1,3-Dimethoxy-2-propanol

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  • Identifiers

    CAS number
    623-69-8

    Molecular formula
    C5H12O3

    SMILES
    COCC(COC)O

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Ethereal 56.45%
    Alcoholic 42.52%
    Fruity 38.82%
    Sweet 38.34%
    Odorless 32.41%
    Solvent 31.54%
    Fermented 25.87%
    Buttery 23.42%
    Musty 22.17%
    Fresh 21.65%

     

    Flavor
    Alcoholic 39.91%
    Sweet 38.82%
    Odorless 34.75%
    Bitter 34.62%
    Musty 31.51%
    Creamy 25.92%
    Vegetable 25.46%
    Very slight 24.89%
    Oily 24.55%
    Fatty 24.08%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.7

    pKa est.
    6.16 (neutral)

    Molecular weight
    120.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    172°C

    Flash point

    • 68.39 ˚C est.

  • Synonyms

    • 1,3-DIMETHOXY-2-PROPANOL
    • RefChem:414506
    • 801-583-1
    • 1,3-dimethoxypropan-2-ol
    • 623-69-8
    • 2-Propanol, 1,3-dimethoxy-
    • Glycerol 1,3-dimethyl ether
    • Glycerin 1,3-dimethyl ether
    • MFCD01076303
    • A0JF0DT9XK
    • 1,3-dimethoxy-2-hydroxypropane
    • NSC-263483
    • UNII-A0JF0DT9XK
    • AI3-03551
    • NSC263483
    • 2-Propanol,3-dimethoxy-
    • 1,3-dimethoxy-propan-2-ol
    • glycerol-1,3-dimethyl ether
    • SCHEMBL55052
    • SCHEMBL4492370
    • SCHEMBL6434717
    • SCHEMBL6435529
    • DTXSID30211364
    • 1 pound not3-Dimethoxypropan-2-ol
    • AKOS006345951
    • CS-W018661
    • NSC 263483
    • AS-17261
    • SY021402
    • NS00127163
    • EN300-97405
    • D23150
    • 623D698
    • F078746
    • Q27273467
    • 623-69-8

  • Applications

    1,3-Dimethoxy-2-propanol is primarily used as a solvent and reaction medium in industrial manufacturing; it serves as a polyol component in polyurethane and other polymer systems; it acts as an intermediate for the synthesis of functional organic compounds and ether derivatives; it is used as a co-solvent in coatings, inks, and adhesives; and it may function as a precursor for more complex organic synthesis and specialty chemical products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1702.22
    methanol 4046.48
    isopropanol 679.19
    water 553.15
    ethyl acetate 82.05
    n-propanol 827.89
    acetone 151.27
    n-butanol 535.33
    acetonitrile 260.83
    DMF 746.55
    toluene 17.8
    isobutanol 324.03
    1,4-dioxane 601.71
    methyl acetate 140.91
    THF 438.3
    2-butanone 92.49
    n-pentanol 200.39
    sec-butanol 364.43
    n-hexane 10.65
    ethylene glycol 1511.48
    NMP 390.95
    cyclohexane 53.01
    DMSO 560.52
    n-butyl acetate 47.14
    n-octanol 56.94
    chloroform 471.84
    n-propyl acetate 46.66
    acetic acid 2519.16
    dichloromethane 436.44
    cyclohexanone 165.01
    propylene glycol 793.63
    isopropyl acetate 24.43
    DMAc 323.4
    2-ethoxyethanol 520.93
    isopentanol 151.67
    n-heptane 23.73
    ethyl formate 223.1
    1,2-dichloroethane 162.23
    n-hexanol 159.8
    2-methoxyethanol 1634.85
    isobutyl acetate 21.24
    tetrachloromethane 95.44
    n-pentyl acetate 28.24
    transcutol 402.38
    n-heptanol 67.17
    ethylbenzene 9.94
    MIBK 14.36
    2-propoxyethanol 327.3
    tert-butanol 341.01
    MTBE 62.27
    2-butoxyethanol 162.9
    propionic acid 653.83
    o-xylene 16.45
    formic acid 3006.89
    diethyl ether 119.05
    m-xylene 9.97
    p-xylene 13.95
    chlorobenzene 43.98
    dimethyl carbonate 37.19
    n-octane 5.92
    formamide 1836.5
    cyclopentanone 174.96
    2-pentanone 43.55
    anisole 40.11
    cyclopentyl methyl ether 100.44
    gamma-butyrolactone 285.59
    1-methoxy-2-propanol 472.0
    pyridine 248.7
    3-pentanone 38.28
    furfural 360.27
    n-dodecane 4.28
    diethylene glycol 528.6
    diisopropyl ether 10.09
    tert-amyl alcohol 200.87
    acetylacetone 35.81
    n-hexadecane 4.39
    acetophenone 38.89
    methyl propionate 84.39
    isopentyl acetate 27.92
    trichloroethylene 268.59
    n-nonanol 48.18
    cyclohexanol 332.79
    benzyl alcohol 96.31
    2-ethylhexanol 60.53
    isooctanol 38.81
    dipropyl ether 63.35
    1,2-dichlorobenzene 41.23
    ethyl lactate 67.33
    propylene carbonate 128.17
    n-methylformamide 850.83
    2-pentanol 141.77
    n-pentane 23.78
    1-propoxy-2-propanol 173.07
    1-methoxy-2-propyl acetate 45.89
    2-(2-methoxypropoxy) propanol 94.06
    mesitylene 6.22
    ε-caprolactone 172.89
    p-cymene 13.53
    epichlorohydrin 242.89
    1,1,1-trichloroethane 76.35
    2-aminoethanol 1572.61
    morpholine-4-carbaldehyde 525.27
    sulfolane 260.34
    2,2,4-trimethylpentane 6.64
    2-methyltetrahydrofuran 207.84
    n-hexyl acetate 42.42
    isooctane 2.8
    2-(2-butoxyethoxy)ethanol 146.31
    sec-butyl acetate 18.01
    tert-butyl acetate 18.26
    decalin 7.77
    glycerin 1205.74
    diglyme 273.78
    acrylic acid 715.12
    isopropyl myristate 15.08
    n-butyric acid 468.9
    acetyl acetate 48.89
    di(2-ethylhexyl) phthalate 29.29
    ethyl propionate 35.55
    nitromethane 959.96
    1,2-diethoxyethane 70.35
    benzonitrile 69.13
    trioctyl phosphate 21.17
    1-bromopropane 87.87
    gamma-valerolactone 343.5
    n-decanol 33.47
    triethyl phosphate 31.94
    4-methyl-2-pentanol 31.47
    propionitrile 185.64
    vinylene carbonate 159.66
    1,1,2-trichlorotrifluoroethane 510.11
    DMS 34.33
    cumene 8.14
    2-octanol 30.78
    2-hexanone 32.44
    octyl acetate 26.38
    limonene 26.08
    1,2-dimethoxyethane 390.81
    ethyl orthosilicate 34.21
    tributyl phosphate 23.4
    diacetone alcohol 53.3
    N,N-dimethylaniline 32.73
    acrylonitrile 256.23
    aniline 116.99
    1,3-propanediol 1419.99
    bromobenzene 27.39
    dibromomethane 234.47
    1,1,2,2-tetrachloroethane 217.66
    2-methyl-cyclohexyl acetate 38.58
    tetrabutyl urea 34.55
    diisobutyl methanol 24.62
    2-phenylethanol 64.27
    styrene 14.87
    dioctyl adipate 35.01
    dimethyl sulfate 57.36
    ethyl butyrate 43.39
    methyl lactate 116.79
    butyl lactate 49.16
    diethyl carbonate 35.08
    propanediol butyl ether 139.9
    triethyl orthoformate 46.12
    p-tert-butyltoluene 13.24
    methyl 4-tert-butylbenzoate 42.24
    morpholine 897.86
    tert-butylamine 183.49
    n-dodecanol 25.54
    dimethoxymethane 214.54
    ethylene carbonate 129.59
    cyrene 111.28
    2-ethoxyethyl acetate 44.54
    2-ethylhexyl acetate 23.26
    1,2,4-trichlorobenzene 56.07
    4-methylpyridine 118.83
    dibutyl ether 32.3
    2,6-dimethyl-4-heptanol 24.62
    DEF 144.83
    dimethyl isosorbide 112.19
    tetrachloroethylene 239.53
    eugenol 68.69
    triacetin 52.89
    span 80 107.68
    1,4-butanediol 438.18
    1,1-dichloroethane 107.82
    2-methyl-1-pentanol 75.03
    methyl formate 441.36
    2-methyl-1-butanol 187.15
    n-decane 7.03
    butyronitrile 172.6
    3,7-dimethyl-1-octanol 35.65
    1-chlorooctane 20.19
    1-chlorotetradecane 8.36
    n-nonane 7.13
    undecane 5.06
    tert-butylcyclohexane 5.87
    cyclooctane 10.14
    cyclopentanol 409.36
    tetrahydropyran 332.01
    tert-amyl methyl ether 46.83
    2,5,8-trioxanonane 178.01
    1-hexene 26.05
    2-isopropoxyethanol 182.85
    2,2,2-trifluoroethanol 755.23
    methyl butyrate 64.0

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction