1,3-Diethoxy-2-propanol

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  • Identifiers

    CAS number
    4043-59-8

    Molecular formula
    C7H16O3

    SMILES
    CCOCC(COCC)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 58.52%
    Ethereal 57.67%
    Alcoholic 47.58%
    Sweet 32.68%
    Solvent 32.37%
    Fermented 31.22%
    Oily 26.35%
    Odorless 25.77%
    Buttery 25.05%
    Caramellic 22.36%

     

    Flavor
    Sweet 50.1%
    Alcoholic 35.56%
    Vegetable 30.35%
    Fruit 30.08%
    Odorless 29.41%
    Fruity 28.91%
    Musty 28.41%
    Fatty 27.79%
    Creamy 26.12%
    Oily 25.26%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.02 (neutral)

    Molecular weight
    148.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    189°C

    Flash point

    • 81.8 ˚C est.

  • Synonyms

    • 1,3-Diethoxy-2-propanol
    • 1,3-Diethoxypropan-2-ol
    • Diethylin
    • Glycerol 1,3-diethyl ether
    • 1,3-Glycerine diethyl ether
    • Glycerol 1,3-bis(ethyl ether)
    • Glycerol alpha,gamma-diethyl ether
    • EINECS 223-736-6
    • NSC 403841
    • UNII-2G6N5234UJ
    • Glycerol .alpha.,.gamma.-diethyl ether
    • AI3-02342
    • 2G6N5234UJ
    • NSC-403841
    • DTXSID20193443
    • 1,3-DIETHYL GLYCERIN ETHER
    • RefChem:72649
    • DTXCID30115934
    • 2-Propanol, 1,3-diethoxy-(8CI)
    • 2-Propanol, 1,3-diethoxy-(8CI)(9CI)
    • WIHIUTUAHOZVLE-UHFFFAOYSA-N
    • 4043-59-8
    • 2-Propanol, 1,3-diethoxy-
    • MFCD00026934
    • 34923-32-5
    • 1-Propanol, 1,3-diethoxy-
    • Glycerol alpha,alpha'-Diethyl Ether
    • 1,3-diethyl glycerol
    • 2-Propanol,3-diethoxy-
    • SCHEMBL698450
    • SCHEMBL4486331
    • SCHEMBL6434999
    • SCHEMBL6436206
    • EAA04359
    • NSC403841
    • AKOS006229410
    • SB83894
    • AS-87037
    • SY034272
    • DB-049592
    • CS-0217718
    • D0460
    • NS00030786
    • EN300-83205
    • D87788
    • F238800
    • Q27254699
    • 4043-59-8

  • Applications

    1,3-Diethoxy-2-propanol (CAS 4043-59-8) is used primarily as a specialty solvent in industrial formulations, including coatings, paints, inks, and adhesives, where it dissolves resinous components and helps adjust viscosity. It also serves as a processing solvent and a potential plasticizer or co-solvent in polymer and plastics formulations, aiding resin compatibility and film formation. The compound is employed in cleaning formulations and industrial degreasers as a relatively moderate-evaporating solvent. In chemical manufacturing, it acts as an intermediate for the synthesis of specialty chemicals and other downstream products. In cosmetics/personal care, it may be used as a solvent or humectant in certain formulations, subject to regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 536.43
    methanol 939.57
    isopropanol 354.46
    water 23.44
    ethyl acetate 177.73
    n-propanol 392.84
    acetone 239.97
    n-butanol 306.74
    acetonitrile 222.43
    DMF 498.37
    toluene 60.95
    isobutanol 255.2
    1,4-dioxane 443.62
    methyl acetate 207.29
    THF 485.09
    2-butanone 183.61
    n-pentanol 166.03
    sec-butanol 288.81
    n-hexane 34.16
    ethylene glycol 312.72
    NMP 478.24
    cyclohexane 95.85
    DMSO 558.92
    n-butyl acetate 149.68
    n-octanol 92.83
    chloroform 737.68
    n-propyl acetate 109.46
    acetic acid 950.31
    dichloromethane 577.66
    cyclohexanone 342.89
    propylene glycol 278.85
    isopropyl acetate 95.09
    DMAc 403.62
    2-ethoxyethanol 349.13
    isopentanol 187.23
    n-heptane 40.34
    ethyl formate 186.78
    1,2-dichloroethane 292.54
    n-hexanol 188.06
    2-methoxyethanol 649.41
    isobutyl acetate 77.5
    tetrachloromethane 173.79
    n-pentyl acetate 94.33
    transcutol 501.65
    n-heptanol 89.72
    ethylbenzene 37.92
    MIBK 69.46
    2-propoxyethanol 310.06
    tert-butanol 378.86
    MTBE 181.18
    2-butoxyethanol 167.27
    propionic acid 430.28
    o-xylene 61.22
    formic acid 534.06
    diethyl ether 173.48
    m-xylene 46.12
    p-xylene 63.44
    chlorobenzene 134.53
    dimethyl carbonate 66.39
    n-octane 14.57
    formamide 361.28
    cyclopentanone 347.84
    2-pentanone 117.96
    anisole 91.95
    cyclopentyl methyl ether 203.71
    gamma-butyrolactone 423.45
    1-methoxy-2-propanol 342.69
    pyridine 289.96
    3-pentanone 109.09
    furfural 441.21
    n-dodecane 12.91
    diethylene glycol 374.25
    diisopropyl ether 41.61
    tert-amyl alcohol 269.35
    acetylacetone 142.03
    n-hexadecane 14.15
    acetophenone 105.89
    methyl propionate 146.86
    isopentyl acetate 118.29
    trichloroethylene 569.35
    n-nonanol 81.16
    cyclohexanol 319.41
    benzyl alcohol 124.31
    2-ethylhexanol 111.63
    isooctanol 72.34
    dipropyl ether 117.66
    1,2-dichlorobenzene 139.93
    ethyl lactate 102.47
    propylene carbonate 246.32
    n-methylformamide 319.53
    2-pentanol 159.95
    n-pentane 40.9
    1-propoxy-2-propanol 209.51
    1-methoxy-2-propyl acetate 128.0
    2-(2-methoxypropoxy) propanol 144.7
    mesitylene 35.53
    ε-caprolactone 322.29
    p-cymene 50.15
    epichlorohydrin 373.69
    1,1,1-trichloroethane 287.18
    2-aminoethanol 395.39
    morpholine-4-carbaldehyde 456.51
    sulfolane 508.01
    2,2,4-trimethylpentane 26.03
    2-methyltetrahydrofuran 335.38
    n-hexyl acetate 127.43
    isooctane 13.18
    2-(2-butoxyethoxy)ethanol 185.44
    sec-butyl acetate 74.75
    tert-butyl acetate 97.42
    decalin 31.34
    glycerin 409.2
    diglyme 341.97
    acrylic acid 410.72
    isopropyl myristate 57.22
    n-butyric acid 402.31
    acetyl acetate 158.29
    di(2-ethylhexyl) phthalate 69.28
    ethyl propionate 93.91
    nitromethane 610.97
    1,2-diethoxyethane 156.73
    benzonitrile 153.98
    trioctyl phosphate 54.7
    1-bromopropane 183.31
    gamma-valerolactone 444.03
    n-decanol 58.24
    triethyl phosphate 83.52
    4-methyl-2-pentanol 73.92
    propionitrile 204.1
    vinylene carbonate 252.26
    1,1,2-trichlorotrifluoroethane 568.46
    DMS 112.54
    cumene 36.87
    2-octanol 60.51
    2-hexanone 94.77
    octyl acetate 74.05
    limonene 89.04
    1,2-dimethoxyethane 377.85
    ethyl orthosilicate 83.76
    tributyl phosphate 67.17
    diacetone alcohol 138.57
    N,N-dimethylaniline 80.13
    acrylonitrile 249.59
    aniline 145.34
    1,3-propanediol 430.82
    bromobenzene 118.16
    dibromomethane 392.78
    1,1,2,2-tetrachloroethane 521.45
    2-methyl-cyclohexyl acetate 111.41
    tetrabutyl urea 85.23
    diisobutyl methanol 67.22
    2-phenylethanol 115.3
    styrene 52.45
    dioctyl adipate 99.88
    dimethyl sulfate 137.25
    ethyl butyrate 117.62
    methyl lactate 145.73
    butyl lactate 102.64
    diethyl carbonate 91.02
    propanediol butyl ether 163.68
    triethyl orthoformate 109.28
    p-tert-butyltoluene 49.63
    methyl 4-tert-butylbenzoate 116.09
    morpholine 568.35
    tert-butylamine 236.47
    n-dodecanol 46.5
    dimethoxymethane 199.47
    ethylene carbonate 210.38
    cyrene 160.63
    2-ethoxyethyl acetate 112.79
    2-ethylhexyl acetate 101.12
    1,2,4-trichlorobenzene 174.58
    4-methylpyridine 210.43
    dibutyl ether 91.75
    2,6-dimethyl-4-heptanol 67.22
    DEF 230.24
    dimethyl isosorbide 216.46
    tetrachloroethylene 434.21
    eugenol 122.0
    triacetin 152.23
    span 80 153.39
    1,4-butanediol 182.04
    1,1-dichloroethane 280.92
    2-methyl-1-pentanol 124.15
    methyl formate 237.42
    2-methyl-1-butanol 201.91
    n-decane 20.24
    butyronitrile 188.14
    3,7-dimethyl-1-octanol 87.53
    1-chlorooctane 60.5
    1-chlorotetradecane 27.99
    n-nonane 20.2
    undecane 15.42
    tert-butylcyclohexane 29.12
    cyclooctane 24.56
    cyclopentanol 360.29
    tetrahydropyran 417.53
    tert-amyl methyl ether 136.01
    2,5,8-trioxanonane 247.68
    1-hexene 73.09
    2-isopropoxyethanol 203.14
    2,2,2-trifluoroethanol 344.88
    methyl butyrate 144.77

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction