1,2,4-Trichlorobenzene

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  • Identifiers

    CAS number
    120-82-1

    Molecular formula
    C6H3Cl3

    SMILES
    C1=CC(=C(C=C1Cl)Cl)Cl

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 37.11%
    Animal 33.16%
    Floral 30.41%
    Sweet 28.27%
    Burnt 27.15%
    Woody 26.06%
    Odorless 23.94%
    Smoky 23.79%
    Dry 22.97%
    Leathery 22.31%

     

    Flavor
    Bitter 34.45%
    Mild 25.61%
    Odorless 24.38%
    Meaty 21.36%
    Very strong 20.48%
    Nitrile 20.23%
    Indole 20.11%
    Scallion 19.88%
    Rotten 19.62%
    Penetrating 19.61%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 2.96 [mmHg]. Odor threshold from AIHA
    • Industrial data report an odor threshold of approx 3 ppm ...
    • Low odor threshold= 24.0 mg/cu m; High odor threshold= 24.0 mg/cu m; Irritating concn= 40.0 mg/cu m

  • Properties

    XLogP3-AA
    4.0

    pKa est.
    6.23 (neutral)

    Molecular weight
    181.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Melting point expt.

    • 63 °F (NTP, 1992)
    • 16.92 °C
    • 17 °C
    • 63 °F

    Boiling point

    • 415 °F at 760 mmHg (NTP, 1992)
    • 213.5 °C
    • 213 °C
    • 416 °F

    Flash point

    • 91.16 ˚C est.
    • 230 °F (NTP, 1992)
    • 105 °C
    • 105 °C (222 °F)
    • 105 °C c.c.
    • 222 °F

    Solubility expt.

    • less than 1 mg/mL at 70 °F (NTP, 1992)
    • Sparingly soluble in alcohol. Miscible with ether, benzene, petroleum ether, carbon disulfide
    • In water, 49.0 mg/L at 25 °C
    • Solubility in water, mg/l: 34.6
    • 0.003%

  • Synonyms

    • 1,2,4-trichlorobenzene
    • 120-82-1
    • Benzene, 1,2,4-trichloro-
    • unsym-Trichlorobenzene
    • Hostetex L-pec
    • Trojchlorobenzen
    • 1,2,4-Trichlorbenzol
    • 1,2,4-Trichlorobenzol
    • 1,3,4-Trichlorobenzene
    • 1,2,5-Trichlorobenzene
    • as-trichlorobenzene
    • Trichlorobenzene A
    • Trojchlorobenzen [Polish]
    • 1,2,4-trichloro-benzene
    • 63697-18-7
    • Trichlorobenzol
    • CCRIS 5945
    • NSC 406697
    • HSDB 1105
    • 1,2, 4-Trichlorobenzene
    • EINECS 204-428-0
    • BRN 0956819
    • DTXSID0021965
    • CHEBI:28222
    • AI3-07775
    • 05IQ959M1N
    • 1,2,4-TCB
    • MFCD00000547
    • NSC-406697
    • DTXCID701965
    • EC 204-428-0
    • 1,2,4-TRICHLOROBENZENE [MI]
    • 1,2,4-TRICHLOROBENZENE [HSDB]
    • TROJCHLOROBENZEN (POLISH)
    • CAS-120-82-1
    • 1,2,4-Triclorobenceno
    • UNII-05IQ959M1N
    • Hostetex Lpec
    • Hipochem GM
    • Trichlorobenzol A
    • Trichlorobenzol H
    • unsymTrichlorobenzene
    • 1,4-Trichlorobenzol
    • 1,4-Trichlorobenzene
    • 1,2,4trichlorobenzene
    • 1,2,4Trichlorobenzol
    • 1,3,4Trichlorobenzene
    • 1,2,4-triclorobenzene
    • Benzene,2,4-trichloro-
    • WLN: GR BG DG
    • bmse000841
    • Benzene, 1,2,4-trichloro-, radical ion(1-)
    • 2,4-dichlorophenyl chloride
    • SCHEMBL22730
    • ghl.PD_Mitscher_leg0.137
    • MLS001050173
    • BIDD:ER0328
    • CHEMBL296348
    • 124-TCB
    • 1,2,4-Trichlorobenzene (ACGIH)
    • 1,2,4-Trichlorobenzene-UL-14C
    • 1,2,4-Triclorobenceno (Spanish)
    • Tox21_201311
    • Tox21_300563
    • NSC406697
    • STL481897
    • AKOS000120900
    • FT41216
    • USEPA/OPP Pesticide Code: 081101
    • MSK000149-1000M
    • NCGC00090833-01
    • NCGC00090833-02
    • NCGC00090833-03
    • NCGC00090833-04
    • NCGC00254336-01
    • NCGC00258863-01
    • SMR001216523
    • 1,2,4-Trichlorobenzene, anhydrous, >=99%
    • NS00001861
    • T0376
    • 1,2,4-Trichlorobenzene, for HPLC, >=99%
    • 1,2,4-Trichlorobenzene, for synthesis, 99%
    • EN300-20533
    • C06594
    • G77194
    • 1,2,4-Trichlorobenzene 100 microg/mL in Hexane
    • 1,2,4-Trichlorobenzene, ReagentPlus(R), >=99%
    • 1,2,4-Trichlorobenzene, Spectrophotometric Grade
    • Benzene,1,2,4-trichloro-,radical ion(1-)(9ci)
    • Q1876830
    • 1,2,4-Trichlorobenzene 10 microg/mL in Cyclohexane
    • 1,2,4-Trichlorobenzene 5000 microg/mL in Methanol
    • 1,2,4-Trichlorobenzene, UV HPLC spectroscopic, 99.5%
    • F0001-0333
    • Z104478594
    • 1,2,4-Trichlorobenzene Solution in Methanol, 1000ug/mL
    • 1,2,4-Trichlorobenzene, PESTANAL(R), analytical standard
    • 1,2,4-Trichlorobenzene, certified reference material, TraceCERT(R)
    • 104810-41-5
    • 204-428-0

  • Applications

    1,2,4-Trichlorobenzene (CAS number: 120-82-1) is used primarily as a non-polar solvent and reaction medium in industrial manufacturing, notably in coatings, inks, and adhesive formulations where it helps dissolve resinous components and enables processing at elevated temperatures. It also serves as an intermediate in the production of dyes, pigments, and other fine chemicals, providing a chlorinated aryl building block. In agrochemical and related specialty chemistry, it is used as a precursor for certain pesticides and other organochlorine compounds. As a specialty solvent and chemical building block, it may be used for synthesis and purification of chlorinated aromatics and related intermediates in various manufacturing workflows.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15.96
    methanol 9.91
    isopropanol 14.97
    water 0.1
    ethyl acetate 101.62
    n-propanol 20.66
    acetone 108.22
    n-butanol 22.07
    acetonitrile 49.11
    DMF 73.1
    toluene 111.65
    isobutanol 17.2
    1,4-dioxane 200.01
    methyl acetate 124.63
    THF 200.15
    2-butanone 133.02
    n-pentanol 29.39
    sec-butanol 31.11
    n-hexane 11.12
    ethylene glycol 4.05
    NMP 110.54
    cyclohexane 16.97
    DMSO 53.93
    n-butyl acetate 131.93
    n-octanol 33.85
    chloroform 260.14
    n-propyl acetate 119.25
    acetic acid 30.94
    dichloromethane 218.01
    cyclohexanone 143.92
    propylene glycol 5.66
    isopropyl acetate 83.06
    DMAc 173.32
    2-ethoxyethanol 66.36
    isopentanol 27.26
    n-heptane 23.56
    ethyl formate 48.75
    1,2-dichloroethane 117.65
    n-hexanol 36.98
    2-methoxyethanol 53.28
    isobutyl acetate 79.5
    tetrachloromethane 59.32
    n-pentyl acetate 86.87
    transcutol 323.57
    n-heptanol 28.7
    ethylbenzene 98.61
    MIBK 75.01
    2-propoxyethanol 75.13
    tert-butanol 31.93
    MTBE 98.02
    2-butoxyethanol 62.71
    propionic acid 26.11
    o-xylene 99.37
    formic acid 7.62
    diethyl ether 78.85
    m-xylene 81.42
    p-xylene 128.75
    chlorobenzene 90.09
    dimethyl carbonate 40.89
    n-octane 12.22
    formamide 25.29
    cyclopentanone 149.38
    2-pentanone 92.68
    anisole 214.63
    cyclopentyl methyl ether 104.24
    gamma-butyrolactone 136.98
    1-methoxy-2-propanol 46.28
    pyridine 167.42
    3-pentanone 92.85
    furfural 158.37
    n-dodecane 10.0
    diethylene glycol 39.91
    diisopropyl ether 48.98
    tert-amyl alcohol 51.15
    acetylacetone 147.52
    n-hexadecane 11.63
    acetophenone 190.35
    methyl propionate 69.24
    isopentyl acetate 121.89
    trichloroethylene 345.32
    n-nonanol 34.74
    cyclohexanol 35.35
    benzyl alcohol 73.16
    2-ethylhexanol 50.27
    isooctanol 30.86
    dipropyl ether 89.68
    1,2-dichlorobenzene 105.99
    ethyl lactate 38.96
    propylene carbonate 88.14
    n-methylformamide 29.59
    2-pentanol 26.71
    n-pentane 8.53
    1-propoxy-2-propanol 72.85
    1-methoxy-2-propyl acetate 132.86
    2-(2-methoxypropoxy) propanol 119.29
    mesitylene 62.58
    ε-caprolactone 138.57
    p-cymene 76.84
    epichlorohydrin 199.83
    1,1,1-trichloroethane 191.14
    2-aminoethanol 9.08
    morpholine-4-carbaldehyde 177.1
    sulfolane 117.77
    2,2,4-trimethylpentane 13.97
    2-methyltetrahydrofuran 164.84
    n-hexyl acetate 98.02
    isooctane 9.96
    2-(2-butoxyethoxy)ethanol 117.03
    sec-butyl acetate 105.17
    tert-butyl acetate 122.66
    decalin 23.76
    glycerin 10.2
    diglyme 275.49
    acrylic acid 25.82
    isopropyl myristate 62.77
    n-butyric acid 36.83
    acetyl acetate 95.97
    di(2-ethylhexyl) phthalate 49.65
    ethyl propionate 95.77
    nitromethane 97.4
    1,2-diethoxyethane 222.43
    benzonitrile 98.24
    trioctyl phosphate 30.78
    1-bromopropane 77.09
    gamma-valerolactone 198.27
    n-decanol 28.24
    triethyl phosphate 71.98
    4-methyl-2-pentanol 26.61
    propionitrile 42.97
    vinylene carbonate 86.34
    1,1,2-trichlorotrifluoroethane 124.96
    DMS 112.44
    cumene 67.99
    2-octanol 29.31
    2-hexanone 134.62
    octyl acetate 63.19
    limonene 95.13
    1,2-dimethoxyethane 206.29
    ethyl orthosilicate 75.13
    tributyl phosphate 43.68
    diacetone alcohol 91.1
    N,N-dimethylaniline 143.02
    acrylonitrile 55.42
    aniline 62.91
    1,3-propanediol 16.89
    bromobenzene 122.71
    dibromomethane 138.7
    1,1,2,2-tetrachloroethane 210.36
    2-methyl-cyclohexyl acetate 121.37
    tetrabutyl urea 65.03
    diisobutyl methanol 44.4
    2-phenylethanol 89.6
    styrene 108.93
    dioctyl adipate 92.43
    dimethyl sulfate 66.22
    ethyl butyrate 129.66
    methyl lactate 29.67
    butyl lactate 55.44
    diethyl carbonate 89.46
    propanediol butyl ether 47.49
    triethyl orthoformate 102.11
    p-tert-butyltoluene 76.59
    methyl 4-tert-butylbenzoate 120.4
    morpholine 152.36
    tert-butylamine 24.08
    n-dodecanol 24.15
    dimethoxymethane 78.73
    ethylene carbonate 64.04
    cyrene 113.56
    2-ethoxyethyl acetate 144.09
    2-ethylhexyl acetate 126.15
    1,2,4-trichlorobenzene 151.02
    4-methylpyridine 156.3
    dibutyl ether 90.59
    2,6-dimethyl-4-heptanol 44.4
    DEF 107.72
    dimethyl isosorbide 269.49
    tetrachloroethylene 149.54
    eugenol 113.37
    triacetin 138.25
    span 80 78.34
    1,4-butanediol 11.27
    1,1-dichloroethane 114.95
    2-methyl-1-pentanol 42.24
    methyl formate 31.99
    2-methyl-1-butanol 29.25
    n-decane 15.38
    butyronitrile 42.87
    3,7-dimethyl-1-octanol 49.43
    1-chlorooctane 45.18
    1-chlorotetradecane 24.0
    n-nonane 14.5
    undecane 11.93
    tert-butylcyclohexane 23.55
    cyclooctane 11.9
    cyclopentanol 32.81
    tetrahydropyran 135.16
    tert-amyl methyl ether 116.27
    2,5,8-trioxanonane 216.43
    1-hexene 37.31
    2-isopropoxyethanol 68.02
    2,2,2-trifluoroethanol 21.02
    methyl butyrate 115.42

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction