(12)-Gingerol

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  • Identifiers

    CAS number
    104264-55-3

    Molecular formula
    C23H38O4

    SMILES
    CCCCCCCCCCC[C@@H](CC(=O)CCC1=CC(=C(C=C1)O)OC)O

    Safety labels

  • Odor profile

    Fragrance
    Spicy 36.77%
    Odorless 33.73%
    Sweet 31.68%
    Waxy 29.76%
    Balsamic 28.18%
    Milky 27.84%
    Floral 27.48%
    Oily 26.59%
    Fatty 26.22%
    Creamy 24.82%

     

    Flavor
    Woody 42.54%
    Herbal 36.24%
    Mild 34.36%
    Bland 31.03%
    Odorless 30.08%
    Oily 24.49%
    Spicy 24.45%
    Slightly waxy 21.27%
    Warm 21.24%
    Fatty 21.18%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.4

    pKa est.
    9.76 (weak base)

    Molecular weight
    378.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    573°C

    Flash point

    • 198.16 ˚C est.

  • Synonyms

    • DTXSID00873731
    • 104264-55-3
    • RefChem:1049335
    • DTXCID801012022
    • (12)-Gingerol
    • 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)hexadecan-3-one
    • 3-Hexadecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-
    • 12-Gingerol
    • (5S)-5-HYDROXY-1-(4-HYDROXY-3-METHOXYPHENYL)HEXADECAN-3-ONE
    • SCHEMBL29801691
    • 104264-55-3

  • Applications

    (12)-Gingerol (CAS 104264-55-3) is a ginger-derived phenolic compound with a characteristic ginger aroma, commonly used as a fragrance and flavor ingredient. In practice, it may serve as a natural flavoring in food processing; as an odorant in perfumery and fragrance formulations; as a fragrance additive in cosmetics and personal care; as a scenting agent in household cleaning and other consumer products; and as an intermediate or starting material in industrial chemistry for the synthesis of ginger-related fragrance compounds. Applications are typically subject to formulation limits and regulatory requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 255.78
    methanol 426.04
    isopropanol 149.86
    water 0.14
    ethyl acetate 264.76
    n-propanol 191.14
    acetone 789.16
    n-butanol 122.6
    acetonitrile 136.62
    DMF 469.6
    toluene 39.93
    isobutanol 106.7
    1,4-dioxane 394.04
    methyl acetate 215.5
    THF 1093.65
    2-butanone 339.2
    n-pentanol 83.19
    sec-butanol 115.16
    n-hexane 1.35
    ethylene glycol 18.25
    NMP 321.41
    cyclohexane 9.86
    DMSO 1744.24
    n-butyl acetate 113.51
    n-octanol 40.26
    chloroform 392.74
    n-propyl acetate 175.96
    acetic acid 299.76
    dichloromethane 465.61
    cyclohexanone 577.01
    propylene glycol 54.56
    isopropyl acetate 170.92
    DMAc 583.96
    2-ethoxyethanol 254.46
    isopentanol 105.27
    n-heptane 1.67
    ethyl formate 154.31
    1,2-dichloroethane 406.86
    n-hexanol 47.33
    2-methoxyethanol 434.44
    isobutyl acetate 99.77
    tetrachloromethane 54.23
    n-pentyl acetate 147.43
    transcutol 697.4
    n-heptanol 45.64
    ethylbenzene 23.92
    MIBK 159.33
    2-propoxyethanol 176.36
    tert-butanol 207.38
    MTBE 150.1
    2-butoxyethanol 155.66
    propionic acid 167.08
    o-xylene 30.39
    formic acid 74.75
    diethyl ether 98.75
    m-xylene 25.58
    p-xylene 35.02
    chlorobenzene 89.84
    dimethyl carbonate 84.79
    n-octane 1.76
    formamide 182.12
    cyclopentanone 745.66
    2-pentanone 286.93
    anisole 83.36
    cyclopentyl methyl ether 190.18
    gamma-butyrolactone 600.9
    1-methoxy-2-propanol 272.64
    pyridine 243.74
    3-pentanone 159.95
    furfural 328.8
    n-dodecane 1.88
    diethylene glycol 108.94
    diisopropyl ether 22.27
    tert-amyl alcohol 144.65
    acetylacetone 463.16
    n-hexadecane 2.21
    acetophenone 117.51
    methyl propionate 186.22
    isopentyl acetate 113.75
    trichloroethylene 570.76
    n-nonanol 40.2
    cyclohexanol 143.45
    benzyl alcohol 85.5
    2-ethylhexanol 33.27
    isooctanol 44.17
    dipropyl ether 40.7
    1,2-dichlorobenzene 94.13
    ethyl lactate 79.67
    propylene carbonate 241.34
    n-methylformamide 211.16
    2-pentanol 54.58
    n-pentane 1.09
    1-propoxy-2-propanol 121.45
    1-methoxy-2-propyl acetate 160.6
    2-(2-methoxypropoxy) propanol 115.19
    mesitylene 16.96
    ε-caprolactone 424.18
    p-cymene 17.23
    epichlorohydrin 665.19
    1,1,1-trichloroethane 258.93
    2-aminoethanol 75.71
    morpholine-4-carbaldehyde 330.59
    sulfolane 828.5
    2,2,4-trimethylpentane 2.69
    2-methyltetrahydrofuran 369.4
    n-hexyl acetate 133.5
    isooctane 1.6
    2-(2-butoxyethoxy)ethanol 180.32
    sec-butyl acetate 102.2
    tert-butyl acetate 204.45
    decalin 4.74
    glycerin 78.75
    diglyme 438.13
    acrylic acid 114.86
    isopropyl myristate 41.29
    n-butyric acid 303.13
    acetyl acetate 164.23
    di(2-ethylhexyl) phthalate 47.46
    ethyl propionate 121.25
    nitromethane 682.17
    1,2-diethoxyethane 165.65
    benzonitrile 93.6
    trioctyl phosphate 34.99
    1-bromopropane 101.92
    gamma-valerolactone 833.64
    n-decanol 25.83
    triethyl phosphate 54.85
    4-methyl-2-pentanol 37.62
    propionitrile 93.91
    vinylene carbonate 192.18
    1,1,2-trichlorotrifluoroethane 394.05
    DMS 109.75
    cumene 17.09
    2-octanol 32.64
    2-hexanone 158.11
    octyl acetate 57.75
    limonene 27.73
    1,2-dimethoxyethane 416.51
    ethyl orthosilicate 52.54
    tributyl phosphate 44.47
    diacetone alcohol 255.05
    N,N-dimethylaniline 49.38
    acrylonitrile 120.13
    aniline 77.23
    1,3-propanediol 163.83
    bromobenzene 81.27
    dibromomethane 237.58
    1,1,2,2-tetrachloroethane 513.97
    2-methyl-cyclohexyl acetate 85.03
    tetrabutyl urea 62.65
    diisobutyl methanol 23.42
    2-phenylethanol 67.26
    styrene 30.98
    dioctyl adipate 82.15
    dimethyl sulfate 183.64
    ethyl butyrate 95.13
    methyl lactate 104.8
    butyl lactate 120.28
    diethyl carbonate 64.55
    propanediol butyl ether 130.41
    triethyl orthoformate 73.99
    p-tert-butyltoluene 16.41
    methyl 4-tert-butylbenzoate 118.22
    morpholine 540.78
    tert-butylamine 65.4
    n-dodecanol 17.65
    dimethoxymethane 318.57
    ethylene carbonate 196.17
    cyrene 131.28
    2-ethoxyethyl acetate 218.1
    2-ethylhexyl acetate 78.64
    1,2,4-trichlorobenzene 110.94
    4-methylpyridine 164.37
    dibutyl ether 57.43
    2,6-dimethyl-4-heptanol 23.42
    DEF 234.12
    dimethyl isosorbide 216.3
    tetrachloroethylene 291.52
    eugenol 112.11
    triacetin 180.16
    span 80 102.65
    1,4-butanediol 53.35
    1,1-dichloroethane 256.65
    2-methyl-1-pentanol 73.05
    methyl formate 167.25
    2-methyl-1-butanol 93.4
    n-decane 3.71
    butyronitrile 113.34
    3,7-dimethyl-1-octanol 41.02
    1-chlorooctane 25.83
    1-chlorotetradecane 7.93
    n-nonane 2.98
    undecane 2.47
    tert-butylcyclohexane 3.91
    cyclooctane 1.89
    cyclopentanol 176.83
    tetrahydropyran 434.79
    tert-amyl methyl ether 86.45
    2,5,8-trioxanonane 241.33
    1-hexene 10.99
    2-isopropoxyethanol 152.02
    2,2,2-trifluoroethanol 103.1
    methyl butyrate 195.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction