12-Hydroxystearic acid

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  • Identifiers

    CAS number
    106-14-9

    Molecular formula
    C18H36O3

    SMILES
    CCCCCCC(CCCCCCCCCCC(=O)O)O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fatty 58.58%
    Waxy 54.36%
    Oily 49.65%
    Citrus 38.51%
    Fresh 34.41%
    Coconut 30.49%
    Milky 30.48%
    Dairy 30.0%
    Creamy 29.05%
    Odorless 28.75%

     

    Flavor
    Fatty 57.23%
    Waxy 48.55%
    Mild 36.27%
    Fat 35.73%
    Oily 34.98%
    Soapy 28.93%
    Coconut 28.84%
    Odorless 28.31%
    Bland 26.12%
    Floral 25.14%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.5

    pKa est.
    6.41 (neutral)

    Molecular weight
    300.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    388°C

    Melting point expt.

    • 82 °C

    Flash point

    • 199.93 ˚C est.

    Solubility expt.

    • Soluble in alcohol, ether, chloroform; insoluble in water

  • Synonyms

    • 12-Hydroxystearic acid
    • 12-HYDROXYOCTADECANOIC ACID
    • 106-14-9
    • DL-12-Hydroxystearic acid
    • Cerit Fac 3
    • Hydrofol acid 200
    • Ceroxin GL
    • Barolub FTO
    • Stearic acid, 12-hydroxy-
    • Loxiol G 21
    • NSC 2385
    • 12-hydroxy-octadecanoic acid
    • HSDB 5368
    • EINECS 203-366-1
    • EINECS 253-004-1
    • UNII-933ANU3H2S
    • BRN 1726730
    • 933ANU3H2S
    • DTXSID8026725
    • AI3-19730
    • CASID HSA
    • NSC-2385
    • DL-12-HYDROXYOCTADECANOIC ACID
    • DTXCID606725
    • KOW
    • CHEBI:85208
    • EC 203-366-1
    • 4-03-00-00942 (Beilstein Handbook Reference)
    • 12-HYDROXYSTEARIC ACID (USP-RS)
    • 12-HYDROXYSTEARIC ACID [USP-RS]
    • RefChem:6726
    • 203-366-1
    • Hydroxystearic acid
    • Octadecanoic acid, 12-hydroxy-
    • 36377-33-0
    • DL-12-hydroxy stearic acid
    • MFCD00004592
    • 12-hydroxy stearic acid
    • CAS-106-14-9
    • 12-Hydroxyoctadecanoicacid
    • 12-hydroxy-stearic acid
    • SCHEMBL17773
    • WLN: QV10YQ6
    • 12-HSA
    • CHEMBL292352
    • orb1693720
    • SCHEMBL3700272
    • MSK1717
    • NSC2385
    • (?)-12-Hydroxyoctadecanoic acid
    • 12-Hydroxyoctadecanoic acid, 99%
    • 12-Hydroxystearic acid (Standard)
    • AAA10614
    • HY-W127329R
    • EINECS 227-283-5
    • EINECS 242-295-0
    • Tox21_201492
    • Tox21_303035
    • LMFA02000130
    • AKOS016010128
    • HY-W127329
    • NCGC00164350-01
    • NCGC00164350-02
    • NCGC00257021-01
    • NCGC00259043-01
    • 78642-86-1
    • MS-24336
    • PD150654
    • SY048149
    • 12-HYDROXYOCTADECANOIC ACID [HSDB]
    • DB-180778
    • Octadecanoic acid, 12-hydroxy-, (+/-)-
    • CS-0185570
    • H0308
    • NS00008165
    • Octadecanoic acid, 12-hydroxy-, (A+/-)-
    • ST51039859
    • E82291
    • F241605
    • Q27158401
    • 12-Hydroxystearic acid, United States Pharmacopeia (USP) Reference Standard
    • InChI=1/C18H36O3/c1-2-3-4-11-14-17(19)15-12-9-7-5-6-8-10-13-16-18(20)21/h17,19H,2-16H2,1H3,(H,20,21
    • 106-14-9

  • Applications

    12-Hydroxystearic acid (CAS 106-14-9) is a biobased fatty acid used as a versatile building block in specialty polymers and as an additive in lubricants. In industry, it serves as a polyol precursor for the synthesis of polyesters and polyurethanes, and as an intermediate for ester formation to produce waxy esters and plasticizers. It is commonly employed as a thickener and rheology modifier for lubricants and cleaners, typically via conversion to metal soaps (for example lithium or calcium soaps) to form thickened formulations. In cosmetics and personal care, it is used as an emollient and rheology modifier due to its waxy character. In coatings, inks, and adhesives, it can act as a wax-like additive to improve gloss and film-forming properties. It may also be used as a precursor for specialty surfactants or internal wax components in polymer formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 77.9
    methanol 82.32
    isopropanol 78.28
    water 0.02
    ethyl acetate 79.68
    n-propanol 68.33
    acetone 69.96
    n-butanol 75.69
    acetonitrile 15.34
    DMF 189.92
    toluene 26.74
    isobutanol 65.13
    1,4-dioxane 118.07
    methyl acetate 47.86
    THF 539.82
    2-butanone 86.61
    n-pentanol 69.04
    sec-butanol 70.03
    n-hexane 11.76
    ethylene glycol 4.67
    NMP 348.38
    cyclohexane 25.43
    DMSO 432.84
    n-butyl acetate 165.48
    n-octanol 60.63
    chloroform 133.86
    n-propyl acetate 155.82
    acetic acid 47.27
    dichloromethane 132.37
    cyclohexanone 306.36
    propylene glycol 20.79
    isopropyl acetate 114.75
    DMAc 290.32
    2-ethoxyethanol 150.22
    isopentanol 104.28
    n-heptane 10.25
    ethyl formate 44.02
    1,2-dichloroethane 129.63
    n-hexanol 72.87
    2-methoxyethanol 164.72
    isobutyl acetate 118.04
    tetrachloromethane 33.18
    n-pentyl acetate 193.52
    transcutol 772.86
    n-heptanol 61.44
    ethylbenzene 31.03
    MIBK 148.25
    2-propoxyethanol 178.09
    tert-butanol 147.09
    MTBE 135.7
    2-butoxyethanol 173.78
    propionic acid 51.99
    o-xylene 33.72
    formic acid 13.54
    diethyl ether 68.68
    m-xylene 32.8
    p-xylene 41.08
    chlorobenzene 47.31
    dimethyl carbonate 23.5
    n-octane 5.14
    formamide 26.11
    cyclopentanone 325.47
    2-pentanone 121.47
    anisole 75.25
    cyclopentyl methyl ether 209.36
    gamma-butyrolactone 278.68
    1-methoxy-2-propanol 199.3
    pyridine 93.69
    3-pentanone 74.89
    furfural 193.96
    n-dodecane 3.53
    diethylene glycol 75.4
    diisopropyl ether 42.75
    tert-amyl alcohol 131.23
    acetylacetone 155.29
    n-hexadecane 4.26
    acetophenone 109.89
    methyl propionate 64.35
    isopentyl acetate 191.57
    trichloroethylene 198.58
    n-nonanol 60.75
    cyclohexanol 116.38
    benzyl alcohol 58.4
    2-ethylhexanol 68.91
    isooctanol 68.28
    dipropyl ether 104.18
    1,2-dichlorobenzene 66.7
    ethyl lactate 67.91
    propylene carbonate 154.94
    n-methylformamide 52.23
    2-pentanol 64.44
    n-pentane 6.02
    1-propoxy-2-propanol 190.08
    1-methoxy-2-propyl acetate 183.75
    2-(2-methoxypropoxy) propanol 156.47
    mesitylene 29.74
    ε-caprolactone 269.12
    p-cymene 30.84
    epichlorohydrin 277.66
    1,1,1-trichloroethane 115.31
    2-aminoethanol 27.32
    morpholine-4-carbaldehyde 256.06
    sulfolane 618.84
    2,2,4-trimethylpentane 10.05
    2-methyltetrahydrofuran 276.16
    n-hexyl acetate 189.35
    isooctane 7.32
    2-(2-butoxyethoxy)ethanol 235.3
    sec-butyl acetate 128.87
    tert-butyl acetate 206.18
    decalin 16.75
    glycerin 38.22
    diglyme 453.38
    acrylic acid 29.25
    isopropyl myristate 66.32
    n-butyric acid 142.23
    acetyl acetate 53.1
    di(2-ethylhexyl) phthalate 57.31
    ethyl propionate 108.05
    nitromethane 90.29
    1,2-diethoxyethane 214.7
    benzonitrile 55.58
    trioctyl phosphate 46.56
    1-bromopropane 72.16
    gamma-valerolactone 443.91
    n-decanol 39.21
    triethyl phosphate 75.23
    4-methyl-2-pentanol 60.46
    propionitrile 25.67
    vinylene carbonate 94.94
    1,1,2-trichlorotrifluoroethane 213.76
    DMS 78.54
    cumene 29.38
    2-octanol 52.11
    2-hexanone 147.02
    octyl acetate 80.49
    limonene 58.57
    1,2-dimethoxyethane 278.13
    ethyl orthosilicate 79.05
    tributyl phosphate 62.83
    diacetone alcohol 232.54
    N,N-dimethylaniline 69.38
    acrylonitrile 26.75
    aniline 40.94
    1,3-propanediol 65.33
    bromobenzene 50.8
    dibromomethane 89.7
    1,1,2,2-tetrachloroethane 232.29
    2-methyl-cyclohexyl acetate 144.88
    tetrabutyl urea 94.72
    diisobutyl methanol 53.23
    2-phenylethanol 66.62
    styrene 32.33
    dioctyl adipate 114.48
    dimethyl sulfate 76.41
    ethyl butyrate 142.08
    methyl lactate 54.68
    butyl lactate 149.24
    diethyl carbonate 68.38
    propanediol butyl ether 152.48
    triethyl orthoformate 123.66
    p-tert-butyltoluene 32.46
    methyl 4-tert-butylbenzoate 148.64
    morpholine 223.3
    tert-butylamine 83.58
    n-dodecanol 26.66
    dimethoxymethane 121.22
    ethylene carbonate 88.45
    cyrene 148.09
    2-ethoxyethyl acetate 195.47
    2-ethylhexyl acetate 145.79
    1,2,4-trichlorobenzene 84.7
    4-methylpyridine 97.21
    dibutyl ether 119.27
    2,6-dimethyl-4-heptanol 53.23
    DEF 168.96
    dimethyl isosorbide 315.88
    tetrachloroethylene 138.19
    eugenol 121.75
    triacetin 190.57
    span 80 145.5
    1,4-butanediol 25.17
    1,1-dichloroethane 86.39
    2-methyl-1-pentanol 84.84
    methyl formate 29.63
    2-methyl-1-butanol 81.02
    n-decane 8.55
    butyronitrile 45.34
    3,7-dimethyl-1-octanol 73.31
    1-chlorooctane 48.41
    1-chlorotetradecane 13.62
    n-nonane 7.79
    undecane 5.12
    tert-butylcyclohexane 15.08
    cyclooctane 7.68
    cyclopentanol 120.46
    tetrahydropyran 213.33
    tert-amyl methyl ether 120.23
    2,5,8-trioxanonane 267.16
    1-hexene 40.54
    2-isopropoxyethanol 136.47
    2,2,2-trifluoroethanol 20.32
    methyl butyrate 171.73

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction