1,2-Distearoyl-sn-glycero-3-phosphocholine

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  • Identifiers

    CAS number
    816-94-4

    Molecular formula
    C44H88NO8P

    SMILES
    CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC

    Safety labels

  • Odor profile

    Fragrance
    Waxy 62.34%
    Fatty 47.29%
    Odorless 41.0%
    Oily 37.73%
    Alcoholic 20.96%
    Sweet 19.72%
    Creamy 19.37%
    Milky 18.36%
    Balsamic 18.24%
    Woody 16.86%

     

    Flavor
    Bland 44.29%
    Mild 39.82%
    Waxy 33.13%
    Odorless 32.23%
    Fatty 31.65%
    Faint 29.85%
    Oily 29.82%
    Slightly waxy 23.09%
    Bay oil 22.1%
    Beer 21.69%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    15.6

    pKa est.
    8.14 (weak base)

    Molecular weight
    790.1 g/mol

    Flash point

    • 87.96 ˚C est.

  • Synonyms

    • 816-94-4
    • 1,2-Distearoyl-sn-glycero-3-phosphocholine
    • DSPC
    • Distearoyl phosphatidylcholine
    • PC(18:0/18:0)
    • 1,2-Distearoyl-sn-3-phosphacholine
    • 043IPI2M0K
    • L-DISTEAROYLLECITHIN
    • NSC-725285
    • CHEBI:83718
    • DTXSID20231218
    • distearoyl-sn-glycero-3-phosphocholine
    • 1,2-DISTEARIN SN-3-PHOSPHORYLCHOLINE
    • L-DSPC
    • RefChem:906756
    • DSPC R-
    • 1,2-distearoyllecithin, (R)-
    • DTXCID20153709
    • 212-440-2
    • PC(36:0)
    • (R)-2,3-Bis(stearoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
    • 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine
    • MFCD00036905
    • DSPC (Excipient)
    • C44H88NO8P
    • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
    • Di-stearoyl-phosphatidylcholine
    • 1,2-distearoyl-sn-glycero-3-phosphorylcholine
    • Phosphatidylcholine(18:0/18:0)
    • GPCho(18:0/18:0)
    • L-alpha-Phosphatidyl choline, distearoyl
    • (2R)-2,3-bis(octadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
    • 1,2-DSPC
    • UNII-043IPI2M0K
    • (R)-2,3-Bis(stearoyloxy)propyl [2-(Trimethylammonio)ethyl] Phosphate
    • EINECS 212-440-2
    • L-beta,gamma,Disteroyl-alpha-lecithin
    • 1,2-Distearoyl-sn-glycerophosphocholine
    • DSPC R-ISOMER
    • Distearoyl-L-|A-Lecithin
    • SCHEMBL24563
    • Phosphatidylcholine Hydrogenated
    • orb1298055
    • DSPC;L-,-Distearoyl--lecithin
    • 1,2-DSPC?
    • 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE (DSPC)
    • 18:0 PC (DSPC)
    • HY-W040193A
    • Distearoyl Phosphatidylcholine(DSPC)
    • LMGP01010006
    • MSK001064
    • NSC725285
    • DISTEAROYL-L-.ALPHA.-LECITHIN
    • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylammonio)ethyl phosphate
    • AKOS016012934
    • DISTEAROYL GLYCEROPHOSPHOCHOLINE
    • CS-W020933
    • GS-6169
    • HY-W040193
    • NSC 725285
    • (R)-(7-Lauroyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacosyl)trimethylammonium 4-oxide
    • 4-Hydroxy-N,N,N-trimethyl-10-oxo-7-((1-oxooctadecyl)oxy)-3,5,9-trioxa-4-phosphaheptacosan-1-aminium hydroxide, inner salt, 4-oxide, (R)-
    • BP-25623
    • SY057807
    • GPC(18:0/18:0)
    • CS-1096704
    • D3926
    • PC (18:0)2
    • PC 18:0/18:0
    • 1,2-Distearoyl-sn-Glycero-3-Phosphatidylcholine
    • PC(18_0/18_0)
    • F793317
    • 1,2-DIASTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE
    • 1,2-Distearoyl-sn-glycero-3-phosphocholine, >=99%
    • Q27157143
    • 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE [II]
    • 1,2-Distearoyl-sn-glycero-3-phosphocholine, >=99% (TLC)
    • (2R)-2,3-bis(octadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
    • 18:0 PC (DSPC), 1,2-distearoyl-sn-glycero-3-phosphocholine, powder
    • (2-{[(2R)-2,3-bis(octadecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium
    • 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-10-oxo-7-((1-oxooctadecyl)oxy)-, hydroxide, inner salt, 4-oxide, (R)-
    • 3,5,9-TRIOXA-4-PHOSPHAHEPTACOSAN-1-AMINIUM, 4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-7-((1-OXOOCTADECYL)OXY)-, INNER SALT, 4-OXIDE, (7R)-
    • 816-94-4

  • Applications

    1,2-Distearoyl-sn-glycero-3-phosphocholine (CAS 816-94-4) is a phospholipid commonly used as a pharmaceutical excipient and lipid carrier; in liposome and lipid nanoparticle formulations, DSPC acts as a structural lipid that helps encapsulate and stabilize active ingredients for drug delivery and vaccines. It is also employed in research as a model membrane component to study bilayer properties and protein interactions. In cosmetics and personal care, DSPC serves as a biocompatible emulsifier and conditioning lipid that aids in stabilizing oil-in-water formulations and provides desirable skin feel. In industrial and household formulations, it can function as a surfactant and emulsifier to improve dispersion of actives and the stability of emulsions. In coatings and inks, DSPC may be used as a surface-active additive to tune compatibility with lipophilic components.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 11.07
    methanol 24.32
    isopropanol 8.92
    water 5.84
    ethyl acetate 38.74
    n-propanol 13.74
    acetone 45.04
    n-butanol 8.82
    acetonitrile 21.92
    DMF 142.69
    toluene 14.32
    isobutanol 10.08
    1,4-dioxane 30.5
    methyl acetate 47.09
    THF 65.64
    2-butanone 41.78
    n-pentanol 9.53
    sec-butanol 12.07
    n-hexane 1.19
    ethylene glycol 8.02
    NMP 351.41
    cyclohexane 2.14
    DMSO 111.46
    n-butyl acetate 23.3
    n-octanol 9.92
    chloroform 151.52
    n-propyl acetate 31.03
    acetic acid 116.88
    dichloromethane 138.13
    cyclohexanone 70.76
    propylene glycol 13.7
    isopropyl acetate 29.37
    DMAc 269.94
    2-ethoxyethanol 36.08
    isopentanol 7.55
    n-heptane 1.27
    ethyl formate 33.93
    1,2-dichloroethane 61.74
    n-hexanol 6.52
    2-methoxyethanol 41.06
    isobutyl acetate 17.98
    tetrachloromethane 30.16
    n-pentyl acetate 41.93
    transcutol 109.16
    n-heptanol 10.47
    ethylbenzene 8.91
    MIBK 18.28
    2-propoxyethanol 30.43
    tert-butanol 11.52
    MTBE 11.83
    2-butoxyethanol 40.04
    propionic acid 58.98
    o-xylene 17.21
    formic acid 74.72
    diethyl ether 10.24
    m-xylene 12.93
    p-xylene 13.18
    chlorobenzene 26.97
    dimethyl carbonate 58.6
    n-octane 0.99
    formamide 94.67
    cyclopentanone 111.87
    2-pentanone 29.48
    anisole 19.08
    cyclopentyl methyl ether 34.54
    gamma-butyrolactone 187.82
    1-methoxy-2-propanol 37.52
    pyridine 45.82
    3-pentanone 35.84
    furfural 149.98
    n-dodecane 0.69
    diethylene glycol 23.14
    diisopropyl ether 4.84
    tert-amyl alcohol 15.34
    acetylacetone 71.84
    n-hexadecane 0.76
    acetophenone 43.05
    methyl propionate 54.42
    isopentyl acetate 20.8
    trichloroethylene 185.46
    n-nonanol 9.94
    cyclohexanol 15.74
    benzyl alcohol 21.75
    2-ethylhexanol 5.84
    isooctanol 9.28
    dipropyl ether 9.92
    1,2-dichlorobenzene 42.56
    ethyl lactate 35.62
    propylene carbonate 110.73
    n-methylformamide 75.73
    2-pentanol 7.21
    n-pentane 1.0
    1-propoxy-2-propanol 27.21
    1-methoxy-2-propyl acetate 41.44
    2-(2-methoxypropoxy) propanol 39.53
    mesitylene 8.55
    ε-caprolactone 91.6
    p-cymene 7.7
    epichlorohydrin 105.01
    1,1,1-trichloroethane 83.18
    2-aminoethanol 17.24
    morpholine-4-carbaldehyde 146.66
    sulfolane 318.24
    2,2,4-trimethylpentane 1.25
    2-methyltetrahydrofuran 38.14
    n-hexyl acetate 34.4
    isooctane 0.54
    2-(2-butoxyethoxy)ethanol 42.24
    sec-butyl acetate 21.39
    tert-butyl acetate 34.64
    decalin 1.82
    glycerin 30.89
    diglyme 93.15
    acrylic acid 75.08
    isopropyl myristate 9.95
    n-butyric acid 51.87
    acetyl acetate 57.07
    di(2-ethylhexyl) phthalate 19.68
    ethyl propionate 32.8
    nitromethane 194.32
    1,2-diethoxyethane 25.49
    benzonitrile 24.17
    trioctyl phosphate 12.73
    1-bromopropane 18.84
    gamma-valerolactone 159.22
    n-decanol 6.28
    triethyl phosphate 26.48
    4-methyl-2-pentanol 4.89
    propionitrile 17.45
    vinylene carbonate 112.62
    1,1,2-trichlorotrifluoroethane 183.69
    DMS 56.15
    cumene 7.15
    2-octanol 8.29
    2-hexanone 22.79
    octyl acetate 15.83
    limonene 10.04
    1,2-dimethoxyethane 41.0
    ethyl orthosilicate 22.06
    tributyl phosphate 17.04
    diacetone alcohol 40.77
    N,N-dimethylaniline 21.23
    acrylonitrile 31.52
    aniline 21.25
    1,3-propanediol 16.07
    bromobenzene 30.55
    dibromomethane 66.92
    1,1,2,2-tetrachloroethane 156.26
    2-methyl-cyclohexyl acetate 26.3
    tetrabutyl urea 25.43
    diisobutyl methanol 4.23
    2-phenylethanol 15.83
    styrene 10.41
    dioctyl adipate 23.27
    dimethyl sulfate 159.7
    ethyl butyrate 24.68
    methyl lactate 55.7
    butyl lactate 52.35
    diethyl carbonate 22.67
    propanediol butyl ether 38.62
    triethyl orthoformate 24.83
    p-tert-butyltoluene 7.8
    methyl 4-tert-butylbenzoate 63.05
    morpholine 39.74
    tert-butylamine 5.93
    n-dodecanol 4.18
    dimethoxymethane 58.23
    ethylene carbonate 78.46
    cyrene 67.69
    2-ethoxyethyl acetate 67.18
    2-ethylhexyl acetate 18.22
    1,2,4-trichlorobenzene 66.9
    4-methylpyridine 41.51
    dibutyl ether 9.26
    2,6-dimethyl-4-heptanol 4.23
    DEF 62.46
    dimethyl isosorbide 82.75
    tetrachloroethylene 104.72
    eugenol 53.22
    triacetin 98.15
    span 80 36.54
    1,4-butanediol 11.55
    1,1-dichloroethane 52.18
    2-methyl-1-pentanol 8.98
    methyl formate 70.82
    2-methyl-1-butanol 10.15
    n-decane 1.36
    butyronitrile 11.73
    3,7-dimethyl-1-octanol 8.19
    1-chlorooctane 6.91
    1-chlorotetradecane 2.31
    n-nonane 1.22
    undecane 0.91
    tert-butylcyclohexane 1.42
    cyclooctane 1.13
    cyclopentanol 24.87
    tetrahydropyran 21.89
    tert-amyl methyl ether 15.38
    2,5,8-trioxanonane 58.56
    1-hexene 3.61
    2-isopropoxyethanol 24.82
    2,2,2-trifluoroethanol 108.31
    methyl butyrate 41.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction