEMBL13322163
    • 1,3-Dimethoxybenzene, >=98%
    • NSC8699
    • STR00616
    • Tox21_302348
    • 1,3-Dimethoxybenzene, >=98%, FG
    • AKOS000120162
    • CS-W018510
    • FD02251
    • NCGC00256016-01
    • 1,3-Dimethoxybenzene, analytical standard
    • CAS-151-10-0
    • HY-34487
    • DB-013763
    • D0628
    • NS00013171
    • EN300-16149
    • Resorcinol dimethyl ether;2,4-Dimethoxybenzene
    • Q27162036
    • F0001-0538
    • 205-783-4

  • Applications

    1,3-Dimethoxybenzene (CAS 151-10-0), also known as m-dimethoxybenzene or resorcinol dimethyl ether, is a versatile aromatic compound widely employed across industry and academia due to its mild pleasant odor, chemical stability and selective electrophilic substitution behavior; in fragrance and cosmetic formulations it is valued as a note-building ingredient that imparts warm woody-sweet nuances to fine perfumes, soaps and scented candles; in pharmaceuticals it serves as an intermediate for semi-synthetic antibiotics, anticonvulsants and anti-inflammatory agents because the meta-disubstituted benzene core can be readily functionalized; in agrochemistry it is a key precursor for herbicides and plant growth regulators; in materials science it is incorporated into epoxy resins and high-performance polymers as a viscosity modifier and thermal resistance enhancer; additionally 1,3-Dimethoxybenzene is utilized as a specialized solvent, a GC-MS reference standard and a mechanistic probe in theoretical and computational studies focusing on the electronic effects in substituted aromatic rings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 577.32
    methanol 523.23
    isopropanol 450.66
    water 5.03
    ethyl acetate 554.37
    n-propanol 475.01
    acetone 557.97
    n-butanol 348.4
    acetonitrile 808.48
    DMF 923.13
    toluene 309.87
    isobutanol 318.38
    1,4-dioxane 1376.05
    methyl acetate 703.84
    THF 869.35
    2-butanone 479.52
    n-pentanol 207.39
    sec-butanol 383.87
    n-hexane 46.37
    ethylene glycol 401.32
    NMP 480.02
    cyclohexane 183.81
    DMSO 1170.24
    n-butyl acetate 166.35
    n-octanol 118.5
    chloroform 2178.82
    n-propyl acetate 208.11
    acetic acid 567.73
    dichloromethane 1981.65
    cyclohexanone 495.51
    propylene glycol 368.92
    isopropyl acetate 189.17
    DMAc 638.74
    2-ethoxyethanol 471.3
    isopentanol 195.79
    n-heptane 70.89
    ethyl formate 483.1
    1,2-dichloroethane 970.64
    n-hexanol 222.58
    2-methoxyethanol 919.78
    isobutyl acetate 106.17
    tetrachloromethane 450.42
    n-pentyl acetate 108.34
    transcutol 550.25
    n-heptanol 98.21
    ethylbenzene 140.44
    MIBK 133.38
    2-propoxyethanol 403.28
    tert-butanol 516.98
    MTBE 296.81
    2-butoxyethanol 179.0
    propionic acid 501.17
    o-xylene 211.16
    formic acid 203.01
    diethyl ether 417.94
    m-xylene 168.64
    p-xylene 182.58
    chlorobenzene 367.68
    dimethyl carbonate 237.79
    n-octane 28.6
    formamide 378.84
    cyclopentanone 560.75
    2-pentanone 283.01
    anisole 303.2
    cyclopentyl methyl ether 371.59
    gamma-butyrolactone 748.62
    1-methoxy-2-propanol 538.36
    pyridine 826.19
    3-pentanone 289.37
    furfural 670.78
    n-dodecane 24.36
    diethylene glycol 430.22
    diisopropyl ether 87.59
    tert-amyl alcohol 340.43
    acetylacetone 352.79
    n-hexadecane 27.42
    acetophenone 236.25
    methyl propionate 511.85
    isopentyl acetate 124.82
    trichloroethylene 1533.67
    n-nonanol 104.64
    cyclohexanol 403.96
    benzyl alcohol 259.96
    2-ethylhexanol 125.19
    isooctanol 75.81
    dipropyl ether 191.09
    1,2-dichlorobenzene 312.12
    ethyl lactate 148.28
    propylene carbonate 411.19
    n-methylformamide 577.77
    2-pentanol 208.17
    n-pentane 59.89
    1-propoxy-2-propanol 227.98
    1-methoxy-2-propyl acetate 212.38
    2-(2-methoxypropoxy) propanol 167.02
    mesitylene 100.21
    ε-caprolactone 451.19
    p-cymene 86.27
    epichlorohydrin 929.11
    1,1,1-trichloroethane 975.57
    2-aminoethanol 471.89
    morpholine-4-carbaldehyde 726.75
    sulfolane 730.69
    2,2,4-trimethylpentane 29.1
    2-methyltetrahydrofuran 601.09
    n-hexyl acetate 166.29
    isooctane 20.18
    2-(2-butoxyethoxy)ethanol 228.97
    sec-butyl acetate 115.45
    tert-butyl acetate 181.22
    decalin 58.24
    glycerin 475.79
    diglyme 487.96
    acrylic acid 447.47
    isopropyl myristate 79.83
    n-butyric acid 438.19
    acetyl acetate 329.71
    di(2-ethylhexyl) phthalate 78.42
    ethyl propionate 220.4
    nitromethane 958.55
    1,2-diethoxyethane 215.36
    benzonitrile 340.56
    trioctyl phosphate 57.88
    1-bromopropane 485.06
    gamma-valerolactone 673.28
    n-decanol 81.67
    triethyl phosphate 109.37
    4-methyl-2-pentanol 84.48
    propionitrile 531.45
    vinylene carbonate 463.36
    1,1,2-trichlorotrifluoroethane 754.21
    DMS 189.82
    cumene 89.76
    2-octanol 71.49
    2-hexanone 169.52
    octyl acetate 102.86
    limonene 131.03
    1,2-dimethoxyethane 678.89
    ethyl orthosilicate 99.38
    tributyl phosphate 68.36
    diacetone alcohol 233.59
    N,N-dimethylaniline 191.87
    acrylonitrile 655.32
    aniline 400.25
    1,3-propanediol 502.18
    bromobenzene 415.16
    dibromomethane 1216.17
    1,1,2,2-tetrachloroethane 1239.62
    2-methyl-cyclohexyl acetate 126.97
    tetrabutyl urea 96.23
    diisobutyl methanol 78.9
    2-phenylethanol 198.91
    styrene 191.78
    dioctyl adipate 119.44
    dimethyl sulfate 356.26
    ethyl butyrate 178.99
    methyl lactate 270.78
    butyl lactate 98.18
    diethyl carbonate 157.33
    propanediol butyl ether 164.14
    triethyl orthoformate 127.09
    p-tert-butyltoluene 87.22
    methyl 4-tert-butylbenzoate 177.9
    morpholine 1275.96
    tert-butylamine 290.29
    n-dodecanol 68.61
    dimethoxymethane 579.4
    ethylene carbonate 390.9
    cyrene 192.39
    2-ethoxyethyl acetate 162.48
    2-ethylhexyl acetate 102.9
    1,2,4-trichlorobenzene 379.28
    4-methylpyridine 599.06
    dibutyl ether 129.09
    2,6-dimethyl-4-heptanol 78.9
    DEF 443.9
    dimethyl isosorbide 277.1
    tetrachloroethylene 814.25
    eugenol 170.23
    triacetin 191.5
    span 80 151.14
    1,4-butanediol 202.16
    1,1-dichloroethane 991.51
    2-methyl-1-pentanol 140.9
    methyl formate 517.77
    2-methyl-1-butanol 219.86
    n-decane 37.27
    butyronitrile 404.77
    3,7-dimethyl-1-octanol 101.71
    1-chlorooctane 108.51
    1-chlorotetradecane 50.32
    n-nonane 38.89
    undecane 28.93
    tert-butylcyclohexane 45.82
    cyclooctane 54.77
    cyclopentanol 442.16
    tetrahydropyran 861.98
    tert-amyl methyl ether 213.05
    2,5,8-trioxanonane 353.78
    1-hexene 123.66
    2-isopropoxyethanol 259.11
    2,2,2-trifluoroethanol 268.75
    methyl butyrate 280.86

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction