1,2-Epoxybutane

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  • Identifiers

    CAS number
    106-88-7

    Molecular formula
    C4H8O

    SMILES
    CCC1CO1

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Sweet 68.84%
    Ethereal 64.17%
    Solvent 57.74%
    Fermented 43.43%
    Caramellic 39.87%
    Musty 37.89%
    Alcoholic 37.52%
    Fruity 34.69%
    Buttery 32.23%
    Nutty 31.91%

     

    Flavor
    Sweet 59.36%
    Caramel 49.79%
    Herbal 39.6%
    Vegetable 31.4%
    Warm 27.54%
    Oily 25.62%
    Burnt 24.86%
    Nutty 24.68%
    Green 24.32%
    Cauliflower 23.53%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 0.07 [mmHg]. Odor Threshold High: 0.71 [mmHg]. [ICSC] Odor threshold low (absolute perception limit), and high (recognition) from CHEMINFO
    • Low: 0.0202 mg/cu m; High: 2.0874 mg/cu m

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    4.8 (weak acid)

    Molecular weight
    72.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -76 °F (NTP, 1992)
    • -150 °C
    • Below -50 °C (freezing point)

    Boiling point

    • 145 °F at 760 mmHg (NTP, 1992)
    • 63.4 °C
    • 59-63 °C @ 760 mm Hg
    • 63.3 °C

    Flash point

    • -12.89 ˚C est.
    • 10 °F (NTP, 1992)
    • -22 °C
    • -7 °F (-22 °C) (closed cup)
    • 5 °F (Closed cup)
    • -22 °C c.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)
    • In water, 95.5 g/L at 25 °C (OECD Method 105)
    • In water, 8.68 g/100 g water at 25 °C
    • In water, 59 g/L at 20 °C
    • Very soluble in ethanol, acetone; miscible with ether
    • Miscible with common aliphatic and aromatic solvents
    • Miscible with aliphatic and aromatic solvents
    • Approx 9 g/100 g water @ 25 °C
    • Solubility in water, g/100ml at 20 °C: 5.9 (moderate)

  • Synonyms

    • 1,2-Epoxybutane
    • 2-Ethyloxirane
    • 106-88-7
    • 1,2-Butylene oxide
    • Ethyloxirane
    • Oxirane, ethyl-
    • Epoxybutane
    • 1-BUTENE OXIDE
    • Oxirane, 2-ethyl-
    • Ethylethylene oxide
    • 1,2-Butene oxide
    • 1-Butylene oxide
    • 1,2-Monoepoxybutane
    • Ethylene oxide, ethyl-
    • Butane, 1,2-epoxy-
    • Butene oxide
    • DL-1,2-Epoxybutane
    • n-Butene-1,2-oxide
    • alpha-Butylene oxide
    • Ethyl ethylene oxide
    • But-1-ene oxide
    • 1,2-butyleneoxide
    • NCI-C55527
    • CCRIS 1015
    • .alpha.-Butylene oxide
    • HSDB 2855
    • (S)-1,2-Epoxybutane
    • 2-Ethyl-oxirane
    • EINECS 203-438-2
    • NSC 24240
    • UN3022
    • UNII-FR67H5388O
    • BRN 0102411
    • DTXSID6020569
    • NSC-24240
    • (.+/-.)-2-Ethyloxirane
    • DTXCID40569
    • 1,2-Butylene oxide, stabilized
    • CHEBI:82326
    • ETHYLOXIRANE, (+/-)-
    • 1,2-EPOXYBUTANE [IARC]
    • EC 203-438-2
    • FR67H5388O
    • 5-17-01-00056 (Beilstein Handbook Reference)
    • 2-ETHYLOXIRANE, (+/-)-
    • 1,2-EPOXYBUTANE (IARC)
    • (+-)-2-Ethyloxirane
    • 1,2-Butene oxide (VAN)
    • 1,2-BUTYLENE OXIDE, (STABILIZED)
    • 1,2-BUTYLENE OXIDE, [STABILIZED]
    • (+-)-Ethyloxirane
    • (S)-(-)-Butylene Oxide
    • 2ethyloxirane
    • ethyl oxirane
    • propyl oxirane
    • 1Butylene oxide
    • ()Ethyloxirane
    • Oxirane, ethyl
    • a-butylene oxide
    • nButene1,2oxide
    • 1,2 epoxybutane
    • 1,2Butene oxide
    • alphaButylene oxide
    • Butane,2-epoxy-
    • DL1,2Epoxybutane
    • (+)2Ethyloxirane
    • 1,2butylene oxide
    • 1,2Monoepoxybutane
    • EBU
    • 1,2-epoxy butane
    • 1,2-epoxy-butane
    • (2S)-Ethyloxirane
    • Butane, 1,2epoxy
    • MFCD00005153
    • 1,2 butylene oxide
    • 1.2-butylene oxide
    • Ethylene oxide, ethyl
    • racemic 1,2-epoxybutane
    • (R)-1,2-Epoxybutane
    • (+/-)-2-Ethyloxirane
    • 1,2Butene oxide (VAN)
    • 1,2-Epoxybutane, 99%
    • WLN: T3OTJ B2
    • BUTENE 1,2-EPOXIDE
    • (R)-1,2-Epoxybutane;(R)-1,2-Epoxybutane;(R)-Ethyloxirane
    • 1,2-BUTYLENE EPOXIDE
    • 1, 2-BUTYLENE OXIDE
    • 1,2-Epoxybutane, >=99%
    • CHEMBL1378095
    • DTXSID9051452
    • UNII-FR67H53880
    • BUTYLENE OXIDE (STABILIZED)
    • NSC24240
    • Tox21_200207
    • BBL011530
    • STL146646
    • N-BUTENE-1,2-OXIDE [HSDB]
    • AKOS000121478
    • AKOS017278428
    • NCGC00091511-01
    • NCGC00091511-02
    • NCGC00257761-01
    • CAS-106-88-7
    • 1-Butene oxide, purum, >=99.0% (GC)
    • DB-300994
    • B0719
    • NS00007838
    • EN300-21093
    • C19237
    • Q2539029
    • 1,2-Butylene oxide, stabilized [UN3022] [Flammable liquid]
    • 247-545-2

  • Applications

    1,2-Epoxybutane (CAS 106-88-7), also known as butylene oxide, is a reactive epoxide that serves as an industrial chemical intermediate. It is used as a building block for epoxy resin systems and related glycidyl-containing derivatives and as a precursor for polyether polyols used in polyurethane formulations. It can participate in ring-opening polymerization to prepare specialty polymers and is often employed as a reactive processing aid or solvent component in coatings, adhesives, and other formulations where epoxy functionality enables crosslinking and curing. Because of its reactive nature, handling and use are subject to appropriate regulatory controls and formulation-specific safety considerations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 430.59
    methanol 456.5
    isopropanol 227.43
    water 2.21
    ethyl acetate 225.66
    n-propanol 284.05
    acetone 182.71
    n-butanol 253.47
    acetonitrile 383.95
    DMF 142.42
    toluene 86.49
    isobutanol 177.36
    1,4-dioxane 306.66
    methyl acetate 225.38
    THF 336.78
    2-butanone 183.39
    n-pentanol 167.75
    sec-butanol 201.46
    n-hexane 22.94
    ethylene glycol 108.39
    NMP 127.45
    cyclohexane 34.19
    DMSO 227.96
    n-butyl acetate 164.41
    n-octanol 62.01
    chloroform 893.82
    n-propyl acetate 118.78
    acetic acid 524.96
    dichloromethane 710.09
    cyclohexanone 168.92
    propylene glycol 127.39
    isopropyl acetate 116.43
    DMAc 134.02
    2-ethoxyethanol 232.75
    isopentanol 187.47
    n-heptane 21.78
    ethyl formate 155.5
    1,2-dichloroethane 304.32
    n-hexanol 152.68
    2-methoxyethanol 361.83
    isobutyl acetate 72.0
    tetrachloromethane 165.28
    n-pentyl acetate 84.08
    transcutol 688.22
    n-heptanol 70.84
    ethylbenzene 41.45
    MIBK 87.49
    2-propoxyethanol 227.31
    tert-butanol 226.14
    MTBE 148.94
    2-butoxyethanol 146.45
    propionic acid 273.15
    o-xylene 52.15
    formic acid 198.51
    diethyl ether 190.69
    m-xylene 48.84
    p-xylene 58.15
    chlorobenzene 153.64
    dimethyl carbonate 45.87
    n-octane 8.53
    formamide 216.12
    cyclopentanone 194.97
    2-pentanone 137.59
    anisole 105.42
    cyclopentyl methyl ether 123.1
    gamma-butyrolactone 258.08
    1-methoxy-2-propanol 223.0
    pyridine 356.6
    3-pentanone 91.07
    furfural 316.94
    n-dodecane 7.21
    diethylene glycol 210.21
    diisopropyl ether 47.8
    tert-amyl alcohol 183.68
    acetylacetone 151.03
    n-hexadecane 7.77
    acetophenone 90.94
    methyl propionate 125.35
    isopentyl acetate 127.88
    trichloroethylene 590.33
    n-nonanol 56.33
    cyclohexanol 139.44
    benzyl alcohol 122.11
    2-ethylhexanol 91.23
    isooctanol 60.95
    dipropyl ether 91.32
    1,2-dichlorobenzene 128.82
    ethyl lactate 62.17
    propylene carbonate 160.89
    n-methylformamide 155.97
    2-pentanol 139.8
    n-pentane 28.72
    1-propoxy-2-propanol 162.99
    1-methoxy-2-propyl acetate 132.54
    2-(2-methoxypropoxy) propanol 123.89
    mesitylene 32.1
    ε-caprolactone 190.93
    p-cymene 37.52
    epichlorohydrin 351.83
    1,1,1-trichloroethane 338.89
    2-aminoethanol 208.31
    morpholine-4-carbaldehyde 204.21
    sulfolane 191.51
    2,2,4-trimethylpentane 16.26
    2-methyltetrahydrofuran 247.25
    n-hexyl acetate 99.47
    isooctane 12.03
    2-(2-butoxyethoxy)ethanol 192.89
    sec-butyl acetate 77.39
    tert-butyl acetate 101.14
    decalin 15.09
    glycerin 157.35
    diglyme 324.5
    acrylic acid 251.73
    isopropyl myristate 41.3
    n-butyric acid 321.8
    acetyl acetate 151.2
    di(2-ethylhexyl) phthalate 48.21
    ethyl propionate 91.44
    nitromethane 410.97
    1,2-diethoxyethane 205.11
    benzonitrile 178.72
    trioctyl phosphate 30.48
    1-bromopropane 196.33
    gamma-valerolactone 264.76
    n-decanol 41.87
    triethyl phosphate 49.71
    4-methyl-2-pentanol 84.17
    propionitrile 240.52
    vinylene carbonate 170.89
    1,1,2-trichlorotrifluoroethane 312.76
    DMS 85.64
    cumene 31.65
    2-octanol 43.04
    2-hexanone 102.17
    octyl acetate 51.44
    limonene 52.34
    1,2-dimethoxyethane 250.27
    ethyl orthosilicate 51.55
    tributyl phosphate 41.98
    diacetone alcohol 126.0
    N,N-dimethylaniline 58.11
    acrylonitrile 286.64
    aniline 154.22
    1,3-propanediol 252.39
    bromobenzene 146.09
    dibromomethane 460.67
    1,1,2,2-tetrachloroethane 403.52
    2-methyl-cyclohexyl acetate 76.55
    tetrabutyl urea 43.25
    diisobutyl methanol 54.68
    2-phenylethanol 123.54
    styrene 61.86
    dioctyl adipate 64.65
    dimethyl sulfate 58.54
    ethyl butyrate 117.38
    methyl lactate 79.51
    butyl lactate 72.45
    diethyl carbonate 84.76
    propanediol butyl ether 119.95
    triethyl orthoformate 82.44
    p-tert-butyltoluene 34.88
    methyl 4-tert-butylbenzoate 78.62
    morpholine 352.58
    tert-butylamine 158.17
    n-dodecanol 32.54
    dimethoxymethane 113.03
    ethylene carbonate 129.89
    cyrene 82.19
    2-ethoxyethyl acetate 135.2
    2-ethylhexyl acetate 97.32
    1,2,4-trichlorobenzene 155.72
    4-methylpyridine 223.13
    dibutyl ether 80.37
    2,6-dimethyl-4-heptanol 54.68
    DEF 128.95
    dimethyl isosorbide 155.46
    tetrachloroethylene 315.59
    eugenol 89.9
    triacetin 111.7
    span 80 114.65
    1,4-butanediol 97.74
    1,1-dichloroethane 350.73
    2-methyl-1-pentanol 138.12
    methyl formate 99.56
    2-methyl-1-butanol 177.72
    n-decane 11.92
    butyronitrile 253.05
    3,7-dimethyl-1-octanol 72.1
    1-chlorooctane 40.78
    1-chlorotetradecane 17.32
    n-nonane 11.67
    undecane 8.89
    tert-butylcyclohexane 15.23
    cyclooctane 11.08
    cyclopentanol 153.55
    tetrahydropyran 242.9
    tert-amyl methyl ether 101.69
    2,5,8-trioxanonane 208.24
    1-hexene 76.76
    2-isopropoxyethanol 153.51
    2,2,2-trifluoroethanol 151.92
    methyl butyrate 123.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction