12-hydroxy-E-gamma-bisabolene

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  • Identifiers

    CAS number
    99112-26-2

    Molecular formula
    C15H24O

    SMILES
    CC1=CC/C(=C(\C)/CC/C=C(\C)/CO)/CC1

    Safety labels

  • Odor profile

    Fragrance
    Floral 80.21%
    Sweet 58.41%
    Woody 52.82%
    Fruity 52.45%
    Waxy 50.05%
    Balsamic 42.68%
    Powdery 39.91%
    Tropical 38.88%
    Rose 37.6%
    Fresh 35.0%

     

    Flavor
    Floral 63.52%
    Spicy 47.83%
    Woody 44.1%
    Herbal 42.47%
    Sweet 42.41%
    Fresh 38.97%
    Citrus 37.83%
    Balsam 32.85%
    Rose 30.38%
    Wood 28.99%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.5

    pKa est.
    9.75 (weak base)

    Molecular weight
    220.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    325°C

    Flash point

    • 139.66 ˚C est.

  • Synonyms

    • 12-OH-Egb
    • 12-Hydroxy-E-gamma-bisabolene
    • 99112-26-2
    • (E,6E)-2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-en-1-ol
    • 2-Hepten-1-ol, 2-methyl-6-(4-methyl-3-cyclohexen-1-ylidene)-, (E,E)-
    • RefChem:78212
    • 99112-26-2

  • Applications

    12-hydroxy-E-gamma-bisabolene (CAS 99112-26-2) is a sesquiterpene alcohol used primarily as a fragrance ingredient and odorant. In perfumery and cosmetics/personal care, it often serves as a fragrance component and occasional fixative, contributing to woody-green aroma profiles. It may be used as an intermediate or building block in fragrance chemistry for synthesizing related bisabolane-derived aroma compounds. In household products such as air fresheners and cleaners, it provides characteristic aroma contributions. In coatings and inks, it can function as a fragrance additive to impart or maintain a pleasant scent in finished products. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 636.04
    methanol 338.17
    isopropanol 479.62
    water 0.08
    ethyl acetate 958.14
    n-propanol 548.95
    acetone 168.68
    n-butanol 619.0
    acetonitrile 269.63
    DMF 78.35
    toluene 343.23
    isobutanol 270.76
    1,4-dioxane 1261.96
    methyl acetate 373.07
    THF 824.67
    2-butanone 431.0
    n-pentanol 320.42
    sec-butanol 467.1
    n-hexane 86.62
    ethylene glycol 16.53
    NMP 40.68
    cyclohexane 129.45
    DMSO 127.97
    n-butyl acetate 487.7
    n-octanol 88.89
    chloroform 778.01
    n-propyl acetate 322.29
    acetic acid 115.32
    dichloromethane 575.05
    cyclohexanone 294.55
    propylene glycol 68.18
    isopropyl acetate 455.16
    DMAc 147.11
    2-ethoxyethanol 417.19
    isopentanol 430.46
    n-heptane 56.71
    ethyl formate 178.44
    1,2-dichloroethane 410.94
    n-hexanol 391.27
    2-methoxyethanol 519.03
    isobutyl acetate 185.94
    tetrachloromethane 116.9
    n-pentyl acetate 188.73
    transcutol 1950.3
    n-heptanol 128.39
    ethylbenzene 155.51
    MIBK 243.21
    2-propoxyethanol 502.88
    tert-butanol 569.71
    MTBE 945.29
    2-butoxyethanol 260.12
    propionic acid 123.76
    o-xylene 157.51
    formic acid 28.81
    diethyl ether 1657.37
    m-xylene 201.54
    p-xylene 136.03
    chlorobenzene 164.56
    dimethyl carbonate 53.98
    n-octane 16.74
    formamide 60.44
    cyclopentanone 179.23
    2-pentanone 425.79
    anisole 299.76
    cyclopentyl methyl ether 377.38
    gamma-butyrolactone 177.58
    1-methoxy-2-propanol 445.4
    pyridine 508.93
    3-pentanone 306.36
    furfural 195.31
    n-dodecane 8.82
    diethylene glycol 182.33
    diisopropyl ether 297.78
    tert-amyl alcohol 443.25
    acetylacetone 256.51
    n-hexadecane 10.39
    acetophenone 163.58
    methyl propionate 300.9
    isopentyl acetate 374.56
    trichloroethylene 552.54
    n-nonanol 88.53
    cyclohexanol 261.56
    benzyl alcohol 152.05
    2-ethylhexanol 211.41
    isooctanol 109.19
    dipropyl ether 543.75
    1,2-dichlorobenzene 141.52
    ethyl lactate 80.14
    propylene carbonate 120.75
    n-methylformamide 77.26
    2-pentanol 457.77
    n-pentane 96.75
    1-propoxy-2-propanol 425.69
    1-methoxy-2-propyl acetate 407.39
    2-(2-methoxypropoxy) propanol 248.9
    mesitylene 123.8
    ε-caprolactone 314.99
    p-cymene 89.15
    epichlorohydrin 436.64
    1,1,1-trichloroethane 370.73
    2-aminoethanol 89.68
    morpholine-4-carbaldehyde 222.7
    sulfolane 114.39
    2,2,4-trimethylpentane 38.71
    2-methyltetrahydrofuran 624.78
    n-hexyl acetate 210.95
    isooctane 38.11
    2-(2-butoxyethoxy)ethanol 392.36
    sec-butyl acetate 280.45
    tert-butyl acetate 400.91
    decalin 43.94
    glycerin 72.32
    diglyme 723.39
    acrylic acid 58.83
    isopropyl myristate 87.92
    n-butyric acid 369.45
    acetyl acetate 243.67
    di(2-ethylhexyl) phthalate 69.46
    ethyl propionate 277.41
    nitromethane 161.11
    1,2-diethoxyethane 994.54
    benzonitrile 153.17
    trioctyl phosphate 43.72
    1-bromopropane 466.12
    gamma-valerolactone 345.59
    n-decanol 62.35
    triethyl phosphate 108.68
    4-methyl-2-pentanol 210.1
    propionitrile 347.3
    vinylene carbonate 111.23
    1,1,2-trichlorotrifluoroethane 177.1
    DMS 125.55
    cumene 97.14
    2-octanol 75.6
    2-hexanone 276.23
    octyl acetate 94.79
    limonene 131.42
    1,2-dimethoxyethane 795.42
    ethyl orthosilicate 132.66
    tributyl phosphate 59.62
    diacetone alcohol 280.04
    N,N-dimethylaniline 158.86
    acrylonitrile 203.58
    aniline 243.02
    1,3-propanediol 235.16
    bromobenzene 188.47
    dibromomethane 450.9
    1,1,2,2-tetrachloroethane 486.83
    2-methyl-cyclohexyl acetate 181.88
    tetrabutyl urea 66.41
    diisobutyl methanol 139.06
    2-phenylethanol 194.8
    styrene 175.68
    dioctyl adipate 114.3
    dimethyl sulfate 47.68
    ethyl butyrate 378.54
    methyl lactate 71.27
    butyl lactate 114.18
    diethyl carbonate 191.05
    propanediol butyl ether 151.07
    triethyl orthoformate 265.1
    p-tert-butyltoluene 92.39
    methyl 4-tert-butylbenzoate 156.02
    morpholine 1356.01
    tert-butylamine 467.84
    n-dodecanol 46.28
    dimethoxymethane 310.31
    ethylene carbonate 114.71
    cyrene 110.47
    2-ethoxyethyl acetate 335.36
    2-ethylhexyl acetate 278.15
    1,2,4-trichlorobenzene 156.85
    4-methylpyridine 383.72
    dibutyl ether 255.89
    2,6-dimethyl-4-heptanol 139.06
    DEF 303.52
    dimethyl isosorbide 324.94
    tetrachloroethylene 291.12
    eugenol 142.34
    triacetin 179.79
    span 80 179.03
    1,4-butanediol 58.48
    1,1-dichloroethane 436.73
    2-methyl-1-pentanol 260.65
    methyl formate 39.1
    2-methyl-1-butanol 347.86
    n-decane 18.69
    butyronitrile 449.8
    3,7-dimethyl-1-octanol 118.8
    1-chlorooctane 70.91
    1-chlorotetradecane 25.26
    n-nonane 18.05
    undecane 12.04
    tert-butylcyclohexane 46.19
    cyclooctane 46.35
    cyclopentanol 137.05
    tetrahydropyran 1314.68
    tert-amyl methyl ether 502.5
    2,5,8-trioxanonane 450.09
    1-hexene 285.06
    2-isopropoxyethanol 280.38
    2,2,2-trifluoroethanol 22.99
    methyl butyrate 306.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction