1,3-Bis-(2,4-diaminophenoxy)propane tetrahydrochloride

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  • Identifiers

    CAS number
    74918-21-1

    Molecular formula
    C15H24Cl4N4O2

    SMILES
    C1=CC(=C(C=C1N)N)OCCCOC2=C(C=C(C=C2)N)N.Cl.Cl.Cl.Cl

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fruity 32.95%
    Odorless 31.63%
    Meaty 29.42%
    Sweet 27.78%
    Burnt 26.48%
    Grape 26.32%
    Animal 24.71%
    Savory 23.65%
    Cooked 20.87%
    Roasted 20.82%

     

    Flavor
    Bitter 55.55%
    Sweet 50.68%
    Fruity 50.61%
    Floral 35.58%
    Mild 32.72%
    Powdery 28.6%
    Grape 25.58%
    Orange blossom 21.87%
    Orange flower 21.76%
    Chocolate 21.13%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.43 (weak acid)

    Molecular weight
    434.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    277°C

    Flash point

    • 268.33 ˚C est.

  • Synonyms

    • 74918-21-1
    • 1,3-BIS(2,4-DIAMINOPHENOXY)PROPANE TETRAHYDROCHLORIDE
    • Colorex 13bis
    • Q80X769AD4
    • EINECS 278-022-7
    • 1,3-bis-(2,4-diaminophenoxy)propane tetrahydrochloride
    • DTXSID40225891
    • 4,4'-(Propane-1,3-diylbis(oxy))bisbenzene-1,3-diamine tetrahydrochloride
    • 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL
    • 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE TETRAHYDROCHLORIDE
    • 1,3-Benzenediamine, 4,4'-[1,3-propanediylbis(oxy)]bis-, tetrahydrochloride
    • 4,4'-[propane-1,3-diylbis(oxy)]bisbenzene-1,3-diamine tetrahydrochloride
    • 1,3-BENZENEDIAMINE, 4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS-, HYDROCHLORIDE (1:4)
    • 1,3-BENZENEDIAMINE, 4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS-, TETRAHYDROCHLORIDE
    • 4,4'-(PROPANE-1,3-DIYLBIS(OXY))BISBENZENE-1,3-DIAMINETETRAHYDROCHLORIDE
    • RefChem:414058
    • DTXCID70148382
    • 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL [INCI]
    • 4,4'-(Propane-1,3-diylbis(oxy))bis(benzene-1,3-diamine) tetrahydrochloride
    • MFCD07368624
    • 1,3-Bis(2,4-diaminophenoxy)propane 4HCl
    • C15H24Cl4N4O2
    • 4-[3-(2,4-diaminophenoxy)propoxy]benzene-1,3-diamine;tetrahydrochloride
    • 1,3-Bis(2,4-diaminophenoxy)propane tetraHCl
    • UNII-Q80X769AD4
    • 1,3-bis(2,4-diaminophenoxy)propane hydrochloride
    • SCHEMBL1426505
    • SCHEMBL30994761
    • MSK15612A
    • UXPUOLAAWYPPLE-UHFFFAOYSA-N
    • 4-[3-(2,4-diaminophenoxy)propoxy]benzene-1,3-diamine tetrahydrochloride
    • AKOS015895592
    • AC-8292
    • DS-2687
    • SY033519
    • NS00022747
    • O11111
    • 1,3-Bis(2,4-diaminophenoxy)propane 4HCl, 80%
    • 918B211
    • Q27287097
    • 4,4'-(PROPANE-1,3-DIYLBIS(OXY))BIS(BENZENE-1,3-DIAMINE) TETRAHCL
    • 4,4'-(Propane-1,3-diylbis(oxy))bis(benzene-1,3-diamine)tetrahydrochloride
    • 4,4'-[Propane-1,3-diylbis(oxy)]di(benzene-1,3-diamine)--hydrogen chloride (1/4)
    • 74918-21-1

  • Applications

    1,3-Bis-(2,4-diaminophenoxy)propane tetrahydrochloride (CAS 74918-21-1) is typically used as a curing agent and crosslinker for epoxy resins in coatings, adhesives, and composite materials, enabling enhanced hardness, chemical resistance, and adhesion. It also serves as an intermediate in the synthesis of specialty dyes and pigment chemistries due to its amine functionality. In electronics and encapsulation or potting formulations, the salt form can facilitate resin formulation and processing. In general polymer formulations, it acts as a bi-functional crosslinker to improve network formation. In waterborne coating systems, the tetrahydrochloride salt can improve handling and formulation compatibility.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.81
    methanol 20.91
    isopropanol 7.03
    water 0.58
    ethyl acetate 12.79
    n-propanol 11.29
    acetone 36.22
    n-butanol 8.98
    acetonitrile 17.67
    DMF 51.52
    toluene 2.12
    isobutanol 5.56
    1,4-dioxane 23.36
    methyl acetate 14.82
    THF 164.55
    2-butanone 20.02
    n-pentanol 7.84
    sec-butanol 6.31
    n-hexane 0.36
    ethylene glycol 6.47
    NMP 48.01
    cyclohexane 0.51
    DMSO 404.12
    n-butyl acetate 5.96
    n-octanol 3.66
    chloroform 22.64
    n-propyl acetate 7.49
    acetic acid 62.42
    dichloromethane 25.46
    cyclohexanone 30.15
    propylene glycol 8.89
    isopropyl acetate 5.86
    DMAc 78.61
    2-ethoxyethanol 36.62
    isopentanol 6.12
    n-heptane 0.66
    ethyl formate 21.16
    1,2-dichloroethane 14.96
    n-hexanol 5.92
    2-methoxyethanol 57.59
    isobutyl acetate 3.84
    tetrachloromethane 2.95
    n-pentyl acetate 5.15
    transcutol 40.01
    n-heptanol 4.53
    ethylbenzene 1.11
    MIBK 5.85
    2-propoxyethanol 27.73
    tert-butanol 7.79
    MTBE 4.78
    2-butoxyethanol 15.95
    propionic acid 18.95
    o-xylene 1.65
    formic acid 40.56
    diethyl ether 7.01
    m-xylene 1.37
    p-xylene 1.54
    chlorobenzene 4.38
    dimethyl carbonate 13.22
    n-octane 0.32
    formamide 74.11
    cyclopentanone 72.01
    2-pentanone 12.32
    anisole 5.74
    cyclopentyl methyl ether 16.77
    gamma-butyrolactone 85.34
    1-methoxy-2-propanol 29.85
    pyridine 19.76
    3-pentanone 10.6
    furfural 55.35
    n-dodecane 0.22
    diethylene glycol 25.85
    diisopropyl ether 1.34
    tert-amyl alcohol 6.39
    acetylacetone 21.52
    n-hexadecane 0.25
    acetophenone 8.47
    methyl propionate 15.85
    isopentyl acetate 5.65
    trichloroethylene 32.07
    n-nonanol 4.02
    cyclohexanol 7.48
    benzyl alcohol 8.42
    2-ethylhexanol 3.79
    isooctanol 3.59
    dipropyl ether 6.04
    1,2-dichlorobenzene 4.59
    ethyl lactate 9.67
    propylene carbonate 28.32
    n-methylformamide 39.12
    2-pentanol 4.04
    n-pentane 0.33
    1-propoxy-2-propanol 16.17
    1-methoxy-2-propyl acetate 12.16
    2-(2-methoxypropoxy) propanol 12.74
    mesitylene 0.88
    ε-caprolactone 23.67
    p-cymene 1.51
    epichlorohydrin 74.97
    1,1,1-trichloroethane 7.85
    2-aminoethanol 13.19
    morpholine-4-carbaldehyde 43.11
    sulfolane 114.98
    2,2,4-trimethylpentane 0.25
    2-methyltetrahydrofuran 29.91
    n-hexyl acetate 6.21
    isooctane 0.14
    2-(2-butoxyethoxy)ethanol 17.82
    sec-butyl acetate 3.63
    tert-butyl acetate 6.68
    decalin 0.28
    glycerin 21.7
    diglyme 39.48
    acrylic acid 22.84
    isopropyl myristate 2.49
    n-butyric acid 23.97
    acetyl acetate 10.91
    di(2-ethylhexyl) phthalate 4.08
    ethyl propionate 7.28
    nitromethane 126.08
    1,2-diethoxyethane 9.89
    benzonitrile 6.93
    trioctyl phosphate 3.23
    1-bromopropane 4.98
    gamma-valerolactone 67.85
    n-decanol 2.88
    triethyl phosphate 6.56
    4-methyl-2-pentanol 2.51
    propionitrile 9.68
    vinylene carbonate 25.15
    1,1,2-trichlorotrifluoroethane 60.82
    DMS 7.5
    cumene 0.95
    2-octanol 2.53
    2-hexanone 8.0
    octyl acetate 3.8
    limonene 2.16
    1,2-dimethoxyethane 45.66
    ethyl orthosilicate 5.97
    tributyl phosphate 3.89
    diacetone alcohol 13.35
    N,N-dimethylaniline 4.3
    acrylonitrile 15.32
    aniline 7.95
    1,3-propanediol 21.28
    bromobenzene 3.24
    dibromomethane 12.29
    1,1,2,2-tetrachloroethane 22.38
    2-methyl-cyclohexyl acetate 6.52
    tetrabutyl urea 5.46
    diisobutyl methanol 2.24
    2-phenylethanol 7.15
    styrene 1.37
    dioctyl adipate 5.44
    dimethyl sulfate 31.74
    ethyl butyrate 7.4
    methyl lactate 17.94
    butyl lactate 7.38
    diethyl carbonate 6.45
    propanediol butyl ether 10.71
    triethyl orthoformate 7.89
    p-tert-butyltoluene 1.36
    methyl 4-tert-butylbenzoate 9.71
    morpholine 37.3
    tert-butylamine 3.17
    n-dodecanol 2.05
    dimethoxymethane 39.37
    ethylene carbonate 20.19
    cyrene 20.55
    2-ethoxyethyl acetate 10.57
    2-ethylhexyl acetate 4.22
    1,2,4-trichlorobenzene 6.51
    4-methylpyridine 11.98
    dibutyl ether 3.69
    2,6-dimethyl-4-heptanol 2.24
    DEF 18.9
    dimethyl isosorbide 24.06
    tetrachloroethylene 14.4
    eugenol 10.3
    triacetin 10.88
    span 80 9.89
    1,4-butanediol 8.96
    1,1-dichloroethane 7.73
    2-methyl-1-pentanol 5.6
    methyl formate 38.03
    2-methyl-1-butanol 5.93
    n-decane 0.42
    butyronitrile 9.08
    3,7-dimethyl-1-octanol 3.02
    1-chlorooctane 1.7
    1-chlorotetradecane 0.66
    n-nonane 0.36
    undecane 0.29
    tert-butylcyclohexane 0.24
    cyclooctane 0.24
    cyclopentanol 13.91
    tetrahydropyran 17.8
    tert-amyl methyl ether 4.84
    2,5,8-trioxanonane 26.03
    1-hexene 1.28
    2-isopropoxyethanol 16.92
    2,2,2-trifluoroethanol 28.13
    methyl butyrate 10.81

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction